The aim of the study is to present and tune a fully automatic deep learning algorithm to segment colorectal cancers (CRC) on MR images, based on a U-Net structure. It is a multicenter study, including 3 different Italian institutions, that used 4 different MRI scanners. Two of them were used for training and tuning the systems, while the other two for the validation. The implemented algorithm consists of a pre-processing step to normalize and to highlight the tumoral area, followed by the CRC segmentation using different U-net structures. Automatic masks were compared with manual segmentations performed by three experienced radiologists, one at each center. The two best performing systems (called mdl2 and mdl3), obtained a median Dice Similarity Coefficient of 0.68(mdl2) - 0.69(mdl3), precision of 0.75(md/2) - 0.71(md/3), and recall of 0.69(mdl2) - 0.73(mdl3) on the validation set. Both systems reached high detection rates, 0.98 and 0.95, respectively, on the validation set. These encouraging results, if confirmed on larger dataset, might improve the management of patients with CRC, since it can be used as a fast and precise tool for further radiomics analyses. Clinical Relevance - To provide a reliable tool able to automatically segment CRC tumors that can be used as first step in future radiomics studies aimed at predicting response to chemotherapy and personalizing treatment.

The aim of the research was to determine whether the age of the patient affects the duration of the procedure and the amount of ionizied radiation delivered when performing diagnostic coronary angiography. The research was conducted at the Clinic for Invasive Cardiology of the Public Health Institution "University Clinical Center" Tuzla in the period from December 2018. to January 2020. The research included a total sample of 240 respondents, average chronological age of 62.60 ± 9.22 years, ranging from 24 to 85 years. Out of a total of 240 respondents, in 121 respondents coronarny angiography was performed using transradial arterial approach and 119 by performing a transfemoral arterial approach. The total sample was divided into two subsamples of respondents. The first sub-sample consists of respondents up to 65 years of age, and the second sub-sample consists of respondents over 65 years of age. During each performance of coronary angiography, the duration of the procedure (in minutes and seconds) and the amount of radiation delivered during the procedure (in mGy) were measured. The research data were processed using the method of parametric and non- parametric statistics. The Mann-Whitney U test was used to verify the research objective. Based on the obtained research results, it can be concluded that in patients over 65 years of age, the duration of the coronary angiography procedure is longer, and is at the limit of statistical significance (p= 0.057). The amount of delivered radiation is higher in respondents over 65 years of age, but it is not statistically significant (p= 0.396). Keywords: Coronary angiography, coronary disease, procedure duration, age, amount of delivered radiation.

The majority of refractories used today are associated with the iron and steel industries. Typically, the refractory lining of a blast furnace consists of a combination of different refractory materials chosen for different portions of the furnace, as well as distinct process conditions and temperature ranges. Knowledge and requirements for the iron manufacturing system in conjunction with the physical, mechanical, and chemical qualities of the proposed refractories determine the choice of refractory combination. Inadequate understanding of the aforementioned components frequently results in refractory failure, which then becomes a difficult problem to tackle. A blast furnace's refractory liner typically fails owing to any number or combination of these variables. To facilitate comprehension, we will explain the types of refractory lining required in a blast furnace by region, as well as the observed trend in refractory lining patterns over the past few decades.

Key Points The aptamer rondoraptivon pegol improved VWF/FVIII levels, multimer patterns, and thrombocytopenia in type 2B von Willebrand disease. Once weekly subcutaneous injections of rondoraptivon pegol may in the future be used for prophylaxis or treatment of VWD.

C. jejuni and C. coli have the greatest zoonotic potential. In humans, they cause campylobacteriosis with symptoms of food poisoning. Epidemics are mostly related to the consumption of non-chlorinated water and contaminated chicken food and in the spring-summer season. Since 2005, according to the European Food Safety Agency and the European Center for Disease Prevention and Control, campylobacteriosis has been considered the leading alimentary intoxication. A review of the literature was published in Medline, PubMed, Google Scholar, electronically available scientific journals, books, textbooks, proceedings books and reports EFSA/ ECDC, FAO/ WHO. Only literature in English, Bosnian/Croatian/Serbian is included. As a measure to prevent campylobacteriosis, sanitation is recommended in the primary production of chicken meat, and the use of probiotics in meat as biological preservatives is being investigated

INTRODUCTION Although vaccines are the safest and most effective means to prevent and control infectious diseases, the increasing rate of vaccine hesitancy and refusal (VHR) has become a worldwide concern. We aimed to find opinions of parents on vaccinating their children and contribute to available literature in order to support the fight against vaccine refusal by investigating the reasons for VHR on a global scale. METHODOLOGY In this international cross-sectional multicenter study conducted by the Infectious Diseases International Research Initiative (ID-IRI), a questionnaire consisting of 20 questions was used to determine parents' attitudes towards vaccination of their children. RESULTS Four thousand and twenty-nine (4,029) parents were included in the study and 2,863 (78.1%) were females. The overall VHR rate of the parents was found to be 13.7%. Nineteen-point three percent (19.3%) of the parents did not fully comply with the vaccination programs. The VHR rate was higher in high-income (HI) countries. Our study has shown that parents with disabled children and immunocompromised children, with low education levels, and those who use social media networks as sources of information for childhood immunizations had higher VHR rates (p < 0.05 for all). CONCLUSIONS Seemingly all factors leading to VHR are related to training of the community and the sources of training. Thus, it is necessary to develop strategies at a global level and provide reliable knowledge to combat VHR.

Distributional shift, or the mismatch between training and deployment data, is a significant obstacle to the usage of machine learning in high-stakes industrial applications, such as autonomous driving and medicine. This creates a need to be able to assess how robustly ML models generalize as well as the quality of their uncertainty estimates. Standard ML baseline datasets do not allow these properties to be assessed, as the training, validation and test data are often identically distributed. Recently, a range of dedicated benchmarks have appeared, featuring both distributionally matched and shifted data. Among these benchmarks, the Shifts dataset stands out in terms of the diversity of tasks as well as the data modalities it features. While most of the benchmarks are heavily dominated by 2D image classification tasks, Shifts contains tabular weather forecasting, machine translation, and vehicle motion prediction tasks. This enables the robustness properties of models to be assessed on a diverse set of industrial-scale tasks and either universal or directly applicable task-specific conclusions to be reached. In this paper, we extend the Shifts Dataset with two datasets sourced from industrial, high-risk applications of high societal importance. Specifically, we consider the tasks of segmentation of white matter Multiple Sclerosis lesions in 3D magnetic resonance brain images and the estimation of power consumption in marine cargo vessels. Both tasks feature ubiquitous distributional shifts and a strict safety requirement due to the high cost of errors. These new datasets will allow researchers to further explore robust generalization and uncertainty estimation in new situations. In this work, we provide a description of the dataset and baseline results for both tasks.

The role of ECG segmentation tool has been pivotal in automated analysis of real-time ECG signals for detection of non-invasive cardiovascular and physiological conditions. Most of the existing approaches focus on traditional signal processing and/or traditional machine learning based approaches which are highly dependent on signal noise, inter/intra subject variability, etc. With the advent of deep learning based networks, it is possible to design and develop the classification model based on local features along with spatial and temporal context of the physiological signals. In this paper, we developed the attention based Convolutional Bidirectional Long Short Term Memory (Conv-BiLSTM) architecture network based on local beat features and temporal sequencing while correlating ECG beat across different positions. The performance of our ECG segmentation tool has been evaluated against the state-of-the art approaches in terms of ECG segmentation and fiducial point detection accuracy. The ECG segmentation accuracy was 95% whereas fiducial point detection accuracy was 99.4%.

We evaluate classical macroeconomic theory IS-LM model and expose the paradox of real interest rate (r) which equilibrates S (real goods and services produced and saved in the domestic economy) and I (investments) if the loanable capital is not coming only from real savings but investments can be financed through the money creation or 'money capital' generated either through the credit expansion in the banking system due to fractional reserves banking or through the open market operations by the government. If r is exogenous and lowered through monetary policy, I is expanded beyond S, which paradoxically require higher r to correct for these disbalances in macroeconomic sense. Economic and financial system should eliminate this exogenous influence on r, by separating money creation from r, so that r is left to play its equilibrating role in macroeconomic sense. Separation of r from interest rate on money is in line with prescribed prohibition of setting any fixed reward on money per se, and in general ex-ante setting of reward in productive endeavors which is also forbidden in Islamic jurisprudence. We show that classic macroeconomic theory does not expose the effect that fresh money has on saving and capital markets from the perspective of macroeconomic balance. Therefore, macroeconomic policy should concentrate on achievement of macroeconomic targets without lowering r as it is paradox to lower the return on capital and savings to promote economic growth as higher r on capital promotes investment. This is possible if ex-ante determination of reward on borrowed funds is adopted. However, the phenomena of fresh capital creation in the form of new money and its use in financing of investments should be rethought from macroeconomic perspective and overall social justice as real savings are not of equal opportunity cost as new money (capital)?

The aim of this study was to examine the frequency of consumption of coffee beverages in the city of Mostar. In 2019, an analysis of caffeine content was performed on HPLC in 10 different samples of coffee beverages. Samples of coffee were taken from the market of the city of Mostar by random selection. In addition to the High-performance liquid chromatography (HPLC) method, the study was conducted using empirical and descriptive methods. An assessment of daily (EDI) and weekly intake (EWI) was also performed were on the base of determined values of caffeine content in 10 different coffee samples. The acute toxic dose of caffeine is not well defined, but it is considered more than 10 grams of caffeine per day for adults, while in most countries it is not recommended that more than 450 mg of caffeine be consumed per day. The samples were found to be in accordance with the EFSA Scientific Opinion (European Food Safety Authority) stating that a single dose of 200 mg of caffeine from all sources does not pose a risk to the health of healthy adults. (EFSA, 2015).

Austenitic stainless steel is mostly used at high temperatures. It is known that during heating of the austenitic stainless steel with increasing temperature and time of annealing a microstructure is changed i.e. there is the precipitation of carbides followed by precipitation of secondary phases as a sigma phase. The presence of the delta ferrite in austenitic stainless steel enhances the formation of the sigma phase. This study represents the influence of delta ferrite on the sigma phase formation and the effect of the sigma phase on general corrosion. Corrosion tests were conducted in the corrosion cell according to Standard ASTM G5, on instrument potentiostat/galvanostat, Princeton Applied Research, model 263A-2, with the software PowerCORR® (Standard, ASTM G5-94). Examinations were carried out in 1% HCl and 10% FeCl3 solutions. The Tafel extrapolation method was used for the investigation of general corrosion. The results of corrosion testing indicated that the intensity of the general corrosion increases with the increase of the delta ferrite and sigma phase contents.

Ugledna talijanska izdavačka kuća Mucchi iz Modene u rujnu 2021. godine, pod uredničkom palicom Antonija Saccoccija, redovitog profesora Sveučilišta La Sapienza u Rimu, i Stefana Porcellija, višeg istraživača Sveučilišta u Bresciji, objavila je znanstvenu monografiju pod nazivom Kineski građanski zakonik i rimski pravni sustav (Codice civile cinese e sistema giuridico romanistico). Riječ je o monografiji za kojom se, očekivano, javio veliki interes u romanističkim krugovima, ali i među širom zainteresiranom pravničkom javnošću. Naime, 1. siječnja 2021. godine u Narodnoj Republici Kini, najmnogoljudnijoj i jednoj od ekonomski najsnažnijih zemalja svijeta, stupio je na snagu novi Građanski zakonik (Codex iuris civilis sinicus, dalje: Zakonik), koji je 28. svibnja 2020. godine usvojio Državni narodni kongres Kine. Težnja za uređenjem pravnog sustava, poštujući princip vladavine prava u Kini, prisutna je posljednjih nekoliko desetljeća. U segmentu privatnog prava bili su prisutni veliki napori i različiti iskoraci u cilju uređenja mnogih pitanja značajnih za kinesko društvo u cjelini. Došlo je do usvajanja Zakona o dioničkim društvima, Zakona o ugovorima, Zakona o vlasništvu i stvarnim pravima itd. Pravni znanstvenici koji su pratili te izmjene, poput jednog od urednika predmetne monografije, Stefana Porcellija, ocijenili su kako su revizije ovih zakona bile prilično značajne i temeljite te su se ticale mnogih segmenata duboko vezanih s istinskim potrebama kineskog društva. Donošenje svih tih zakona te kontinuirani rad na modifikacijama unutar pravnog poretka dodijelio je novim zakonima središnju ulogu u kineskom društvu. Iako su nedvojbeno reformski procesi doprinosili jačanju vladavine prava, nastojeći uspostaviti vertikalni niz između kineske prošlosti, sadašnjosti i budućnosti, sve se izvjesnijom činila nužnost kodificiranja prava. Prijedlozi za izradu Zakonika spominjali su se još prije 20-ak godina, ali zauzet je opći stav kako društvo, ako se savinjistički izrazimo, još uvijek nije zrelo za cjelovitu reformu. I tako, nastavljen je niz donošenja novih zakona, što je zbog velike količine propisa uzrokovalo nužnost sustavnog usklađivanja kako bi se ti propisi mogli razumjeti i primijeniti. Zbog svega navedenog u listopadu 2014. godine Središnji odbor Komunističke partije Kine izrazio je želju da se izradi Nacrt građanskog zakonika za Narodnu Republiku Kinu. Radovi na izradi kodifikacije napredovali su velikom brzinom, a u tom procesu došlo je do snažne, u prvom redu akademske, suradnje kineskih i talijanskih pravnika. Na tom tragu rimsko pravo i moderne građanske kodifikacije, osobito talijanski Codice civile, poslužili su kao izvrsni modeli iz kojih se crpila pravnička inspiracija, a sve kako bi se, poštujući pravila o pravnoj transplantaciji, instituti i koncepti na adekvatan način inkorporirali u kinesku pravnu kulturu i omogućili joj daljnji gospodarski rast i razvoj, što je nedvojbeno u korelaciji s osiguranjem pravne sigurnosti. Zakonikom je postavljen cilj osiguravanja pravde kroz reguliranje građanskih, trgovačkih, a jednim dijelom i radnih odnosa, kroz sustavno pružanje jasnog pravnog okvira onima koji posluju ili žele poslovati na području Kine. Kako su sami urednici naglasili u uvodnoj studiji, forma i koncepti predmetne kodifikacije pokazuju kako je kineski zakonodavac i tamošnja pravna znanost prilikom izrade kodifikacije nastojala postići dijalog s rimskim pravnim sustavom, odnosno pravničkim poukama izgrađivanim u rimskoj pravnoj tradiciji posljednjih tisućljeća. Zbog toga, kako bi se istinski razumjeli opsezi primjene i izvorna značenja koncepata primijenjenih u Zakoniku, nužno je, u cilju razumijevanja sadržaja, dobro poznavati te konstantno proučavati rimski pravni sustav i njegov unutarnji razvoj.