A voltage-controlled pulsed current source (VCPCS) capable of generating current pulses with four different waveforms in the time domain is presented in this article. These waveforms are the following: hyperbolic waveform in time domain (HWTD), squared HWTD (SHWTD), quasi-Dirac delta function (QDDF) based on HWTD, and QDDF based on SHWTD. The QDDF is treated as a generalized function (GF) whose limit value leads to the required shape. The controllability of the shapes and frequency of the current pulses is provided by adjustment of the parameters of saw-tooth and triangle control voltages. The design of the proposed VCPCS can be implemented in a standard CMOS technology. However, it has been prototyped here first using discrete off-the-shelf components mounted on a printed circuit board with a single supply voltage of 3.3 V. Measured results confirm the predictions of the analysis performed. Specifically, the measured ratio of the largest and the smallest HWTD current is 7.6 times larger than that in the state-of-the-art, for the same supply voltage, which is of particular importance in optical quantum random number generators (OQRNGs).

Food sovereignty is the human right to healthy and culturally appropriate food produced through ecologically sound and sustainable methods, and the right of people to define their own food and agriculture systems. Food security exists when all people, at all times, have physical and economic access to sufficient, safe, and nutritious food that meets their dietary needs and food preferences for an active and healthy life. In contrast to food security, which focuses on ensuring that enough food is available, food sovereignty emphasizes control over food production and distribution by local communities. Shifting the focus from food security to food sovereignty essentially represents a reconnection between nature, food, and people. The right to seeds is at the basis of each community’s food sovereignty, what is possible to achieve only in the system of farmers’ seeds. Farmer seed systems are a critical contribution to food sovereignty and farmers’ rights. For over 10.000 years, people have freely saved, selected, exchanged, and sold seeds, using and reusing them for sowing and food production. The farmers’ seed system is defined by the long-standing continuous renewal and free distribution of seeds and knowledge among people. Seeds are gifted, shared, or traded in informal and formal markets. These seeds are more resilient to climate change, pests, and pathogens, and they also ensure a more diverse food system and a dynamic global ecosystem. Today, farmers’ rights to seeds, crucial for their survival, are seriously threatened and are in decline worldwide. These seed systems are undermined by inadequate legislation and insufficient support from governments and public research, primarily as the result of a protected seed market based fundamentally on intellectual property rights and trade agreements. Farmers’ seed systems are vital for preservation of plant genetic diversity of all agricultural crops. It is increasingly expected that global climate change, combined with other factors, will significantly alter this agricultural biodiversity. Broad efforts will be needed to help reduce the climate vulnerability of current agricultural production systems and building more resilient and adaptive agroecosystems. The farmers’ seed system and the associated traditional agricultural practices are key factors for adaptation.

The paper is concerned with hexacyclic systems (Fn) and their M¨obius counterparts (Mn). Continuing the studies in MATCH Commun. Math. Comput. Chem. 94 (2025) 477, the characteristic polynomial and the eigenvalues of the Sombor matrix of Fn and Mn, and the respective Sombor energies are determined. Upper and lower bounds for the Sombor energy in terms of the number of hexagons are also obtained.

The hexacyclic system graph Fn is the graph derived from a linear hexagonal chain Ln with n > 1 hexagons by identifying two pairs of ends of Ln. The M¨obious hexacyclic system graph Mn is the graph derived from a linear hexagonal chain Ln with n > 1 hexagons by identifying two pairs of ends of Ln with a twist. In this paper, we compute, in a closed form, the resolvent energy, the Laplacian and the signless Laplacian resolvent energy, as well as the resolvent Estrada index and the resolvent signless Estrada index of Fn and Mn. All five indices are expressed as a rational function in the number n of hexagons, defined in terms of Chebyshev polynomials of the first and the second kind. Those expressions allow for a fast numerical computation of indices and for deducing sharp bounds on their growth.

Background: The etiology of oral ulceration is multicausal with numerous predisposing factors. Studies by various authors cite Helicobacter pylori infection as a possible cause of certain oral ulcerations. Objective: The aim of the study is to prove the presence of Helicobacter pylori in the oral cavity of patients with oral ulcerations, as well as to examine the relationship between the presence of Helicobacter pylori in the oral cavity and the development of oral ulcerations. Methods: The study included regular patients at the Department and Clinic of Oral Medicine and Periodontology, Faculty of Dental Medicine, University of Sarajevo, suffering from oral ulcerations, as well as healthy patients without oral diseases. The diagnosis of oral ulceration is based on a thorough history, clinical examination, and exclusion of other oral diseases. All patients were taken anamnestic data on the existence of digestive system diseases, and by reviewing medical documentation, a previously diagnosed digestive system disease by a gastroenterologist was recorded. A cytological smear was taken in all 80 cases, in patients with ulcerative lesions a smear was taken from the lesion and in healthy subjects from the mucous membrane of the palate, cheek and tongue. Highly sensitive and specific polymerase chain reaction (PCR) was used to determine the presence of Helicobacter pylori in the oral cavity and oral lesions. Results: The results of our study showed that there is no statistically significant difference between the presence of Helicobacter pylori in the oral cavity of patients with oral ulcerations and subjects with healthy mucosa. Conclusion: Helicobacter pylori is not a risk factor for the development of oral ulcerations and can be found on the oral mucosa as a transient pathogen.

Background: Normal sleep duration is crucial for maintaining brain homeostasis. Sleep disorders in Parkinson's disease are numerous, multifactorial, and result in significant morbidity. Objective: The aim of the study was to investigate the association between gender and the duration of therapy on sleep quality in patients with Parkinson's disease. Methods: The study is prospective, and includes 40 consecutively hospitalized patients with verified Parkinson's disease. The study included subjects of both genders and all age groups. To analyze the data on the subjects, we used: medical histories, nursing documentation of patients, a questionnaire with sociodemographic data, and the Parkinson's Disease Sleep Assessment Scale. We divided all subjects into two groups: subjects who have been using therapy for up to 5 years and those who have been using therapy for more than 5 years. Results: Among subjects who have been taking medication for less than 5 years, 33.3% were female and 66.6% were male. Of the total number of respondents who have been taking therapy for more than 5 years, 36.3% are female and 63.6% are male. The duration of the therapy has a statistically significant effect on the quality of sleep in patients with Parkinson's disease (p < 0.05). The subject's gender does not have a significant independent influence on the quality of sleep in patients with Parkinson's disease (p > 0.05). The interaction of gender and length of therapy use has no significant separate effect on the quality of sleep in Parkinson's disease patients (p > 0.05). The quality of sleep is better in male and female subjects who take the therapy until the age of 5. Conclusion: The duration of therapy use has a significant impact on the quality of sleep in Parkinson's disease patients. The gender of the subject has no significant independent influence on the quality of sleep in patients with Parkinson's disease.

Background: Peripheral arterial disease (PAD) is a chronic condition of reduced blood flow through the arteries. Early detection and prevention of PAD, especially in at-risk populations, is crucial to reducing morbidity and mortality. Objective: The aim of the study was to examine the clinical feasibility of vascular ultrasound screening for early detection of PAD, as well as potential financial savings through preventive measures. Methods: The study was conducted as a prospectively designed cross-sectional study with retrospective sample analysis, in which the sample consisted of 826 patients over 60 years of age, of both sexes, divided into two groups, conducted from January 2023 to May 2024. Results: The study included 826 patients aged 60 and over, divided into two groups after ultrasound examination of the arteries (Group A with atherosclerosis /63.8%/; Group B - without atherosclerosis /36.2%/). The average age was 65.44±5.9 years, 60-65 years was 64.3%, and over 65 years was 35.7%. A statistically significant difference was recorded between the analyzed groups in terms of comorbidities and risk factors. We found that age, gender, hypertension, hyperlipidemia, diabetes, smoking and chronic obstructive disease have a significant relationship with the degree of atherosclerosis. Multivariate analysis showed that the age of the subjects, hyperlipidemia, hypertension and smoking are significant predictors of atherosclerosis. The prevalence for hemodynamically significant stenosis of ACI/ACC was 5.0%, for peripheral arteries 4.2%, the prevalence of aneurysm abdominal aorta (>3 cm) was 2.3%, and 0.5% for diameter >5 cm. Conclusion: The results show the high efficiency of ultrasound diagnostics in identifying asymptomatic patients with advanced atherosclerosis, emphasizing the need for better organization of preventive programs, which could lead to potential savings in healthcare costs through earlier detection and treatment.

Background/Aim: The aim of this study was to conduct a comparative analysis of the oral health promotion programmes in the Balkan countries, to compare key measures and activities in the implementation of the programme, and to analyse the results achieved after the implementation of the programme. Material and Methods: Data were obtained through an electronic search of publicly available documents published in the field of dental healthcare in the Balkan countries. The search terms were: "national programme", "strategy", "action plan", "project", and "oral health". The search was conducted in English and in the native languages of the Balkan Peninsula countries. A comparative analysis of valid documents and those whose validity period has expired was carried out. Results: This study illuminates the information on preventive programmes for each country and discusses the challenges faced in the Balkans region. While countries in the Balkan Peninsula have made progress in improving the oral health of their inhabitants, the absence of national oral health promotion programmes is striking. Greater involvement of the community in activities to maintain and improve oral health is needed, as is more comprehensive dental care for vulnerable populations. Conclusions: The findings of this study may be employed to enhance oral health in the delineated regions, and to confer benefits upon the population of the region and beyond. The findings from this analysis provide valuable insights for policymakers and public health professionals aiming to strengthen oral health initiatives and ensure more equitable access to dental care across the Balkan Peninsula. This paper (Part II) describes specifics of oral health promotion programmes, dental health care, and key epidemiological indicators in each Balkan country.

Background: The prevalence of obesity and obesity-related clinical conditions, including metabolic-associated steatotic liver disease (MASLD), sarcopenia, and a wide spectrum of pathological manifestations, is rising globally. According to WHO, BMI is the only anthropometric measure currently used to classify obesity, overweight, and underweight. However, emerging research suggests that obesity is a complex pathological state influenced by multiple etiological factors. Given the limitations of BMI, there is a growing need for a more comprehensive assessment of body composition, particularly fat mass quantity and distribution. Bioelectrical impedance analysis (BIA) provides valuable anthropometric data that can help differentiate obesity phenotypes and guide improved therapeutic approaches. Objective: This study aims to analyze body composition using BIA in a randomly selected sample of adults from primary healthcare settings in Bosnia and Herzegovina. The primary goal is to assess total body weight, fat mass quantity, fat distribution, and obesity types prevalent in this population. Additionally, the study seeks to establish reference values for further diagnostic, preventive, and therapeutic strategies to improve public health outcomes. Methods: A cross-sectional study was conducted on adults (≥18 years) in Gračanica, Bosnia & Herzegovina (B6H), from January 2021 to January 2025. Inclusion criteria required participants to provide signed informed consent, while exclusion criteria included acute systemic diseases, severe dehydration, and fasting for more than 24 hours. Anthropometric parameters measured included age, height, weight, BMI, body fat mass (BFM), fat-free mass (FFM), percent body fat (PBF), waist-hip ratio (WHR), and bone mineral content (BMC). Data were analyzed using SPSS (version 18), with results presented as medians, interquartile ranges, and percentiles (5th, 25th, 50th, 75th, and 95th). Results: A total of 4,628 adults participated in the study, of whom 2,824 (61.0%) were female and 1,804 (39.0%) were male. The median age was 45 years (IQR: 29 years). The findings revealed that over one-quarter of the B&H population is obese, with abdominal obesity being the predominant type. This phenotype is associated with the highest risk for metabolic syndrome and MASLD. Conclusion: Our study highlights a high prevalence of obesity among the examined individuals in primary care settings in B&H, with abdominal obesity being the most common type. This phenotype is strongly associated with metabolic complications. BIA-derived parameters of fat distribution and visceral fat mass may serve as valuable tools for improving obesity classification and developing more effective preventive and therapeutic strategies.

The COVID-19 pandemic, caused by the SARS-CoV-2 virus, has underscored the significant role of cardiovascular risk factors in determining the severity and outcomes of the disease. Pre-existing conditions such as hypertension, diabetes, obesity, and cardiovascular diseases have emerged as key contributors to increased susceptibility to severe forms of COVID-19, influencing both short-term and long-term health outcomes. This review examines the complex interplay between these risk factors and the virus’s direct impact on the cardiovascular system. Key findings suggest that conditions like hypertension, diabetes, and obesity not only predispose individuals to more severe disease but also exacerbate complications such as myocardial injury, arrhythmias, and heart failure. Furthermore, the long-term cardiovascular effects of COVID-19, including myocarditis and pericarditis, are of growing concern, particularly in patients with pre-existing cardiovascular conditions. The virus’s ability to induce myocardial damage through mechanisms involving ACE2 receptor binding and inflammatory cytokine storms has been well-documented. The pandemic has also highlighted significant cardiovascular complications, including left and right ventricular dysfunction, myocardial injury, and elevated pulmonary arterial pressure, with the right ventricle being particularly affected due to pulmonary damage. Imaging modalities such as echocardiography and cardiac magnetic resonance have proven valuable for diagnosing myocardial injury and complications, although accessibility may be limited in routine clinical practice. Survivors of severe COVID-19, especially those with pre-existing cardiovascular conditions, face an elevated risk of major adverse cardiovascular events for up to two years post-infection. Evaluation of post-COVID patients includes ECGs, laboratory tests, echocardiography, and cardiac MRI, which provide critical insights into myocardial injury and complications. Preventive measures, including vaccination, regular monitoring of cardiovascular health, and lifestyle modifications, play a crucial role in reducing the long-term risk of cardiovascular complications. The role of vaccination in mitigating the risk of severe disease and cardiovascular complications is well-established, despite rare cases of vaccine-related myocarditis. Understanding these interactions is essential for developing targeted management strategies, improving patient outcomes in both acute and long-term COVID-19 effects, and addressing the broader challenges posed by COVID-19’s impact on cardiovascular health.

Soybean yield potential is strongly impacted by environmental conditions. Soybean yield variability could be explained by climatic variables. Choice of tolerant varieties adapted to different limited environmental conditions could be used as adaptive strategies to sustain the development of soybean areas. Three soybean varieties with high seed and oil content (Balkan, Novosađanka and Vojvođanka) were analyzed in three localities of Vojvodina Province in Serbia: Novi Sad (45°20′00″ S; 19°51′00″), Pančevo (44°52′15″ S; 20°38′51″) and Laćarak (44°59′45″ S; 19°34′03″). The highest yield of the three examined soybean varieties was shown by Vojvođanka (3365.0 kg ha-1), whereas the statistically highest yield was in 2010 (4301.1 kg ha-1) in the investigated period (2006-2011). All three varieties gave the lowest seed yield at the Pančevo locality, due to the deficit of precipitation and lower content of humus in the soil. The oil content in the seeds was also influenced by all three examined factors. The soybean varieties Vojvođanka and Balkan had statistically higher oil content than Novosađanka. The agroecological and soil conditions of Novi Sad were the most suitable for the synthesis of oil in the seeds of all genotypes. Oil content was statistically highest in 2010 (22.31%) compared to all tested years. The analysis has shown that Vojvođanka was the most promising of all soybean’s varieties.

This paper investigates the impact of different accounting bases and financial reporting frameworks on the Corruption Perceptions Index (CPI) in the public sector. Specifically, it examines how various accounting approaches (cash, modified cash, accrual, and modified accrual) and reporting frameworks (national accounting standards, International Public Sector Accounting Standards-IPSAS with or without modifications, and other frameworks) influence the perception of corruption in public institutions. The study uses a sample of 147 countries, with the CPI as the dependent variable and accounting basis and financial reporting framework as independent variables. The results of the ANOVA analysis reveal a statistically significant difference in corruption perception indices among countries employing different accounting bases. The results of this study indicate that countries applying simpler accounting frameworks, such as national standards and IPSAS modified for the local context, show a lower perception of corruption, as evidenced by a higher CPI value. In contrast, more complex frameworks, including IPSAS or national standards referencing IPSAS, combined with cash and partial accrual bases, do not significantly reduce corruption perception. Additionally, countries using national standards based on IFRS exhibit the lowest levels of perceived corruption in the public sector.

The paper aims to explore the impact of state audits of grants in the public sector on reducing non-compliance with legal regulations. The research was conducted over a ten-year period among federal and cantonal ministries in the Federation of Bosnia and Herzegovina (FBiH) responsible for planning and distributing grant funds as part of their regular duties. The research results show that the total number of recommendations given during the observed 10-year period was 1,666, including: 245 recommendations related to grant planning, 684 recommendations related to the distribution of grant funds, 554 recommendations concerning the oversight of the designated expenditure of allocated funds, 74 recommendations concerning grant implementation reporting, and 109 recommendations regarding the accuracy of accounting records. During the observed ten-year period, the number of recommendations decreased by 75%. The research results also indicate that the adoption of stricter guidelines for grant management has a strong impact on reducing the number of identified irregularities. The paper also presents an analysis of the most common causes of irregularities. The results of the conducted research will contribute to filling the literature gap on the importance of grant audits, the most common causes of identified irregularities, and the significance of stricter legal regulations and clearer rules related to grant management.

Selecting a tractor is one of the most complex investment decisions an agricultural producer faces. There are numerous types of tractors on the market, each differing in technical, economic, and ecological characteristics. The aim of this research is to demonstrate how multi-criteria analysis methods can aid in this decision-making process, using a practical example of selecting an optimal tractor for the Myzeqe area in Albania. In this study, a decision-making model was developed based on a hybrid fuzzy methodology, combining the fuzzy LOPCOW (Logarithmic Percentage Change-Driven Objective Weighting) and fuzzy MABAC (Multi-Attributive Border Approximation Area Comparison) methods. The findings show that the determination of criterion weights is less crucial, with the T15 tractor exhibiting the best overall indicators. This research primarily contributes to developing a methodology in agriculture that enhances production outcomes.