Introduction: Several decades of basic science and animal research provided considerable support for significant role of plasma free fatty acids (FFAs) in etiology of Type 2 diabetes mellitus (T2DM). Contradicting data related to signifi cance of elevated FFAs in plasma of patients with Type 2 diabetes prompted us to study concentrations of palmitic acid, stearic acid, and linoleic acid, in patients and healthy controls in an attempt to possibly use them as potential biomarkers in progression of the disease. Since aging is associated withincreased plasma glucose and insulin levels that are consistent with an insulin resistant state, in this study,age differences in the concentration of the above mentioned acids were tested.Methods: Progressive changes in their concentrations were followed through a period 6 months. All subjects included in the study were free of evidence of hepatitis B or C viral infection or active liver and kidney damage. Analysis of glucose and glycated hemoglobin levels were performed on BT PLUS 2000 analyzer using standard IFCC protocols, while concentrations of FFAs were analyzed by gas chromatography.Results: Our data demonstrated signifi cantly higher FFA values in plasma of diabetic patients as compared to healthy controls. There was a trend of correlation of FFAs levels with the blood glucose levels in diabetic patients, which was more prominent in diabetic men than in women.Conclusion: With aging, levels of free fatty acids signifi cantly increased in plasma of diabetic patients, and this effect was also more profound in male than in female diabetics.

Introduction: This study is the fi rst study about the distribution ABO blood types at children with acute leukemia in Federation of Bosnia and Herzegovina. The aim of the study is to point out distribution of blood type groups at children with acute leukemia (AL)Methods: The number of children in this study was the following: 145 children with acute leukemia and 27 of children with acute myeloblastic leukemia (AML). All of the children were treated at Hemato- Oncology Unitof Pediatric Clinic in Sarajevo, in the period January 2000 until December 2010. Age of children was between 1 month and 15 years.Results: The results showed that different blood types were registered in 93. 1% of children who got ill and treated from acute leukemia for the mentioned period. At 6. 9 % of children, none of the blood types wereregistered. It was noticed that 40.9 % children who have registered blood type O, 37% blood type A,16% blood type B and 6.5% blood type AB had AL, too. It has been observed that children with following bloodtypes had AML: O, 47.8%, A, 47.7% and AB, 30.4%.Conclusion: Signifi cance ABO types distribution was confi rmed for children with ALL, p<0, 05. The analysis of the distribution of ABO types based on gender showed that signifi cance was confi rmed at females with both ALL and AML (p<0.05).

This issue of the International Journal of Nephrology focused on kidney diseases within a devil's triangle, oxidative stress (OS), mediators, inflammation, specifically relating to the clinical significance of identification, and prevention. Every creature in need of oxygen faces OS. It has a critical role in the molecular mechanisms of renal injury in several kidney diseases, and many complications of these diseases are mediated by OS, mediators, and inflammation. There is a complex relationship between these three; mostly they induce each other. While some of the diseases themselves can contribute to OS, reactive oxygen species (ROS) produced by activated leukocytes and endothelial cells in sites of inflammation cause tissue damage. Although inflammation looks dangerous for the organism, it is a normal reaction of organs and tissues to protect themselves against several invasion(s). It enables the immune system to remove the injurious stimuli and initiate the healing process of tissues. However, the interactions between OS, mediators, and inflammation may result in glomerular damage, proteinuria, electrolyte, and volume instabilities which cause nephron loss, on the long view. Detailed studies on this topic are included in this issue. The kidney can easily be damaged by ROS, due to the rich structure of long-chain polyunsaturated fatty acids. The article by E. Ozbek summarizes the induction of OS within kidney in several conditions, including diabetes, hypertension, hypercholesterolemia, obesity, aging, urinary obstruction, environmental toxins, and molecular mechanisms of these inductions in the light of existing literature data. Diabetic nephropathy is one of the most common microvascular complications of type 1 and type 2 diabetes mellitus and the leading cause of end-stage renal disease worldwide [1]. Rojas-Rivera et al. reviewed the biological bases of oxidative stress and its role especially on diabetic nephropathy, as well as the role of the Keap1-Nrf2 pathway, and recent clinical trials targeting this pathway with bardoxolone methyl, a novel synthetic triterpenoid with antioxidant and anti-inflammatory properties. Obesity continues to be a public health problem throughout the world. Epidemiologic studies have shown that 66% of adults and 16% of children and adolescents are overweight or obese [2]. Obesity-related glomerulopathy is an increasing cause of end-stage renal diseases. J. Tang et al. stressed the chronic low-grade systemic inflammation in obesity and discussed the roles of inflammation and oxidative stress in the progression of obesity-related glomerulopathy and possible treatment modalities to prevent kidney injury in obesity, such as the usage of anti-IL-6 receptor antibody, TNF-α antagonist, adiponectin, nutritional and surgical interventions to reduce OS. Hypertension is an another important global health issue both in adults and children. It is one of the major risk factors for the progression of kidney diseases. The relationship between blood pressure and dietary sodium and salt sensitivity has been well known, and renal sodium handling is a key determinant of long-term blood pressure regulation [3]. There is a limited knowledge in the literature regarding the role of ROS-mediated fibrosis and renal proximal tubule sodium reabsorption through the Na/K-ATPase. S. Liu et al. reviewed the possible role of ROS in the regulation of Na/K-ATPase activity. The authors emphasized the importance of further researches whether ROS signaling is a link between the Na/K-ATPase/c-Src cascade and NHE3 regulation and how OS, stimulated by high salt and cardiotonic steroids, regulates Na/K-ATPase/c-Src signaling in renal sodium handling and fibrosis. Urotensin-II is the most potent mammalian vasoconstrictor identified to date, almost tenfold more potent than endothelin-I [4]. A. Balat and M. Buyukcelik discussed the role of urotensin-II on renal hemodynamics and its possible role on several kidney diseases, such as the minimal change nephrotic syndrome. The article includes a detailed discussion of urotensin-II immunoreactivity in renal biopsy specimens of children with membranoproliferative glomerulonephritis, membranous nephropathy, IgA nephropathy, Henoch-Schonlein nephritis, and focal segmental glomerulosclerosis. Because of its complex relation with OS and other mediators, authors describe it as “more than a mediator” in glomerular diseases. They briefly mention from the effectiveness of U-II antagonism, as a new promising pharmacological treatment target in some kidney diseases. Given the potential impact of OS, mediators, and inflammation trio, the importance of prevention has come into question. Strong evidence indicates the importance of new molecules that are able to diminish them which in turn may help to decrease the prevalence and/or progression of several kidney diseases. Therefore, further researches are needed to the better understanding of the molecular and clinical mechanisms of this triad. They may help to provide new therapeutical strategies to control several complications in patients with kidney diseases. Ayse Balat Halima Resic Guido Bellinghieri Ali Anarat

We present a new approach to quantifying pole parameters of single-channel processes based on Laurent expansion of partial wave T-matrices. Instead of guessing the analytical form of non-singular part of Laurent expansion as it is usually done, we represent it by the convergent series of Pietarinen functions. As the analytic structure of non-singular term is usually very well known (physical cuts with branhcpoints at inelastic thresholds, and unphysical cuts in the negative energy plane), we show that we need one Pietarinen series per cut, and the number of terms in each Pietarinen series is automatically determined by the quality of the t. The method is tested on a toy model constructed from two known poles, various background terms, and two physical cuts, and shown to be robust and condent up to three Pietarinen series. We also apply this method to Zagreb CMB amplitudes for the N(1535) 1/2- resonance, and conrm the full success of the method on realistic data. This formalism can also be used for tting experimental data, and the procedure is very similar as when

U pogledu pedagoskog aspekta tjelesnog odgoja i sporta, treba istaci postojanje vesestruke vrijednosti za sve uzrasne generacije odgojno-obrazovnog procesa. Cinjenica jeste da tjelesna aktivnost kao i sport predstavljaju integralni dio kulture življenja svakog covjeka, a tjelesni odgoj integralni dio cjelokupnog odgojno-obrazovnog procesa, koji zajedno sa intelektualnim, radnim, moralnim i estetskim formiranjem licnosti, obezbjeđuje kontinuitet i svestranost odgoja i obrazovanja djece i mladih (Mejovsek ,1979). Upravo to i jeste cilj ovog istraživanja, da kroz primjenu razlicitih sadržaja kao i njihove realizacije uz primjenu adekvatnih metoda i organizacijsko-metodickih oblika rada, kod djece mlađeg skolskog uzrasta, pokusaju unaprijediti motoricke sposobnosti i motoricka znanja te da se isti uvažavajuci nivo motorickog dara pokusaju usmjeriti u sport. Dobijeni rezultati u ovom istraživanju, govore da uz adekvatnu primjenu i postivanje pedagoskih principa rada u nastavi tjelesnog odgoja, ne samo da ce se doprinijeti racionalizaciji redovne nastave tjelesnog odgoja sa djecom razredne nastave, vec ce se stvoriti adekvatni uslovi uz pravilno planiranje, programiranje i primjenu pedagoskih metoda i organizacijsko-metodickih oblika rada, da se djeca ovog a i mlađeg skolskog uzrasta blagovremeno i pravilno usmjere u određenu granu sporta.

The study was conducted on a sample of 92 participants at the age of 13-15, who were in the training process at least a year. The sample of participants is composed of two groups of judo athletes, 50 from Macedonia and 42 from Bosnia and Herzegovina. The aim of this study was to compare the anthropological dimensions between these two groups of participants. For the purposes of this study 28 variables were used: 9 variables for anthropometrical measures, 14 variables for motor dimensions and 5 variables for assessing situational movement structures of judo athletes. The univariate and multivariate statistical methods were identical in some anthropometrical measures, in particular the motor skills and situational movement structures of judo athletes, between groups.