Maintaining item banks that continually reflect the measured construct can be achieved through periodically removing obsolete items and adding validated items.

ABSTRACT Introduction: There are growing concerns among European health authorities regarding increasing prices for new cancer medicines, prices not necessarily linked to health gain and the implications for the sustainability of their healthcare systems. Areas covered: Narrative discussion principally among payers and their advisers regarding potential approaches to the pricing of new cancer medicines. Expert opinion: A number of potential pricing approaches are discussed including minimum effectiveness levels for new cancer medicines, managed entry agreements, multicriteria decision analyses (MCDAs), differential/tiered pricing, fair pricing models, amortization models as well as de-linkage models. We are likely to see a growth in alternative pricing deliberations in view of ongoing challenges. These include the considerable number of new oncology medicines in development including new gene therapies, new oncology medicines being launched with uncertainty regarding their value, and continued high prices coupled with the extent of confidential discounts for reimbursement. However, balanced against the need for new cancer medicines. This will lead to greater scrutiny over the prices of patent oncology medicines as more standard medicines lose their patent, calls for greater transparency as well as new models including amortization models. We will be monitoring these developments.

Fagus sylvatica is widely distributed across Europe thanks to its high adaptability in a wide variety of soils and climate. Microbial communities are essential for maintaining forest soil quality a...

In Bosnia and Herzegovina, there is a large number of non-sanitary landfills and landfills where pharmaceutical waste from households is being disposed, as well as the medical waste from different health institutions. Expired pharmaceuticals are mostly being disposed there, because there is very little attention paid on waste sorting at the place of its origin. Now days, there are thousands of different medicine, and mainly, along with the other household waste, expired antibiotics are disposed of too. Degradation of expired pharmaceuticals in the environment very often leads to formation of products with completely different properties in regards to the original compound, but also it is not uncommon for those newly formed products to be more toxic than the original ones. This paper analyses the impact of rainwater infiltration on the body of the landfill where expired pharmaceuticals are being disposed of, as well as other medical waste at municipal landfills in Bosnia and Herzegovina. Field studies on the size of the rainwater infiltration as a function of different parameters have been conducted, and also degradation analysis of different expired drugs that are being disposed of in landfills has been performed.

Water, whether in a concrete or abstract sense, has an irreplaceable role in every culture and literary tradition in Bosnia and Herzegovina – from the elementary essential-biological to the ambient and psychological in the representations of space and people. This paper will, through concrete examples, examine the role of water topos in works of Bosnian literature precisely through these segments. The theoretical part indicates what the water topos represents, and the interpretive part sees water as a motif and symbol in the structure of the literary text and emphasizes the inscription of factional geographical toponyms/hydronyms, as well as fictitious abstract (a) topos in the poetic identities of the text (and opus in its entirety). In all this, we try to prove the hypothesis that water is an identifying determinant of a certain space and time, and in the cognitive-identity sense an important marker of cultures, social communities and individuals.

This paper presents the results of a preliminary study, which utilizes a hashtag-based approach and mixed-method procedures to describe the nexus between commemoration practices and visual social media. It mainly focuses on Instagram hashtags for the Day of the Republic of Srpska, a disputed and controversial public holiday celebrated on the 9th of January in the Republic of Srpska, to track how commemoration practices related to national memories are shaped through the process of digital (re)mediation.

Uncertainty, unfolding in the most extreme forms in the period of one of the greatest global challenges – a threat to the health and wellbeing of people, caused by the pandemic, is gaining a form difficult to conceive in temporal and conceptual terms. In the perception of students, the young people on the brink of the first employment, the uncertainty primarily reflects in the estimate of possibilities of finding a job and opportunities to construct a professional identity. This paper examines the potential role of personal branding in the improvement of student opportunities to find the desired job, as well as the importance of higher education institutions as strategic partners in the process. This paper, among others, also emphasizes the importance of empowering students towards the recognition of the role of their knowledge and competencies acquired during the studies; the role which does not correspond to banal, oversimplified reduction of the role of education as means to meet the labour market needs.

Introduction/Objectives: Health authorities are facing increasing challenges to the sustainability of their healthcare systems because of the growing expenditures on medicines, including new, high-priced oncology medicines, and changes in disease prevalence in their ageing populations. Medicine prices in European countries are greatly affected by the ability to negotiate reasonable prices. Concerns have been expressed that prices of patented medicines do not fall sufficiently after the introduction of lower-cost generic oncology medicines. The objective of this study was to examine the associations over time in selected European countries between the prices of oral oncology medicines, population size, and gross domestic product (GDP) before and after the introduction of generic versions. Evidence of periodic reassessments of the price, value, and place in treatment of these medicines was also looked for. The goal of this review was to stimulate debate about possible improvements in approaches to reimbursement negotiations. Methodology: Analysis was performed of reimbursed prices of three oral oncology medicines (imatinib, erlotinib and fludarabine) between 2013 and 2017 across Europe. Correlations were explored between GDP, population size, and prices. Findings were compared with previous research regarding prices of generic oral oncology medicines. Results: The prices of imatinib, erlotinib and fludarabine varied among European countries, and there was limited price erosion over time in the absence of generics. There appeared to be no correlation between population size and price, but higher prices of on-patent oral cancer medicines were seen among countries with higher GDP per capita. Conclusion: Limited price erosion for patented medicines contributed to increases in oncology medicine budgets across the region. There was also a concerning lack of evidence re-assessments of the price, value, and place in treatment of patented oncology medicines following the loss of patent protection of standard medicines. The use of such proactive re-assessments in negotiating tactics might positively impact global expenditures for oncology medicines.

In the teaching process, the relationship between students and university teachers is an important determinant of the quality learning and teaching process. The concepts of didactic theories provide a different approach to the didactic - methodical determination of teaching, and the position of students in the scientific - teaching process in relation to the concept of the old school and the traditional pedagogical paradigm of teaching. The student is observed and experienced as a collaborator, learning partner, authoritarian teaching styles are abandoned, democratically oriented communication and interaction are developed, with mutual respect, tolerance and respect for all participants in the teaching process. The analytical - descriptive method, comparative analysis and content analysis were used. The relationship and position of students and university teachers in the teaching process through the prism of didactic theories advocated by Christina Moller and Felix von Cube are presented. The issues of selectivity, cooperation and competitiveness as a starting point for defining the position of students in teaching, purposes and goals of learning, based on the modern pedagogical paradigmatic orientation of the “learning society”, and the analysis of the position and position of students and university teachers through the prism of cyber-information didactic theories and curriculum theories.

Generation Z falls into the internet generation because it is the first generation born after the popularisation of the internet. Even though scientists don’t agree on when this generation starts and when it ends, after all, it is believed that the generation Z is made of people that are born in the nineties until today. Their parents belong to the millennial generation that is born in the eighties. Generation Z is the first generation that was raised as a part of the trend of being in the publics' eye, always posting about their lives on social networks. This potentially makes them an egocentric generation and a generation that does not have enough empathy. Although empathy is one of the key characteristics for happiness, generation Z finds happiness in their personal appearance and they care a lot about the opinions of others, that is, they care about the number of likes and the number of followers on social networks. Even though empathy is a key trait of happiness, generation Z finds happiness in physical appearance, and in others' opinion, that is they care about how many likes and how many followers on social networks they have. The purpose of this paper is to examine emotional empathy with the generation that is born in the late nineties, until generations 2006-2007, on a sample of 200 primary and high school students with an assumption that later generations are more empathic and that there is a difference between male and female subjects, that is that females are more empathic. Also, the paper provides case reports that represent the clinical population and not the average representatives of this generation and whose psychological problems may be associated with excessive use of the Internet and social networks. The results of the research indicate that the feeling of insecurity and lack of empathy in this generation is a risk factor for the development of low self-esteem and self-confidence, and ultimately more severe mental disorders, which can be reduced and prevented by a different approach to this generation.

The aim of the study was to test two assumptions about the lateralization of the processing of emotional facial expressions: the assumption of right hemisphere dominance and the valence assumption and to egsamine the influence of gender of the presented stimulus (chimera) and depression as an emotional state of participants. The sample consisted of 83 female students, with an average age of 20 years. Participants solved the Task of Recognizing Emotional Facial Expressions on a computer and then completed the DASS-21, Depression subscale. The results of the study partially confirmed the assumption of valence for the dependent variable - the accuracy of the response. Participants were recognizing more accurately the emotion of sadness than happiness when it is presented on the left side of the face, which is consistent with the valence hypothesis, according to which the right hemisphere is responsible for recognizing negative emotions. However, when it comes to the right side of the face, participants were equally accurately recognizing the emotion of sadness and happiness, which is not consistent with the valence hypothesis. The main effect of the gender of the chimera was statistically significant for the accuracy of the response, the recognition accuracy was higher for the male chimeras compared to the female. A statistically significant negative correlation was obtained between the variable sides of the face (left and right) with the achieved result on the depression subscale for the dependent variable - reaction time. The higher the score on the depressive subscale, the slower (longer) is reaction time to the presented chimera, both on the left and on the right.

This review paper offers a definition and explanation of the self-care concept as one of the basic ways of developing and nurturing professional and personal capacities and maintaining healthy boundaries between the professional and personal life of helpers. The paper also emphasizes the ethical components of self-care as an imperative of helpers to take care of their own mental and physical health. Challenges for the development and maintenance of skills and conditions for the sustainability of self-care in the helping professions are described and analyzed from the perspective of personal responsibility and the institution’s obligation to ensure healthy working conditions and professional growth and development. Introduction to the self-care concept and comparative analysis is presented through the presentation of various, mostly foreign studies that have monitored the effects of self-care on the overall health of helpers and their professional effects. The paper also describes the adverse consequences of the lack of self-care skills and activities that encourage it. It also emphasizes the negative effects on the health of the helpers and their work potential. In conclusion, guidelines are defined for the development and maintenance of the helper's self-care, important both for his satisfaction in personal life and especially in professional success and self-actualization.

The proper application of retrosynthesis to identify possible transformations for a given target compound requires a lot of chemistry knowledge and experience. However, because the complexity of this technique scales together with the complexity of the target, efficient application on compounds with intricate molecular structures becomes almost impossible for human chemists. The idea of using computers in such situations has existed for a long time, but the accuracy was not sufficient for practical applications. Nevertheless, with the steady improvement of machine learning and artificial intelligence in recent years, computer-assisted retrosynthesis has been gaining research attention again. Because of the overall lack of chemical reaction data, the main challenge for the recent retrosynthesis methods is low exploration ability during the analysis of target and intermediate compounds. The main goal of this research is to develop a novel, template-free approach to address this issue. Only individual molecular substructures of the target are used to determine potential disconnection sites, without relying on additional information such as chemical reaction class. The model for the identification of potential disconnection sites is trained on novel molecular substructure fingerprint representations. For each of the disconnections suggested using the model, a simple structural similarity-based reactant retrieval and scoring method is applied, and the suggestions are completed. This method achieves 47.2% top-1 accuracy for the single-step retrosynthesis task on the processed United States Patent Office dataset. Furthermore, if the predicted reaction class is used to narrow down the reactant candidate search space, the performance is improved to 61.4% top-1 accuracy.