Pre‐exposure prophylaxis (PrEP) for HIV infection is an important intervention for control of the HIV epidemic. The incidence of HIV infection is increasing in the countries of Central and Eastern Europe (CEE). Therefore, we investigated the change in PrEP use in CEE over time.

Este trabalho teve o objetivo de estudar a influencia que a informacao light exerce no consumidor em termos sensorial e de atitudes. Os dados foram obtidos por meio da aplicacao de um instrumento de coleta padronizado, teste de aceitacao sensorial e determinacao do teor de gordura de diferentes marcas de requeijao light por meio do Metodo de Gerber. A analise estatistica foi realizada por meio da estatistica descritiva, como frequencia, alem do teste t para amostra pareada e correlacao de Pearson, adotando nivel de significância de 5%. Os resultados obtidos a partir da analise dos questionarios mostraram que existe elevada demanda em relacao aos produtos light , estando essa procura relacionada especialmente a saude. Alem disso, foi possivel detectar que apesar dos entrevistados terem alegado entender o termo light , muitos entrevistados apresentaram um conceito erroneo do termo. No teste de influencia da informacao light na aceitacao sensorial de requeijao, observou-se que 38% dos provadores nao tiveram sua aceitacao influenciada pela informacao light , 34% foram influenciados negativamente e 28% foram influenciados positivamente. Alem disso, por meio da determinacao do teor de gordura de requeijao light , observou-se que todas as marcas possuem reducao superior a 25%, atendendo aos aspectos legais para usar o termo light em seus rotulos. Assim, conclui-se que os alimentos light ainda precisam avancar em estudos para diminuir a influencia negativa da expressao light , bem como devem apresentar aos consumidores mais esclarecimentos sobre o termo e, tambem, em caracterizacao da composicao centesimal e padronizacao de produtos.

The study aims to critically analyze the EU's political identity and how the migrant crisis embodies the most challenging political issue facing the E.U., implicating growing xenophobia and questioning European multiculturalism. Moreover, the author provides insight into the migrant crisis's socio-political and security challenges, followed by ethnographic research of the migrant's religious identity within the Balkan route. Migrations are a central issue for Europe's future, security, and identity. The EU's cultural integrity remains unclear, and the migrant crisis opens up a multiculturalism discourse. The nationstate model has undergone significant globalized world changes, becoming less sustainable and less critical for cultural, political, and economic processes. Due to the growing economic insecurity and the fear of losing national identities in an environment of globalized culture, some have perceived multiculturalism as a threat. The humanitarian and security discourse reflects the micro-level of the situation on the ground and the mass media's macro levels and political action. Acceptance of ethnoreligious or political diversity does not relieve immigrants of the duty to recognize all the rules necessary to conduct productive coexistence. Migrants' participation in socio-economic and political systems means realizing the preconditions for the beginning of cultural integration. The crisis triggered an avalanche 1 BSc Psychology, Economics, MSc Security Studies,Criminal Justice and Law Enforcement, Diploma,(MBTA),Mindfulness Based Transactional Analysis Research, Society and Development, v. 9, n.10, e4809108685, 2020 (CC BY 4.0) | ISSN 2525-3409 | DOI: http://dx.doi.org/10.33448/rsd-v9i10.8685 2 of anti-Islam sentiments that became a reference matrix for radical populism. The sense of identification with the housing society-Bosniaks, where Islamic regulations on the matrix are legitimized by recognizing a universal theological pattern, is a symbolic moment and a participative approach to understanding both religion and integration. Constructing immigrants as a group, whether they are migrants, refugees, or asylum seekers, tends to encourage the perception that "their "interests, values, and traditions are competing with "ours, "stimulating negative emotions in the form of prejudice.

Checkpoint inhibitor (CPI) therapy has significantly improved overall survival for metastatic melanoma, and is now approved for use in the adjuvant setting. Modulating the immune system is recognized to cause cutaneous immune‐related adverse events (irAEs). We conducted a retrospective observational cohort study of adult patients with melanoma at our tertiary referral centre, who received CPI therapy from 2006 to March 2018. This is the single largest study of cutaneous irAEs occurring on CPI therapy in patients with melanoma to date and encompasses 12 years. The results showed that cutaneous toxicity occurs in 24% of patients but is generally manageable, with < 5% patients discontinuing treatment.

Antimicrobial peptides (AMPs) are molecules with antimicrobial activity and could be a promising alternative to classical antibiotics, whose clinical efficiency is undermined by emergence of resistance. Our group is studying one such antibiotic alternative – the antimicrobial peptide TAT-RasGAP317-326. We recently reported the antimicrobial activity of this peptide against a range of Gram-positive and Gram-negative bacteria. In this article, we show that the presence of divalent cations and low pH levels have an impact on TAT-RasGAP317-326 activity, whereas serum proteins only partially reduce the antibacterial activity of TAT-RasGAP317-326. In addition, we show that iron supplementation reduces TAT-RasGAP317-326 binding to bacteria. Using a transcriptomics approach and screening of bacterial mutant libraries, we map the transcriptional response of bacteria when exposed to TAT-RasGAP317-326 and identify cellular pathways that may play a role in bacterial resistance to TAT-RasGAP317-326. We test combinations of TAT-RasGAP317-326 with other AMPs and detect no evidence for an additive effect between any of the peptide combinations. Finally, we perform a resistance selection screen that reveals differences between bacterial strains with respect to their rate of resistance emergence against the TAT-RasGAP317-326 peptide. Taken together, our findings bring a better understanding of how extracellular factors might impact the antimicrobial activity of TAT-RasGAP317-326 peptide and thus contribute basic biology insight into the mechanisms behind TAT-RasGAP317-326 activity, potentially aiding future strategies to improve the efficiency of this peptide in vivo.

Surf-riding/broaching failure mode is one of the Second Generation Intact Stability Criteria (SGISC) dealt by IMO. The SGISC are structured with a multi-tiered approach: Level 1, Level 2 and Direct Stability Assessment (DSA). When a ship does not verify one level, the next once must be applied, or the ship design must be modified. If ship changes are not feasible, Operational Measures (OM) can be provided to avoid dangerous situations and reduce the likelihood of stability failures. The OM are divided into Operational Limitations (OL) related to areas or routes and related to maximum significant wave heights and Operational Guidance (OG). The surf-riding criterion has been applied on the parent hull of the Systematic Series D, a fast semi-displacement naval hull with forms typically vulnerable to surf-riding phenomenon. The 90 m length ship results vulnerable to Level 1 and 2, therefore Operational Measures have been discussed and provided for a hypothetical route in the Mediterranean Sea (Area 26). Following the OL, in considered Area 26 the ship operations are limited when significant wave heights exceed 3.8 m. The simplified OG define critical ship speeds to be avoided for each considered sea state.

The International Maritime Organization (IMO) finalized the Second Generation Intact Stability Criteria (SGISC), in February 2020. They are intended to be included in Part A of the 2008 International Code on Intact Stability in the following years. The SGISC consider five modes of dynamic stability failure in waves: parametric roll, pure loss of stability, surf-riding/broaching to, dead ship condition and excessive acceleration. In this paper, two semi-displacement, round bilge and transom stern hull forms, the parent hull of the Systematic Series D and the ONR Tumblehome, i.e. typical naval hull forms, are examined. Although naval ships are not directly impacted by SGISC, they are sensitive to dynamic stability failure phenomena due to their geometry and range of service speeds. The procedures to assess the ship vulnerability to the dead ship condition and excessive acceleration criteria, referring to the latest drafts of the criteria (SDC 7/5, 2019), were implemented in Matlab®,. The limiting KG curves associated with this set of criteria were obtained for each vessel. The minimum allowable KG curve associated with the excessive acceleration criterion was compared with the maximum allowable KG curve associated with dead ship condition, to investigate the existence of a safe operational area.

This paper contains results from ichthyofaunal research of freshwater fish in Bosnia and Herzegovina during 20th and at the beginning of twenty-first century. We found presence of more than 100 parasitic species from different groups in 52 freshwater fish species from Black Sea and Adriatic basins and some breeding ponds. Detected parasites belong to Trematoda – 25 species, Monogenea – 15, Cestoda – 16, Nematoda – 15, Acanthocephala - 11, Oligohymenophorea - 5, Phyllopharyngea - 3, and Copepoda – 2 species. Other detected parasite groups are Kinetoplastea, Trepomonadea, Myxosporea, Myxoza, Ichthyostraca, Clitellata and Bivalvia with one species each. This study shows the necessity of research of complete parasitic fauna of freshwater fish in Bosnia and Herzegovina.

: The main objective of this study was to examine the characteristics and the relationship between walnuts in the Una-Sana Canton based on phenotypic properties. This is the first study of preselection of walnut variability in this area. In this study, we evaluated the phenological and morphological characteristics of 75 selected genotypes during 2014 and 2015. Twenty-four phenotypic traits were monitored throughout 2 years on different sites. The results of the PCA analysis showed a very high heterogeneity of walnut seedlings on the examined sites, from the aspect of observed parameters. A limited number of superior genotypes were found, but individual genotypes with high nut and kernel weight, as well as the colour of the kernel were determined, which would classify them as high-ranked parents in hybridization programs. Certain number of genotypes with high values of traits such as: nut weight, kernel weight and a high percentage of kernel were selected for future studies. Amongst the selected trees, genotype G25 had the highest weight of nuts and kernel, as well as a satisfactory color of the kernel. This genotype could be used as a superior tree for further breeding programs in the future. A highlevel of phenotypic variability in this studyrevealed the existence of a rich genetics pool of nuts variation. The genetic diversity of walnuts obtained from our studies will represent a valuable source of information for breeding programs of Persian walnut in future.