Bosnia and Herzegovina (B&H) has difficulty integrating and moving closer to the goal of becoming a member of the European Union (EU). From the legal perspective, the main issue is the need to fulfil the accession criteria. The article aims to examine the relationship between the obligations under the European Convention on Human Rights and Basic Freedoms (ECHR) and the obligations related to the European Union (EU) accession process, with emphasis on Bosnia and Herzegovina (B&H) as an EU membership candidate country. At first sight, those two obligations are separate. However, upon close examination, a strong link between those two obligations can be established using normative research with a historical approach, statute and case-based approach. On the other hand, the constitutional system of B&H has been described as discriminatory by numerous judgments of the European Court of Human Rights (ECtHR) and, most prominently, by the Sejdic-Finci case. B&H has difficulties implementing those judgments. Implementing those judgments is also set as one of the requirements of EU accession. Even if the two obligations seem separate at first sight, the ECHR has a special position within the law of the EU and is especially important in the accession of new Member States, including B&H. The research results show a special position of the ECHR in EU law and a link between the obligations under the ECHR and EU accession.

<p style="text-align: justify;">There are many ways to accomplish optimization of machining process. In the experimental part of this paper, the optimization of machining process is accomplished from the aspect of cutting conditions, which are independent variables (speed, feed, and cutting depth), whereas the dependent variables refer to the surface roughness, more precisely, arithmetic average of surface heights and resultant cutting force, including<br />main cutting force, feed force and thrust force. Once the matrix of the experimental plan has been created, on the basis of a complete multifactor plan with eight points, with previously determined upper, middle and lower levels of cutting parameters for turning, the experiment followed. Once the results of surface roughness were measured by perthometer, as well as results of cutting forces by dynamometer, the optimization of<br />machining process was treated by means of predetermined methodologies,<br />described in this paper.</p>

This paper presents data on the diversity and distribution of Balkan endemic vascular plants on the Konjuh Mountain in northeastern Bosnia and Herzegovina. Konjuh is characterized by geological heterogeneity and a significant proportion of ophiolitic substrate, which supports the development of endemic-relict serpentinophytes. A total of 31 endemic and four subendemic taxa were recorded in the surveyed area. Among these, Caryophyllaceae, with five recorded endemic taxa, is the most abundant family. The analysis of life forms and chorological spectra showed a dominance of hemicryptophytes and taxa from the South European and Mediterranean-Sub-Mediterranean chorological groups. The majority of endemic and relict taxa in the surveyed area are serpentinophytes. A total of 18 recorded taxa are listed as threatened according to the Red List of Flora of the Federation of Bosnia and Herzegovina. The species findings are presented with a distribution map. The distribution range of endemic and endangered taxa in Konjuh extends beyond the protected area. The results provide a list of locations of particular interest for further research and potential protection due to the diversity of endemic taxa.

The effects of diabetes can be divided into short, medium and long term and various human organ systems can be effected. The present study aimed to determine how much the duration of diabetes mellitus (DM) affect the reparative ability of the body, immune response and the development of DM complications. Interleukin 1-β (IL-1β) and Interleukin 6 (IL-6) were monitored as specific indicators of inflammatory reaction and C-reactive protein (CRP), leukocyte count (WBC) and sedimentation rate (ESR) as general markers of inflammatory reaction. Tumour necrosis factor α (TNF-α) and transforming growth factor β1 (TGF-β1) were observed as indicators of reparative ability and polyneuropathy. All interleukins were determined by ELISA and evaluated spectrophotometrically. Michigan Neuropathy Screening Instrument (MNSI) is performed for neuropathy examination. Patients with diabetes mellitus were divided into 3 groups, according to duration of diabetes mellitus. IL-6 levels correlated with clinical stage of diabetic polyneuropathy at p  = 0.025 R  = 0.402; with CRP at p  = 0.0001, R  = 0.784 as well as correlation of CRP and MNSI score ( R  = 0.500, p  = 0.034) in a group of patients with DM lasting up to 10 years. The reparative ability of the body is reduced by physiological age and ages of DM duration. The immune response is weakened in DM additionally. The dual activity of cytokines IL-6 and TGF-β1 is present in long-duration Diabetes Mellitus.

The goal of this prospective longitudinal study was to explore whether co-occurrent internalizing difficulties and aggression in early childhood convey increased risk for later mental health problems in middle childhood. Participants were mothers from the Norwegian Mother, Father and Child Cohort Study (MoBa), who provided assessments of child internalizing difficulties and aggression at ages 3 years (n = 54,644; 26,750 girls) and 5 years (n = 38,177; 18,794 girls), as measures of child depressive, anxiety, conduct-related, and oppositional defiant (OD) symptoms at age 8 years. Using latent profile analyses (LPA) of internalizing difficulties and aggression, four profiles were identified: low-symptom/normative; primarily internalizing; primarily aggressive; and co-occurrent. Among the other results, the co-occurrent group exhibited the highest levels of depressive, anxiety, and oppositional defiant symptoms at 8 years. Most children (78%) remained stable in their profile between ages 3 and 5 years. Among the transition patterns that emerged, transitions were observed both from the normative to a risk profile and vice versa. Children who remained stable within the co-occurrent profile or who transitioned from the co-occurrent profile to one of the other two risk profiles also exhibited more depressive, anxiety, and OD symptoms at 8 years of age, when compared with children who transitioned from the co-occurrent to the normative profile. The heterogeneity between early manifestation of internalizing difficulties and aggression, and specific type of later mental health symptoms not only supports a shared etiology between internalizing and externalizing difficulties but also points toward the need for person-centered monitoring in early childhood with further implications for early identification of difficulties and preventive measures.

A higienização deficitária das próteses e dentes é uma das principais causas para o insucesso na reabilitação com próteses parciais removíveis a grampos (PPRG), visto que acarreta o aparecimento de lesões, como cárie, doença periodontal, estomatiteprotética, e hiperplasia inflamatória. O Projeto Prevenção em Prótese Removível (PPPR), fundado em 2014, na Universidade Federal do Ceará, tem como finalidade difundir o conhecimento acerca da higiene bucal e prevenção de doenças bucais, sobretudo para pacientes da Disciplina de Prótese Parcial Removível. Atualmente, o PPPR ampliou seu exercício atuando também em ambulatório endócrino, de transplante hepático e de transplante renal do Hospital Universitário Walter Cantídio. O projeto promove semanalmente reuniões, seminários internos, ações de educação em saúde nos ambulatórios e postagens de materiais de estudo nas redes sociais, além de ofertar, ao final de cada semestre, oficinas de prevenção com os pacientes da Disciplina de prótese parcial removível. O PPPR já realizou dois ciclos de palestras abertos aos acadêmicos e possui pesquisas laboratoriais e clínicas em andamento. Dado o exposto, as atividades promovidas pelo projeto têm contribuídosignificativamente para o engajamento, informação e autonomia dos pacientes acerca de sua higiene, saúde oral e cuidados com a prótese, tal como para odesenvolvimento profissional dos membros e comunidade acadêmica.

Simple Summary Peptides are ubiquitous molecules abundantly found in nature, and their diverse functions and biological activities have been extensively examined over the years. In the past, in vitro and in vivo biological effects of flaxseed oil have been well-examined and reported in numerous studies. However, the effects of many individual components from the flaxseed are yet to be examined. Cyclolinopeptides (CLPs), one of the components, have gained significant attention due to their cyclic nature and hydrophobic properties. CLPs are isolated from flaxseed and typically consist of eight, nine, or ten amino acid residues. Experimental investigations into the biological activities of CLPs began in the 1980s and early 1990s, revealing their potential therapeutic applications. In recent years, particularly, there has been interest in examining the anticancer effect of CLPs. Diverse bioactivities and potential therapeutic CLPs aspects seek novel approaches and further investigation to maximize utility. Abstract Novel therapeutic agents to combat cancer is an active area of research, as current treatment options have limitations in efficacy and tolerability. One of these therapeutic agents in our immediate environment is cyclolinopeptides (CLPs). CLPs have several advantages that make them suitable for daily consumption and potential therapeutics in cancer research. They are natural compounds, having high specificity, low toxicity, low cost, and an overall simple extraction process. Over the years, numerous in vitro studies in cancer cells demonstrated CLPs to possess anti-proliferative, apoptotic, and anti-angiogenic effects, as well as the ability to induce cell cycle arrest and inhibit cancer cell growth in various cancer types, including breast cancer, gastric cancer, and melanoma. This paper provides an overview of the significance and potential of CLPs as therapeutic agents, emphasizing their promising role in cancer treatment based on different cancer cell lines. The mechanism of action of CLPs in cancer cells is multifaceted. It involves the modulation of multiple signaling pathways, including inhibition of protein kinases, modulation of apoptosis-related proteins, and regulation of oxidative stress and inflammation.

Given Krein and Hilbert spaces $\left( \mathcal{K},[.,.] \right)$ and $\left( \mathcal{H}, \left( .,. \right) \right)$, respectively, the concept of the boundary triple $\Pi =(\mathcal{H}, \Gamma _{0}, \Gamma_{1})$ is generalized through the abstract Green's identity for the isometric relation $\Gamma$ between Krein spaces $\left( \mathcal{K}^{2}, \left[ .,.\right]_{\mathcal{K}^{2}} \right) $ and $\left(\mathcal{H}^{2}, \left[ .,.\right]_{\mathcal{H}^{2}} \right) $ without any conditions on $\dom\, \Gamma$ and $\ran\, \Gamma$. This also means that we do not assume the existence of a closed symmetric linear relation $S$ such that $\dom\, \Gamma=S^{+}$, which is a standard assumptions in all previous research of boundary triples. The main properties of such a general Green's boundary model are proven. In the process, some useful properties of the isometric relation $V$ between two Krein spaces $X$ and $Y$ are proven. Additionally, surprising properties of the unitary relation $\Gamma : \mathcal{K}^{2} \rightarrow\mathcal{H}^{2}$ and the self-adjoint main transformation $\tilde{A}$ of $\Gamma$ are discovered. Then, two statements about generalized Nevanlinna families are generalized using this Green's boundary model. Furthermore, several previously known boundary triples involving a Hilbert space $\mathcal{K}$ and reduction operator $\Gamma : \mathcal{K}^{2} \rightarrow\mathcal{H}^{2}$, such as AB-generalized, B-generalized, ordinary, isometric, unitary, quasi-boundary, and S-generalized boundary triples, have been extended to a Krein space $\mathcal{K}$ and linear relation $\Gamma$ using the Green's boundary model approach.

The evolving customer demands have significantly influenced the operational landscape of agricultural companies, including the transformation of their supply chains. As a response, many organizations are increasingly adopting green supply chain practices. This paper focuses on the initial step of selecting a green supplier, using the case study of the Semberka Company. The objective is to align the company with customer requirements and market trends. Expert decision making, grounded in linguistic values, was employed to facilitate the transformation of these values into fuzzy numbers and subsequently derive rough number boundaries. Ten economic-environmental criteria were identified, and six suppliers were evaluated against these criteria. The fuzzy rough LMAW (Logarithm Methodology of Additive Weights) method was employed to determine the criteria weights, with emphasis placed on the quality criterion. The fuzzy rough MABAC (Multi-Attributive Border Approximation Area Comparison) method was then utilized to rank the suppliers and identify the top performer. The validity of the results was established through validation techniques and sensitivity analysis. This research contributes a novel approach to green supplier selection, employing the powerful tool of fuzzy rough sets. The flexible nature of this approach suggests its potential application in future investigations. The limitation of this study is more complicated calculations for the decision maker. However, this approach is adapted to human thinking and minimizes ambiguity and uncertainty in decision making, and in future research, it is necessary to combine this approach with other methods of multi-criteria analysis.

Ankylosing spondylitis is a serious ailment that affects people, and the first signs or symptoms usually occurr between the ages of 15 and 45. While the condition is mostly prevalent in men, women are not immune to this disease. This problem is diagnosed with a combination of clinical history and X-rays, pathology and HLAB27 test. The aim of this case study is to demonstrate how macroscopic and microscopic analysis can be used for identification of the disease from a forensic point of view. In April 2018, we exhumed 11 remains near the city Višegrad, twenty-five years after the last war. All the remains were completely skeletonized. The skeleton of a female was specific and shaped like a bamboo branch, with a partial knitting of vertebral bodies in the lumbar region of spine and with total knitting in the thoracic part. The spinous processes were completely knitted. Her son gave informations for verbal autopsy that she had trouble walking and doing normal activities during life. Samples for analysis and pathological diagnostics were used to determine the real bone condition for forensic purposes. To our best knowledge our case is first one in the literature which combines macroscopic and microscopic analysis of AK in exhumed skeletal remains after 25 years of death in modern era of Europe.

Due to their appealing physiochemical properties, particularly in the pharmaceutical industry, deep eutectic solvents (DESs) and ionic liquids (ILs) are utilized in various research fields and industries. The presented research analyzes the thermodynamic properties of a deep eutectic solvent created from natural molecules, menthol and lauric acid in a 2:1 molar ratio, and an ionic liquid based on two active pharmaceutical ingredients, benzocainium ibuprofenate. Initially, the low solubility of benzocainium ibuprofenate in water was observed, and a hydrophobic natural deep eutectic mixture of menthol:lauric acid in a 2:1 ratio was prepared to improve benzocainium ibuprofenate solubility. In order to determine the solvent properties of DESs and ILs mixtures at different temperatures and their molecular interactions to enhance the solvent performance, the apparent molar volume, limiting apparent molar expansibility, and viscosity B coefficient were estimated in temperature range from 293.15 K to 313.15 K and varying concentration of benzocainium ibuprofenate.

Survivin, a well-known member of the inhibitor of apoptosis protein family, is upregulated in many cancer cells, which is associated with resistance to chemotherapy. To circumvent this, inhibitors are currently being developed to interfere with the nuclear export of survivin by targeting its protein-protein interaction (PPI) with the export receptor CRM1. Here, we combine for the first time a supramolecular tweezer motif, sequence-defined macromolecular scaffolds, and ultrasmall Au nanoparticles (us-AuNPs) to tailor a high avidity inhibitor targeting the survivin-CRM1 interaction. A series of biophysical and biochemical experiments, including surface plasmon resonance measurements and their multivalent evaluation by EVILFIT, reveal that for divalent macromolecular constructs with increasing linker distance, the longest linkers show superior affinity, slower dissociation, as well as more efficient PPI inhibition. As a drawback, these macromolecular tweezer conjugates do not enter cells, a critical feature for potential applications. The problem is solved by immobilizing the tweezer conjugates onto us-AuNPs, which enables efficient transport into HeLa cells. On the nanoparticles, the tweezer valency rises from 2 to 16 and produces a 100-fold avidity increase. The hierarchical combination of different scaffolds and controlled multivalent presentation of supramolecular binders was the key to the development of highly efficient survivin-CRM1 competitors. This concept may also be useful for other PPIs.