INTRODUCTION/AIM In acute organophosphate poisoning the issue of special concern is the appearance of muscle fasciculations and convulsions that cannot be adequately antagonised by the use of atropine and oxime therapy. The aim of this study was to examine atidotal effect of obidoxime or HI-6 combinations with memantine in mice poisoned with soman, dichlorvos or heptenophos. METHODS Male Albino mice were pretreated intravenously (iv) with increasing doses of oximes and/or memantine (10 mg/kg) at various times before poisoning with 1.3 LD-50 of soman, dichlorvos or heptenophos, in order to determine the median effective dose and the efficacy half-time. In a separate experiment, cerebral extravasation of Evans blue dye (40 mg/kg iv) was examined after application of memantine (10 mg/kg iv), midazolam (2.5 mg/kg intraperitonealy--ip) and ketamine (20 mg/kg ip) 5 minutes before soman (1 LD-50 subcutaneously--sc). RESULTS Coadministration of memantine induced a significant decrease in median effective dose in null time of both HI-6 (7.96 vs 1.79 gmoL/kg in soman poisoning) and obidoxime (16.80 vs 2.75 micromoL/kg in dichlorvos poisoning; 21.56 vs 6.63 micromoL/kg in heptenophos poisoning). Memantine and midazolam succeded to counteract the soman-induced proconvulsive activity. CONCLUSION Memantine potentiated the antidotal effect of HI-6 against a lethal dose of soman, as well as the ability of obidoxime to antagonize the toxic effects of dichlorvos and heptenophos probably partly due to its anticonvulsive properties.

UDK 630*93:502(497) Within last few years, all Western Balkan countries have adopted new forest legislation aiming to introduce internationally accepted concepts of forest management. Due to specific social, political and economical realities that these countries have passed through, a number of nature protection regulations have been integrated into forest legislation. This paper compares nature protection regulations in Laws on Forests in Croatia (2005), Federation of Bosnia and Herzegovina (2002) and Serbia (2010). It examines differences and commonalities in above mentioned Laws. Furthermore, the paper analyzes the level of consistencies between Laws on Forests and Laws on Nature Protection in Croatia (2005), Federation of Bosnia and Herzegovina (2003) and Serbia (2009) in terms of “openness” and “greening” of forest related legislation. The results show that protection regulations within forest legislation, particularly those referring to forests with special management regime, can be strengthened by introducing the concept of high conservation value forests (HCVF). This concept includes also strategic changing of forestry sector position - from an inferior towards more proactive role in nature protection dialogue. The results of this paper can contribute to further improvements of current countries’ forest related legislation in domain of analyzed issues as well as creation of consistent forest and nature protection policies aimed at fostering cross-sectoral dialogue and cooperation.