Purpose: The development and evaluation of machine learning models that automatically identify the body part(s) imaged, axis of imaging, and the presence of intravenous contrast material of a CT series of images. Methods: This retrospective study included 6955 series from 1198 studies (501 female, 697 males, mean age 56.5 years) obtained between January 2010 and September 2021. Each series was annotated by a trained board-certified radiologist with labels consisting of 16 body parts, 3 imaging axes, and whether an intravenous contrast agent was used. The studies were randomly assigned to the training, validation and testing sets with a proportion of 70%, 20% and 10%, respectively, to develop a 3D deep neural network for each classification task. External validation was conducted with a total of 35,272 series from 7 publicly available datasets. The classification accuracy for each series was independently assessed for each task to evaluate model performance. Results: The accuracies for identifying the body parts, imaging axes, and the presence of intravenous contrast were 96.0% (95% CI: 94.6%, 97.2%), 99.2% (95% CI: 98.5%, 99.7%), and 97.5% (95% CI: 96.4%, 98.5%) respectively. The generalizability of the models was demonstrated through external validation with accuracies of 89.7 - 97.8%, 98.6 - 100%, and 87.8 - 98.6% for the same tasks. Conclusions: The developed models demonstrated high performance on both internal and external testing in identifying key aspects of a CT series. Graphical Abstract

The contributions of two energetically highest molecular orbitals to the harmonic emission rate are analysed for a two-component laser field. For diatomic molecules exposed to the elliptically polarised field, the emission from the highest-occupied molecular orbital (HOMO) is dominant for various molecular orientations with respect to the laser field. However, the contribution of the lower molecular orbital (HOMO-1) can become significant or even dominant for some molecular orientations. We introduce the ratio of the coherent over the incoherent sum of the HOMO and HOMO-1 contributions as a quantitative measure of the significance of the particular molecular orbital. Also, the gaseous medium response is different for the left and right elliptically polarised light and the molecular characteristics are imprinted into this difference. Moreover, for the orthogonally polarised two-colour (OTC) laser field the relative contributions of HOMO and HOMO-1 depend to a great extent on the relative phase between the field components. The importance of the HOMO-1 can be assessed by the relative error which is made if the harmonic spectra are obtained only with the HOMO contribution. Finally, we investigate the interference of the contributions of two highest molecular orbitals. We show that, for the OTC field, the destructive interference depends linearly on the intensity of the field components. Also, the interference minima shift towards the higher energies with the increase of the component wavelength.

Connectedness is a multidimensional human experience that is essential to successful aging. The aims of this cross-sectional study were to assess connectedness and self-perception of successful aging in older people, to examine whether there are differences in relation to basic characteristics, and to examine whether there is a connection between connectedness and self-perception of successful aging. The respondents were elderly people in the Republic of Croatia. Data were collected using two validated scales: Croatian versions of the Register–Connectedness Scale for Older Adults and the Self-Assessment Scale of Successful Aging. The study included 824 respondents, of which 319 (38.7%) were men and 505 (61.3%) were women. The median age was 72 years. The median connectivity of the respondents was 8.9 (IQR= 7.6–10.2), and the median rating of successful aging was 3.25 (IQR = 1–5). Spearman’s correlation coefficient ρ (p value) was 0.585 (<0.001). Connectivity was rated better by respondents with a higher level of education, who were married, resided in their own homes, used modern technologies, and were active in the community. There is a significant positive association between connectedness and the self-perception of successful aging overall, as well as in all individual connectedness domains.

Introduction We evaluated whether 12-week intake of molecular hydrogen (H2) in 5 overweight adults (3 women; age: 50.2 ±11.9 years, body mass index: 29.4 ±2.1 kg/m2) affects brain levels of the glutamate-glutamine-GABA cycle, critical amino acid neurotransmitters in the mechanism of neuronal activation during appetite regulation. Methods A 1.5-T single-voxel proton magnetic resonance spectroscopy was used to assess the tissue concentrations of relevant metabolites. Results The mean glutamate and glutamate-plus-glutamine levels at the posterior cingulate gyrus decreased significantly during the study; this was accompanied by a significant drop in GABA levels at left prefrontal white matter, and glutathione levels at anterior cingulate gyrus. No changes in the brain metabolites were found in the comparable group of overweight individuals (n = 4, 2 women; age: 41.0 ±13.9, BMI 26.8 ±1.3 kg/m2) followed-up in the past without this treatment. Conclusions We showed a possible hydrogen-driven upregulation of neurotransmitters involved in appetite stimulation leading to hunger suppression and weight loss. Further studies analyzing appetite-controlling metabolic pathways affected by H2 would require monitoring of additional biomarkers of satiation and satiety during different feeding regimens.

Introduction: The most general definition of quality of life states that “quality of life is the degree of what makes life good.” Contemporary disability research increasingly relies on examining the quality of life of the whole family. Health and developmental outcomes are affected by the health of children and their environment. The objective of this study is to determine the difference in quality of life between families with children with disabilities and families with children without disabilities in the area of family health. Methods: The Family Quality of Life Questionnaire was used to assess quality of life. The test group consisted of 41 families of children with intellectual disabilities and developmental disabilities who use day care centers. The control group consisted of 69 families of children without disabilities whose members are employed in day care centers. Results: A statistically significant difference was found in the quality of life of families of children with disabilities and families of children without disabilities in the area of family health within the concept of satisfaction with family health (p = 0.0001), with respondents in the test group reporting a lower mean score of 3.1 ± 0.86 compared to subjects in the control group 3.94 ± 0.62. None of the respondents in the test group reported being very satisfied with family health, while for most respondents in both groups, 38 (92.8%) in the test group and 66 (95.7%) in the control group, family health was very important for quality of life. Conclusion: A statistically significant difference was found in the quality of life of families of children with disabilities and families of children without disabilities within the concept of achievement, the concept of satisfaction with family health and the determination is a statistically significant difference in relation to the existence of health services in the place of residence.

Conventional co-design methods, such as storyboarding and focus groups, are not always appropriate for people living with dementia (PLwD). In pilot robot co-design workshops in a local memory care facility, we noticed PLwD struggled to understand, express themselves, fully participate, and benefit from the experience. After reflecting on challenges with the facility’s director of program development and education, we redesigned the workshops prioritizing elements of the Eden Alternative’s well-being for PLwD: identity, connectedness, security, and autonomy. We delivered these new workshops over five weeks with 12 PLwD participants. Analysis of resulting video recordings and transcripts shows the new activities allowed participants to see themselves as having knowledge relevant to social robot design; to relate to each other, the robot, and the researchers; to feel comfortable; and to actively contribute to and offer valuable insights for robot design. Participants reported feeling meaning, growth, and joy during the workshops.

Telepresence robots are meant to provide physical access to digital remote spaces. However, they have a range of limitation that make spaces less accessible for remote participants. In this study we reveal, catalogue, and examine telepresence limitations in the context of the classroom. Based on ongoing field study results from participatory observations, surveys and interviews with 22 participants we discuss the extent to which telepresence robots make the classroom accessible and whether the telepresence robots are "disabled."

Objective: Walking is a key component of daily-life mobility. We examined associations between laboratory-measured gait quality and daily-life mobility through Actigraphy and Global Positioning System (GPS). We also assessed the relationship between two modalities of daily-life mobility i.e., Actigraphy and GPS. Methods: In community-dwelling older adults (N = 121, age = 77±5 years, 70% female, 90% white), we obtained gait quality from a 4-m instrumented walkway (gait speed, walk-ratio, variability) and accelerometry during 6-Minute Walk (adaptability, similarity, smoothness, power, and regularity). Physical activity measures of step-count and intensity were captured from an Actigraph. Time out-of-home, vehicular time, activity-space, and circularity were quantified using GPS. Partial Spearman correlations between laboratory gait quality and daily-life mobility were calculated. Linear regression was used to model step-count as a function of gait quality. ANCOVA and Tukey analysis compared GPS measures across activity groups [high, medium, low] based on step-count. Age, BMI, and sex were used as covariates. Results: Greater gait speed, adaptability, smoothness, power, and lower regularity were associated with higher step-counts (0.20<|ρp| < 0.26, p < .05). Age(β = −0.37), BMI(β = −0.30), speed(β = 0.14), adaptability(β = 0.20), and power(β = 0.18), explained 41.2% variance in step-count. Gait characteristics were not related to GPS measures. Participants with high (>4800 steps) compared to low activity (steps<3100) spent more time out-of-home (23 vs 15%), more vehicular travel (66 vs 38 minutes), and larger activity-space (5.18 vs 1.88 km2), all p < .05. Conclusions: Gait quality beyond speed contributes to physical activity. Physical activity and GPS-derived measures capture distinct aspects of daily-life mobility. Wearable-derived measures should be considered in gait and mobility-related interventions.

At a time of progressive development of public international law, the internal self-determination of peoples has no alternative, but external self-determination is justifi ed in a situation where, as a result of oppression, dispossession, and collective discrimination, a certain people have full rights to freely determine its political, social, economic, and cultural setting. In the case of Kosovo, the right to “remedial secession” based on the right to external self-determination has been achieved. According to many legal scholars, the related right is an exception and could be realized outside the colonial context, in limited circumstances that resemble the colonial paradigm. Modern customary public international law provides a legal basis for the introduction of the concept of the right to “remedial secession” and forms an argument that is supported by the “Great Powers” and is consistent with international institutional practice provided that the people’s fundamental human rights are threatened. Th is article aims to explain through the case of Kosovo that the external form of self-determination, which includes secession, is possible only exceptionally in the case of grave violations of human rights and freedoms, war crimes, repression, and systematic oppression, and that the internal self-determination of the peoples is a more acceptable form of realizing this collective human right, which should be realized through broad constitutional and legal reforms in every multi-ethnic state (a certain degree of autonomy or decentralization).

The scoring of sleep stages is one of the essential tasks in sleep analysis. Since a manual procedure requires considerable human and financial resources, and incorporates some subjectivity, an automated approach could result in several advantages. There have been many developments in this area, and in order to provide a comprehensive overview, it is essential to review relevant recent works and summarise the characteristics of the approaches, which is the main aim of this article. To achieve it, we examined articles published between 2018 and 2022 that dealt with the automated scoring of sleep stages. In the final selection for in-depth analysis, 125 articles were included after reviewing a total of 515 publications. The results revealed that automatic scoring demonstrates good quality (with Cohen's kappa up to over 0.80 and accuracy up to over 90%) in analysing EEG/EEG + EOG + EMG signals. At the same time, it should be noted that there has been no breakthrough in the quality of results using these signals in recent years. Systems involving other signals that could potentially be acquired more conveniently for the user (e.g. respiratory, cardiac or movement signals) remain more challenging in the implementation with a high level of reliability but have considerable innovation capability. In general, automatic sleep stage scoring has excellent potential to assist medical professionals while providing an objective assessment.