Computerization of education process is a contemporary trend that is emerging at the global scale, but with substantial regional disparities in the level of its implementation. The present study is aimed at revealing the current situation regarding computer technology use in geographical education in primary and secondary education in Bosnia and Herzegovina through a survey conducted among geography teachers from two typical regions – Canton of Sarajevo with predominantly urban features and Central Bosnia region, where majority of population lives in rural areas. The obtained results suggest that general situation with regard to the level of computer skills identified among geography teachers is satisfying, but that there are still certain disparities across different categories of respondents. It turns out that younger teachers, as well as those from urban region possess a higher level of IT skills and use this technology more frequently for the preparation and implementation of teaching process. At the same time, significant differences regarding the respondents gender have not been found, except in the context of extracurricular activities.

The novel coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is still progressing and has been recorded in more than 210 countries and territories worldwide. In Bosnia and Herzegovina, the first cases of COVID-19 were detected on March 5, 2020 in the entity of the Republic of Srpska and on March 9, 2020 in the entity of the Federation of Bosnia and Herzegovina. By May 16, 2020, more than 2,200 COVID-19 cases had been recorded in both entities, with a mortality rate of 5.8% (131 of 2,231 cases). The aim of this ongoing study is to present the current epidemiological and sociodemographic parameters of 380 COVID-19 patients diagnosed at the University Clinical Hospital Mostar (UCH Mostar) during the first two months of the COVID-19 pandemic. Of those 380 patients, 60 (15.8%) required hospitalization. The mortality rate was 5% (19/380). The highest mortality rate (15.2%, 12/79) was recorded in the patients aged ≥65 years. In addition to this single-center experience of the ongoing COVID-19 pandemic, we discuss the epidemiological measures imposed in Bosnia and Herzegovina, with an emphasis on the restrictive measures. The COVID-19 pandemic is still ongoing in Bosnia and Herzegovina.

This case trial reports the effects of L-carnosine supplementation on neuromuscular performance, brain metabolism, and various patient- and clinician-reported outcomes in a case series of patients with multiple sclerosis (MS). Two women (aged 37 and 48) and a man (age 48 years) who fulfilled the 2017 McDonald criteria for MS diagnosis, and were free of other major chronic diseases or acute disorders were recruited for this case study. The duration of illness was 4 years in CASE 1 (37-year old women), 5 years in CASE 2 (48-year old men), and 15 years in CASE 3 (48-year old women). L-carnosine (2 g/day) was administered orally during 8 weeks in all MS patients. The trial was registered at ClinicalTrials.gov (ID NCT03995810). The intensity of symptoms and signs of MS after L-carnosine administration diminished in 5 out of 7 domains in CASE 1, in 3 out of 7 domains in CASE 2, and one domain in CASE 3; general fatigue has been reduced in all three cases at the follow-up. The Visual Analog Scale scores for numbness, weakness, pain, and depression decreased in all MS patients at post-administration. This was accompanied by an improved walking distance to exhaustion in all patients, with values improved for 51.1% in CASE 1, 19.5% in CASE 2, and 2.1% in CASE 3 at 8-week follow-up. An increase in serum total antioxidant capacity was found at 8-week follow-up in all patients (from 4.6 to 49.6%); this was accompanied by lower blood lactates at follow-up in all cases (23.5% on average). Single-voxel 1.5 T MRS revealed an increased brain choline-contained compounds (18.9% on average), total creatine (21.2%), and myo-inositol levels (12.3%) in girus cinguli at 8-week follow; this was accompanied by a drop in brain glutamate for 22.6% on average. This case report suggests the favorable effects of medium-term L-carnosine as a possible adjuvant treatment to improve selected patient- and clinician-reported outcomes in a man and two women suffering from MS. There is a need for larger and more rigorous human intervention studies to corroborate these preliminary findings. This study was funded by the Serbian Ministry of Education, Science and Technological Development (#175,037); the Provincial Secretariat for Higher Education and Scientific Research (#114–451-710); the Faculty of Sport and Physical Education, Novi Sad; and CarnoMed LLC, Novi Sad.

Abstract Xanthene derivatives have become a group of molecules of great importance in discovering of new anticancer drugs. Recent studies of our group performed on xanthen-3-one and xanthen-1,8-dione derivatives have shown their antiproliferative activity on HeLa cervical cell lines. Obtained IC50 values together with calculated molecular descriptors were subjected to Quantitative Structure–Activity Relationship (QSAR) study in order to identify the most relevant molecular features responsible for the observed antiproliferative activity of compounds. Partial least square statistical method and the same training and test set were used to obtain statistical parameters for internal and external validation in 2D- and 3D-QSAR study. The obtained QSAR models have shown next results: 2D-QSAR: R 2 = 0.741, Q 2 = 0.792, R 2 pred = 0.875 and 3D-QSAR: R 2 = 0.951, Q 2 = 0.830, R 2 pred = 0.769. Based on the performed QSAR analysis and calculated ADMET properties, novel xanthene derivatives with enhanced antiproliferative activity were designed. Communicated by Ramaswamy H. Sarma

This study strives to explore the nexus between entrepreneurial orientation (EO), total quality management (TQM), competitive intensity (CI) and firm performance in the context of an emerging laggard economy in the South-Eastern European region. Moreover, the present study aims to examine the effect of each dimension of EO (innovativeness, proactiveness, and risk-taking) on the TQM and firm performance. The proposed conceptual model and research hypotheses were tested through structural equation modelling (SEM). Our results show that TQM partially mediates the relationship between EO and firm performance and that as the intensity of competition increases, the direct effect of EO on firm performance becomes stronger. Thus, this study contributes to the EO and TQM literature by arguing that EO as a strategic orientation is positively related to firm performance outcomes through the mechanism of TQM practices. Moreover, this study adds to the current literature by revealing that the effectiveness of the synergetic effect of EO and TQM of firm performance outcomes is contingent on the market environment conditions (i.e. competitive intensity). Regarding the relative importance of EO dimensions, findings indicate that innovativeness and proactiveness are vital pillars of organisational processes aimed at developing TQM practices to enhance firm performance outcomes.

Abstinence is a conscious and voluntary waiver of one original political right, the right to vote. Often, the very act of abstinence is understood as a kind of election, as an expression of disagreement with political alternatives, candidates and parties participating in the elections. Abstinence is close to the notion of apolitical, that is the disinterest and indifference of citizens, of individuals and groups to politics and participation in the political life of the community. The paper analyzes the difference between abstinence in elections and apoliticality and attempts to point to the problem of increasing abstinence from voting in general elections in post-Dayton Bosnia and Herzegovina.

The purpose of this recommendation of the Oncology Task Force of the European Society of Paediatric Radiology (ESPR) is to indicate reasonable applications of whole-body MRI in children with cancer and to address useful protocols to optimize workflow and diagnostic performance. Whole-body MRI as a radiation-free modality has been increasingly performed over the last two decades, and newer applications, as in screening of children with germ-line mutation cancer-related gene defects, are now widely accepted. We aim to provide a comprehensive outline of the diagnostic value for use in daily practice. Based on the results of our task force session in 2018 and the revision in 2019 during the ESPR meeting, we summarized our group’s experiences in whole-body MRI. The lack of large evidence by clinical studies is challenging when focusing on a balanced view regarding the impact of whole-body MRI in pediatric oncology. Therefore, the final version of this recommendation was supported by the members of Oncology Task Force.

Conference Report: Izvještaj sa Međunarodne naučne konferencije „Migracije i njihov uticaj na društvena i privredna kretanja na širem području Brčkog od početka XVII do kraja XX stoljeća, Brčko, 13. i 14. septembar 2019.

In this paper, the author emphasizes the specific case of the Bosnian-Herzegovinian intraparty dispute in the context of the reconstruction of the republican leaderships in Yugoslavia, the change of “Croatian Spring participants” and “liberals” as well as the so-called “senior cadres” at the beginning of 1970s. Pasaga Mandzic's years-long dispute with the current political leadership in Tuzla and also in the Republic will touch upon various issues, from plans and results of economic and urban development, integration of enterprises, organization and activities of political and party leadership to establishing the "historical truth" about the events throughout the war years 1941 and 1942. Considering the current socio-political discourse, Mandzic will come out very boldly, demanding that it is finally time to "speak openly" about the actual war events, the consequences of Partisan-Chetnik cooperation at the end of 1941, the dominance of the Serb element in the communist leadership and its attitude towards the Bosniaks during the war, but also in the post-war period. The insistence on establishing the "real truth" entailed a revision of the existing image of a "glorious war past", which also raised the question of consistent application of the principles of brotherhood and unity. Ultimately, years of clarification resulted in the political elimination and moral discredit of Pasaga Mandzic.

Abstract Biodiesel fuels are alternatives to petrodiesel, especially in the transport sector where they have lower carbon footprint. Notwithstanding the environmental benefit, biodiesel fuels may have other toxicological properties than petrodiesel. Particulate matter (PM) from petrodiesel causes cancer in the lung as a consequence of delivery of genotoxic polycyclic aromatic hydrocarbons, oxidative stress and inflammation. We have reviewed articles from 2002 to 2019 (50% of the articles since 2015) that have described toxicological effects in terms of genotoxicity, oxidative stress and inflammation of biodiesel exhaust exposure in humans, animals and cell cultures. The studies have assessed first generation biodiesel from different feedstock (e.g. rapeseed and soy), certain second generation fuels (e.g. waste oil), and hydrogenated vegetable oil. It is not possible to rank the potency of toxicological effects of specific biodiesel fuels. However, exposure to biodiesel exhaust causes oxidative stress, inflammation and genotoxicity in cell cultures. Three studies in animals have not indicated genotoxicity in lung tissue. The database on oxidative stress and inflammation in animal studies is larger (13 studies); ten studies have reported increased levels of oxidative stress biomarkers or inflammation, although the effects have been modest in most studies. The cell culture and animal studies have not consistently shown a different potency in effect between biodiesel and petrodiesel exhausts. Both increased and decreased potency have been reported, which might be due to differences in feedstock or combustion conditions. In conclusion, combustion products from biodiesel and petrodiesel fuel may evoke similar toxicological effects on genotoxicity, oxidative stress and inflammation.

In this paper, we present a 5G trace dataset collected from a major Irish mobile operator. The dataset is generated from two mobility patterns (static and car), and across two application patterns (video streaming and file download). The dataset is composed of client-side cellular key performance indicators (KPIs) comprised of channel-related metrics, context-related metrics, cell-related metrics and throughput information. These metrics are generated from a well-known non-rooted Android network monitoring application, G-NetTrack Pro. To the best of our knowledge, this is the first publicly available dataset that contains throughput, channel and context information for 5G networks. To supplement our real-time 5G production network dataset, we also provide a 5G large scale multi-cell ns-3 simulation framework. The availability of the 5G/mmwave module for the ns-3 mmwave network simulator provides an opportunity to improve our understanding of the dynamic reasoning for adaptive clients in 5G multi-cell wireless scenarios. The purpose of our framework is to provide additional information (such as competing metrics for users connected to the same cell), thus providing otherwise unavailable information about the base station (eNodeB or eNB) environment and scheduling principle, to end user. Our framework permits other researchers to investigate this interaction through the generation of their own synthetic datasets.