[This corrects the article DOI: 10.3389/fpubh.2022.795841.].

Aicardi–Goutières syndrome (AGS) is a genetically determined early-onset progressive encephalopathy caused by mutations leading to overexpression of type I interferon (IFN) and resulting in various clinical phenotypes. A gain-of-function (GOF) mutation in the IFIH1 gene is associated with robust production of type I IFN and activation of the Janus kinase (JAK) signal transducer and activator of the transcription (STAT) pathway, which can cause AGS type 7. We detail the clinical case of an infant who initially presented with Pneumocystis jirovecii pneumonia (PCP), had recurrent respiratory infections, and was later treated with a JAK inhibitor, baricitinib, because of a genetically confirmed GOF mutation in the IFIH1 gene. This spectrum of IFIH1 GOF mutations with overlapping features of hyperinflammation and severe opportunistic infection, which mimics combined immunodeficiency (CID), has not been described before. In this case, therapy with baricitinib effectively blocked IFN-α activation and reduced STAT1 signaling but had no effect on the progression of the neurological disease.

Climate factors have an impact on plant life cycle, yield, productivity, economy and profitability of agricultural production. There are not a lot of studies on understanding of influence of climate factors variation on maize yield in agro-ecological conditions of Serbia. The aim of this paper is analysis of variation of climatic factors over a long-time period, as well as assessment of impact of the examined climate parameters on maize yield in two localities in the Republic of Serbia. For the analysis of climatic factors (temperature, precipitation, sunshine, humidity) in the region of Central Serbia and Vojvodina, the data of meteorological stations Kragujevac and Sombor during two thirty-year periods (1961–1990 and 1991–2020) were used. In order to determine the existence and strength of the relationship between the observed climatic factors and maize yield, a correlation analysis of these indicators for the period 2005–2020 years, was performed. In the period 1991–2020, the average values of temperature were annually increased for 0.046 °C in Kragujevac and for 0.05 °C in Sombor, and in the same period the average value of sunshine on an annual level was increased for 1.3 h in Kragujevac and for 5.01 h in Sombor, 2020 in comparison to average values in period of 1961–1990. The humidity was decline annually for 1.3 in Kragujevac and for 3.4 in Sombor in period 1991–2020 in comparison to average humidity in period of 1961–1990. The results of the correlation analysis showed that the maize yield was significantly lower in the years with expressed high temperatures and precipitation deficit. Based on these studies, established effect of climate change on maize yield and that this demand developing adaptation agricultural practice through creating maize hybrids and varieties with greater adaptability and improvement of agrotechnic measure.

ABSTRACT Background The aim of this study was to identify trends in total, deceased donor (DD) and living donor (LD) kidney transplantation (KT) rates in European countries. Methods The European Renal Association (ERA) Registry and the Global Observatory on Donation and Transplantation (GODT) databases were used to obtain the number of KTs in individual European countries between 2010 and 2018. General population counts were obtained from Eurostat or the national bureaus of statistics. The KT rate per million population (p.m.p.) and the average annual percentage change (APC) were calculated. Results The total KT rate in the 40 participating countries increased with 1.9% annually [95% confidence interval (CI) 1.5, 2.2] from 29.6 p.m.p. in 2010 to 34.7 p.m.p. in 2018, reflecting an increase of 3.4 p.m.p. in the DD-KT rate (from 21.6 p.m.p. to 25.0 p.m.p.; APC 1.9%; 95% CI 1.3, 2.4) and of 1.5 p.m.p. in the LD-KT rate (from 8.1 p.m.p. to 9.6 p.m.p.; APC 1.6%; 95% CI 1.0, 2.3). The trends in KT rate varied widely across European countries. An East–West gradient was observed for DD-KT rate, with Western European countries performing more KTs. In addition, most countries performed fewer LD-KTs. In 2018, Spain had the highest DD-KT rate (64.6 p.m.p.) and Turkey the highest LD-KT rate (37.0 p.m.p.). Conclusions The total KT rate increased due to a rise in the KT rate from DDs and to a lesser extent from LDs, with large differences between individual European countries.

The purpose of the study is to scientifically substantiate the positive influence of football on the physical and intellectual development of athletes. Material and methods. When conducting experimental research, a student questionnaire was first conducted to identify the success of studies and the specific interests of students who play football, play other sports, and students who do not play sports at all. 82 fifth-grade students of schools No. 38, 49 took part in the survey. The formative experiment was conducted on the basis of Kindergarten No. 38, in the fifth grades. It was found that the largest percentage of the total number of students are those engaged in other sports (58.5%). A large number are students who do not play any sports (34.10% of the total number of students). The smallest percentage was found among students who play football (7.3% of the total number of students). Results. It has been established that among the students who play football, there are absolutely no students who study at the first level of competence (in the final grades there are grades of 1-3 points on a 12-point scale), 33.3% are those whose academic success is level 2 competence (among the final grades there are grades of 4-6 points), and the largest percentage are students studying at the third level of competence (66.7%) (among the final grades there are no grades below 7 points). Among the students who are engaged in other sports, there are also absolutely no students who study at the first level of competence. Among students who do not play sports, the largest number of those who study are dissatisfied and satisfied. This shows that playing sports, both football and other sports, provide conditions for improving academic performance Conclusions. The obtained data indicate that the practice of sectional work on football provides conditions for the combined physical, intellectual and artistic development of children, about the possibility of a comprehensive all-round influence on the process of child development through the use of effective means of comprehensive development of children.

The presence of plastic waste in large quantities in the environment is a major problem and therefore a challenge for many researchers to examine the most effective methods of their disposal. In this paper, the source of microplastic and its hazardous effect on human health and interactions of plastics with plants were studied. Due to the specific physical-chemical features of micro- and nano-plastics, they are ideal candidates for the adsorption of organic pollutants, pathogens and heavy metals. The uptake and accumulation of nanoplastics by plants, adsorption studies, and bioaccumulation are shown here. In addition, recent research on the interaction of polystyrene micro- and nanoplastics with plants has been discussed. Many studies have shown that the most affected part of the plant was the roots, followed by leaves, shoots, and then the stem. Nanoplastics are found to be more harmful than microplastics due to permeation through the biological membranes of plants, while microplastics adhere to leaves.

Key Points Question Is the recent use of direct oral anticoagulants (confirmed ingestion within 48 hours) associated with increased risk of symptomatic intracranial hemorrhage following intravenous thrombolysis for ischemic stroke? Findings In this cohort study including 33 207 patients with ischemic stroke who received intravenous thrombolysis at 64 centers in Europe, Asia, Australia, and New Zealand, the risk of symptomatic intracranial hemorrhage was lower among the 832 patients taking direct oral anticoagulant treatment compared with controls with no anticoagulation. This result was consistent among subgroups and different selection strategies. Meaning This study found insufficient evidence of excess harm associated with the use of off-label intravenous thrombolysis in selected patients who had taken a direct oral anticoagulant within the previous 48 hours.

: The effect of emotions and personalisation on continuance use intentions in online health services is underexplored. Accordingly, we propose a research model for examining the impact of emotion- and personalisation-based factors on cancer website reuse intentions. We conducted a study using a real-world NGO cancer-support website, which was evaluated by 98 participants via an online questionnaire. Model relations were estimated using the PLS-SEM method. Our findings indicated that pre-use emotions did not significantly influence perceived personalisation. However, satisfaction with personalisation, and perceived usefulness mediated by satisfaction, increased reuse intentions. In addition, post-use positive emotions potentially influenced reuse intentions. Our paper, therefore, illustrates the applicability of theory regarding continuance use intentions to cancer-support websites and highlights the importance of personalisation for these purposes.

The Night Watch, painted in 1642 and on view in the Rijksmuseum in Amsterdam, is considered Rembrandt's most famous work. X-ray powder diffraction (XRPD) mapping at multiple length scales revealed the unusual presence of lead(II) formate, Pb(HCOO)2, in several areas of the painting. Until now, this compound was never reported in historical oil paints. In order to get insights into this phenomenon, one possible chemical pathway was explored thanks to the preparation and micro-analysis of model oil paint media prepared by heating linseed oil and lead(II) oxide (PbO) drier as described in 17th century recipes. Synchrotron radiation based micro-XRPD (SR-µ-XRPD) and infrared microscopy were combined to identify and map at the micro-scale various neo-formed lead-based compounds in these model samples. Both lead(II) formate and lead(II) formate hydroxide Pb(HCOO)(OH) were detected and mapped, providing new clues regarding the reactivity of lead driers in oil matrices in historical paintings.

SUMMARY Maize, the most common energy feed ingredient in poultry diets, has a high starch proportion in the grain endosperm, ranging from 65 to 75% in various hybrids. The rate and extent of digestion are major determinants of maize starch nutritive value. Starch digestion follows the first-order kinetics, and according to the digestibility kinetics, starch can be divided into rapidly digestible (RDS), slowly digestible (SDS), and resistant starch (RS). Different intrinsic and extrinsic features of maize grain affect the rate and extent of starch digestibility. Differences in starch granule composition, such as amylose-to-amylopectin ratio, crystallisation, association with lipids and zeins, as well as shape, size and presence of surface pores affect starch digestibility kinetics. More so, an important factor affecting digestion is grain processing. Particle size affects feed intake, the passage of bolus and susceptibility to enzyme-starch binding, while hydrothermal processing leads to starch gelatinisation. However, too high temperatures can lead to RS formation. This review summarises the available literature data on factors identified as crucial in the digestibility kinetics of maize starch.

With no expected vaccine for HIV in the near future, we aimed to define the current situation and challenges for pre- and post-exposure prophylaxis (PrEP and PEP) in Central and Eastern Europe (CEE). The Euroguidelines CEE Network Group members were invited to respond to a 27-item survey including questions on PrEP (response rate 91.6%). PrEP was licensed in 68.2%; 95 centers offered PrEP and the estimated number on PrEP was around 9000. It was available in daily (40.1%), on-demand (13.3%), or both forms (33.3%). The access rate was <1–80%. Three major barriers for access were lack of knowledge/awareness among people who are in need (59.1%), not being reimbursed (50.0%), and low perception of HIV risk (45.5%). Non-occupational PEP was available in 86.4% and was recommended in the guidelines in 54.5%. It was fully reimbursed in 36.4%, only for accidental exposures in 40.9%, and was not reimbursed in 22.72%. Occupational PEP was available in 95.5% and was reimbursed fully. Although PrEP scale-up in the region has gained momentum, a huge gap exists between those who are in need of and those who can access PrEP. Prompt action is required to address the urgent need for PrEP scale-up in the CEE region.

Background and Objectives: In the development of type 2 diabetes mellitus (T2DM) and its complications, genetic and environmental factors play important roles. Diabetic nephropathy (DN), one of the major microangiopathic chronic diabetic complications, is associated with an increased risk of major cardiovascular events and all-cause mortality. The present study was designed to investigate the possible modifying effect of glutathione transferase polymorphisms (GSTM1, GSTT1, GSTP1 rs1138272/rs1695, GSTO1 rs4925 and GSTO2 rs156697) in the susceptibility to T2DM and diabetic nephropathy. Materials and Methods: GSTM1 and GSTT1 deletion polymorphisms were determined by multiplex PCR, whereas GSTO1, GSTO2, and GSTP1 polymorphisms were determined by the real-time PCR in 160 T2DM patients and 248 age- and gender-matched controls. Advanced glycation end products (AGEs) were measured by ELISA. Results: Among six investigated GST polymorphisms, a significant association between the GST genotypes and susceptibility for development of diabetes mellitus was found for the GSTM1, GSTT1, GSTP1 (rs1138272) and GSTO1 polymorphisms. When the GST genotypes’ distribution in diabetes patients was assessed in the subgroups with and without diabetic nephropathy, a significant association was found only for the GSTO2 rs156697 polymorphism. Diabetic patients, carriers of the GSTM1 null, GSTT1 null and variant GSTO1*AA genotypes, had significantly increased levels of AGEs in comparison with carriers of the GSTM1 active, GSTT1 active and referent GSTO1*CC genotypes (p < 0.001, p < 0.001, p = 0.004, respectively). Conclusions: The present study supports the hypothesis that GST polymorphisms modulate the risk of diabetes and diabetic nephropathy and influence the AGEs concentration, suggesting the potential regulatory role of these enzymes in redox homeostasis disturbances.

This article presents a novel circuit configuration of a high-voltage direct current circuit breaker (HVdcCB) test bench that is based on a modified H-bridge modular multilevel cascaded converter (MMCC). The modified MMCC is composed of fewer H-bridge cells, and it can be reconfigured during operation to allow the proposed test bench to output large current or high voltage for the current breaking and dielectric withstand tests. Although simultaneous output of large current and high voltage is not possible, the maximum transient interrupt voltage (TIV) withstand test can be performed with reduced ratings. The controllable output allows generation of complex waveforms to simulate a wide range of fault conditions. Furthermore, the modified MMCC has some inherent safety features that can reduce the need for additional protective equipment in case of operational failure of the HVdcCB. In contrast, the conventional charged capacitor and inductor-based designs cannot generate arbitrary waveforms, are only suitable for current breaking tests, and require additional circuits to generate initial conditions for the HVdcCB. AC short-circuit generator-based designs offer one degree of freedom for control of the output waveforms and can sustain the maximum TIV withstand test. However, the ac output is unsuitable for the dielectric withstand test, and additional circuits are required to provide initial conditions for the HVdcCB. The proposed test bench circuit configuration is verified using a downscaled experimental test bench that consists of a total of nine H-bridge cells with an equivalent switching frequency of 92.5 kHz.