In athletic sprint disciplines, the segments of start and start acceleration occupy an important place that significantly generates the final outcome of the race. The question is to what extent the start time of the reaction (latent time) has a contribution to achieving the results of sprint disciplines. The aim of the current research was to determine the influence and connection between the reaction time and the result performance of running in the disciplines of 100 m, 200 m, 400 m finalists of ten world championships. The results of a total of 456 finalists (231 men) and 225 (women) competitors who competed in the final races of the championships (from Edmonton, 2001 to Doha, 2019) were analyzed. The evaluation of the start reaction time and sprint results was based on reports officially published by the International Association of Athletics Federation (IAAF). Central and dispersion parameters were calculated for all variables. The relationship between reaction time and sprint results was calculated using the Pearson correlation coefficient, and simple regression analysis determined the direct influence of reaction time on the result success and calculated the relevant coefficients for the level of statistical significance p < 0.05. Based on the obtained results, a positive but low correlation was recorded between the mean values of the 100 m sprint results and the reaction time in men (r = 0.230p<0.044), which was also confirmed by regression analysis. In other correlations and values of regression coefficients, no significant numerical values of the influence of reaction time on the result success were recorded in both categories of finalists.

SUMMARY The prevalence of asthma in adults varies widely around the world, ranging from 0.2% to 21.0%. Population-based studies suggest that from 20% to 70% of people with asthma in the community remain undiagnosed. On the opposite side of the spectrum, 30–35% of adults and children diagnosed with asthma do not have current asthma. Overdiagnosis of current asthma can occur due to various reasons: 1. Physicians’ failure to confirm airflow limitation; 2. New signs and symptoms in patients with long-term clinical remission of previous asthma; 3. Alternative diagnoses that mimic signs and symptoms of asthma. The most common differential diagnosis of asthma in adults is vocal cord dysfunction, airflow obstruction (e.g. tumors and foreign bodies), congestive heart failure, chronic obstructive pulmonary disease (COPD), chronic sinusitis and infection of upper airways. The consequences of the overdiagnosis of asthma are: 1. Not diagnosing and treating the actual disease; 2. Prolonged use of medication for asthma treatment in patients without asthma leads to the occurrence of adverse effects and complications caused by medication; 3. Unnecessary costs of treatment or increased insurance rates .

To date, the prevalence of CHD worldwide is ∼9 per 1000 newborns, with substantial geographic variation. The latest knowledge in the world for the last 50 years about their origin, diagnosis and therapy has contributed to their care. Since adult patients with CHD now present increasing numbers at advanced ages, including the elderly, the term grown-up CHD no longer appears appropriate and was therefore replaced with adult CHD (ACHD) according to the ESC guidelines published in 2020 year. Due to medical, surgical, and technological evolutions over the past decades, >90% of individuals who are born with CHD now survive into adulthood. ACHD represent a challenge for clinicians. Despite optimal medical and surgical treatment, many will experience a progressive decline in cardiopulmonary function leading to advanced heart failure. Severe ventricular dysfunction and/or pulmonary hypertension may not be amenable to corrective repair. Their early recognition and follow-up in adolescence will contribute to better care for these patients. Importantly, the care for ACHD patients is a lifelong process and requires advance care planning strategies.

Nitrogen oxides play a major role in atmospheric chemistry, like primary pollutants, in the formation of secondary air pollutants or greenhouse gases (GHGs). This research study was conducted in the Western Pannonian sub-region of Croatia with the aim to determine the suitability of our internally developed passive sampler and static chamber method for N-NO2 concentration measurement. The aim was also to determine the impact of mineral soil fertilization on the N-NO2 flux during triticale vegetation. The research showed that the method used was suitable. Average daily N-NO2 flux ranged from 2.78 to 5.09 mg ha−1 day−1 depending on phenophase and treatment. Statistically significant differences in N-NO2 flux between two monitored treatments (300 kg N ha−1 and 0 kg N ha−1) were not observed, nor between two investigated phenophases.

Cardiovascular medicine is an area of clinical practice with a continually rapid expansion of knowledge, guidelines, best practices and new technology in adult cardiovascular medicine as well as in paediatric cardiology medicine. Cardiovascular diseases (CVD) are the leading cause of mortality in the world and cause major costs for the health sector and economy. Cardiovascular imaging indices have a significant impact on the prevention, diagnosis, and treatment of cardiac diseases. Advanced imaging technologies have dramatically improved our ability to detect and treat cardiovascular disease at an early stage. Multimodality imaging techniques - echocardiogram, cardiac computerized tomography, magnetic resonance imaging, simulation 3D models, artificial intelligence - are being used more frequently as their utility is better appreciated. Coronavirus disease 2019 (COVID-19) exerts an unprecedented global impact on public health and health care delivery. Severe acute respiratory syndrome coronavirus 2 (SARSCoV-2) causing COVID-19 has reached pandemic levels since March 2020. Patients with cardiovascular (CV) risk factors and established CVD represent a vulnerable population when suffering from COVID-19, and have an increased risk of morbidity and mortality. Severe COVID-19 infection is associated with myocardial damage and cardiac arrhythmia. Diagnostic workup during SARS infection revealed electrocardiographic changes, sub-clinical left ventricular (LV) diastolic impairment and troponin elevation. All professionals in cardiovascular medicine, as a part of lifelong learning process, have the continuous imperative in reviewing novelties, with results data from numerous researches in order to treat all patients according to best practices and evidence-based medicine, especially on this journey through corona pandemic.

Modern use of drugs in the treatment of diseases of children and newborns is increasingly based on off-label use of drugs. The lack of adequate formulations for the pediatric population, the lack of appropriate therapeutic parallels for the treatment of children's diseases and the small number of clinical trials involving the pediatric population have contributed to the mass use of these drugs. The use of these drugs implies extrapolation of doses and indications registered for adults to children, although it is known that the pharmacodynamics and pharmacokinetics of children and adults differ significantly. In the past two decades, many legislative and regulatory initiatives have been taken around the world to improve the use of drugs in children. However, children are still prescribed off-label and unlicensed drugs. The aim of this study was to present a review of the literature in which off-label and unlicensed use in the pediatric population was investigated. Literature was searched through the Google Scholar and Pub Med search engines and using the keywords off label drug, pediatric medicine, use in pediatrics, in the period from May to August 2019. Selected and presented in this article are studies published in the period from 1996 to 2015, which as a subject of research had the use of off-label and unlicensed drugs in the pediatric population. Medicines prescribed for children should be registered for use in the pediatric population and used in accordance with approved indications for children, whenever possible. It is necessary to take measures for more rational use of medicines in pediatrics, which include the collaboration of health workers in order to provide medicines for children that are proven to be effective, high quality and safe to use.

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Abstract – Modern Bosnia and Herzegovina is a state consisting of multiple ethnicities and regions located in the Western Balkan, with a very complex history. The earliest historical findings show that its area was inhabited since the Paleolithic. From that time, this part of Europe, especially the region of the Modern Bosnia and Herzegovina, could be recognized as the crossroad for the different human migration and the meeting point for different cultures, religions and gene pools. Mitochondrial DNA is being used for maternal lineage testing, while the Y chromosome is being used for paternal lineage testing. Therefore, these markers are being referred to as lineage markers. Lineage markers are often used for parental lineage monitoring in population genetics, human genetics, as well as in forensic genetics. The main intention of this paper is to construct a short overview of the Y chromosome studies performed in Bosnia and Herzegovina within the last two decades.

This study seeks to test the existence of the crowding-out (orin) hypothesis in a sample of 17 Emerging Europe countries divided in two panels. The study employs a panel autoregressive distributed lag (ARDL) model based on three estimators, Mean Group Estimator (MG), Pooled Mean Group (PMG) and Dynamic Fixed Effect (DFE), in order to evaluate the of stability of short run and long run coefficients using consistently compiled public borrowing and private investment data between 2000 and 2019. The empirical findings of the paper generally confirm the existence of a crowding out effect in both long run and short run in European post-transition countries, and in the long run for European transition countries. More specifically, elasticity of private investment with respect to public debt is greater in the European transition countries than in the European post-transition countries. However, the findings on the crowding out (in) effect of government spending and economic growth on private investment are mixed and conflicting in both the long run and the short run. Accordingly, the study recommends that selected countries should reassess their austerity agendas employed for lowering debt levels, and follow new strategies for managing public debt burden.

Filtering of unwanted frequencies represents the main aspect of digital signal processing (DSP) in any modern communication system. The main role of the filter is to perform attenuation of certain frequencies and pass only frequencies of interest. In a DSP system, sampled or discrete-time signals are processed by digital filters using different mathematical operations. Digital filters are commonly categorized as Finite Impulse Response (FIR) and Infinite Impulse Response (IIR). This research focuses on the full VHDL implementation of digital second-order lowpass IIR filter for reducing the noisy frequencies on the FPGA board. The initial step is to determine, from continuous time domain function, the transfer function in the complex {s} domain, then map transfer function in complex {z} domain and finally calculate the difference equation in discrete-time domain of the system with adequate coefficients. Prior to the FPGA implementation, the IIR filter is tested in MATLAB using a signal with mixed frequencies and signal with randomly generated noise. The digital implementation is completed by using fixed-point binary vectors and clocked processes.