Zakon o digitalnim uslugama EU nastoji da uredi usluge koje se pružaju na internetu i suzbije zloupotrebu ličnih podataka i proliferaciju štetnih sadržaja poput govora mržnje i dezinformacija, odnosno da unapredi opštu bezbednost korisnika. S obzirom na njegovu složenu i slojevitu strukturu, implementacija ovog propisa predstavlja izazov za EU i države članice. Pored prikaza same strukture i pozicioniranja novog propisa u širem kontekstu politika EU u oblasti digitalnih tehnologija, centralno pitanje ovog rada jeste dejstvo Zakona o digitalnim uslugama na legislativu Zapadnog Balkana. Kroz analizu trenutnih prilika u pravnim okvirima u Bosni i Hercegovini i Srbiji, rad izdvaja ključne odredbe ove regulative iz perspektive potencijalnih rizika i interesa za ekonomije Zapadnog Balkana, ukazuje na moguća lokalna rešenja principa podele nadležnosti između institucija EU i država članica, te druga pitanja implementacije.

Research Question (RQ): Start-up companies represent the support of the development of every economy. However, this is a more fragile part of the economy, because a large number of start-up companies fail in the first years of their development. The results of previous research indicate that there are several reasons for the failure of start-ups, and one of the key ones is the difficult application of innovations. In today's modern and turbulent times, in the embrace of globalization, innovations are an absolute must have. All companies that are not innovatively oriented are doomed to failure. Even large, multinational companies pay for the lack of innovation, so this is a signal to start-ups that investing in innovation is the most important thing in their budget. However, there are numerous challenges and obstacles in the application of innovations at start-ups. The main problem of the research is to detect what are the most important obstacles and challenges for the application of innovations in Bosnian start-ups, and by what methods it is possible to overcome them. Purpose: The main purpose of the research is to point out the obstacles and challenges faced by start-up companies in Bosnia and Herzegovina and to give adequate recommendations for start-ups as well as all interest groups, how to eliminate them effectively, in order to make the economy and business operations of the company more propulsive and proactive. Method: In the theoretical explanation of the problem, sufficient information contained in previous researches will be gathered, regarding the considered issue. Through empirical research, it will be determined what the most common types of obstacles are and challenges faced by start-ups in Bosnia and Herzegovina, what types of innovations are most often implemented in start-up companies in Bosnia and Herzegovina and which methods and ways can be used to overcome the mentioned obstacles. The research will be done on a sample of 10 start-up companies in BiH. Results: The results of the research will show what are the obstacles and challenges in the implementation of innovations recorded in the sample of observed start-ups, what types of innovations are most often implemented in start-ups in Bosnia and Herzegovina, and how to most effectively overcome obstacles in the implementation of innovations in start-ups, with the aim of their better and more successful business. Organization: Through research of this type, managers of start-ups (or those who intend to become one) can more easily identify the basic obstacles in the implementation of innovations in their business, and use the proposed methods to overcome them, in order to make their business more stable and sustainable. Society: Increasing the stability of start-ups brings long-term benefits for the entire society. Socially responsible business of start-ups can contribute to a better distribution of resources in society, which is desirable for all participants in society, but also for the environment. Originality: Research of this type represents one of the rare researches on start-ups in Bosnia and Herzegovina. It is a pioneering research in the context of challenges and obstacles in the implementation of innovations at start-ups in Bosnia and Herzegovina. Limitations / further research: Limitations: small sample size, difficulties in data collection. Recommendations: research on the implementation of innovations according to the areas in which start-ups operate.

Resin and charcoal production have historically shaped the cultural and economic life of Bosnia and Herze-govina, particularly in its rural and mountainous regions. Drawing on a historical-descriptive methodological approach, this overview traces the evolution of resin tapping and charcoal production in Bosnia and Herze-govina, outlines traditional and modern techniques, and evaluates their present industrial relevance as well as future development prospects. Although largely supplanted by modern industry, traditional practices continue to provide valuable ecological and engineering insights, particularly for sustainable forest management. In the context of climate change and the growing demand for renewable raw materials, these forest-based activities may acquire renewed significance. Potential directions include the modernisation of production tech - nologies, the integration of circular economy principles, and the diversification of biomass resources. With its abundant forest resources, inherited expertise, and established industrial base, Bosnia and Herzegovina is well-positioned to re-emerge as a competitive and sustainable producer of resin, charcoal, and related products for regional and European markets.

Abstract: The Sava Center in Belgrade is one of the most iconic architectural and cultural landmarks of Yugoslav Modernism. Built between 1976 and 1979, it functioned as a major congress and cultural venue, embodying ideals of civic ambition, technological innovation, and public accessibility. With its monumental Brutalist aesthetic and an all-encompassing spatial program, it remains a uniquely significant example of the region’s architectural innovation and technological advancement. This research presents a performance-based retrofit framework for historically significant buildings of this scale and typology, using the Sava Center as a hypothetical case study. Developed through a multi-method approach - bridging architectural history, building science, and digital performance modeling - the study demonstrates how design, technology, and heritage values can be aligned to improve energy performance without compromising architectural and cultural integrity. Methods include archival research, BIM modeling, hygrothermal and thermal envelope simulations (Revit, WINDOW, THERM, WUFI), and whole-building energy analysis (IES VE). Results suggest that the proposed design strategies could reduce energy use by over 50% while preserving the building’s original character, programmatic intent, and civic function. Initiated in 2021, the study coincided with actual renovations to the Sava Center’s Congress Hall building following its simultaneous privatization and designation as a cultural heritage site. These interventions, though aimed at energy efficiency, were completed rapidly, with minimal transparency and significant programmatic changes. Although the renovations concluded before the study’s completion, the presented case study remains a critical reference for more systematic and preservation-sensitive retrofits. In a region where too many significant buildings built between 1945 and 1991 are being rapidly privatized and, unfortunately, demolished, this framework helps illuminate the substantial potential for their protection - both through cultural heritage designation and sensitive, energy-efficient renewal. This research introduces the overarching framework, key findings, and policy implication, with future work to expand on detailed analysis.

Sodium-glucose cotransporter 2 inhibitors (SGLT2is) and glucagon-like peptide-1 receptor agonists (GLP-1 RAs) have transformed the management of type 2 diabetes, obesity and cardiorenal disease. Beyond their established glycaemic and weight-lowering effects, both drug classes consistently lower blood pressure (BP), a benefit that remains relatively underrecognized. This review provides an integrated synthesis of trial evidence, real-world data and meta-analyses examining the antihypertensive effects of SGLT2is and GLP-1 RAs. Across cardiovascular, heart failure, renal and obesity trials, modest but clinically meaningful BP reductions have been observed in diverse populations, including individuals without diabetes. These effects appear largely independent of glycaemic control and offer additive value in high-risk patients with overlapping comorbidities. The totality of evidence supports the strategic incorporation of these agents into future antihypertensive frameworks, warranting further investigation in dedicated blood pressure-focused trials.

Coniferous forests cover 41% of Bosnia and Herzegovina, with Norway spruce ( Picea abies ) being an ecologically and economically important species. Bark beetles, especially the European spruce bark beetle ( Ips typographus ), pose a major threat, often causing large-scale dieback. Factors such as wind, drought, terrain exposure, and slope can increase susceptibility to outbreaks. This study aimed to assess the influence of these factors on forest health in bark beetle outbreak areas, based on stump measurements after sanitary logging.Fieldwork was conducted in spring 2024 on five known bark beetle hotspots managed by “Šumsko privredno društvo Zeničko-dobojskog kantona” d.o.o. Zavidovići. Data collected included stump diameter, wood decay, bark thickness, tree coordinates (via AlpineQuest), exposure, and slope. Analyses were performed in STATGRAPHICS Plus using one-way ANOVA and Bonferroni correction.A total of 507 stumps were analyzed. About 81% were in diameter classes 31–50 cm and 51–80 cm and nearly 48% showed central wood decay. Terrain exposure and slope significantly influenced stump diameters, with the largest averages on SW exposure and 2–5% slopes. Stump diameter also significantly affected decay size, while bark thickness showed no significant variation across exposure or slopes.This research confirmed that Norway spruce in diameter size categories 31–50 cm and 51–80 cm is most vulnerable to bark beetle attacks. This susceptibility is further intensified if trees are located on south-facing, moderate slopes. Central wood decay was present in nearly half of the observed tree stumps, leading to the conclusion that its presence is another predisposing factor for bark beetle attacks. Bark thickness on the observed tree stumps did not vary significantly on different terrains, which is a result that differed from the results obtained in other similar studies.

<p>The traditional role of the fa&ccedil;ade, historically centered on providing protection against environmental conditions and reducing CO₂ emissions, has been significantly redefined through advances in software technologies and material sciences. These developments have led to the emergence of the fa&ccedil;ade system as a structurally independent component functioning as an active regulator of energy consumption, thereby creating new opportunities for research and innovation. One approach to studying these systems involves the application of folding principles derived from origami, which facilitates the design of modular geometric structures capable of dynamic environmental responses. Fa&ccedil;ades composed of interconnected, homogeneous elements can effectively regulate daylight penetration and thermal energy accumulation, particularly in zones exposed to direct external influences.</p> <p>To further develop such systems, it is essential to design an origami pattern whose geometric and mechanical characteristics can potentially respond to the given structural and technical challenges. This study explores the potential application of selected origami patterns in kinetic fa&ccedil;ade systems, with a focus on analyzing the actuation mechanisms that control the movement of geometric modules. Furthermore, the research evaluates the justification for integrating kinetic fa&ccedil;ade systems into contemporary architectural practice, with the aim of contributing to the development of sustainable, adaptive, and energy-efficient building envelopes.</p>

Food, especially fish meat, is extremely vulnerable to oxidation and microbiological deterioration. Therefore, effective analytical techniques for quality control and safety monitoring are required. Electrochemical biosensors have become reliable, rapid, and affordable devices for in-field and real-time food quality assessment. However, their application is often limited in point-of-need scenarios due to the requirement for intensive sample preparation. Here, we introduce a microneedle array (MNA)-based electrochemical biosensor, designed for direct food safety and quality analysis without the need for sample preparation. A gold (Au)-coated polymeric MNA was functionalized with a chitosan-gold nanoparticles (Ch-AuNP) nanocomposite and further modified by immobilizing xanthine oxidase (XO) for selective hypoxanthine (HX) detection. The MNA-based biosensor exhibited a linear range between 5 and 50 μM, and 50 to 200 μM, with a sensitivity of 0.024 μA/μM and a limit of detection (LOD) of 2.18 ± 0.75 μM for HX, with a response time of approximately 100 s. Furthermore, the MNA-based biosensor was successfully utilized for monitoring HX levels in fish tissue samples over 48 h, showing strong agreement with results obtained from a commercial Amplex Red assay kit. The technology can be used for real-time food quality assessment and food safety monitoring due to its high sensitivity, interference tolerance, and lack of requirement for sample preparation.

The global energy transition is characterized by the simultaneous challenges of decarbonization, digitalization, and decentralization [...]

Broadcasting meteorology is the part of meteorology which deals with communicating the data and information to the public. Nowadays it has gained momentum in parallel with the rise of extreme weather conditions, providing the beneficial opportunity to inform and educate the public. This implies breaking down abstract terminology and using the most advanced visual aids to simplify the complex language. However, the extreme weather perception is skewed due to climatic and meteorological illiteracy, the inability to comprehend the importance of the planetary energy budget and the overall contribution of greenhouse gases to the climate system. One of the greatest challenges for the broadcast meteorologists is the short lifespan of the forecasts – they may be verified in a few minutes, hours or days. Annually, it is not a rare occurrence that a frontal system is delayed or a convective storm degrades faster or changes the trajectory for which the broadcast meteorologist is crucified by the public. Therefore, narrow space and time references are often the biggest enemies. Another very recent issue is the colour bar scheme choice as the red and pink shades are to be the most fearmongering for the public and often used to be compared with past events. In July 2022, the conspiracy theories skyrocketed when the Met Office announced its first 40 °C in the UK, with the accusation of meteorologists being “harbingers of doom.” However, this was not an isolated case, as in April 2023, due to an exceptional heatwave for the time of the year, meteorologists at AEMET (Spanish Hydrometeorological Service) faced life threats, severely raising the pressure and affecting their contribution to society. Moreover, the probabilistic approach pours the confusion in the traditional weather reports and applications to the end users, often which cannot be perceived by the public to decide whether they will need an umbrella if the rain is expected, or not to stay dry. These issues remain the challenges for the foreseeable future, raising the concerns of presenting factual information, seeking alternative solutions for the numerical values in presenting the data to the public and the role of a broadcast meteorologis

We determine how much TeV-scale new physics can deviate from flavor universality, $U(3)^5$, while respecting stringent bounds on flavor-changing neutral currents. The minimal continuous subgroup that must be approximately preserved is identified as $SU(2)_{q} \times U(1)_{X}$. With only a few symmetry-breaking spurions of $\mathcal{O}(10^{-2})$, all observed fermion hierarchies may be reproduced, offering a new perspective on the SM flavor puzzle. Remarkably, this framework provides structural flavor protection for generic TeV-scale new physics within the SMEFT, enlarging the space of collider-accessible scenarios beyond MFV and $U(2)^5$ and allowing for richer patterns of flavor violation.

Irritable bowel syndrome (IBS), a disorder of gut–brain interaction, is diagnosed using symptom-based Rome criteria. These criteria classify IBS patients into four subtypes in accordance to their stool patterns. However, whether this subtyping approach is based on true differences in the underlying biology of IBS patients, is unclear. Volatile organic compounds (VOCs) in the faecal headspace reflect both the gut microbial and host intestinal intraluminal processes and thereby may be used to study pathophysiological differences between IBS and its subtypes. We profiled faecal headspace VOCs in a cohort of 164 patients with IBS and 143 healthy controls using gas chromatography-mass spectrometry. Random forest models were employed to impute missing values and identify discriminatory VOCs to differentiate IBS patients from healthy controls. We corrected for faecal water content using partial least squares regression. Multivariate associations between the obtained volatile profiles and Rome III IBS subtypes were evaluated using regularized MANOVA. A total of 39 VOCs, including short-chain fatty acid esters, neurotransmitter-related metabolites, alcohols, and sulphides, were selected as significantly altered in patients with IBS. Our classification model achieved an area under the curve of 0.82 on both training and independent test sets, demonstrating robust separation between IBS patients and healthy individuals. However, VOC profiles did not associate to Rome III -based IBS subtypes. This study highlights the potential of faecal VOC profiling as a non-invasive tool for studying and characterizing IBS, yet they also reveal a disconnect between metabolic signatures and current stool-based subtypes. While the Rome criteria remain the clinical standard for diagnosis and subtyping of IBS, they offer limited insight into underlying disease mechanisms. Future research should focus on integrating VOC analysis with other omics approaches to refine IBS sub-classification into biologically relevant clusters, which may aid to improve personalized therapeutic strategies.

Summary Background The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2023 estimates health loss from migraine, tension-type headache, and medication-overuse headache. This study presents updated results on headache-attributed burden from 1990 to 2023, along with clinical and public health implications. Methods Data on the prevalence, incidence, or remission of migraine, tension-type headache, and medication-overuse headache were extracted from published population-based studies. We used hierarchical Bayesian meta-regression modelling to estimate global, regional, and country-level prevalence of headache disorders. For the first time in GBD 2023, age-specific and sex-specific estimates of time in symptomatic state were applied by meta-analysing individual participant data from 41 653 individuals from the general populations of 18 countries from all parts of the world. Disability weights were applied to calculate years lived with disability (YLDs). Since medication-overuse headache is a sequela of a mistreated primary headache (due to medication overuse), its burden was reattributed to migraine or tension-type headache, informed by a meta-analysis of three longitudinal studies. Findings In 2023, 2·9 billion individuals (95% uncertainty interval 2·6–3·1) were affected by headache disorders, with a global age-standardised prevalence of 34·6% (31·6–37·5) and a YLD rate of 541·9 (373·4–739·9) per 100 000 population, with 487·5 (323·0–678·8) per 100 000 population attributed to migraine. The prevalence rates of these headache disorders have remained stable over the past three decades. YLD rates due to headache disorders were more than twice as high in females (739·9 [511·2–1011·5] per 100 000) as in males (346·1 [240·4–481·8] per 100 000). Medication-overuse headache contributed 58·9% of the YLD estimates for tension-type headache in males and 56·1% in females, as well as 22·6% of the YLD estimates for migraines in males and 14·1% in females. Interpretation Headache disorders, in particular migraine, continue to be a major global health challenge, emphasising the need for effective management and prevention strategies. Much headache-attributed burden could be averted or eliminated by avoiding overuse of medication (including over-the-counter medication), underscoring the importance of public education. Funding Gates Foundation.

Recent excavations at Pompeii’s Regio IX have uncovered an intact ancient construction site, offering insights into Roman building techniques at the time of the eruption of Mount Vesuvius in 79 CE. Microstructural and chemical analysis of materials collected from previously constructed walls, walls under construction, and adjacent dry, raw material piles show unequivocally how quicklime was pre-mixed with dry pozzolan before adding water in the creation of Roman concrete. This construction method, also known as hot mixing, results in an exothermic reaction within the mortar and the formation of lime clasts, key contributors to the self-healing and post-pozzolanic reactivity of hydraulic mortars. The analysis of reaction rims around volcanic aggregates demonstrate aggregate/matrix interfacial remodeling, where calcium ions originating from the dissolution of lime clasts diffuse and remineralize, producing amorphous phases and various polymorphs of calcium carbonate (including calcite and aragonite). Furthermore, the parallel discovery of masonry materials and tools permits elucidation of the entire construction workflow, including the steps required to process binding mortars and larger aggregates (caementa). These findings advance our understanding of ancient Roman construction and long-term material evolution, providing a scientific basis for developing more durable and sustainable concretes and restoration materials inspired by ancient practices. Here the authors combine microstructural and chemical analysis of building materials collected from an active construction site in Pompeii prior to the eruption of Mount Vesuvius in 79 CE. Through these analyses, they identify the key raw materials and processes used in the production of Roman concrete.