Objective. To determine anxiety and depression levels inadolescents with acne vulgaris in relation to clinical severityand gender. Patients and methods. Using a sectional study,the anxiety and depression level was analyzed of 90 adolescentsof both sexes, aged 16 to 21 years, who were sufferingfrom acne vulgaris. The study was conducted between February1st 2008 and January 31st 2009 at the Dermatovenerologydepartment of the Cantonal Hospital “Dr. Irfan Ljubijankic”,Bihac. According to the type of efflorescence, its localizationand severity of clinical features, respondents were classifiedin three groups: the first group consisted of adolescents withmild forms of acne, the second group had moderate formsof acne and the third had severe forms of acne. Evaluationof anxiety levels in patients with acne vulgaris was made usingSTAI questionnaire (Spielberger’s state and trait AnxietyInventory) that consists of 20 questions about the essentialcharacteristics of anxiety as the condition, and the level ofdepression was determined using the BDS-scale (Back DepressionInventory) which consists of 18 items that were usedby the respondents to perform self-evaluation of depressionlevel. Results. In the study group there were 54 (60%) femalerespondents and 36 (40%) male, mean age 17.5 years (range15.6-20.6). Of the total number of patients with acne vulgaris,nine of them or 10% (4 female and 5 male) had a mild form ofacne (first group), 72 of them or 80% (46 female and 26 male)a moderate form of acne (second group) and 9 of them or 10% (4 female and 5 male) a severe form of acne (third group)(p > 0.95). 1.1% of the respondents had an exceptionally lowanxiety level, 13.3% had low level, moderate 76.8% and 8.8%had a high level. 37.8% had distinct signs of depression, therisk group consisted of 44.4%, and a normal value was foundin 17.7%. The values of the STAI questionnaire expressed asmedian (range) in the first, second and third groups were 58.7(39-70), 57.7 (20-70) and 60.2 (40-70) (p = 0.36), while thevalues of the BDS scale within the same groups were 13.4 (8-16), 15.1 (3-29) and 14.4 (7-24) (p = 0.367). Conclusion. Thelevel of depression and anxiety in patients with acne vulgarisis not related to severity and patient sex.

The measured forward-backward asymmetry in the tt production at the Tevatron might be explained by the additional exchange of a colored weak singlet scalar. Such state appears in some of the grand unified theories, and its interactions with the up-quarks are purely antisymmetric in flavor space. We systematically investigate the resulting impact on charm and top quark physics. The constraints on the relevant Yukawa couplings come from the experimentally measured observables related to D{sup 0}-D{sup 0} oscillations, as well as dijet and single-top production measurements at the Tevatron. After fully constraining the relevant Yukawa couplings, we predict possible signatures of this model in rare top quark decays. In a class of grand unified models we demonstrate how the obtained information enables to constrain the Yukawa couplings of the up-quarks at very high energy scale.

Diazepam is one of most frequently prescribed benzodiazepines. It is classified as a class I substance according to the Biopharmaceutics Classification Scheme (BCS). Diazepam tablets were prepared using different API rawmaterials. Before the formulation, we measured particle size distribution on Malvern Instruments Ltd Mastersizer 2000. The tablets were prepared by employing conventional wet granulation. The formulations were evaluated for hardness, friability, content uniformity, in vitro disintegration time (DT), release profiles. The dissolution profile testing is performed on the two formulations with different particles size distribution. Test parameters were: medium 0.1 mol / l hydrochloric acid, 900 ml, temperature 37°C ± 0.5°C, Mixing Speed 100 rpm, Number of tested tablets 12, Testing Cycle 10, 15, 20, 25 and 30 min. Instrument: Varian Van Kel VK7025, Varian Cary 50. We used the spectrophotometric method with absorbance measuring on 242 nm for quantification. Results for particle size distribution for first Diazepam API particle distribution were d (0.10): 88.743 μm; d (0.50): 305.231 μm; d (0.90): 655.911 μm, and for the second raw-material of API was d (0.10):1.998 μm; d (0.50): 4.419 μm; d (0.90): 8.845 μm. The results of diazepam dissolution for two formulations and f2 value with reference drug are presented in Table 1:

Metoprolol is a cardioselective β-blocker that is classified as a class I substance according to the Biopharmaceutics Classification Scheme BCS, meaning that it is highly soluble and highly permeable. [...]

The separation of solids in adhesive contact, or the fracture of solid bodies, often results in the emission of high-energy photons, e.g., visible light and X-rays. This is believed to be related to charge separation. We propose that the emission of high-energy photons involves surface roughness and surface diffusion of ions or electrons, resulting in the concentration of charge at the tips of high asperities, and to electric-field enhancement, which facilitate the discharging process which result in the high-energy photons. If the surface diffusion is too fast, or the separation of the solid surfaces too slow, discharging starts at small interfacial separation resulting in low-energy photons.

Onychomycoses, fungal nail infections, are responsible for 50% of all nail disorders affecting up to 18% of general population in some countries [1]. [...]

Amlodipine is a long-acting calcium channel blocker used in the treatment of hypertension and angina pectoris. [...]