Southeast Asia has the most significant tropical peat/peat carbon storage area in the world, with Indonesia being the primary location for much of it. Anthropogenic changes to peatlands have resulted in a threat to these endangered ecosystems; policies that have favored industrial and elite interests above those of local communities have resulted in severe consequences for the environment and public health, not only in Indonesia and its region, but for the world community in terms of contributions to climate change. Decentralization has been seen as a means of sharing authority and accountability with lower government levels and providing additional opportunities for shared governance. Still, there is reason to question the means of these approaches and the results of such efforts. The research question is: What can be learned about the administration’s role in leading stakeholder involvement from the case of Indonesian peatland management? The authors utilize outcome additionality as a framework connected to the resilience of peatlands.

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Abstract Jennings, J, Štaka, Z, Wundersitz, DW, Sullivan, CJ, Cousins, SD, Čustović, E, and Kingsley, MI. Position-specific running and technical demands during male elite-junior and elite-senior Australian rules football match-play. J Strength Cond Res 37(7): 1449–1455, 2023—The aim of this study was to compare position-specific running and technical demands of elite-junior and elite-senior Australian rules football match-play to better inform practice and assist transition between the levels. Global positioning system and technical involvement data were collated from 12 Victorian U18 male NAB League (n = 553) and 18 Australian Football League (n = 702) teams competing in their respective 2019 seasons. Players were grouped by position as nomadic, fixed, or ruck, and data subsets were used for specific analyses. Relative total distance (p = 0.635, trivial effect), high-speed running (HSR) distance (p = 0.433, trivial effect), acceleration efforts (p = 0.830, trivial effect), deceleration efforts (p = 0.983, trivial effect), and efforts at >150 m·min−1 (p = 0.229, trivial effect) and >200 m·min−1 (p = 0.962, trivial effect) did not differ between elite-junior and elite-senior match-play. Elite juniors covered less total and HSR distance during peak periods (5 seconds–10 minutes) of demand (p ≤ 0.022, small-moderate effects). Within both leagues, nomadic players had the greatest running demands followed by fixed position and then rucks. Relative disposals (p = 0.330, trivial effect) and possessions (p = 0.084, trivial effect) were comparable between the leagues. During peak periods (10 seconds to 2 minutes), elite juniors had less technical involvements than elite seniors (p ≤ 0.001, small effects). Although relative running demands and positional differences were comparable between the leagues, elite juniors perform less running, HSR, and technical involvements during peak periods when compared with elite seniors. Therefore, coaching staff in elite-senior clubs should maintain intensity while progressively increasing the volume of training that recently drafted players undertake when they have transitioned from elite-junior leagues.

Abstract Background Small renal masses (SRMs) are defined as contrast-enhanced masses with a diameter of ≤4 cm, usually consistent with clinical stage T1a renal cell carcinoma (RCC). This study aimed to explore the histopathological features of a contemporary series of SRMs and investigate parameters that could predict their pathological nature, metastatic potential, and recurrence potential. Materials and methods Small renal masses were identified in 166 of 427 patients who underwent surgery for suspected RCC. The radical nephrectomy/partial nephrectomy ratio was 1:44, and autotransplantation was performed in a single case. Variables associated with metastatic recurrence of SRM were analyzed using χ2 and logistic regression models. Results Renal cell carcinoma was confirmed in 86% (n = 143) of cases, whereas benign tumors were present in 14% (n = 23) of cases. Seventeen percent of the RCC cases were high-grade (Fuhrman G3–4). Among SRMs with a diameter of >2 cm, 71% were malignant. The mean ± standard deviation diameter of the removed SRMs was 28 ± 12 mm, significantly higher in the malignant SRMs group (31 ± 8 vs. 24 ± 9 mm) (p = 0.005). During follow-up, local recurrence was identified in 4 patients versus new distant metastasis in 11 patients. Metastatic lesions were detected in the lungs (1.8%), bone (1.2%), distant (1.9%) and regional lymph nodes (1.2%), liver (0.6%), and multiple organs (2.4%). Patients with malignant SRMs were significantly older than those with benign tumors (p = 0.036). The multivariate analysis identified tumor size, Fuhrman grade, stage, nodal and distant metastasis status, tumor localization, and treatment modality as characteristics significant for tumor recurrence. Conclusions The majority of treated neoplasms were malignant, but their incidence was low among SRMs with a diameter of <2 cm. Our results emphasized the importance of histopathological features and treatment modalities in predicting malignant recurrence.

According to the WHO, as of January 2023, more than 850 million cases and over 6.6 million deaths from COVID-19 have been reported worldwide. Currently, the death rate has been reduced due to the decreased pathogenicity of new SARS-CoV-2 variants, but the major factor in the reduced death rates is the administration of more than 12.8 billion vaccine doses globally. While the COVID-19 vaccines are saving lives, serious side effects have been reported after vaccinations for several premature non-communicable diseases (NCDs). However, the reported adverse events are low in number. The scientific community must investigate the entire spectrum of COVID-19-vaccine-induced complications so that necessary safety measures can be taken, and current vaccines can be re-engineered to avoid or minimize their side effects. We describe in depth severe adverse events for premature metabolic, mental, and neurological disorders; cardiovascular, renal, and autoimmune diseases, and reproductive health issues detected after COVID-19 vaccinations and whether these are causal or incidental. In any case, it has become clear that the benefits of vaccinations outweigh the risks by a large margin. However, pre-existing conditions in vaccinated individuals need to be taken into account in the prevention and treatment of adverse events.

The SI4CARE project is a transnational project which aims to develop both strategy and action plans to improve health and social care in the Adriatic–Ionian region. Starting from a survey of the status quo, each partner has developed some pilots to support the development and monitoring of the policy actions. In particular, partner number three, the Municipality of Miglierina, designed and developed a pilot related to the use of wearable devices for monitoring elderly patients in rural areas. With the collaboration of the complex unity of primary care (UCCP) of the Reventino area, the pilot is based on the use of smart wearable devices to monitor some parameters of older adults after their vaccinations for flu and covid. This paper focused on the design and implementation of the system. It describes its application in the Municipality of Miglierina. Presentation of the results and a discussion of the strengths and weaknesses will be presented, in detail, in future work. Finally, the possibility of extending the experiment to other Adriatic–Ionian regions is addressed.

The number of female trainees is on the rise, and so too are the issues surrounding fertility and barriers to family planning. Over the past decade, studies of surgical residents across the United States have demonstrated a strong prevalence of fertility challenges. Strenuous training requirements have American female surgical trainees delaying pregnancy, having fewer children, and reporting increased rates of pregnancy complications, infertility, and use of assistive reproductive technology. Similarly, a survey of British surgical trainees showed over a quarter of trainees felt unsupported by their department during pregnancy, while almost a quarter of both of male and female trainees experienced difficulty in arranging parental leave. Our recent article investigated how our long training programmes are affecting Australasian surgical trainees’ ability to start families, particularly when compared with other specialities. While we acknowledge there are limitations to online surveys, the results of this survey of 1099 doctors demonstrated that surgeons, when compared with physicians and GPs, are experiencing greater challenges in balancing work and family, across multiple areas of fertility and child-caring. Surgical training occurs in the prime reproductive years and as a consequence, when many trainees finally complete their training, they are living the real-world consequences of reduced fertility because of their age. This highlights the critical need for a cultural change that’s becoming increasingly important as the surgical workforce demographic changes. Training bodies are in a prime position to provide solutions to the many obstacles surgical trainees face in family planning. There are several ways the colleges and hospitals can support a more equitable future for its members who want to pursue parenthood.

Background: The vast majority of cancer deaths can be attributed to tumor metastases. Disseminated tumor cells (DTCs) are thought to act as a reservoir of tumor clones which can lie dormant before causing overt metastases. Their presence has been shown to be a poor prognostic indicator in several tumor types. Despite their importance, the timing and source of DTCs is unclear across most solid cancers and even less is known about them in late-stage disease. The Posthumous Evaluation of the Advanced Cancer Environment (PEACE) post-mortem study enables extensive sampling of malignant lesions but also normal tissues, thereby allowing study of DTCs in patients with advanced cancer. Methods: We performed research autopsy sampling of macroscopically normal bone, lung and liver in 3 patients with advanced clear cell renal cell carcinoma (RCC). In addition, we performed bone marrow aspiration at autopsy from vertebral bodies and the ilium using an anterior approach. Mechanical disaggregation followed by collagenase digestion was used to generate single cell suspensions. Detection of tumor cells was carried out using antibodies against known tumor or epithelial markers carbonic anhydrase IX (CAIX). Epithelial cell adhesion molecule (EpCAM) was also used for bone marrow samples as native bone marrow cells do not express this marker. These sub-populations were then isolated using fluorescence activated cell sorting and DNA was extracted and amplified from single cells. Results: We performed and optimised collagenase-based digestion on all solid tissues collected. The percentage of viable cells generated varied significantly between subjects and tissues with bone marrow samples more viable than lung and liver. Rare and distinct populations of CAIX+ and EpCAM+ cells were detected in normal tissues between 0.5-2%. DNA amplification was successful on single cells isolated from normal lung and liver but not from bone tissue. Pilot shallow coverage whole genome sequencing revealed genomically aberrant cells ranging from single chromosome arm losses to widespread copy number aberrations. Conclusion: We demonstrate feasibility of sequencing single cells from autopsy study subjects. Rare populations of single cells with markers of clear cell RCC were detected and isolated both in normal tissues of patients with advanced disease. Genomic analyses of these cells will lead to insights into their relationship to the primary tumor and overt metastatic lesions. Citation Format: Haixi Yan, Cristina Cotobal Martin, Christie English, Annelien Verfaillie, Jonas Demeulemeester, Andrew Rowan, Annika Fendler, Anne-Laure Cattin, Sucheta Mahapatra, Lewis Au, Scott Shepherd, Ben Shum, Charlotte Spencer, Zayd Tippu, Ula Mahadeva, Anna Green, Eleanor Carlyle, Cristina Naceur-Lombardelli, PEACE consortium, Mariam Jamal-Hanjani, Charles Swanton, Samra Turajlic, Peter Van Loo. Detection of disseminated tumor cells in advanced clear cell renal cell carcinoma through research autopsy [abstract]. In: Proceedings of the AACR Special Conference: Cancer Metastasis; 2022 Nov 14-17; Portland, OR. Philadelphia (PA): AACR; Cancer Res 2022;83(2 Suppl_2):Abstract nr A011.

Elite female karatekas should have specific morphological characteristics suitable for their specializations. This study aimed to determine the differences in morphological characteristics and body composition of female karatekas according to different specializations. This study consisted of a total of 15 female karatekas divided according to specialization in kumite (fighting) and kata (form or movement pattern) disciplines. The subject sample included healthy, female senior karatekas, with no prior injuries divided into kumite (n-8, 22.75±4.65 years) and kata (n-7, 22.00±4.58 years) athletes. Morphological characteristics and body composition were evaluated by a battery of 11 variables: body height (BH), body mass (BM), triceps skinfold (TS), biceps skinfold (BiS), back skinfold (BS), abdominal skinfold (AS), upper leg skinfold (UlS), lower leg skinfold (LlS), body mass index (BMI), fat percentage (FP), and muscle mass percentages (MP). Based on the t-test for small independent samples, findings showed that female kata and kumite karatekas do not have different morphological characteristics. Although there was no difference in morphological characteristics, for more complete conclusions an analysis should be performed on a larger sample of elite female karate athletes.

In this scientific research, tomato powder was obtained from two tomato varieties, Pink rock and Big beef, by drying in a dehydrator at two temperatures, namely 50 and 75 °C. The results showed that tomato powder is very rich in phytochemicals, such as lycopene, vitamin C, total phenols. The highest content of vitamin C (mg/100 g of dry matter) was in fresh tomatoes compared to tomato powder, because vitamin C is thermolabile. On the other hand, the highest content of total phenols was 62.916 mg/100 g dry matter, lycopene whose value was 66.6 mg/100 mg, FRAP 4868.75 ?mol Fe/100 g sample in tomato powder dried at 75 °C. Therefore, it can be concluded that tomato powder is rich in antioxidants and that it is recommended in the diet of people when the weather conditions are not suitable for the consumption of fresh tomatoes.

We show that a subtle coupling between the thermal and solutal gradients driven by the thermodiffusion, cross-diffusion, and buoyancy force can lead to oscillatory dynamic behavior of a ternary mixture in the thermo-gravitational column. The potentially unstable stratification results from the interplay of mass fluxes of the two heaviest components where the leading role belongs to one of them. Our experiments and numerical analysis evidence not only the presence of oscillatory instability, but demonstrate the emergence of the secondary instability in the form of swinging pattern in addition to the large-scale standing wave. We suggest that the region, where oscillatory instability occurs, is characterized by opposite signs of Soret S'T1 and thermodiffusion D'T1 coefficients due to large cross-diffusion contribution.

This letter presents a measurement of the nuclear modification factor of large-radius jets in sqrt[s_{NN}]=5.02  TeV Pb+Pb collisions by the ATLAS experiment. The measurement is performed using 1.72  nb^{-1} and 257  pb^{-1} of Pb+Pb and pp data, respectively. The large-radius jets are reconstructed with the anti-k_{t} algorithm using a radius parameter of R=1.0, by reclustering anti-k_{t} R=0.2 jets, and are measured over the transverse momentum (p_{T}) kinematic range of 158<p_{T}<1000  GeV and absolute pseudorapidity |y|<2.0. The large-radius jet constituents are further reclustered using the k_{t} algorithm in order to obtain the splitting parameters, sqrt[d_{12}] and ΔR_{12}, which characterize the transverse momentum scale and angular separation for the hardest splitting in the jet, respectively. The nuclear modification factor, R_{AA}, obtained by comparing the Pb+Pb jet yields to those in pp collisions, is measured as a function of jet transverse momentum (p_{T}) and sqrt[d_{12}] or ΔR_{12}. A significant difference in the quenching of large-radius jets having single subjet and those with more complex substructure is observed. Systematic comparison of jet suppression in terms of R_{AA} for different jet definitions is also provided. Presented results support the hypothesis that jets with hard internal splittings lose more energy through quenching and provide a new perspective for understanding the role of jet structure in jet suppression.