Objetivo:identificar os motivos que familiares atribuem a busca por tratamento pelo dependente quimico.Metodo:estudo qualitativo descritivo, desenvolvido em 2012 e 2013, em uma unidade de reabilitacao para dependentes quimicos localizada no Parana. Foram realizadas 19 entrevistas semiestruturadas com familiares de dependentes quimicos em tratamento. Os dados foram analisados a luz do Modelo Transteorico de Mudanca Comportamental e organizados em categorias tematicas de acordo com a Interpretacao Qualitativa de Dados.Resultados:a busca por tratamento pelos dependentes quimicos ocorreu: no estagio de pre-contemplacao por influencias externas; no estagio de contemplacao pela ambivalencia quanto a necessidade de mudanca comportamental; no estagio de acao por conscientizacao da dependencia quimica e de necessidade de ajuda profissional; e no estagio de manutencao pela nao conservacao das mudancas comportamentais.Conclusao:e imprescindivel a avaliacao dos estagios motivacionais no inicio do tratamento para a ampliacao das possibilidades de sucesso no processo de reabilitacao.

Abstract The paper deals with metonymies having body parts as source domains in English and Bosnian. According to Cognitive Linguistics standpoint, human cognition is based on bodily functioning. Therefore, we started from the hypothesis that most body part metonymies are very similar across languages and cultures, and share similar properties. The aim of the paper was threefold: first, to examine whether metonymies with body parts as source domains have common grammatical and conceptual properties in English, secondly to examine whether they share the same properties in Bosnian, and thirdly to compare the two languages in this respect. We analysed body part metonymies in terms of some grammatical properties such as the use of singular and plural, specific and generic reference, grammatical recategorisation from count to mass nouns, noun-to-verb conversion, and some conceptual properties such as source-in-target vs. target-in-source metonymies, metonymic chains and combination of metaphor and metonymy. Many common features were found both within the respective languages under consideration and in cross-linguistic analysis. The minor differences found in contrasting the data from the two languages are mainly the result of differences in grammatical systems.

Aim: This study sought to assess whether the volume and osmolarity of contrast media (CM) influences the occurrence of contrast induced nephropathy (CIN) following coronarography procedure. CIN can be defined as an increase in the serum concentration of creatinine greater than a 25% from baseline during the period of 12 to 48 hours after the administration of radiocontrast media. Material and methods: We examined 100 patients without diabetes with serum creatinine concentration from 45 mmol/l to 141 mmol/l and 100 patients with diabetes with serum creatinine concentration from 46 mmol/l to 161 mmol/l who underwent coronary angiography. During procedure they received iso-osmolar contrast medium, Visipaque 320 (iodixanol-320), for group without diabetes from 40 to 340 ml and for group with diabetes from 49 to 310 ml. Results: CIN occurred in 27 (13,5%) of the 200 study patients. There was a trend toward higher prevalence of CIN (16% vs.11%, p = 0.086) in the diabetic group compared with the non-diabetic group. Patient with diabetes received less contrast media, they are younger but number patients with CIN are higher. Conclusion: Increasing contrast media dose is associated with the occurrence of CIN following coronarography. But, another risk factors like diabetes mellitus, old age, male sex and preexisting kidney disease have influence of developing CIN after coronarography.

Background/Aims: Residual renal function (RRF) has been shown to influence survival of peritoneal dialysis (PD) patients. This study examined the relations between RRF and left ventricular hypertrophy (LVH) before switching on dialysis treatment and observed during 18 months on PD treatment. Methods: A prospective longitudinal study was performed in 50 non-anuric (defined as >200 mL urine output in a 24-hour period) PD patients. Echocardiography, RRF and other known risk factors for the increase of LV mass index (LVMi) were determined at study baseline and the end of follow-up. Results: There was 78% patients with LVH in end-stage renal disease (ESRD) baseline and 60% at the end of follow-up. RRF at the start of the study showed no significant difference between patients with normal and increased LVMi, as well as in daily collection of urine. After 18 months, patients with decreased LVMi had better RRF, lower CRP and better Kt/V compared to patients with increased LVMi (p < 0.001). Patients with better preserved RRF not only had significantly higher total Kt/V, but were less anemic and hypoproteinemic and lesser presence of LVH. Conclusions: PD in non-anuric ESRD patients the first 18 months has a positive effect on the preservation of RRF and partial regression of left ventricular remodeling.

Introduction: Starting from the point that the chronic kidney disease (CKD) is chronic, inflammatory and hypercoagulable state characterized by an increase in procoagulant and inflammatory markers high cardiovascular morbidity and mortality in these patients could be explained. Aim: The aim of the research was to monitor inflammatory markers and procoagulants in various stages of kidney disease (stage 1-4). Materials and Methods: The research included 120 subjects older than 18 years with CKD stages 1-4 examined and monitored in Clinic of Nephrology, University Clinical Centre Sarajevo over a period of 24 months. The research included determining the following laboratory parameters: serum creatinine, serum albumin, C-reactive protein, leukocytes in the blood, plasma fibrinogen, D-dimer, antithrombin III, coagulation factors VII (FC VII) and coagulation factor VIII (FC VIII). Results: With the progression of kidney disease (CKD stages 1-4), there was a significant increase of inflammatory and procoagulant markers: CRP, fibrinogen and coagulation factor VIII, and an increase in the average values of leukocytes and a reduction in the value of antithrombin III, but without statistical significance. Also, there were no significant differences in the values of D-dimer and coagulation factor VII. Conclusion: The progression of kidney disease is significantly associated with inflammation, which could in the future be useful in prognostic and therapeutic purposes. Connection of CKD with inflammation and proven connection of inflammation with cardiovascular risk indicates the potential value of some biomarkers, which could in the future identify as predictors of outcome and could have the benefit in the early diagnosis and treatment of cardiovascular disease in CKD.