The aim of this research is to develop a functional food and halal Omega 3 eggs by dietary manipulation of laying hens as well as to investigate the influence of nutrient composition on egg yolk content of PUFAs. The research was conducted on the farm Pećigrad, Velika Kladuša, which has 21,162 laying hens, with an egg production rate of 70%. Laying hens were fed with halal and NON GMO feed mixtures from three suppliers. Omega 3 eggs contained 318 mg of Omega 3 PUFAs, which is 6 times more than the standard eggs. The n-6:n-3 PUFAs ratio was 18.4:1.9=9.9 in egg yolks of laying hens fed with standard feed mixture, while in egg yolks produced by laying hens fed with feed mixture enriched with flaxseed this ratio was 17.8:5.3=3.4. Consumption of eggs with the latter n-6:n-3 ratio can prevent cardiovascular diseases and provides the intake of RDA of Omega 3 FAs. Traceability and established HrCCP in the chain of suppliers, in processes of primary and industrial production, application of good practices, sustainable development resulted in halal products with additional functional properties.

A malignant peripheral nerve sheath tumour (MPNST) is a highly aggressive sarcoma. This disease develops in a number of people with neurofibromatosis type 1 (NF1), which is a common genetic disease. The paper presents a patient with typical manifestations of a malignant tumour of the peripheral nerve sheath, in the form of a large tumour of primary localisation in the distal part of the left thigh and left popliteal fossa and with significant dissemination into the lung parenchyma, which was accompanied by respiratory risk. The first operation of the tumour was done four years earlier, after which the patient did not come for regular check-ups. Nine cycles of chemotherapy were performed by Doxorubicin / Ifosfamide / Mesna protocol with clinical improvement and stabilisation, but without a significant impact on the dynamics of the disease and the overall survival was 14 months. It is of utmost importance to early recognise clinical presentation of the malignant form of this tumour and active supervision of a patient with a benign form by experts. In this way, it is possible to apply the optimal treatment modality in a timely manner.

Background/Aim: Therapy of diabetes mellitus type 2 includes drugs that act as inhibitors of dipeptidyl peptidase 4 (DPP-4) enzyme. Several DPP-4 inhibitors are marketed today and although they have favourable safety profile and tolerability, they show moderate activity in controlling glycaemia. The 3D quantitative structure-activity relationship (3D-QSAR) methodology was employed in order to find pharmacophore responsible for good DPP-4 inhibitory activity and designed new compounds with enhanced activity. Methods: For 3D-QSAR model development, 48 compounds structurally related to sitagliptin were collected from ChEMBL database. Structures of all compounds were optimised in order to find the best 3D conformations prior to QSAR modelling. To establish correlation between structure and biological activity Partial Least Squares (PLS) regression method integrated in Pentacle software was used. Results: Parameters of internal and external validation (R2 = 0.80, Q2 = 0.64 and R2 pred = 0.610) confirmed reliability of developed QSAR model. Analysis of obtained structural descriptors enabled identification of key structural characteristics that influenced DPP-4 inhibitory activity. Based on that information, new compounds were designed, of which 35 compounds had a better predicted activity, compared to sitagliptin. Conclusion: This QSAR model can be used for DPP-4 inhibitory activity prediction of structurally related compounds and resulting pharmacophore contains information useful for optimisation and design of new DPP-4 inhibitors. Finally, authors propose designed compounds for further synthesis, in vitro and in vivo testing, as new potential DPP-4 inhibitors.

Considering the expectations of customers on service and information availability 24x7, complete operations suspension in case of adverse events is not an option. Modern businesses have become dependent on their information systems (IS) whose incidents and failures can highly affect business operations. Ensuring continuity in IS is related to the reliable delivery information. In order to lower the negative impact of IS incidents, organizations should get prepared for them. Business continuity management (BCM) is a holistic management approach whose aim is to identify, prevent or mitigate operational risks. BCM consists of business continuity planning (BCP), contingency planning (CP) and disaster recovery planning (DRP). BCP defines the strategies that organizations should implement in order to ensure their survival when a crisis event occurs. The aim of this paper is to identify the relevant elements of continuity in IS.

S ciljem zaštite tradicionalne „Visočke pečene janjetine“ oznakom geografskog porijekla pro-vedena su istraživanja na nacionalnom nivou. Po prvi put je detaljno praćen cjelokupni tehnološki po-stupak proizvodnje, od faze iskrvarenja životinje, primarne obrade trupa i konfekcioniranja mesa, do termičke obrade. Osnovni motiv istraživanja bio je ustanoviti autentičnost ovog specifičnog načina ter-mičke obrade janjećeg mesa i njegovu vezu sa ispitivanim područjem (Visoko). Uz navedeno, jedan od ciljeva je bio laboratorijskim ispitivanjima kvantificirati osnovne kvalitativne parametre. Ustanovlje-ni indikatori kvalitete „Visočke pečene janjetine“ poslužit će kao referentni pokazatelji u predstojećim aktivnostima, prilikom utvrđivanja proizvođačke specifikacije. U radu su utvrđivani senzorni, kemijski i mikrobiološki parametri kvalitete „Visočke pečene janjetine“. Senzorna ocjena pokazala je da je kva-liteta Visočke pečene janjetine ekstra visoka, pri čemu je boja najbolje ocijenjeno svojstvo. Srednje vri-jednosti kemijskih parametara iznosile su kako slijedi: 54,18 % vode, masti 19,44 %, proteina 25,28 %, pepela 1,10 %, NaCl 0,20 %. Prosječna pH vrijednost iznosila je 6,47, a aw 0,958.