A combined inorganic and organic geochemical study was carried out on marls and mudstones collected from the Lower Miocene Lopare Basin, Bosnia and Herzegovina. A total of 46 samples collected from two boreholes, Pot 1 (depth of 193 m) and Pot 3 (depth of 344 m), showed that element abundances like boron (B), lithium (Li), strontium (Sr), uranium (U), chromium (Cr), nickel (Ni), magnesium (Mg), sodium (Na) and calcium (Ca) are much higher than average than in the upper continental crust (UCC). Chemical composition indicates at least two sources: (i) Mesozoic ophiolites occurring in the north of the investigated area, and (ii) dacito‐andesitic pyroclastics (Mesozoic to Cenozoic). Lopare Basin sedimentation was influenced by strong evaporation resulting in a partly hypersaline lake, which formed during a warm climatic period, probably during the Miocene Climatic Optimum. A brief episode of humid climate conditions resulted in the basin filling‐up and deposition of felsic sediments enriched in thorium (Th). Organic geochemistry shows that the majority of studied sediments contains predominantly immature to marginally mature algal organic matter (OM). The biomarker patterns are generally in agreement with the geological history of the Lopare Basin and inorganic and mineralogical data. Conversely, the molecular distribution of n‐alkanes as reliable climatic and δ‐MTTC as paleosalinity indicators do not support this conclusion.

Introduction: Symptomatic and etiopathologic heterogeneity of schizophrenia (SCH) and bipolar disorder (BD) can be adequately addressed using a dimensional approach to psychopathology, as well as interpreting physiological properties and markers as predictors of disease onset and relapse. Risk factors, genetic and environmental, are likely to modify the neurobiological processes characteristic of certain physiological processes that manifest to a greater degree of overlapping symptoms. One of the most common laboratory tests in psychiatric patients is a standard laboratory blood test. It gives us an insight into the general somatic condition of the patient. It assesses the ability to transport oxygen to tissues and carbon dioxide back to the lungs via erythrocytes (RBC) and hemoglobin (HGB) as their most important constituents, and is also an indicator of iron status and blood oxygenation. Aim: Schizophrenia (SCH) and bipolar disorder (BD) are psychiatric disorders whose complex etiology and pathogenesis are still far from known. A correlation between red blood cell abnormalities and these diseases has been recognized in some studies. One of the most common laboratory tests in psychiatric patients is a standard laboratory blood test. However, so far there is a small number of published papers that relate to the relationship between laboratory parameters of blood and the aim of this paper is to reveal more light in this subject. Methods: The research was done as an observational prospective clinical study that has evaluated different physiological and pathological parameters in patients with BD and SCH over a two-year period. A total of 159 patients with schizophrenia, 61 patients diagnosed with bipolar disorder and 82 healthy subjects participated in this study. Results: At baseline, BD compared to SCH patients had higher mean lymphocyte count (2,6±0,7 vs. 2,0±0,6x109; p=0,006) and haemoglobin concentration (146,8±12,2 vs. 140,2±14,7 g/L; p=0,03), and significantly lower red cell distribution width (13,6±2,2 vs. 14,7±1,8%; p=0,008). In both BD and SCH patients there was a significant number of patients with low red blood cells count and low haemoglobin concentration, and high MCH and MCHC at baseline and at 3 and 6 months of follow up. Conclusions: The finding that SCH as well as BD differed from controls with respect to red blood cells, hemoglobin, lymphocytes, and average platelet count was consistent with previous findings and could be understood as a qualitative measure in the evaluation of this sample. The fact that no association with other parameters was found, as well as an association with the diagnosis, does not exclude that these associations can be found in larger samples.

Basal ganglia calcifications 2/12 (16.7%) Elevated IFN Score 17/17 (100%)* Short stature 15/24 (62.5%) O001 Clinical features and outcomes in sting-associated vasculopathy with onset in infancy (SAVI) S. Torreggiani, A. Almeida de Jesus, S. Alehashemi, J. Mitchell, G. Souto Adeva, J. Wade, G. A. Montealegre Sanchez, B. Lin, R. Goldbach-Mansky, on behalf of SAVI Study Group TADS/NIAID, NIH, Bethesda, United States; Università degli Studi di Milano, Milano, Italy Correspondence: S. Torreggiani Pediatric Rheumatology 2020, 18(Suppl 2):O001

Background: Respiratory distress syndrome (RDS) in premature neonates has high morbidity, and it is encountered as one of the most common pathological conditions in these patients. This prospective study included 51 patients with a mean gestational age of 31 gestational weeks, hospitalized in the neonatal intensive care unit (NICU) in a tertiary-level university hospital. Aims and Objectives: The aim of our study is a comparison between lung ultrasound (US) and chest radiography in diagnosing RDS in premature neonates. Materials and Methods: US findings were classified into three profile scales and X-ray findings into a four-grade radiographic scale. Results: The results show a good concordance between chest radiography and lung US with kappa, sensitivity, and negative predictive value results in favor of US. Most of the patients had US-profile 1, which corresponds to X-ray profiles 3 and 4. US finding included the presence of confluent B lines, “white lungs,” subpleural consolidations, and thick pleura, but also A-lines, mostly found in a resolution of the disease and mild cases. Conclusion: Lung US still is not a routine procedure despite its wide use in NICUs, and as non-harmful, repeatable method, it can be used as a complementary modality to a chest X-ray. By introducing lung US as a standard method of examination in day-to-day work, it would be possible to reduce the use of X-ray studies in premature neonates.

Introduction: Many evidence indicates that Carcinoembryonic antigen (CEA) and Carbohydrate antigen 19-9 (CA 19-9) have strong reactivity with tumor cells and may serve as a useful marker in identifying patients with colorectal cancer (CRC). Objectives: The goal of this study was to evaluate the relationship between preoperative concentration of serum levels of CEA and CA 19-9 and progression of colorectal cancer. Methods: The retrospective study included 80 patients operated for colorectal cancer at the Clinic for General and Abdominal Surgery, Clinical Center of University of Sarajevo, from 2013 to 2018. The following clinical and laboratory parameters were observed: age, sex, preoperatively measured concentrations of CEA and CA 19-9 antigens, CRC localization, postoperative histopathological findings and CRC stage (TNM classification). All of the data above were processed by relevant statistical methods, with an accepted level of statistical significance of p <0.05. Results: The highest serum levels of CEA and CA 19-9 were observed in stage IV of CRC. Average CEA and CA 19-9 values did not differ significantly between tumor stages (p>0.05). Preoperatively measured serum concentrations of CEA and CA 19-9 in patients with CRC were significantly correlated (rho = 0.328, p = 0.001). An increase in the depth of tumor invasion of the intestinal wall tumor (pT) is followed by an increase in the serum value of the CEA marker, but this ratio was not statistically significant (rho=0.194, p=0.080), while the relationship between depth of intestinal wall invasion and serum level of CA 19-9 was significantly positive correlation (rho = 0.252, p = 0.024). However, the linear regression analysis model showed that serum levels of CEA and CA 19-9 could not be predictors of CRC stage and depth of tumor invasion of the intestinal wall (p> 0.05). Conclusion: Preoperatively measured serum values of CEA and CA 19-9 cannot indicate the specific stage and histopathological size of the CRC.

The purpose of this study was to examine the relationship between leg muscle power, balance, coordination, and shooting skills in soccer. Participants in this study used 89 soccer athletes with an age range of 15-18 years (M = 17.6; SD: 1.30). The research instrument used a coordination test (soccer wall volley test), balance test (modified bass test), leg muscle power (standing long jump test or broad jump), and shooting skills test. Data collection techniques, namely by measuring tests and measurements by the implementation procedure. Data analysis in this study was using Pearson correlation and regression analysis with the help of the IBM SPSS 24 application. The results showed that: 1) There was a relationship between leg muscle power and shooting ability using instep; 2) There is a relationship between balance and the ability to shoot using the instep; 3) There is a coordination relationship with the ability to shoot using the instep; and 4) There is a relationship between leg muscle power, balance, and coordination with the shooting ability using the instep. Recommendations for further research are suggested to involve other independent variables (X) that are relevant to this study, such as leg length, running speed, and angle of impact.

Demographic data suggest a rapid aging trend in the active workforce. The concept of aging at work comes from the urgent requirement to help the aging workforce of the contemporary industries to maintain productivity while achieving a work and private life balance. While there is plenty of research focusing on the aging population, current research activities on policies covering the concept of aging at work are limited and conceptually different. This paper aims to review publications on aging at work, which could lead to the creation of a framework that targets governmental decision-makers, the non-governmental sector, the private sector, and all of those who are responsible for the formulation of policies on aging at work. In August 2019 we searched for peer-reviewed articles in English that were indexed in PubMed, IEEE Xplore, and Springer and published between 2008 and 2019. The keywords included the following phrases: “successful aging at work”, “active aging at work”, “healthy aging at work”, “productive aging at work”, and “older adults at work”. A total of 47,330 publications were found through database searching, and 25,187 publications were screened. Afterwards, 7756 screened publications were excluded from the further analysis, and a total of 17,431 article abstracts were evaluated for inclusion. Finally, further qualitative analysis included 1375 articles, of which about 24 are discussed in this article. The most prominent works suggest policies that encourage life-long learning, and a workforce that comprises both younger and older workers, as well as gradual retirement.

Crossed fused renal ectopia (CFRE) is a rare congenital abnormality of the urinary tract where the kidneys are fused on one side, while the ureter of the ectopic kidney crosses the midline with the normal entrance in the bladder on the contralateral side. Congenital anomalies are associated with a stone formation whose management represents a real challenge. To our knowledge, we report the second case of CFRE associated with ureteral stone, which has been successfully resolved with Extracorporeal Shockwave Lithotripsy (ESWL) and the first of its kind where a sufficient degree of stone disintegration has been achieved after a single session with a complete stone clearance during the follow-up. Radiological examination showed an inferior type of CFRE with stone in the proximal part of the ureter of the upper kidney. ESWL is an acceptable and effective treatment option in CFRE patients due to the minimally invasive approach, potentially high stone-free rate, and rare complications.

Enabling humans and robots to safely work close to each other deserves careful consideration. With the publication of ISO/TS 15066 directives on this matter, two different strategies, namely the Speed and Separation Monitoring and the Power and Force Limiting, have been proposed. This letter proposes a method to efficiently combine the two aforementioned safety strategies for collaborative robotics operations. By exploiting the combination of the two, it is then possible to achieve higher levels of productivity, while still preserving safety of the human operators. This is achieved by the optimal scaling of the initially prescribed velocity, while preserving the path consistency of the robot trajectory. In a nutshell, the state of motion of each point of the robot is monitored so that at every time instant the robot is able to modulate its speed to eventually come into contact with a body region of the human, consistently with the corresponding biomechanical limit. Validation experiments have been conducted to establish that the proposed method enables substantially less stringent limits on robot performance while still allowing for the safety limits prescribed by ISO directives.

Increasing evidence suggests that apoptosis of tubular cells and renal inflammation mainly determine the outcome of sepsis-associated acute kidney injury (AKI). The study aim was to investigate the molecular mechanism involved in the renoprotective effects of simvastatin in endotoxin (lipopolysaccharide, LSP)-induced AKI. A sepsis model was established by intraperitoneal injection of a single non-lethal LPS dose after short-term simvastatin pretreatment. The severity of the inflammatory injury was expressed as renal damage scores (RDS). Apoptosis of tubular cells was detected by Terminal deoxynucleotidyl transferase-mediated dUTP Nick End Labeling (TUNEL assay) (apoptotic DNA fragmentation, expressed as an apoptotic index, AI) and immunohistochemical staining for cleaved caspase-3, cytochrome C, and anti-apoptotic Bcl-xL and survivin. We found that endotoxin induced severe renal inflammatory injury (RDS = 3.58 ± 0.50), whereas simvastatin dose-dependently prevented structural changes induced by LPS. Furthermore, simvastatin 40 mg/kg most profoundly attenuated tubular apoptosis, determined as a decrease of cytochrome C, caspase-3 expression, and AIs (p  <  0.01 vs. LPS). Conversely, simvastatin induced a significant increase of Bcl-XL and survivin, both in the strong inverse correlations with cleaved caspase-3 and cytochrome C. Our study indicates that simvastatin has cytoprotective effects against LPS-induced tubular apoptosis, seemingly mediated by upregulation of cell-survival molecules, such as Bcl-XL and survivin, and inhibition of the mitochondrial cytochrome C and downstream caspase-3 activation.

Abstract The aim of this study was to assess contamination and potential human health risks of heavy metals in street dust from the Federation of Bosnia and Herzegovina (FB&H). In total, 117 street dust samples were analyzed for Cd, Cr, Cu, Fe, Mn, Ni, Pb and Zn by flame atomic absorption spectrometry (FAAS). Health risk assessment was applied to determine potential health risks, non-carcinogenic and carcinogenic risks, in children and adults. According to mass concentrations of studied trace metals, the dust samples were arranged as the following diminishing series: industrial zone > high traffic streets > streets with moderate traffic > parking place > parks, school yards, sports facilities, medical facilities. Cd, Cr, Cu, Fe, Mn, Ni, Pb and Zn mean concentrations are 3.18, 33.17, 30.01, 3150, 236, 73.00, 52.49 and 81.72 mg/kg, respectively. In order to identify possible metals sources correlation analysis was applied. Strong correlations between Cd-Mn, Fe-Mn, Ni-Cr, and Cr-Fe were obtained, suggesting a common dependence or source of these metals in street dust in FB&H. Contributor that most impact the carcinogenic and non-carcinogenic risk is the ingestion route for both, children and adults, followed by the dermal and inhalation pathways. The risk assessment shows that the population of FB&H is at increased lifetime risk of experiencing cancer because of exposure to Cr and Pb concentrations in street dust of FB&H.

Determination of multiphase flow inside PC boiler plant is of particular importance for the process control of the boiler and its efficient operation. Nowadays numerical modeling is used as an advanced tool in improvement of this or similar process. Separation of coal particle in aero-mixture channel, after pulverization, represent an important process which has a big effect on boiler efficiency, and its determination represents an important step. In this paper, numerical modeling of multiphase flow inside aero-mixture channel and low emission burner of boiler OB-650 are exposed in several steps from 3D modeling, discretization of fluid domain, setting the physical and mathematical model to validation of same model. Main goals of the same process is to obtain valid numerical model of observed problematic, that will give us data about model parameters that can be used for modeling of the same process with different inlet boundary conditions, and also to obtain appropriate specific process parameters that can be used for rising of level of efficiency and utility of boiler plant in some steady operating modes.