The paper analyzes the organization of local self-government in the Republic of Kosovo through the prism of the Constitution, the Law on Local Self-Government, and other laws that affect the work and functioning of municipalities. In the social context, local self-government is very important. Citizens exercise most of their rights through the competencies of local self-government. With the European Charter of Local Self-Government, the Council of Europe has set the standards of local self-government that are implemented by its members. Kosovo is not a member of the Council of Europe, but through UNMIK regulations and its normative acts, it applies the standards of the Charter. The Republic of Kosovo, with the help of the international community and non-governmental organizations, strives to become a modern, democratic state and a member of the European Union. Along the way, Kosovo is implementing the reforms needed to comply with EU acts. In addition to presenting the organization of local self-government in Kosovo, this paper intends to determine the extent to which the Law on Local Self-Government is harmonized with the European Charter of Local Self-Government.

Human gene F5, encoding coagulation factor V, was previously reported to be highly polymorphic. Apart from FV Leiden, several other rare variants have been detected in clinical practice and associated with thrombotic events, especially in cases when patient’s phenotype and FV Leiden genotype were not in agreement. In this study, the prevalence of 17 rare F5 variants has been studied on a sample of 130 healthy adult individuals from the general Bosnian-Herzegovinian population. DNA was isolated from buccal swab samples, while genotyping was performed using MALDI-TOF MS method. The results have shown that Asp2194Gly and Met2120Thr are polymorphic in the study population with minor allele frequencies of 0.077 and 0.073, respectively. Additionally, these two variants were mutually exclusive with FV Leiden and none of them was positively associated with participants’ family history of cardiovascular or cerebrovascular diseases. While the obtained results are in agreement with previously reported data for the general Caucasian populations, it is worth noting that only two rare F5 variants were detected in the study population, albeit at considerable frequencies. Still, scientific information on rare F5 variants is rather scarce and further studies aiming to assess functional importance of these variants, as well as their role as prothrombotic factors are necessary.

Although of little aesthetic significance, the song ˝Ostante se tutuna˝ sejh Hasan Kaimija has been the subject of various controversies in the Bosnian scientific community for a whole century. This paper aims to show how the poem, from its first publication until modern times, has been used as an “ally” to deny or support certain narratives. As the central theme of all the texts in the dispute throughout the 20th and the beginning of the 21st century, the “thesis of Bogumilism” was imposed, apropos whether Kaimija could have known about Bogumils in the 17th century. The text is mostly used as an “ally” in historiography, identity theory, economics, religion, and only to some extent in literary history. Also, the aim was to show how the poem figured in these discourses, and especially the “controversial verses”, but also what kind of interpretation and valorization poem had in different historical contexts.

High-risk human papillomaviruses (HPVs) are present and can cooperate with Epstein–Barr virus (EBV) to initiate and/or enhance the progression of several types of human carcinomas including cervical as well as head and neck; in parallel, it has been recently pointed out that these oncoviruses can be detected in human breast cancers. Thus, we herein explored the presence/co-presence of high-risk HPVs and EBV in breast cancer in Lebanese women. A cohort of 102 breast cancer samples and 14 normal breast tissues were assessed for the presence of HPVs and EBV. Polymerase chain reaction (PCR) and immunohistochemistry (IHC) analysis in addition to tissue microarray (TMA) platform were used in this study. We found the presence of HPV in 66/102 (65%) of our samples, while EBV is present in 41/102 (40%) of the cohort. Additionally, our data showed that high-risk HPV types (52, 35, 58, 45, 16 and 51) are the most frequent in breast cancer in Lebanese women. Meanwhile, we report that high-risk HPVs and EBV are co-present in 30/102 (29%) of the samples; more significantly, our results indicate that their co-presence is associated with tumor grade (p = 0.03). Our data revealed that HPVs and EBV are present/co-present in human breast cancer where they may play an important role in its development and/or progression; thus, we believe that further investigations are essential to confirm and elucidate the presence/co-presence of these oncoviruses and the underlying mechanisms of their interaction in breast carcinogenesis.

Given that recordings of wars, terrorist attacks, earthquakes, tsunamis, floods, and other tragic and catastrophic events have become commonplace and ubiquitous in the modern mediated world, this paper questions the importance and role of the media as a mediator in distributing these recordings to the public. The role of the media in providing credible information in situations of crisis is very important, but also difficult, especially when it comes to live reporting, when there is no possibility to control the situation and when no one can know whether we will see death or hear it live. The paper uses a case study of two regional news televisions (N1 and Al Jazeera Balkans) reporting on the earthquake in Petrinja (Croatia), to show the weight of dilemmas and challenges that a journalist faces when he experiences, sees, and records a tragic event, and must report about it immediately - ethically, professionally and objectively. The aim of the paper is therefore to point out the reality of the journalistic profession in which sometimes, not with the intention of relativizing journalistic objectivity, there may still be a gap between ideals and practice.

We present phenomenological study of the most minimal realistic SU(5) model that owns its predictivity solely to the gauge symmetry and the representational content. The model is built entirely out of the fields residing in the first five lowest dimensional representations that transform non-trivially under the SU(5) gauge group. It has eighteen real parameters and fourteen phases, all in all, to address experimental observables of the Standard Model fermions and accomplishes that via simultaneous use of three different mass generation mechanisms. Furthermore, it inextricably links the origin of the neutrino mass to the experimentally observed difference between the down-type quark and charged lepton masses. The main predictions of the model are that (i) the neutrinos are Majorana particles, (ii) one neutrino is massless, (iii) the neutrinos have normal mass ordering, and (iv) there are four new scalar multiplets at or below a 120TeV mass scale. A one-loop analysis demonstrates that an improvement of the current p→ πe partial lifetime limit by a factor of 2, 15, and 96 would require these four scalar multiplets to reside at or below the 100TeV, 10TeV, and 1TeV mass scales, respectively.

ABSTRACT Although diverse European policy initiatives have been developed to integrate young NEETs – “Not in Employment, Education or Training”, it is particularly relevant to question how NEETs are perceived by their counterparts who are actively engaged in society. For this reason, we aimed to examine the Social Representations (SRs) of NEETs in France, using the classic free evocation technique. French NEETs (n = 71) and matched controls (n = 66; people employed, in education or in training) were interviewed. Results showed the scope of SRs for the semantic field of the term NEET and its associated terms. The need to develop effective communication to talk about work, education, and training with NEETs and implications for career counselling are discussed.

We report a case of recurrent painful and disabling granulomatous flexor tenosynovitis of the right wrist in 50-year-old female patient. The proper diagnosis was made ex juvantibus after repeated cultivation of Mycobacteria yielded negative results and local disease control was surgically unsuccessful. It was then decided to start at first with oral Clarithromycin at 500mg 2x daily during 6-month period throughout which there was no sign of local recurrence. However, synovectomy had to be performed 3 times in total during the period of two years. While the noninfectious causes were excluded, and infectious agent was not to be determined, the decision was made to administer full anti-tuberculosis medication therapy. At about the same time, we were finally able to obtain a positive Mycobacterium tuberculosis culture after a sudden onset of right axillary lymphadenitis, but only two and half years from the occurrence of first symptoms related to right wrist tenosynovitis.

Aim of our study was to provide insight into the temporal and spatial expression of FGFR1, FGFR2 and CTGF during normal human lung development which may have an important impact on understanding occurrence of developmental lung anomalies. Morphological parameters were analysed using double immunofluorescence on human embryonal (6th and 7th developmental week-dw) and foetal (8th, 9th and 16th developmental week) human lung samples. FGFR1 and FGFR2 was positive during all the dw in both the epithelium and mesenchyme. The highest number of FGFR1 positive cells was observed during the 6th dw (112/mm2) and 9th dw (87/mm2) in the epithelium compared to the 7th, 8th and 16th dw (Kruskal-Wallis test, p < 0.001, p < 0.0001). The highest number of FGFR1 positive cells in the mesenchyme was observed during the 8th dw (19/mm2) and 16th dw (13/mm2) compared to the 6th, 7th, and 9th dw (Kruskal-Wallis test, p < 0.001, p < 0.0001). The number of FGFR1 positive cells in the epithelium was higher for FGFR2 compared to number of positive cells (Mann-Whitney test, p < 0.0001). FGFR2 showed the highest number in the epithelium during the 7th dw (111/mm2) and 9th dw (87/mm2) compared to 6th, 8th and 16th dw (Kruskal-Wallis test, p < 0.001, p < 0.0001, p < 0.01 respectively). The highest number of FGFR2 positive cells in the mesenchyme was observed during the 9th dw (26/mm2), compared to the 6th, 7th,8th and 16th dw (Kruskal-Wallis test, p < 0.0001), while the number of FGFR2 positive cells in the epithelium was significantly higher than in the mesenchyme (Mann-Whitney test, p < 0.0001). CTGF was negative in both epithelium and mesenchyme during all except the 16th dw in the mesenchyme where it co-localized with FGFR2. FGFR1 and FGFR2 might be essential for epithelial-mesenchymal interactions that determine epithelial branching and mesenchymal growth during early lung development. Sudden increase in FGF1 in the epithelium and FGF2 in the mesenchyme in the foetus at 9th dw could be associated with the onset of foetal breathing movements. CTGF first appear during the foetal lung development.

Supplemental Digital Content is available in the text. Objectives: The investigation of auditory cognitive processes recently moved from strictly controlled, trial-based paradigms toward the presentation of continuous speech. This also allows the investigation of listening effort on larger time scales (i.e., sustained listening effort). Here, we investigated the modulation of sustained listening effort by a noise reduction algorithm as applied in hearing aids in a listening scenario with noisy continuous speech. The investigated directional noise reduction algorithm mainly suppresses noise from the background. Design: We recorded the pupil size and the EEG in 22 participants with hearing loss who listened to audio news clips in the presence of background multi-talker babble noise. We estimated how noise reduction (off, on) and signal-to-noise ratio (SNR; +3 dB, +8 dB) affect pupil size and the power in the parietal EEG alpha band (i.e., parietal alpha power) as well as the behavioral performance. Results: Our results show that noise reduction reduces pupil size, while there was no significant effect of the SNR. It is important to note that we found interactions of SNR and noise reduction, which suggested that noise reduction reduces pupil size predominantly under the lower SNR. Parietal alpha power showed a similar yet nonsignificant pattern, with increased power under easier conditions. In line with the participants’ reports that one of the two presented talkers was more intelligible, we found a reduced pupil size, increased parietal alpha power, and better performance when people listened to the more intelligible talker. Conclusions: We show that the modulation of sustained listening effort (e.g., by hearing aid noise reduction) as indicated by pupil size and parietal alpha power can be studied under more ecologically valid conditions. Mainly concluded from pupil size, we demonstrate that hearing aid noise reduction lowers sustained listening effort. Our study approximates to real-world listening scenarios and evaluates the benefit of the signal processing as can be found in a modern hearing aid.

Com a evolucao da tecnologia, os meios eletronicos de contratacao se tornaram praticas comerciais usuais. No caso dos contratos bancarios realizados pelos consumidores diretamente no autoatendimento dos bancos, por exemplo, a apresentacao de telas, por vezes, e o unico meio pelo qual as instituicoes financeiras tem para comprovar contratacoes. Embora atualmente a tecnologia esteja extremamente avancada – inclusive com a implementacao de Inteligencia Artificial pelo Supremo Tribunal Federal – ainda muitos magistrados resistem em aceitar estas telas sistemicas como prova. O objetivo desta pesquisa e discutir o acolhimento de provas digitais em acoes judiciais, especialmente no direito bancario. Como metodologia de estudo sera utilizado metodo hermeneutico e bibliografico, com pesquisa das obras relacionadas ao tema objeto de estudo, e dedutivo. Como resultado da pesquisa demonstrou-se que a utilizacao de provas digitais bancarias e segura, pois a manipulacao de dados internos, alem de ilegais, podem gerar diversos danos com relacao a credibilidade das instituicoes financeiras, fato que, obviamente, nao e de interesse destas.

Abstract The open innovation hub Digital Health and Patient Safety Platform (DHPSP) was recently established with the purpose to invigorate collaborative scientific research and the development of new digital products and personalized solutions aiming to improve human health and patient safety. In this study, we evaluated the effectiveness of a Twitter-based campaign centered on using the hashtag #DHPSP to promote the visibility of the DHPSP initiative. Thus, tweets containing #DHPSP were monitored for five weeks for the period 20.10.2020-24.11.2020 and were analyzed with Symplur Signals (social media analytics tool). In the study period, a total of 11,005 tweets containing #DHPSP were posted by 3,020 Twitter users, generating 151,984,378 impressions. Analysis of the healthcare stakeholder-identity of the Twitter users who used #DHPSP revealed that the most of participating user accounts belonged to individuals or doctors, with the top three user locations being the United States (501 users), the United Kingdom (155 users), and India (121 users). Analysis of co-occurring hashtags and the full text of the posted tweets further revealed that the major themes of attention in the #DHPSP Twitter-community were related to the coronavirus disease 2019 (COVID-19), medicine and health, digital health technologies, and science communication in general. Overall, these results indicate that the #DHPSP initiative achieved high visibility and engaged a large body of Twitter users interested in the DHPSP focus area. Moreover, the conducted campaign resulted in an increase of DHPSP member enrollments and website visitors, and new scientific collaborations were formed. Thus, Twitter campaigns centered on a dedicated hashtag prove to be a highly efficient tool for visibility-promotion, which could be successfully utilized by healthcare-related open innovation platforms or initiatives.