Questions about cognitive aging are inherent questions about why individuals of different ages or from different subpopulations differ from each other and how these differences change over time. One of the main goals of cognitive gerontology is to describe how cognitive abilities change over time and to link these changes with brain aging. When we talk about the cognitive deterioration in the elderly, we have to consider great individual differences in cognitive functioning, that are greater than in the earlier period of life. In neurophysiology, significant progress has been made in mapping the brain areas responsible for changes in cognitive functioning; whether biological weakening will manifest in our behavior is greatly determined by life experiences and habits. Emotional stability, openness to experience, higher level of education, higher socioeconomic status, enjoyment in intellectual activities through the lifespan, and better physical and mental health are positively correlated with preserved cognitive abilities among older adults.

Characteristics of the vibrations of rotational systems with misalignment and rotating looseness are well known and they are used for fault detection in the rotating machinery. For the better understanding and easier decision make in the fault removing process it is necessary to know how severe each fault is. Lack of procedures for quantification of this faults in rotational machinery is evident. In this paper is investigated the possibility for use of multiple regression analysis for determination of quantity of faults in vibration velocity signal. An experimental motor – coupling – rotor system is created and produced. These systems have capability of changing the values of misalignment and rotational looseness. Measurement of vibrational quantities were conducted on these systems by using piezoelectrical accelerometers for different combinations of fault values. All measurements were stored and processed digitally. All measurements have shown the presence of the main characteristics of introduced faults. It is confirmed that it is not possible to use RMS (root mean square) of vibration velocity, since there is a lot of other factors which has significant impact on the vibration quantity.

Predicting the clinical behavior and trajectory of chromophobe renal cell carcinoma (ChRCC) by histologic features has so far proven to be challenging. It is known that ChRCC represents a heterogeneous group of neoplasms demonstrating variable, yet distinctive morphologic and genetic profiles. In this international multi-institutional study, we aimed to assess the impact of histologic diversity in ChRCC (classic/eosinophilic versus rare subtypes) on survival outcome. This is an international multi-institutional matched case-control study including 14 institutions, examining the impact of histologic subtypes of ChRCC on survival outcome. The study group (cases) included 89 rare subtypes of ChRCC. The control group consisted of 70 cases of ChRCC including classic and eosinophilic features, age- and tumor size-matched. Most of the rare subtypes were adenomatoid cystic/pigmented ChRCC (66/89, 74.2%), followed by multicystic ChRCC (10/89, 11.2%), and papillary ChRCC (9/89, 10.1%). In the control group, there were 62 (88.6%) classic and 8 (11.4%) eosinophilic ChRCC. There were no statistically significant differences between the study and control groups for age at diagnosis, gender distribution, tumor size, presence of tumor necrosis, presence of sarcomatoid differentiation, and adverse outcomes. No statistically significant differences were found in clinical outcome between the rare subtypes and classic/eosinophilic groups by tumor size, necrosis, and sarcomatoid differentiation. Further, no statistically significant differences were found in clinical outcome between the two groups, stratified by tumor size, necrosis, and sarcomatoid differentiation. Our findings corroborated previous studies that both sarcomatoid differentiation and tumor necrosis were significantly associated with poor clinical outcome in classic/eosinophilic ChRCC, and this was proven to be true for ChRCC with rare histologic subtypes as well. This study suggests that rare morphologic patterns in ChRCC without other aggressive features play no role in determining the clinical behavior of the tumor.

As different scientific disciplines begin to converge on machine learning for causal inference, we demonstrate the application of machine learning algorithms in the context of longitudinal causal estimation using electronic health records. Our aim is to formulate a marginal structural model for estimating diabetes care provisions in which we envisioned hypothetical (i.e. counterfactual) dynamic treatment regimes using a combination of drug therapies to manage diabetes: metformin, sulfonylurea and SGLT-2i. The binary outcome of diabetes care provisions was defined using a composite measure of chronic disease prevention and screening elements [27] including (i) primary care visit, (ii) blood pressure, (iii) weight, (iv) hemoglobin A1c, (v) lipid, (vi) ACR, (vii) eGFR and (viii) statin medication. We used several statistical learning algorithms to describe causal relationships between the prescription of three common classes of diabetes medications and quality of diabetes care using the electronic health records contained in National Diabetes Repository. In particular, we generated an ensemble of statistical learning algorithms using the SuperLearner framework based on the following base learners: (i) least absolute shrinkage and selection operator, (ii) ridge regression, (iii) elastic net, (iv) random forest, (v) gradient boosting machines, and (vi) neural network. Each statistical learning algorithm was fitted using the pseudo-population generated from the marginalization of the time-dependent confounding process. Covariate balance was assessed using the longitudinal (i.e. cumulative-time product) stabilized weights with calibrated restrictions. Our results indicated that the treatment drop-in cohorts (with respect to metformin, sulfonylurea and SGLT-2i) may have improved diabetes care provisions in relation to treatment naïve (i.e. no treatment) cohort. As a clinical utility, we hope that this article will facilitate discussions around the prevention of adverse chronic outcomes associated with type II diabetes through the improvement of diabetes care provisions in primary care.

The aim of this research was to determine the influence of the SiO2/Al2O3 molar ratio on the specific commercial properties of NaA zeolite subtypes as final market products (4A,4A-AG and 4A-MS) under the real production and process conditions. The value of the SiO2/Al2O3 molar ratio, so-called silicate module, was set as independently variable and the effect on the physical and chemical properties of each of the subtypes of NaA zeolites was examined. The paper investigates how the SiO2/Al2O3 molar ratio affects specific properties of NaA powders, namely the ion exchange capacity, oil adsorption capacity and water adsorption capacity. Some previous theoretical and experimental studies have shown that the molar ratio plays a crucial role in the formation of these very similar but for final application different subtypes of NaA zeolite. The experimental part of this work was performed and tested in real production conditions, which can be considered as an advantage in relevance to the obtained results. Various analytical and instrumental testing methods were used for the analysis of the obtained powders, including SEM, XRD and PSD analyses.

This study analyzes how service-learning contributes to the level of commitment to environmental sustainability in higher education institutions (HEIs), as perceived by their students. The empirical analysis has been conducted by using the PLS-SEM modelling, on a sample of 366 undergraduate students of business from Croatia and Bosnia & Herzegovina. The obtained results support the hypothesized influence of the service-learning development level on the sustainability commitment in higher education. We also consider the indirect effects within the model. They show that service-learning mediates the relationships between students’ idealism and sustainability commitment, as well as between students’ social trust and sustainability commitment. Implications of obtained empirical results for theory and higher education practice are discussed. The potential for generalizing results for other sustainability interventions is assessed.

Abstract Background CYP3A5 enzyme encoded by CYP3A5 is important for drug metabolism in gut and liver, whereas P-glycoprotein by ABCB1, is an ATP-dependent drug efflux pump which exports endo- and exogenous substances outside the cell. Aim The study was to assess the prevalence of CYP3A5 alleles: *1, *2, *3, *4, *6 and *7, and C and T of ABCB1 in Poles, Belarusians and Bosnians and to compare it with the data reported from other European populations. Subjects and methods Overall, 511 unrelated healthy subjects from Poland (n = 239), Belarus (n = 104) and Bosnia and Herzegovina (n = 168) were included in this study. Allele frequencies and statistical parameters (AMOVA version 2.9.3) were determined. Results In Poles, Belarusians and Bosnians the *3 allele of CYP3A5 was the most common, and wild-type allele *1, were: 5.8%, 1.6% and 2.1%, respectively. Allele *2 was very rare, and alleles *4, *6 and *7 were not detected. For the populations mentioned above, the ABCB1 allele C was: 48.1%, 51.4%, 52.4%, respectively. Conclusion In compared populations, the distribution of CYP3A5 variants but not ABCB1, differed significantly. Alleles *4, *6 and *7 of CYP3A5 did not occur or occurred rarely.

A range of the distinctive physical properties, comprising high surface-to-volume ratio, possibility to achieve mechanical and chemical stability after a tailored treatment, controlled quantum confinement and the room-temperature photoluminescence, combined with mass production capabilities offer porous silicon unmatched capabilities required for the development of electro-optical devices. Yet, the mechanism of the charge carrier dynamics remains poorly controlled and understood. In particular, non-radiative recombination, often the main process of the excited carrier's decay, has not been adequately comprehended to this day. Here we show, that the recombination mechanism critically depends on the composition of surface passivation. That is, hydrogen passivated material exhibits Shockley-Read-Hall type of decay, while for oxidised surfaces, it proceeds by two orders of magnitude faster and exclusively through the Auger process. Moreover, it is possible to control the source of recombination in the same sample by applying a cyclic sequence of hydrogenation-oxidation-hydrogenation processes, and, consequently switching on-demand between Shockley-Read-Hall and Auger recombinations. Remarkably, irregardless of the recombination mechanism, the rate constant scales inversely with the average volume of individual silicon nanocrystals contained in the material. Thus, the type of the non-radiative recombination is established by the composition of the passivation, while its rate depends on the degree of the charge carriers' quantum confinement.

Feminist care ethics has become a prominent ethical theory that influenced theoretical and practical discussions in a variety of disciplines and institutions on a global scale. However, it has been criticized by transnational feminist scholars for operating with Western-centric assumptions and registers, especially by universalizing care as it is practiced in the Global North. It has also been criticized for prioritizing gender over other categories of intersectionality and hence for not being truly intersectional. Given the imperialist and colonial legacies embedded into the unequal distribution of care work across the globe, a Western-centric approach may also carry the danger of paternalism. Hence, a critical approach to care ethics would require reckoning with these challenges. The aim of this article is first to unfold these discussions and the responses to them from care ethics scholars and then to present resources in Beauvoir’s existentialist ethics, specifically the tenet of treating the other as freedom, as productive tools for countering the Western-centric and paternalistic aspects of care practices.

The purpose of this study was to assess the antioxidant activity of the fresh extracts of Croatian and Greek watermelon seeds. Samples were prepared using two extraction methods: Soxhlet and maceration. Ethanol was used as a solvent in the Soxhlet, and methanol in the maceration method. The mass fractions of the extracts obtained by maceration were lower compared to those obtained by the Soxhlet method. The antioxidant capacity of fresh watermelon-seed extracts was determined by DPPH (2,2-diphenyl-1-picrylhydrazyl radical) method. The antioxidant capacity of the extracts was also expressed via IC 50 (half maximal inhibitory concentration). Based on the obtained IC 50 values (1.41 to 2.60 mg ml −1 ), all tested extracts showed antiradical activity but antioxidant capacity was better in extracts obtained by the maceration method. The reason for this may be the use of methanol as a solvent, which was to be expected, since methanol is a more polar solvent than ethanol. The neutralisation capacity of DPPH radicals of analysed extracts was compared to the neutralisation capacity of ascorbic acid as standard. The concentrations of tested extracts required to neutralize 50 % of DPPH radicals were significantly higher than the required concentration of ascorbic acid (0.25 mg ml −1 ).

In modern systems that rely on the use of battery management systems (BMS), longevity and the re-use of battery packs have always been important topics of discussion. These battery packs would require warehouse storage together with adequate monitoring and configuration prior to their reintegration into new systems. Traditional use of wired connections can be very cumbersome, and sometimes even impossible, due to the outer layers and packaging. To circumvent these issues, we propose an extension to the conventional BMS design that incorporates the use of near field communication (NFC) for the purpose of wireless battery pack status readout. Additionally, to ensure that these packs are only managed by authenticated devices and that the data communicated with is protected against outside eavesdropping and tampering, we present a solution in the form of a lightweight security layer on top of the NFC protocol. To show the feasibility of our design, an accompanying prototype has been implemented and evaluated.

The paper addresses the problem of detecting pedestrians using three dimensional data acquired by an autonomous mobile robot equipped with an on-board 3D laser scanner. Previous works in this field have dealt with various approaches for combining 2D and 3D range data features for the use in pedestrian classification. In this paper we propose an image processing pipeline for generating a depth image from point clouds data and then localizing object candidates from the depth image. It involves the image segmentation, feature extraction and human classification processes within unstructured dynamic environments. Three different approaches for the detection of pedestrians, vehicles and cyclists using only 3D range data were employed as a part of this system. We train and test the classifiers in an open environment, with presence of multiple pedestrians, cyclists and vehicles, using only point cloud data. The effectiveness and robustness of the proposed system are verified through experiments with real data. This system is also capable to deal with a real-time framerate (10Hz) with high accuracy.

The paper deals with the mathematical modeling and control of an unmanned aerial vehicle (UAV), called octocopter, based on a linear quadratic regulator (LQR). The complex multivariable and nonlinear UAV model is linearized and represented in the state space form. Optimal LQR control system, which is composed of combination the altitude (UAV height - ${z}$ position) and attitude (orientation) controllers, was first designed. Then, this system is extended to provide an additional control of the translation movement in ${x}$ and ${y}$ directions. The proposed LQR control structure is capable of controlling the UAV for all position and orientation coordinates while tracking desired 3D trajectory. Simulation studies are performed on the UAV model where the designed LQR controller has been compared with previously developed PD controller.

BACKGROUND The exposed pulp has been the topic of numerous studies, but well-designed and well-executed comparative trials on the outcome and treatment of these teeth have been limited. OBJECTIVES This study was conducted to answer the following questions: in patients with non-traumatic pulpitis associated with no or non-spontaneous pain in permanent teeth, (i) is direct pulp capping or pulpotomy (partial/full) as effective as selective or stepwise caries removal [Population/participants, Intervention(s), Comparator(s)/control, Outcome(s) (PICO) 1], (ii) is pulpotomy (partial/full) as effective as direct pulp capping (PICO 2), and (iii) is pulpotomy (partial/full) as effective as a pulpectomy (PICO 3), in terms of a combination of patient and clinical reported outcomes, with "tooth survival" as the most critical outcome? METHODS A literature search was conducted using Clarivate Analytics' Web of Science, Scopus, PubMed, and Cochrane Central Register of Controlled Trials from inception to November 3rd 2021. Grey literature and contents of the major subject journals were examined. Eligibility criteria followed the PICO questions. Two independent reviewers performed study selection, data extraction, and appraisal; disagreements were resolved by a third reviewer. The risk of bias was assessed by the revised Cochrane risk-of-bias tool for randomized trials. RESULTS Three randomized clinical trials (RCTs) were included in the review. No study fulfilled the criteria to answer PICO 1. There were no significant differences in the reported outcomes between investigated treatments in all included RCTs. None of the included studies reported the most critical outcome "tooth survival". A high loss of patients during the follow-up period was observed. DISCUSSION Although a few studies fulfilled strict eligible criteria, the results of this systematic review clearly highlight a paucity of available evidence. At the present time, clinical decisions cannot be substantiated by direct comparative trials. CONCLUSIONS Based on limited evidence, this systematic review discovered no significant differences in effectiveness between compared vital pulp treatments in managing non-traumatic pulpitis associated with no or nonspontaneous pain. Further high-quality RCTs are necessary to investigate the effectiveness of direct pulp capping or pulpotomy (partial/full) compared to selective or stepwise caries removal.