Objectives: The aim of this study was to evaluate visual and refractive outcomes after Veriflex phakic intraocular lenses (pIOL) implantation in moderately myopic eyes as well as postoperative complications. Methods: This prospective clinical study included 40 eyes of 26 patients which underwent implantation of Veriflex for correction of myopia from -6.00 to -14.50 diopters (D) in the Eye Clinic Svjetlost Sarajevo, from January 2011 to January 2014. Uncorrected distance visual acuity (UDVA), manifest residual spherical equivalent (MRSE), intraocular pressure (IOP), endothelial cell (EC) density were evaluated at one, three, six and 12 months. Other complications in postoperative period were evaluated. For statistical analysis SPSS for Windows and Microsoft Excel were used. Results: Out of 26 patients 14 had binocular and 12 monocular procedure, with mean age of 29.8±6.5 years. After 12 months mean UDVA was 0.73±0.20. Mean MRSE was -0.39±0.31D and 90% of eyes had MRSE within ±1D. EC loss was 7.18±4.33%. There was no significant change of IOP by the end of 12 months follow up period. The only intraoperative complication was hyphema and occurred in one eye. Few postoperative complications were: subclinical inflammation in three eyes (7,5%), pigment dispersion in four eyes (10%), ovalisation of papilla in 2 eyes (5%) and decentration of pIOL in 2 eyes (5%). Conclusion: Implantation of iris-claw phakic lenses Veriflex for treating moderately high myopia is a procedure with good visual and refractive results and few postoperative complications.

Introduction: Cysteine protease are biological catalysts which play a pivotal role in numerous biological reactions in organism. Much of the literature is inscribed to their biochemical significance, distribution and mechanism of action. Many diseases, e.g. Alzheimer’s disease, develop due to enzyme balance disruption. Understanding of cysteine protease’s disbalance is therefor a key to unravel the new possibilities of treatment. Cysteine protease are one of the most important enzymes for protein disruption during programmed cell death. Whether protein disruption is part of cell deaths is not enough clear in any cases. Thereafter, any tissue disruption, including proteolysis, generate more or less inflammation appearance. Review: This review briefly summarizes the current knowledge about pathological mechanism’s that results in AD, with significant reference to the role of cysteine protease in it. Based on the summary, new pharmacological approach and development of novel potent drugs with selective toxicity targeting cysteine protease will be a major challenge in years to come.

Non-maleficence represents one of the basic ethical principles that health care providers should be guided by during service delivery. Establishment of patient safety is nowadays recognized as an issue of global concern in health care and a critical component of quality management. The aim of this paper is to provide a literature review of the patient safety and medication errors concept, with special attention given to defining the most significant terms, analyzing the causal factors and reviewing their classification. Raising awareness about the importance of patient safety has resulted in an increase in the number of medication error studies over the last decade. The traditional approach which makes health workers responsible for reduction of incidents is replaced by the modern concept which implies the involvement of all stakeholders at all levels of the system. In developed countries, the application of prospective risk management models for specific health care processes has already started. However, all these studies are mainly carried out at the secondary and tertiary levels of health care, while they are almost non-existent at the primary level. In the Republic of Serbia, a Rulebook on indicators of the quality of health care has been recently adopted, but a trend of significant lack of data regarding patient safety can be noticed due to inadequate reporting. It is necessary to continue with the homogenization of terminology and to increase the number of analyses of causal factors with the aim of prospective risk identification, particularly in developing countries such as the Republic of Serbia. Acta Medica Medianae 2016;55(2):57-64.

Table of contentsOP03 Selective extraction of medically-related radionuclides from proton-irradiated thorium targetsV. Radchenko, J.W. Engle, C. Roy, J. Griswold, M.F. Nortier, E.R. Birnbaum, M. Brugh, S. Mirzadeh, K. D. John, M.E. FassbenderOP04 Comparison of [68Ga]FSC(succ-RGD)3 and [68Ga]NODAGA-RGD for PET imaging of αvβ3 integrin expressionChuangyan Zhai, Gerben M. Franssen, Milos Petrik, Peter Laverman, Clemens DecristoforoOP05 A new NPY-Y1R targeting peptide for breast cancer PET imagingAit-Mohand Samia, Dumulon-Perreault Véronique, Guérin BrigitteOP06 The influence of multivalency on CCK 2 receptor targetingD. Summer, A. Kroess, C. Rangger, H. Haas, P. Laverman, F. Gerben, E. von Guggenberg, C.DecristoforoOP07 SPECT Imaging of αvβ3 Expression by [99mTc(N)PNP43]- Bifunctional Chimeric RGD Peptide not Cross-Reacting with αvβ5Cristina Bolzati, Nicola Salvarese, Fiorenzo Refosco, Laura Meléndez-Alafort, Debora Carpanese, Antonio Rosato, Michele Saviano, Annarita Del Gatto, Daniela Comegna, Laura ZaccaroOP09 New dienophiles for the inverse-electron-demand Diels-Alder reaction and for pretargeted PET imagingEmilie Billaud, Muneer Ahamed, Frederik Cleeren, Elnaz Shahbazali, Tim Noël, Volker Hessel, Alfons Verbruggen and Guy BormansOP10 New complexing agent for Al18F-labelling of heat-sensitive biomolecules: Synthesis and preclinical evaluation of Al18F-RESCA1-HASCleeren F, Lecina J, Koole M, Verbruggen A and Bormans GOP11 A novel versatile precursor efficient for F-18 radiolabelling via click-chemistryB. Lugatoa, S. Stucchia, E.A. Turollaa, L. Giulianoa, S.Toddea, P. FerraboschibOP12 A general applicable method to quantify unidentified UV impurities in radiopharmaceuticalsR.P. Klok, M.P.J. Mooijer, N.H. Hendrikse, A.D. WindhorstOP13 Development of [18F]Fluoro-C-glycosides to radiolabel peptidesCollet C., Petry N., Chrétien F., Karcher G., Pellegrini-Moïse N., Lamandé-Langle S.OP14 A Microfluidic Approach for the 68Ga-labeling of PSMAHBED-CC and NODAGA-RGDSarah Pfaff, Cecile Philippe, Markus Mitterhauser, Marcus Hacker, Wolfgang WadsakOP16 Surprising reactivity of astatine in the nucleophilic substitution of aryliodonium salts: application to the radiolabeling of antibodiesFrançois Guérard, Yong-Sok Lee, Sébastien Gouard, Kwamena Baidoo, Cyrille Alliot, Michel Chérel, Martin W. Brechbiel, Jean-François GestinOP17 64Cu-NOTA-pertuzumab F(ab')2 fragments, a second-generation probe for PET imaging of the response of HER2-positive breast cancer to trastuzumab (Herceptin)Lam K, Chan C, Reilly RMOP18 Development of radiohalogenated analogues of a avb6-specific peptide for high LET particle emitter targeted radionuclide therapy of cancerSalomé Paillas, John Marshall, Jean-Pierre Pouget, Jane SosabowskiOP19 Ligand Specific Efficiency (LSE) as a guide in tracer optimizationEmmanuelle Briard, Yves P. Auberson, John Reilly, Mark Healy, David SykesOP23 The radiosynthesis of an 18F-labeled triglyceride, developed to visualize and quantify brown adipose tissue activityAndreas Paulus, Wouter van Marken Lichtenbelt,Felix Mottaghy, Matthias BauwensOP24 Influence of the fluorescent dye on the tumor targeting properties of dual-labeled HBED-CC based PSMA inhibitorsBaranski, Ann-Christin, Schäfer, Martin, Bauder-Wüst, Ulrike, Haberkorn, Uwe, Eder, Matthias, Kopka, KlausOP25 [18F]MEL050 as a melanin PET tracer : fully automated radiosynthesis and evaluation for the detection of pigmented melanoma in mice pulmonary metastasesChaussard M, Hosten B, Vignal N, Tsoupko-Sitnikov V, Hernio N, Hontonnou F, Merlet P, Poyet JL, Sarda-Mantel L, Rizzo-Padoin NOP26 Design and Preclinical Evaluation of Novel Radiofluorinated PSMA Targeting Ligands Based on PSMA-617J. Cardinale, M. Schäfer, M. Benešová, U. Bauder-Wüst, O. Seibert, F. Giesel, U. Haberkorn, M. Eder, K. KopkaOP27 A novel radiolabeled peptide for PET imaging of prostate cancer: 64Cu-DOTHA2-PEG-RM26Mansour Nematallah, Paquette Michel, Ait-Mohand Samia, Dumulon-Perreault Véronique, Lecomte Roger, Guérin BrigitteOP29 Biodistribution of [18F]Amylovis®, a new radiotracer PET imaging of β-amyloid plaquesFernandez-Maza L, Rivera-Marrero S, Prats Capote A, Parrado-Gallego A, Fernandez-Gomez I, Balcerzyk M, Sablon-Carrazana M, Perera-Pintado A, Merceron-Martinez D, Acosta-Medina E, Rodriguez-Tanty COP30 Synthesis and preclinical evaluation of [11C]-BA1 PET tracer for the imaging of CSF-1RBala Attili, Muneer Ahamed, Guy BormansOP31 In vivo imaging of the MCHR1 in the ventricular system via [18F]FE@SNAPC. Philippe, M. Zeilinger, T. Scherer, C. Fürnsinn, M. Dumanic, W. Wadsak, M. Hacker, M. MitterhauserOP32 Synthesis of the first carbon-11 labelled P2Y12 receptor antagonist for imaging the anti-inflammatory phenotype of activated microgliaB. Janssen, D.J. Vugts, G.T. Molenaar, U. Funke, P.S. Kruijer, F. Dollé, G. Bormans, A.A. Lammertsma, A.D. WindhorstOP33 Radiosynthesis of a selective HDAC6 inhibitor [11C]KB631 and in vitro and ex vivo evaluationKoen Vermeulen, Muneer Ahamed, Michael Schnekenburger, Mathy Froeyen, Dag Erlend Olberg, Marc Diederich, Guy BormansaOP34 Improving metabolic stability of fluorine-18 labelled verapamil analoguesRaaphorst RM, Luurtsema G, Lammertsma AA, Elsinga PH, Windhorst ADOP36 Development of a novel PET tracer for the activin receptor-like kinase 5Lonneke Rotteveel, Uta Funke, Peter ten Dijke, Harm Jan Bogaard, Adriaan A. Lammertsma, Albert D. WindhorstOP37 SPECT imaging and biodistribution studies of 111In-EGF-Au-PEG nanoparticles in vivoLei Song, Sarah Able, Nadia Falzone, Veerle Kersemans, Katherine VallisOP38 Melanoma targeting with [99mTc(N)(PNP3)]-labeled NAPamide derivatives: preliminary pharmacological studiesDavide Carta, Nicola Salvarese, Wiebke Sihver, Feng Gao, Hans Jürgen Pietzsch, Barbara Biondi, Paolo Ruzza, Fiorenzo Refosco, Cristina BolzatiOP39 [68Ga]NODAGA-RGD: cGMP synthesis and data from a phase I clinical studyRoland Haubner, Armin Finkensted, Armin Stegmair, Christine Rangger, Clemens Decristoforo, Heinz Zoller, Irene J. VirgolinOP44 Implementation of a GMP-grade radiopharmacy facility in MaastrichtIvo Pooters, Maartje Lotz, Roel Wierts, Felix Mottaghy, Matthias BauwensOP45 Setting up a GMP production of a new radiopharmaceuticalForsback, Sarita, Bergman Jörgen, Kivelä RiikkaOP48 In vitro and in vivo evaluation of 68-gallium labeled Fe3O4-DPD nanoparticles as potential PET/MRI imaging agentsM. Karageorgou, M. Radović, C. Tsoukalas, B. Antic, M. Gazouli, M. Paravatou-Petsotas, S. Xanthopouls, M. Calamiotou, D. Stamopoulos, S. Vranješ-Durić, P. BouziotisOP49 Fast PET imaging of inflammation using 68Ga-citrate with Fe-containing salts of hydroxy acidsA. S. Lunev, A. A. Larenkov, K.A. Petrosova, O. E. Klementyeva, G. E. KodinaPP01 Installation and validation of 11C-methionine synthesisKvernenes, O.H., Adamsen, T.C.H.PP02 Fully automated synthesis of 68Ga-labelled peptides using the IBA Synthera® and Synthera® Extension modulesRené Martin, Sebastian Weidlich, Anna-Maria Zerges, Cristiana Gameiro, Neva Lazarova, Marco MülleraPP03 GMP compliant production of 15O-labeled water using IBA 18 MeV proton cyclotronGert Luurtsema, Michèl de Vries, Michel Ghyoot, Gina van der Woude, Rolf Zijlma, Rudi Dierckx, Hendrikus H. Boersma, Philip H. ElsingaPP04 In vitro Nuclear Imaging Potential of New Subphthalocyanine and Zinc PhthalocyanineFatma Yurt Lambrecht, Ozge Er, Mine Ince, Cıgır Biray Avci, Cumhur Gunduz, Fatma Aslihan SarıPP05 Synthesis, Photodynamic Therapy Efficacy and Nuclear Imaging Potential of Zinc PhthalocyaninesKasim Ocakoglu, Ozge Er, Onur Alp Ersoz, Fatma Yurt Lambrecht, Mine Ince, Cagla Kayabasi, Cumhur GunduzPP06 Radio-U(H)PLC – the Search on the Optimal Flow Cell for the γ-DetectorTorsten Kniess, Sebastian Meister, Steffen Fischer, Jörg SteinbachPP07 Radiolabeling, characterization & biodistribution study of cysteine and its derivatives with Tc99mRabia Ashfaq, Saeed Iqbal, Atiq-ur-Rehman, Irfan ullah KhanPP08 Radiolabelling of poly (lactic-co.glycolic acid) (PLGA) nanoparticles with 99mTCR Iglesias-Jerez, Cayero-Otero, L. Martín-Banderas, A. Perera-Pintado, I. Borrego-DoradoPP09 Development of [18F]PD-410 as a non-peptidic PET radiotracer for gastrin releasing peptide receptorsInes Farinha-Antunes, Chantal Kwizera, Enza Lacivita, Ermelinda Lucente, Mauro Niso, Paola De Giorgio, Roberto Perrone, Nicola A. Colabufo, Philip H. Elsinga, Marcello LeopoldoPP10 An improved nucleophilic synthesis of 2-(3,4-dimethoxyphenyl)-6-(2-[18F]fluoroethoxy) benzothiazole ([18F]FEDMBT), potential diagnostic agent for breast cancer imaging by PETV.V. Vaulina, O.S. Fedorova, V.V. Orlovskaja, С.L. Chen, G.Y. Li, F.C. Meng, R.S. Liu, H.E. Wang, R.N. KrasikovaPP11 Internal radiation dose assessment of radiopharmaceuticals prepared with accelerator-produced 99mTcLaura Meléndez-Alafort, Mohamed Abozeid, Guillermina Ferro-Flores, Anna Negri, Michele Bello, Nikolay Uzunov, Martha Paiusco, Juan Esposito, Antonio RosatoPP12 A specialized five-compartmental model software for pharmacokinetic parameters calculationLaura Meléndez-Alafort, Cristina Bolzati, Guillermina Ferro-Flores, Nicola Salvarese, Debora Carpanese, Mohamed Abozeid, Antonio Rosato, Nikolay UzunovPP13 Molecular imaging of the pharmacokinetic behavior of low molecular weight 18F-labeled PEtOx in comparison to 89Zr-labeled PEtOxPalmieri L, Verbrugghen T, Glassner M, Hoogenboom R, Staelens S, Wyffels LPP14 Towards nucleophilic synthesis of the α-[18F]fluoropropyl-L-dihydroxyphenylalanineV. V. Orlovskaja, O. F. Kuznetsova, O. S. Fedorova, V. I. Maleev, Yu. N. Belokon, A. Geolchanyan, A. S. Saghyan, L. Mu, R. Schibli, S. M. Ametamey, R. N. KrasikovaPP15 A convenient one-pot synthesis of [18F]clofarabineRevunov, Evgeny, Malmquist, Jonas, Johnström, Peter, Van Valkenburgh, Juno, Steele, Dalton, Halldin, Christer, Schou, MagnusPP16 BODIPY-estradiol conjugates as multi-modality tumor imaging agentsSamira Osati,Michel Paquette,Simon Beaudoin,Hasrat Ali,Brigitte Guerin, Jeffrey V. Leyton, Johan E. van LierPP17 Easy and

Introduction: Musculoskeletal disorders represent a significant problem of modern society which are more pronounced in young people and school children. Etiology of these disorders is found in inadequate ergonomic conditions, too heavy school bag, school furniture inadequate to age, poor posture, sedentary lifestyle, reduction of physical activity and lack of exercise. Material and methods: This cross-sectional study included 1315 pupils aged 8- 12 years. As a method was used “cluster sample” in the selection of subjects. The survey was conducted by questionnaire containing information on the demographic and individual characteristics of participants (age, gender, class), the manner and style of life and the performance of school tasks, followed by standardized Nordic questionnaire. The following parameters were measured: body height and weight for each student, and the weight of full and empty school bag that students that day brought to class. Results: The incidence of musculoskeletal pain regardless of localization was 48%. There is a statistically significant correlation between acute pain in the right shoulder and total weight of school bags, duration of caring the bag in school and time of wearing bag from school to home but not with the manner in which school bag was carried. Acute pain in the right shoulder and acute neck pain were significantly associated with the duration of sitting in school or in front of a computer at home. Acute pain in the shoulder negatively correlated with BMI percentile value of the respondents. Acute pain in the neck is also significantly associated with the weight of a full school bags, as well as time spent sitting at home doing homework. Acute back pain is statistically significantly correlated with the weight of school bags and duration of sitting periods in school. Conclusion: The prevalence of musculoskeletal pain, particularly chronic pain in school children aged 8-12 years is high. Weight of school bags, manner in which the bag is carried to and from school, duration of carrying bags, time spent sitting in the school and in front of the computer, duration of sitting and posture during homework, body mass index are ergonomic reasons for the development of musculoskeletal pain.

Introduction: Analysis of total value of prostate specific antigen (PSAT), with the unavoidable digital rectal examination (DRE) is the basis of prostate cancer detection. Aim: The aim of this study was to determine the specificity and sensitivity of the total value of PSAT in the diagnosis of prostate cancer. The aim was also to determine the significance of PSAT in diagnosis of benign prostate hyperplasia, precancerous conditions and inflammatory and atrophic changes of the prostate. Material and methods: Data were collected from the “Register of PH biopsy” of Clinic of Urology, CCU Sarajevo. Results: Analysis of correlation between the diagnosis and the PSAT value shows statistically significant negative correlation (r =-0,186; p = 0.006) in the sense that the value of the PSAT is highest in cancer patients, and the lowest in patients with benign prostatic hyperplasia. PSAT increases with age (r = 0.152; p = 0.025). For prostate cancer optimal sensitivity and specificity for PSAT value occurs at cut off value of> 8.6 ng /mL. Values lower than 2 ng/mL and higher than 10 ng/mL are most specific, and PPV increases with increasing value of PSAT. PSAT at values of <2 ng/mL and > 10 ng/mL are at high levels of specificity, and value > 10 ng / mL is also of high sensitivity in the detection of prostate cancer, and in this moment these values represent the optimal mode for the subsequent treatment. Conclusion: PSAT has a relative significance in the detection of prostate cancer, and should not be used as a guideline without DRE.

On Saturday 14 May 2016 in Sarajevo, at the Holiday Inn hotel, was organized a reunion meeting of graduates at the Medical Faculty, University of Sarajevo, who graduated during the academic year 1975/76. The reason for the meeting was the celebration of the 40th anniversary of graduation, or so called “Faculty Graduation”. In one word, it was a lovely, wistful, poignant encounter of one, unfortunately, small group of graduates, as I said in my presentation, the best 25th anniversary generation of the Medical Faculty in Sarajevo. Generation that brought on their shoulders the most significant reform of the medical studies in Yugoslavia and that produced more than 40 university teachers worldwide. I said, unfortunately, because gathered a little more than 10% of our generation many were not able to come because of their work and family responsibilities, some were not informed on time about the gathering, some work and live quite far away, out of Bosnia and Herzegovina and Europe, so it is difficult to reconcile work with other circumstances, but, unfortunately, many of our generation are not alive anymore. It was a moving presentation from each of us – these were short personal histories with a mixture of beauty, sadness and melancholy, joy and sorrow, success and failure in life and work, family and personally. Most of our colleagues who attended the gathering dinner are still employed, while a few have retired. The first wail that they had enough, and the second teased them that they have reborn since retirement. Dominated is the love for the profession that we have chosen and which we enjoyed or still enjoy, but everyone emphasized their success to their offspring daughters, sons and grandchildren. Those that reminded of lost family members by their tears, which they could not hide, saddened also the rest of us. Unfortunately, many colleagues are not among us, who left this world by natural causes, lost their lives during the war or otherwise. People talked about the adventures, the small fragments of our student life. As usual in such situations and in our age, we remember good times – also often difficult REVIEW

Introduction: Diabetes is a group of metabolic diseases characterized by hyperglycemia, and represents a disease of the modern age, disease of the 21st century. Prevention of this disease is listed as imperative. Aim of this article was to evaluate questionnaires on the assessment of risk factors for Diabetes Mellitus type 2. Material and Methods: A total of 540 questionnaires handed out randomly to citizens of Canton Sarajevo of all ages, sexes and educational levels (in January 2016) were analyzed. Results: Analyzed questionnaires showed relatively low risk of getting diabetes in the next ten years in the majority of the population. These results are rather encouraging but may in some way be in confrontation with the statistics which show a rapid outburst of diabetes. Conclusion: The life-style is the main reason for such a thing to happen, and looking at these questionnaires, we might get the feeling that we really do live in a, conditionally speaking, physically active society. That, from our everyday experience is not entirely true. It would be wise to continue doing research on this topic on the territory of Bosnia and Herzegovina.

JOSHUA LEDERBERG (1925–2008) Joshua Lederberg (May 23, 1925 - February 2, 2008) was an American molecular biologist known for his work in microbial genetics, artificial intelligence, and the United States space program. He was just 33 years old when he won the 1958 Nobel Prize in Physiology or Medicine for discovering about bacterial genetic information transfer. His father, Zvi Lederberg, was an orthodox rabbi; and his mother Esther a homemaker. Joshua felt drawn to science at an early age, stating in a homework assignment at age seven that his career aspiration was to become “like Einstein,” to “discover a few theories in science.” He graduated from Stuyvesant at the age of fifteen. At the Columbia University, his mentor Francis J. Ryan introduced him to the red bread mold, Neurospora, as an important new experimental system in the emerging field of biochemical genetics. In the United States Navy’s V-12 training program, he performed his military training duties and examined stool and blood specimen from malaria patients. After receiving his bachelor’s degree in zoology in 1944, he enrolled in Columbia University’s College of Physicians and Surgeons and continued to do his research. Lederberg carried out experiments with the intestinal bacterium Escherichia coli which demonstrated that certain strains of bacteria can undergo a sexual stage, that they mate and exchange genes. The most important of his discovery was the discovery of viral transduction, the ability of viruses that infect bacteria to transfer snippets of DNA from one infected bacterium to another and insert them into the latter’s genome. The use of viruses in manipulating bacterial genomes became the basis of genetic engineering in the 1970s. In the year 1958 he received a Nobel Prize in Physiology or Medicine, along with Tatum and George W. Beadle, “for his discoveries concerning genetic recombination and the organization of the genetic material of bacteria.” The launch of Sputnik in 1957 led Lederberg toward an interest in astronomy that lasted 20 years. His concern about the risk of spacecraft returning to Earth with contaminants from space resulted in a quarantine for space travel that remains in effect today. He went on to design experiments intended to detect the presence of life on Mars, resulting in the Mars Viking lander. Lederberg became increasingly aware of the value of computers. He formed collaborations with researchers at Stanford to create a program for analyzing mass-spectrometric data of molecular structures, called DENDRAL, which led to further programs for disease diagnosis and management. It was the first expert system for specialized use in science. Over the course of his life, Lederberg was elected to the National Academy of Sciences, the Institute of Medicine, received the National Medal of Science, was named an honorary life member of the New York Academy of Sciences, was awarded Foreign Membership of the Royal Society of London and holds the title of Commandeur, L’ordre des arts et des lettres in France. Lederberg published over 300 scientific and policy-related articles and was the editor of several books, including Papers in Microbial Genetics: Bacteria and Bacterial Viruses (1951), Emerging Infections: Microbial Threats to Health in the United States (1992), and Biological Weapons: Limiting the Threat (1999). His first marriage ended in divorce and he remarried Marguerite Stein Kirsch, a clinical psychologist, with whom he had two children. Following a battle with pneumonia, Lederberg passed away in New York in 2008 at the age of 82. Interesting facts: As a child, his idol was Einstein. He was a member of Royal Society of London for Improving Natural Knowledge. He studied how astronauts from Sputnik can contaminate Earth with space organisms - modern space quarantine. He invented first expert system for specialized use in science. He won a Nobel Prize at the age of 33.

The main problem dealt with in this paper is the creation of a protocol for improved QoS-aware mobility management support in cellular all-IP networks, whereby we propose a new algorithm for QoS-aware mobility management, based on multidimensional QoS metrics. An analytical framework for performance evaluation was presented as well. The proposed algorithm for QoS-aware dynamic MAP selection relies on multidimensional QoS metrics, defined in QoS-preference spaces of the mobile node and QoS-ability spaces of MAP candidates, in the decision-making process. The metric is chosen to achieve the desired QoS level through three parameters: bandwidth, delay, and reliability, while retaining the balance of MAP's loads in the entire network. For purposes of performance evaluation of the proposed model, we used: algorithm convergence, traffic class distribution by MAP's, and handover delay. Results showed that the standard deviation for each component of the QoS-ability vector is two orders of magnitude smaller than the deviation in the static MAP selection scenario. We achieved a total handover delay decrease from 20 ms to several hundred milliseconds, by simplifying DAD procedures preserving the simplicity of architecture.