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T. Meinel, D. Wilson, H. Gensicke, J. Scheitz, P. Ringleb, I. Goganau, J. Kaesmacher, H. Bae, D. Y. Kim, P. Kermer, Kentaro Suzuki, K. Kimura, Kosmas Macha, M. Koga, S. Wada, V. Altersberger, A. Salerno, L. Palanikumar, A. Zini, S. Forlivesi, L. Kellert, J. Wischmann, E. Kristoffersen, J. Beharry, P. Barber, Jae-Beom Hong, C. Cereda, E. Schlemm, Y. Yakushiji, S. Poli, R. Leker, M. Romoli, M. Zedde, Sami Curtze, B. Ikenberg, T. Uphaus, D. Giannandrea, P. Portela, R. Veltkamp, A. Ranta, M. Arnold, U. Fischer, J. Cha, Teddy Y. Wu, J. Purrucker, D. Seiffge, M. Goeldlin, B. Siepen, M. Mueller, M. Beyeler, A. Scutelnic, Simon Jung, A. Mujanović, C. Kurmann, T. Dobrocky, Eike Piechoviak, R. Wiest, A. Hakim, P. Bücke, Zarzitzky Jana, Lichti Carmen, Dmytrow Diana Isabella, J. Ramos, D. Strambo, Menuela Buehrer, N. Simaan, A. Honig, A. Filioglo, I. Grisendi, Laura Ferri, M. Trapasso, Matteo Benini, R. Pascarella, Claudio Moratti, M. Napoli, S. Sumaria, K. Gröschel, M. Hahn, A. Polymeris, C. Traenka, Annaelle Zietz, P. Lyrer, G. M. DeMarchis, S. Thilemann, Ines Piot, L. Enz, N. Peters, M. Katan, A. Brehm, M. Psychogios, Ulrike Prange, N. Spratt, Laurent Roten, B. Chew, Jakub Stefela, R. von Rennenberg, S. Litmeier, Christoph Riegler, M. Klammer, H. Erdur, Hellwig Simon, Magoni Mauro, Longoni Marco, Cordici Francesco, Biguzzi Sara, P. Tan, M. Ercegovac, I. Berisavac, David Haupenthal, L. Gassmann, Armin Marsch, Gabriela Siedler, L. Weir, L. Pesavento, N. Yassi, Stephen Davis, B. Ip, T. Leung, Alexandra Gomez-Exposito, J. Mbroh, J. Tünnerhoff, G. Barbu, Yi Wang, Annerose Mengel, Feil Katharina, M. Kowarik, U. Ziemann, J. Kim, Jihoon Kang, Moon‐Ku Han, B. Kim, K. Choi, Man-Seok Park, Ki-Hyun Cho, J. Kim, Dong-Ick Shin, K. Yum, Dae-Hyun Kim, J. Cha, Jong-Moo Park, K. Kang, Yong Soo Kim, J. Kim, S. Lee, M. Oh, Byung‐Chul Lee, M. Lee, K. Yu, Hong‐Kyun Park, K. Hong, Yong‐Jin Cho, J. Choi, Joong-Goo Kim, Chul-Hoo Kang, S. Sohn, Jeong‐Ho Hong, S. Jang, Hyungjong Park, T. Park, Sang-Soon Park, K. Lee, J. Kwon, Wook-Joo Kim, Jun Lee, D. Kwon, Dong-Seok Gwak, Dong-Eog Kim, K. Lee, Sang-Hwa Lee, Chulho Kim, H. Jeong, K. Park, J. S. Lee, Juneyoung Lee, N. Martinez-Majander, G. Sibolt, M. Tiainen, M. Gentile, L. Migliaccio, L. Simonetti, M. Paolucci, Alan Flores, L. Seró, G. Turc, C. Oppenheim, O. Naggara, W. Ben Hassen, J. Benzakoun, Y. Yakushiji, T. Kunieda, G. Kägi, S. Engelter, C. Nolte, B. Kallmünzer, P. Michel, T. Kleinig, J. Fink, O. Rønning, B. Campbell, P. Nederkoorn, G. Thomalla, T. Kunieda, Khouloud Poli, Y. Béjot, Y. Soo, C. Garcia-Esperon, G. Ntaios, C. Cordonnier, J. Marto, G. Bigliardi, François Lun, P. Choi, T. Steiner, X. Ustrell, D. Werring, S. Wegener, A. Pezzini, Houwei Du, J. Martí-Fábregas, D. Cánovas-Vergé, D. Strbian, V. Padjen, S. Yaghi, Christoph Stretz, J. Kim
80 3. 1. 2023.

Intravenous Thrombolysis in Patients With Ischemic Stroke and Recent Ingestion of Direct Oral Anticoagulants

Key Points Question Is the recent use of direct oral anticoagulants (confirmed ingestion within 48 hours) associated with increased risk of symptomatic intracranial hemorrhage following intravenous thrombolysis for ischemic stroke? Findings In this cohort study including 33 207 patients with ischemic stroke who received intravenous thrombolysis at 64 centers in Europe, Asia, Australia, and New Zealand, the risk of symptomatic intracranial hemorrhage was lower among the 832 patients taking direct oral anticoagulant treatment compared with controls with no anticoagulation. This result was consistent among subgroups and different selection strategies. Meaning This study found insufficient evidence of excess harm associated with the use of off-label intravenous thrombolysis in selected patients who had taken a direct oral anticoagulant within the previous 48 hours.


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