Background/Objectives: Beyond respiratory problems, COVID-19 can cause a variety of symptoms, such as neurological disorders caused by biological and psychological factors. Brain fog (BF), a post-illness cognitive impairment that many patients report, can be evaluated with reaction time (RT) testing. Response latency is measured by RT, which can be either simple (sRT) or complex (cRT). This study focuses on how COVID-19 affects cognitive function, with particular attention on RT changes, BF prevalence, and implications for daily life. Methods: The study included 599 participants from Bosnia and Herzegovina, Croatia and Serbia. RT was measured using PsyToolkit and participants completed a COVID-19-associated BF questionnaire. Participants who experienced BF after their latest COVID-19 infection rated its severity using a visual analogue scale (VAS). Additional clinical data were obtained from medical records. Results: BF was reported by 40% of participants post-COVID-19. Men reported it less frequently but found it more disruptive. RT progressively declined post-infection, reaching peak impairment at 15 weeks, following recovery, with RT normalizing by six months. Conclusions: COVID-19 is linked to temporary RT impairment, peaking at 15 weeks post-infection and resolving by six months, independent of BF presence. This study emphasizes the need for a biopsychosocial approach to BF management. Easily available RT assessments should be incorporated into routine clinical practice.

Introduction: Noise is the leading cause of hearing loss worldwide. In recent years, reduced hearing ability among young people has been observed, along with an increased frequency of headphone use for sound transmission. The purpose of this study is to determine the frequency and patterns of headphone use for sound reproduction among students and to analyze their impact on the occurrence of symptoms associated with hearing loss. Methods: The cross-sectional study included students from two public universities from three public faculties in Bosnia and Herzegovina. Both qualitative and quantitative analyses were used to process the results. To test the statistical significance of the findings, the Chi-square goodness-of-fit test was applied, with the level of statistical significance set at 0.01. Results: The study sample included 246 participants and it was found that 77.6% of surveyed students use headphones for sound transmission. The longest duration of use was reported by 44.6% of participants, who had been using headphones for more than 5 years. The most common maximum daily use was up to 2 h (28.7%), while 67.5% of respondents reported using headphones every day, most often in the evening (46.4%). The Chi-square test showed statistically significant differences in the frequency of symptom occurrence following headphone use (χ2(6) = 55.466, p < 0.001). The most frequently reported symptoms were tinnitus (28.3%), a sensation of fullness and ear pressure (17.8%), and ear pain (16.2%). Conclusion: The results indicate a high prevalence of headphone use among students, with many reporting daily use over several years. The analysis showed a statistically significant association between headphone use and the occurrence of hearing-related symptoms, suggesting a potential threat to the auditory health of young people. These findings highlight the need to educate youth on the safe use of headphones.

From October 2022 to October 2024, a series of mycological field studies were conducted in peatlands in Bosnia and Herzegovina, focusing on two bogs – Đilda’s bog and Bijambare bog. As a result, several interesting and characteristic fungal species were recorded. This paper presents Phaeonematoloma myosotis, Arrhenia leucotricha, Arrhenia philonotis, Cortinarius flexipes, Geoglossum sphagnophilum, Monilinia baccarum, Elliottinia kerneri, and Sarcoleotia cinnamomea.

The Tracking Cancer Evolution Through Therapy (TRACERx) program represents the most comprehensive effort to characterize tumor evolution in real time. Through longitudinal, multiregion, and multiomic profiling of tumors—and particularly of non-small-cell lung cancer and clear cell renal cell carcinoma—TRACERx has illuminated the dynamic interplay between genetic, nongenetic, and (micro)environmental factors that drive cancer progression, immune evasion, and therapeutic resistance. A central insight from TRACERx has been that not all tumor evolution is genomic: Transcriptomic diversity, epigenetic alterations, RNA editing, and changes in cell–cell interactions also drive adaptation. Methodological innovations—including tumor-informed and ultrasensitive circulating tumor DNA assays, representative sequencing, and integrative immune–genomic analyses—have yielded biomarkers resistant to sampling bias and/or predictive of recurrence, metastasis, and treatment response. By demonstrating that intratumor heterogeneity is a key determinant of clinical outcome and revealing its molecular, transcriptional, and ecosystem-level drivers, TRACERx has established a framework for linking evolutionary dynamics to patient care. As both a scientific framework and a clinical paradigm, TRACERx demonstrates how adaptive, iterative research can refine evolutionary models, improve patient risk stratification, and inspire next-generation cancer evolution studies across malignancies.

Purpose: To emphasize the diagnostic role of magnetic resonance imaging (MRI) in identifying Fitz-Hugh–Curtis syndrome (FHCS) in an adolescent patient with a subtleclinical presentation. Methods: A 17-year-old female presented with acute onset right upper quadrant and right shoulder pain. The initial diagnostic workup, including ultrasound (US), computedtomography (CT), and laboratory testing was inconclusive. Due to persistent symptoms and elevated inflammatory markers, MRI of the abdomen and pelvis was subsequentlyperformed. Results: MRI demonstrated a bilateral pyosalpinx with restricted diffusion, free fluid in the pelvis and subhepatic region, and linear adhesions between the hepatic capsule and peritoneum, which was consistentwith pelvic inflammatory disease (PID) complicated by FHCS. Microbiologic analysis confirmed a Chlamydia trachomatis infection. The patient received targeted antibiotic therapy with clinical improvement. Conclusion: FHCS represents a rare but importantcomplication of PID that may present with non-specificor extra-pelvic symptoms. MRI is the modality of choicefor confirming PID-related complications and perihepatic inflammation, offering high sensitivity and the advantage of radiation-free imaging, which is especially relevant in the adolescent population.

Background: The symptoms of COPD differ based on the stage of the disease, becoming more noticeable in its severe stages and during exacerbations. They are associated with temporary incapacity for work and cause a decrease in working capacity. Also, occupations with special working conditions and exposure to pollutants at work cause increased bronchial secretion and cough. This research aims to identify the most common symptoms in COPD patients and evaluate their work capacity based on symptom prevalence. Methods: 200 subjects were included in the prospective study. Participants were divided into two groups: a study group and a control group. Within each group, subgroups were created based on smoking habits, a key risk factor for COPD development. Results: The dominant symptom in both groups was cough, with 34.67%. In subjects with preserved working capacity, the most common symptoms are chest pressure with 13.33% and shortness of breath with 9.33%, while in the group with reduced working capacity, fatigue (30%) and dyspnea with 26%. In the control group, most subjects had obstructive bronchitis, asthma and chronic simplex bronchitis. Conclusion: According to the GOLD classification, modified working capacity decreased by 51.33%, while retained working capacity declined by 48.67% in relation to disease severity. Cough was the dominant symptom in both groups, while other symptoms varied independently of the stage of the disease.

Previous studies show that interventions to improve attitudes toward stuttering yield inconsistent results on the Public Opinion Survey of Human Attributes–Stuttering (POSHA–S). Comparisons of pre- and post-intervention samples indicate that success depends on the percentage of respondents who improved rather than the magnitude of change. A “crossover” effect emerged: respondents with the most positive pre-test attitudes showed lower post-test ratings, whereas those with the most negative pre-test attitudes showed the greatest improvement; respondents with intermediate attitudes showed little change. Similar patterns appeared in non-intervention samples, where one-third fell into positive, minimal, or negative change groups. The study analyzed 943 respondents from 29 intervention samples classified as unsuccessful (U), marginally successful (MS), successful (S), or very successful (VS), plus 345 respondents from 12 non-intervention samples. Using non-intervention data as a baseline, we calculated percentages shifting among the three change groups. In the VS category, interventions moved people from the negative and minimal change groups into the positive change group. In the S category, gains in the positive change group came from the negative change group. In the MS category, all intervention-related changes began in the negative change group, yielding modest growth in the positive and minimal change group. The U category showed shifts into both the positive and negative change group, mainly reducing the minimal change group. These findings suggest that interventions to improve attitudes toward stuttering should apply strategies tailored to individuals in positive, minimal, and negative change groups.

Ovaj rad pruža (sveobuhvatnu) analizu razvoja rimskog kaznenog (krivičnog) postupka od kraljevskog doba do kraja Republike. Autor istražuje kako je rano rimsko društvo prešlo sa privatne osvete na državno provođenje pravde, naglašavajući nerazdvojivost prava, religije i politike. Kroz detaljno razmatranje institucija kao što su quaestores parricidii, quaestiones perpetuae, te reformi koje su sproveli Sula, Ciceron i Pompej, tekst prikazuje sve veću formalizaciju, specijalizaciju i politizaciju krivičnog prava. Posebna pažnja posvećena je procesnim principima, uključujući pretpostavku nevinosti, akuzatorni model i pravila dokazivanja. Zaključno, rimsko krivično pravo – iako često zapostavljeno u korist privatnog prava – imalo je značajan uticaj na temeljne koncepte savremenih evropskih  krivičnopravnih sistema.

Workplace behaviors and employee outcomes, such as team functioning, job satisfaction, and intentions to leave, are crucial for healthcare quality and safety. It highlights the substantial productivity, societal, and economic costs of worker well-being. Against this backdrop, this study examines how two dimensions of organizational culture: ethical climate and perceived managerial competence, together with team support, relate to job satisfaction and turnover intention among healthcare professionals. A quantitative, cross-sectional survey was conducted with 430 physicians, nurses, and other clinical staff in public and private institutions across the Federation of Bosnia and Herzegovina. Using established scales and structural equation modeling (SEM) in AMOS, we first verified satisfactory reliability and construct validity via exploratory and confirmatory factor analyses. The structural model showed that ethical organizational culture and managerial competence are positively related to team support and, directly or indirectly, to higher job satisfaction and lower turnover intention. Team support was positively related to job satisfaction and negatively related to turnover intention and significantly mediated the effects of both ethical climate and managerial competence on these outcomes. In addition, job satisfaction was strongly and negatively correlated with turnover intention, underscoring its central role in retention.

The aim of this study was to investigate the effectiveness, tolerability and safety of using lisinopril tablets in the treatment of essential hypertension for a period of 12 weeks.Methods:A multicenter, observational, non-interventional, postmarketing clinical trial was conducted on adult patients older than 30 years with a diagnosis of hypertension and blood pressure values ≥ 140/90 mmHg. Patients taking lisinopril were monitored for 12 weeks, during one initial and three control examinations.Main findings: The study included 334 patients:group A-aged 30 to 59 (n=167) and group B -aged 60 and older (n=167). In the group of younger respondents, the systolic/diastolic pressure before therapy was on average 150/95 mmHg, and with the use of lisinopril therapy, decreased to an average of 130/80 mmHg after 4 weeks. For the older respondents, the systolic/diastolic pressure before therapy was on average 155/95 mmHg, while afterstarting the lisinopril therapy, it decreased to an average of 135/80 mmHg. The differences in systolic/diastolic pressure were assessed as very good, namely 70.9% in the older and 87.4% in the younger group. More patients from the elderly group (34 patients) had adverse events compared to the younger group (24 patients). Adherence was generally good. Comparison of the two groups showed better results in the younger group compared to older group, 82.6% vs 69.3%.Principal conclusion:Lisinopril showed goodefficacy and safety in reducing essential hypertension in patients. Tolerability and high adherence to lisinopril therapy was observed. Key words: Lisinopril, hypertension, systolic blood pressure, diastolic blood pressure

Dear editor,We would like to express our sincere gratitude for the attention given to our published scientific paper, as well as for the positive comments, valuable suggestions, and thoughtful questions in the Comment on the article by Bajpai. We consider his contribution extremely important for improving the quality of future research in this field.

Introduction: Breast cancer represents a global public health challenge, often diagnosed at advanced stages due to a lack of awareness and insufficient practice of breast self-examination (BSE). This study aims to assess and compare the knowledge, attitudes, and practices of female students regarding BSE in the context of breast cancer prevention and early detection. Methods: The cross-sectional study was conducted from March to April 2023 and included 151 female students from the Faculty of Health Studies and the Faculty of Economics and Business University of Sarajevo. The research instrument was a modified questionnaire based on an existing questionnaire from previous research and adapted to the objectives of this study. Results: The results showed that almost all participants were familiar with BSE, with no significant differences between faculties. Students from the Faculty of Health Studies were more likely to report knowing the right time for BSE (45.1%), while students from the Faculty of Economics and Business were more uncertain and relied more on information from the internet. The main reason for not performing the BSE was a lack of knowledge about the correct technique, which was most frequently stated by economics students. Nevertheless, the majority of participants (91.4%) recognized BSE as an important method for early detection of breast tumors, highlighting the need for further education to strengthen practical skills. Conclusion: The study found that although most students are aware of the importance of BSE, regular practice is low, mainly due to uncertainty about the correct technique. The results of this study show that there is a need to integrate targeted educational programs into university curricula and health promotion campaigns to reinforce preventive behaviors.