Background: Myocardial injury (MI) is characterized by an increased level of at least one cardiac troponin. Experimental MI can be induced by isoprenaline, a β-adrenergic agonist, and it can lead to heart failure (HF). Liraglutide is glucagon-like 1 peptide receptor agonist used in diabetes management, but it has anti-inflammatory and antioxidative effects, which can be beneficial in treatment of HF. The aim of this study was to investigate the effects of liraglutide on isoprenaline-induced MI and prevention of HF. Methods: Male Wistar albino rats were divided into four groups: Con—received saline the first 2 days + saline the next 7 days; Iso—isoprenaline the first 2 days + saline the next 7 days; Lir—saline the first 2 days + liraglutide the next 7 days; Iso + Lir—isoprenaline the first 2 days + liraglutide the next 7 days. On day 10, blood samples were taken for biochemical analysis and oxidative stress marker evaluation, and hearts were isolated for pathohistological analysis. Cardiac function was assessed by electrocardiography (ECG) and echocardiography (ECHO). Results: Liraglutide treatment significantly attenuated oxidative stress, repaired ECG and ECHO parameters, and mitigated myocardial morphological changes induced by isoprenaline. Conclusions: Liraglutide restores cardiac function in isoprenaline-induced HF.

Background A comprehensive understanding of the anatomy and pathology of the maxillary sinus is paramount for precise diagnosis and effective planning of dental interventions. Cone Beam Computed Tomography (CBCT) offers enhanced visualization of sinus structures, thus facilitating the identification of anatomical variations and pathological conditions which are critical for surgical and dental treatment strategies. Materials and Methods This retrospective descriptive study analyzed 200 CBCT scans, comprising 400 maxillary sinuses from patients treated at the Faculty of Dentistry University of Sarajevo. The study assessed sinus dimensions, volumes, anatomical features, their relationships with adjacent anatomical structures, and the occurrence of pathological alterations. Furthermore, the patient's gender and dental status were studied in relation to these features. The sinus measurements were performed with Sidexis 4 software (Dentsply Sirona, Germany), which is intended for precise linear measurements in three orthogonal planes. Results Significant differences were found in sinus width between patients with full dentition and those with partial or complete edentulism (p<0.01). Male participants exhibited larger mean sinus dimensions compared to females in all dimensions. The maxillary sinus floor was inferior to the nasal floor in 91.5% of cases. Various types of sinus membrane abnormalities were observed, with normal membrane thickness in 53.75% of cases. Sinus septa were most frequently located on the roof of the sinus, and their frequency varied significantly among patients with different dentition statuses. The study also identified 274 Haller cells and documented several pathological changes, with mucosal thickening exceeding 3 mm being the most common alteration. Conclusion This radiographic study of Bosnian and Herzegovian population revealed significant anatomical variations and pathological changes in maxillary sinuses, thus emphasizing the importance of careful preoperative evaluation using CBCT for surgical planning in the posterior maxillary area. The findings highlight gender-based differences in sinus volumes, the impact of dentition status on sinus anatomy, and the prevalence of various pathological conditions, thus contributing to valuable insights in the field of maxillofacial radiology.

Psoriatic arthritis (PsA) is a chronic inflammatory disease that extends beyond musculoskeletal and dermatologic involvement to elevate cardiometabolic risk. Emerging evidence highlights the critical role of systemic inflammation in metabolic dysregulation, accelerating insulin resistance, dyslipidemia, and oxidative stress, all of which contribute to the increased burden of cardiovascular disease in PsA. This review explores the intricate interplay between inflammatory mediators—such as tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), and interleukin-17 (IL-17),—adipokine imbalances, and lipid metabolism abnormalities, all of which foster endothelial dysfunction and atherosclerosis. The dysregulation of adipokines, including leptin, adiponectin, and resistin, further perpetuates inflammatory cascades, exacerbating cardiovascular risk. Additionally, the metabolic alterations seen in PsA, particularly insulin resistance and lipid dysfunction, not only contribute to cardiovascular comorbidities but also impact disease severity and therapeutic response. Understanding these mechanistic links is imperative for refining risk stratification strategies and tailoring interventions. By integrating targeted immunomodulatory therapies with metabolic and cardiovascular risk management, a more comprehensive approach to PsA treatment can be achieved. Future research must focus on elucidating shared inflammatory and metabolic pathways, enabling the development of innovative therapeutic strategies to mitigate both systemic inflammation and cardiometabolic complications in PsA.

BACKGROUND Friendship quality is crucial for psychological well-being, yet is often lower in persons with intellectual disabilities compared to their peers. This study explores the predictors of friendship quality among adults with mild intellectual disability, focusing on age, gender, living setting, psychiatric traits, and social cognition. METHOD The sample comprised 62 adults with mild intellectual disability (32 males, 30 females; ages 19-53), and 30 with significant psychiatric traits. Tools included the Friendship Quality Scale, Edinburgh Social Cognition Test, MINI PAS-ADD scale, and a demographic questionnaire. RESULTS Social cognition and age were the strongest predictors of friendship quality, with higher social cognition scores and younger age correlating with better quality. Gender, living setting, and psychiatric traits had less impact. CONCLUSIONS Social cognition and age are primary determinants of friendship quality in adults with mild intellectual disability, suggesting that interventions to enhance social cognition may benefit this population's social well-being.

Geophysical measurements, such as seismic experiments, are a key target for scientific activities on planetary surfaces. Dense spatial sampling of such measurements is often desirable, and acquisition is traditionally performed at regular intervals. However, achieving regular and dense spatial sampling is made difficult by obstacles and operational constraints of a planetary surface mission. Here, we present an application of compressive sensing (CS) in the design of seismic surveys on planetary surfaces for imaging the shallow subsurface. This approach is based on more flexible, randomized subsampling and requires fewer sources or receivers compared to traditional methods. We illustrate the potential of CS on synthetic data and measurements made along an active seismic transect across a lunar analog site. We then explore the use of CS‐assisted seismic acquisition at a terrestrial analog site in the San Francisco Volcanic Field. We show how irregularly acquired data can be interpolated to reconstruct data at finer spatial sampling and yield seismic images comparable to those from regularly acquired high‐density data. Finally, we apply our approach to reanalyze the legacy data collected by the Active Seismic Experiments during the Apollo 14 and 16 missions. The results show that the CS method can recover missing data and increase the amount of data available for refraction analysis. Our study highlights the potential of CS in future planetary surface exploration missions for (a) an order‐of‐magnitude improvement in survey efficiency and (b) improved imaging quality to gain a deeper understanding of the geologic processes of planetary bodies.

Abstract The adoption of the United Nations General Assembly Resolution A/RES/78/282, designating 11 July as the International Day of Reflection and Commemoration of the 1995 Srebrenica genocide, embodies a significant effort in combating genocide denial. However, the Resolution generated substantial preemptive and reactive backlash, sparked by a global network of actors committed to revising the history of the 1990s. This article provides a detailed account of the resolution’s contextual history within the UN, as well as an analysis of the geopolitical and ideological underpinnings of Srebrenica genocide denial as a tool of regional nationalist and revisionist agendas. As a salient example, the article explores the coordinated campaign led by Serbia and Republika Srpska to undermine the resolution, utilizing it to mobilize nationalist tropes, discredit international institutions, and reinforce denialist narratives.

Abstract Pike-perch Sander lucioperca is a native species originally present in the Black Sea basin of Bosnia and Herzegovina. In the 1990s, it was introduced to the Neretva River and its reservoir system, and since 2009 the species has been recorded in Lake Boračko and Buško Blato Reservoir. The aim of this study is to analyse the distribution of S. lucioperca in Bosnia and Herzegovina based on literature data (1975–2024) and to define areas where the species has been introduced in order to assess the risk of potential invasiveness. The results indicate that S. lucioperca belongs to the high-risk category. Since the same risk ranking has been confirmed in recent studies on aquatic ecosystems in other geographical areas, the conclusion is that pike-perch could soon pose a potential threat to native species and aquatic ecosystems in Bosnia and Herzegovina if mitigation measures are not implemented.