Background: Accurate human body composition assessment is becoming very important in clinical practice due to the possibility of early diagnosis and preventive interventions of metabolic disorders. Fats are one of the most important elements in maintaining normal body structure and different methods are used to determine its total amount and distribution. The amount and distribution of abdominal white adipose tissue, and especially the visceral type, provides important parameters in the development assessment of central obesity, insulin resistance, diabetes and other chronic non-infectious diseases. Objective: The aim of the study was to determine the amount of visceral adipose tissue in adults who are overweight and then estimate the probability of developing insulin resistance (IR) in those with higher amounts of visceral adipose tissue. Based on a comparison of the amount of visceral adipose tissue and the frequency of IR, evaluate the clinical significance of a routine procedure for body structure assessment in relation to the amount of visceral adipose tissue. Methods: Subjects were adults of both sexes aged 20 to 77 years, who were patients in two family medicine clinics. Including criteria for the study were: increased body weight (BMI≥25) and normal blood glucose values (4.0 – 5.4 mmol/L). All subjects underwent anthropometric measurements (BMI, waist circumference, waist-hip ratio) and body structure assessment with bioelectrical impedance. According to the values for the amount of visceral adipose tissue (below and above 110 cm2), the subjects were divided into two groups. All subjects underwent an IR test. We used the HOMA 1 value of 2 as a cut off for the risk of chronic non- infectious diseases in non-diabetic population. Results: The study included 80 patients. 14 patients did not complete the study, so the total number of subjects was 66 (39 women and 27 men). 36 subjects had elevated values of visceral adipose tissue (over 110 cm2). In this group, the presence of IR was registered in 30 patients or 81%. In the control group with a normal amount of visceral adipose tissue, IR was registered in 10 subjects or 33%, which is a statistically significant difference. Conclusion: Increased amount of visceral adipose tissue in overweight patients significantly affects the occurrence of IR. For the patients with an increased amount of visceral adipose tissue, it is necessary to introduce intensive preventive measures to stop the development of diabetes and other complications as a result of IR presence.

Background: Enormous number of medical journals published around the globe requires standardization of editing practice. Objective: The aim of this article was to enlist main principles of editing biomedical scientific journals adopted at annual meeting of Academy of Medical Sciences of Bosnia & Herzegovina (AMSB&H). Methods: The evidence for writing this Guideline was systematically searched for during September 2020 in the PUBMED and GOOGLE SCHOLAR databases. The inclusion criteria were: original studies, systematic reviews, invited expert opinions, guidelines and editorials. The exclusion criteria were narrative reviews and uninvited opinion articles. The retrieved evidence was analyzed by members of the AMSB&H, then discussed at 2020 annual meeting of the AMSB&H and adopted by nominal group technique. Results: In total 14 recommendations were made, based on A to C class of evidence. The editors should educate potential authors and instruct them how to structure their manuscript, how to write every segment of the manuscript, and take care about correct use of statistical tests. Plagiarism detection softwares should be used regularly, and statistical and technical editing should be rigorous and thorough. International standards of reporting specific types of studies should be followed, and principles of ethical and responsible behavior of editors, reviewers and authors should be published on the journal’s web site. The editors should insist on registration of clinical studies before submission, and check whether non-essential personal information is removed from the articles; when essential personal information has to be included, an article should not be published without signed informed consent by the patient to whom these information relate. Conclusions: Principles of editing biomedical scientific journals recommended in this guideline should serve as one of the means of improving medical journals’ quality.

Background: One of the most vulnerable group to cope with the consequences of COVID-19 pandemic are women, particularly pregnant ones. Objective: The aim of this article was to make review of the scientific literature to show clearly that pandemic is not so dangerous neither for mother nor her unborn and newborn children. Results and Discussion: It should be stated that most of the scientific papers on COVID-19 are currently being conducted in a way that would probably be completely unacceptable to serious science in any other circumstances. Taking into account everything we have learned about the SARS-CoV-2 virus so far it comes as a surprise that there has not been a more intense scientific debate on whether the blind lockdown model, implemented by most national governments, was truly an appropriate response to the challenges posed by the pandemic. Conclusion: Deep analysis what science in perinatal medicine did assess and what it recommended to perinatal world it may be followed by principles that the research of the members of the Academy will not be the first to be published, but we certainly aim that the scientific evidence published by Academy is fast, reliable and implementable.

Background: From 2013 the World Medical Association’s Declaration of Helsinki explicitly requires pre-registration of a study involving human subjects. The registration gives a chance for improvement of design and avoidance of bias. Objective: The aim of this article was to describe process of bearing decision to create regional registry of clinical studies for Balkan countries. Methods: After finding relevant studies about research registries and designing the concept and structure of future regional registry an article was published in IJBH journal. The article was than used as basis for discussion at 2020 meeting of Academy of Medical Sciences of Bosnia and Herzegovina (AMSBH), and final decision was made by the Academy to create the research registry. Results: Regional registry of clinical studies will be under the auspices of AMSBH and web-based, with the option of online registration of new studies. The data required to be entered in the moment of registration relate to key elements of research plan: topic, variables, sample, type of the study and the study population. After applying for registration of a clinical study, the authors will soon receive the review made by the AMSBH expert committee. The application could be accepted, rejected or returned for major or minor revision. After an application is accepted, it will be deposited in the searchable database and given the registration number. Conclusion: The AMSBH’s decision to create the regional registry of clinical studies will satisfy needs of researchers from Balkan countries in the first place, who share cultural and lingual similarities. It will also help with increasing standards of clinical research in the region.

This short biography details the life and medical activities of Rosa Einhorn, mariée Bloch (1872-1950), who practised as an Austro-Hungarian (AH) official female physician in Travnik in occupied Bosnia and Herzegovina (BH) from 1902 to 1904, and as a semi-official private physician from 1905 to 1912/13. Born in Hrodna district in the Russian Pale of Crescent, Einhorn had qualified and practised as a "feldsheritsa" in Russia and went to Switzerland to study medicine in 1896. Upon receiving her medical doctorate from the University of Lausanne in 1901, she became recommended as a particularly adequate candidate for the not-yet-created position of an AH official female physician in BH. After Einhorn functioned as a general practitioner for women and children in Travnik and the adjacent districts for two years, the AH public health authorities officially dismissed her due to her engagement and marriage to the AH judiciary Sigismund Bloch (1850-1927). However, she obtained a right to private practice in 1905 and was employed as a private physician in AH anti-syphilis campaigning. Struggling for her reinstatement as an official female physician in Travnik, she also strove for the accreditation of her Swiss diploma in Austria, though in vain. After two attempts to emigrate to the United States in 1904 and 1913, Rosa Einhorn finally left Europe to work as a physician in the United States and Mandatory Palestine/Eretz Israel in 1923. She died in New York on May 27, 1950. CONCLUSION: Rosa Einhorn was employed as a provisory official female physician in Travnik in 1903/1904, the AH authorities accepting her only as a local private female physician after her marriage in 1905. Struggling in vain for her reinstatement, she finally left Bosnia in 1913.

Automatic modulation classification (AMC) is a typical technology for identifying different modulation types, which has been widely applied into various scenarios. Recently, deep learning (DL), one of the most advanced classification algorithms, has been applied into AMC. However, these previously proposed AMC methods are centralized in nature, i.e., all training data must be collected together to train the same neural network. In addition, they are generally based on powerful computing devices and may not be suitable for edge devices. Thus, a distributed learning-based AMC (DistAMC) method is proposed, which relies on the cooperation of multiple edge devices and model averaging (MA) algorithm. When compared with the centralized AMC (CentAMC), there are two advantages of the DistAMC: the higher training efficiency and the lower computing overhead, which are very consistent with the characteristics of edge devices. Simulation results show that there are slight performance gap between the DistAMC and the CentAMC, and they also have similar convergence speed, but the consumed training time per epoch in the former method will be shorter than that on the latter method, if the low latency and the high bandwidth are considered in model transmission process of the DistAMC. Moreover, the DistAMC can combine the computing power of multiple edge devices to reduce the computing overhead of a single edge device in the CentAMC.

INTRODUCTION Cervical cancer is the second leading cause of female cancer in Bosnia and Herzegovina, and it is the most common female cancer in women 15 to 44 years old. Cervical cancer is etiologically associated with high-risk human papillomaviruses (HRHPV). Data on the prevalence of HRHPV in Bosnia and Herzegovina are scant. This study investigates the prevalence of HRHPV infection among women of reproductive age compared with cervical cytology in the Tuzla Canton. METHODS We analyzed the results of HRHPV testing and Papanicolaou (Pap) test results in women up to 40 years old diagnosed at the Tuzla University Clinical Center (UCC) from January 2019 to March 2020. RESULTS Among 880 women tested for HRHPV, 27.2% (n = 239) were ≤ 40 years. In this age group HRHPV was detected in 33.5% (n = 80) of women, and 23.8% (n = 19) were women < 30 years. Out of 239 women tested for HRHPV, 60.2% had an abnormal Pap smear result. Therefore, 40.7% (n = 59) of HRHPV-positive women had an abnormal Pap test result. Women with a normal Pap test result had an HRHPV-positive test in 22.3% (n = 21) of cases. CONCLUSION The results obtained contribute to the knowledge about HPV prevalence and the incidence of squamous cell abnormalities in the most populous canton in Bosnia and Herzegovina, possibly reflecting the situation nationally. The high prevalence of HRHPV in women of reproductive age calls for urgent implementation of an organized cervical cancer screening program and HPV vaccination.

OBJECTIVES The goal of this study was to determine the sealing ability of MTA, Biodentine, and Fuji IX as root-end materials after ultrasonic retrograde preparation using a dye penetration method. MATERIALS AND METHODS Seventy permanent anterior teeth were used in this study. Root canals were prepared using rotary endodontic files, and obturated using the lateral condensation technique. The resection of the root apices was performed perpendicularly to the long axis, and 3 mm deep retrocavities were made by ultrasonic tips. The samples were randomly divided into three experimental groups (N=20) and two control groups (N=5). The root-end cavities were filled with mineral-trioxide aggregate (Rootdent MTA, TehnoDent, Russia) in Group 1, Biodentine (Septodont, Saint Maur des Fossés, France) in Group 2 and Fuji IX GP (GC Corporation, Tokyo, Japan) in Group 3. The retrocavities of the positive control group were left unfilled, while retrocavities in the negative control group were sealed using a flowable composite material. The samples were made transparent, and dye penetration was assessed under a stereomicroscope (x10). The data were analyzed with the Kruskal-Wallis test and the Mann-Whitney U-test. RESULTS The Biodentine group had a lower mean leakage value than the MTA and Fuji IX groups, and the difference was statistically significant (P<0.01). No statistical difference in apical microleakage was found between the MTA and Fuji IX groups (P>0.05). CONCLUSION Within the limitations of this study, it was concluded that Biodentine provides better sealing ability as a root-end material than MTA and Fuji IX. There was no statistically significant difference between the sealing ability of MTA and Fuji IX as root-end materials.

Abstract Over the last few decades, many countries in the world have been struggling with high indebtedness. This has been especially emphasized in periods of crisis, and this was not an exception during the last global economic crisis in 2009. The advent of the crisis has further increased the need for borrowing. Increasing indebtedness after the crisis was also characteristic of BiH economy, the country in our research focus, which had an increase of public external debt by over 100% over the last two decades. The paper focuses on the external indebtedness of Bosnia and Herzegovina (BiH) over the period 2004-2017. The empirical part relies on dynamic modelling - Vector Autoregression Model, which is used to explore total external indebtedness. The empirical investigation implies that foreign-trade exchange deficits have had the greatest impact on rising indebtedness in BiH, while movements in EURIBOR interest rates have little influence in explaining this variability. The empirical investigation implies that macroeconomic policy in BiH, if it wants to keep the external debt under control over the longer time horizon, does need to focus on deficits in its foreign exchange more. One of inevitable priorities is to work on supporting production based of export from this economy.

A 31-year-old woman with hepatocellular carcinoma suffered from recurrent oesophageal variceal bleeding due to portal hypertension, which was caused by severe compression of the portal vein by metastatic lymph nodes. Endoscopic band ligation and pharmacological treatment did not suffice to prevent recurrence of variceal bleeding. Eventually, after the fifth variceal bleeding within 6 months, the patient was admitted to the intensive care unit in a haemodynamic shock. A Sengstaken-Blakemore tube was inserted and all treatment options were discussed, but only percutaneous transhepatic recanalisation of the portal vein with stent placement to reduce portal vein pressure was thought to be feasible with any chance to relieve portal vein pressure. After successful portal vein stenting, our patient did not have any recurrent bleeding in the remaining year of her life. We suggest that percutaneous transhepatic portal vein stenting may be a feasible and adequate last line treatment for complications of portal hypertension.

Introduction: A number of nuclear medicine procedures significantly dropped worldwide during the COVID-19 pandemic. Every nuclear medicine department has faced changed working environment in terms of the type of requested procedures, number of requests and personal protection issues. Also, some specificities emerged that affect standard operating procedures. Aim: The aim here is to present different clinical scenarios related to RT PCR molecular testing and COVID-19-associated pulmonary findings on PET/CT in oncologic patients. Methods: A case series of four patients imaged on oncologic PET/CT is presented. Short clinical history followed by description of significant PET/CT findings and their importance from the perspective of COVID-19 pandemic and interpretation of PET/CT findings is presented. Conclusion: PET/CT imaging remains of paramount importance for oncologic patients during the pandemic. Under the unprecedented circumstances, interpretation of PET/CT findings has become more complex having some specificities that must be kept in mind.

Abstract In the process of designing and forming each system, it is necessary to identify potential vulnerabilities and threats to that system and to include appropriate countermeasures. The process that helps to find the problem in the first phase of design is called threat modeling. Threat modeling is based on the idea that every system has valuable resources that need to be protected. These resources have certain weak points that internal or external threats can use to harm them, while there are as well countermeasures used to mitigate them. Therefore, this paper analyses the security of a Web of Things (WoT)-based system for remote management of windows, which is in the design stage by using a threat modeling approach based on STRIDE and DREAD. The results obtained through Microsoft Threat Modeling Tool (MTMT) justified the use of threat modeling in the design phase given that we have identified in total 118 threats, with Elevation of privilege class of threats being the most prominent ones. The Information disclosure threats are found to be the ones characterized as medium and low risk ones, while the most represented high-risk threats again come from the Elevation of privilege class of threats.

Abstract The Web of Things (WoT) emerges from applying Web technologies to the Internet of Things (IoT) to access information and services of physical objects. These systems are likely to characterize the future of digital environment and they put certain security issues in the story. In order to help detect potential threats to WoT-system that is being built and designed, it is advisory to implement a threat modelling process. Threat modelling is an engineering technique that can be used to identify threats, attacks, vulnerabilities and appropriate countermeasures in the context of a particular application and is a process best implemented at the system design stage. In this paper, we will analyse the threats for WoT-based door management system by using Microsoft Threat Modeling Tool (MTMT) in order to identify potential threats for this system in design phase. Obtained results justified the use of threat modelling in the design phase given that we have identified in total 89 threats, with Elevation of privilege and Denial of Service (DoS) being the most prominent ones. Those threats are characterized as high and medium risk ones.

Este estudo objetiva discutir a proposta do Programa de Residencia Pedagogica (PRP), relacionado a Politica Nacional de Formacao de Professores, apresentada pelo MEC em 18 de outubro de 2017. A proposta de Residencia Pedagogica foi apresentada no governo de Michel Temer no ano de 2017, teve seu rumo incerto apos uma breve descontinuidade em 2019 e foi retomada com o lancamento de um novo edital no ano de 2020. Destacamos que o atual contexto politico e educacional do Brasil demanda discussoes aprofundadas que busquem problematizar as concepcoes presentes nos projetos de formacao docente em disputa. Intentamos no desenvolvimento desta pesquisa, analisar a proposta do Programa de Residencia Pedagogica, bem como seus possiveis efeitos para a formacao de professores no Brasil. O estudo se organiza em 4 secoes, buscando uma retomada historica da constituicao da formacao docente no pais para a investigacao acerca das concepcoes de formacao docente presentes no PRP. A presente investigacao esta fundamentada na perspectiva metodologica da pesquisa qualitativa, a partir da analise documental e da analise de conteudo. Com este estudo, foi possivel perceber que o PRP vem ao encontro de premissas tecnicistas do fazer docente e demonstra em sua essencia uma visao pragmatica da formacao de professores, entretanto, a autonomia universitaria permitiu algumas iniciativas contra hegemonicas para a organizacao do projeto. PALAVRAS-CHAVE: Formacao de professores; residencia pedagogica; politicas educacionais. Doi: 10.21703/rexe.20201941caporal17