U ovom se radu analizira sintaksički status akuzativnih klitika u bosanskom jeziku i njihovo pomjeranje u tzv. drugu poziciju (engl. second position clitics / Wackernagel clitics) s teorijskog polazišta tzv. minimalističkog programa (engl. Minimalist Program, Chomsky 1995; 2000; 2001). Derivacija sintaksičkih struktura posmatra se kroz djelovanje sintaksičke operacije spajanja (engl. Merge) i sintaksičke operacije slaganja (engl. Agree). Pri tome, u radu se slijedi tzv. teorija faza (engl. Phase Theory, Chomsky 2001), koja postulira da se derivacija sintaksičke strukture odvija u fazama koje omogućavaju da se minimalni dijelovi strukture sukcesivno šalju u tzv. Spell-out, odnosno u interfejs u kojem dolazi do razdvajanja informacija relevantnih za nivo fonetskog (engl. Phonetic form, PF) i logičkog predstavljanja (engl. Logical form, LF). U radu se zastupa hipoteza da se akuzativne klitike izvorno generiraju u poziciji komplementa glagola za koji su tematski vezane te da, budući da nemaju status fraznih afiksa, ne mogu biti sintaksički spojene s tim glagolom. U tom se smislu transfer akuzativnih klitika u PF komponentu dešava već u vP fazi, dok glagol za koji je klitika tematski vezana nije obuhvaćen ovim transferom jer se pomjera u tzv. rubnu poziciju (engl. edge position) vP faze. Cilj je ovoga rada pokazati da je tzv. druga pozicija akuzativnih klitika rezultat njihovog postsintaksičkog pomjeranja koje slijedi nakon prozodijskog organiziranja strukturnih elemenata na PF nivou. Akuzativne klitike pomjeraju se u tzv. drugu poziciju u svojoj intonacijskoj frazi (engl. Intonation phrase, IP), pri čemu intonacijska fraza korespondira s granicama CP domene klauze koja sadrži akuzativne klitike. Pozicija akuzativnih klitika iza prve naglašene riješi (engl. first word position, 1W) ili iza prvog sintaksičkog konstituenta (engl. first constituent position, 1C) u vezi je s (ne)postojanjem prozodijskih barijera.

Abstract Study Objectives To examine (1) multidimensional sleep profiles in preschoolers (3–6 years) across geocultural regions and (2) differences in sleep characteristics and family practices between Majority World regions (Pacific Islands, Sub-Saharan Africa, Eastern Europe, Northeast Asia, Southeast Asia, South Asia, the Middle East and North Africa, and Latin America) and the Minority World (the Western world). Methods Participants were 3507 preschoolers from 37 countries. Nighttime sleep characteristics and nap duration (accelerometer: n = 1950) and family practices (parental questionnaire) were measured. Mixed models were used to estimate the marginal means of sleep characteristics by region and examine the differences. Results Geocultural region explained up to 30% of variance in sleep characteristics. A pattern of short nighttime sleep duration, low sleep efficiency, and long nap duration was observed in Eastern Europe, Northeast Asia, and Southeast Asia. The second pattern, with later sleep midpoints and greater night-to-night sleep variability, was observed in South Asia, the Middle East and North Africa, and Latin America. Compared to the Minority World, less optimal sleep characteristics were observed in several Majority World regions, with medium-to-large effect sizes (∣d∣=0.48–2.35). Several Majority World regions reported more frequent parental smartphone use during bedtime routines (Northeast Asia, Southeast Asia: 0.77–0.99 units) and were more likely to have electronic devices in children’s bedroom (Eastern Europe, Latin America, South Asia: OR = 5.97–16.57) and co-sleeping arrangement (Asia, Latin America: OR = 7.05–49.86), compared to the Minority World. Conclusions Preschoolers’ sleep profiles and related family practices vary across geocultural regions, which should be considered in sleep health promotion initiatives and policies.

Brain natriuretic peptide (BNP) serves as a crucial cardiac biomarker in human and small animal veterinary medicine, yet its role in equine cardiology remains underexplored.This study aimed to investigate the influence of different exercise types on BNP concentrations and single brief echocardiographic parameters in two distinct horse populations, while also examining potential correlations between BNP concentrations and echocardiographic variables.Forty clinically healthy horses, categorised into working and sports groups, underwent exercise testing exercise to their purposes. BNP concentrations were measured using a horse‐specific ELISA kit, and brief echocardiographic examinations were conducted 24 h post‐exercise.Blood samples were collected before, after exercises, and at rest to determine plasma BNP concentrations. The brief echocardiographic examinations looked only at M‐mode imaging from the right parasternal window, and assessed cardiac chambers and ventricular diameters. BNP concentrations and echocardiographic variables were compared between the two groups.Exercise did not significantly increase BNP concentrations in either group, with sports horses exhibiting higher basal BNP values (18.0–1973.0 pg/mL) compared to work horses (14.4–1074.5 pg/mL). No significant differences in BNP concentrations were observed between breeds, sexes, or pregnancy statuses. Brief echocardiographic examinations using M‐mode imaging from the right parasternal window revealed significant differences in right ventricular dimensions in diastole and relative wall thickness between the groups. A low negative correlation (r = −0.329, p = 0.038) was observed between BNP concentration and fractional shortening.Single pre‐exercise blood sampling, brief M‐mode echocardiography, and lack of exercise standardisation in the endurance horse group limited assessing high biological variability on BNP concentration and echocardiographic parameters in the tested horses.Assessing BNP concentrations and echocardiographic parameters during different exercises can be helpful in examining the functional status of the equine cardiovascular system, guiding tailored exercise regimens for optimal equine well‐being.

AIMS Clustering algorithms have been widely applied to tumor DNA methylation datasets to define methylation-based cancer subtypes. This study aimed to evaluate the agreement between subtypes obtained from common clustering strategies. MATERIALS & METHODS We used tumor DNA methylation data from 409 women with breast cancer from the Melbourne Collaborative Cohort Study (MCCS) and 781 breast tumors from The Cancer Genome Atlas (TCGA). Agreement was assessed using the adjusted Rand index for various combinations of number of CpGs, number of clusters and clustering algorithms (hierarchical, K-means, partitioning around medoids, and recursively partitioned mixture models). RESULTS Inconsistent agreement patterns were observed for between-algorithm and within-algorithm comparisons, with generally poor to moderate agreement (ARI <0.7). Results were qualitatively similar in the MCCS and TCGA, showing better agreement for moderate number of CpGs and fewer clusters (K = 2). Restricting the analysis to CpGs that were differentially-methylated between tumor and normal tissue did not result in higher agreement. CONCLUSION Our study highlights that common clustering strategies involving an arbitrary choice of algorithm, number of clusters and number of methylation sites are likely to identify different DNA methylation-based breast tumor subtypes.

Bosnia and Herzegovina is a country rich in natural resources and geo-strategically positioned in the heartland of the Balkans, which through its turbulent and inspiring history was the desired goal of various conquering empires. From the ancient Romans, through the Ottomans, Austro-Hungarians, Germans and all the way to the closest neighbours. On that difficult path of building a thousand-year statehood, it was affected by various socio-political crises that left a mark and, as a rule, slowed down its economic growth and self-sustainability of both the socio-political system and the general state of security of its critical subjects and infrastructures. In its different stages of statehood and statehood, Bosnia and Herzegovina faced different types of threats, from passive to active resistance, from frequent riots to open wars and opposition to invaders and usurpers of its territory and its wealth. Looking at our history, we learn from our ancestors, preparing based on their experience for the modern challenges of today. It is of great importance for scientists, researchers and practitioners to apply analytical - synthetic and general - social methods of data collection, in order to properly set themselves according to the definition of research problems and objectives, and to determine the methodology that will lead to effective and applicable solutions satisfying social and scientific objectives. Analysing the problem of determining and organizing the area of protection of critical subjects and infrastructures, we cannot help but notice one of the biggest threats to the vital lifeblood of the Bosnian society, namely its complex socio-political organization and the influence it generates as such on all segments of sustainability and security. This work contributes to the development and strengthening of the preventive security awareness of all those who in the future will deal with strengthening the capacity to protect critical entities in Bosnia and Herzegovina.

Introduction Accurate genotyping of Killer cell Immunoglobulin-like Receptor (KIR) genes plays a pivotal role in enhancing our understanding of innate immune responses, disease correlations, and the advancement of personalized medicine. However, due to the high variability of the KIR region and high level of sequence similarity among different KIR genes, the generic genotyping workflows are unable to accurately infer copy numbers and complete genotypes of individual KIR genes from next-generation sequencing data. Thus, specialized genotyping tools are needed to genotype this complex region. Methods Here, we introduce Geny, a new computational tool for precise genotyping of KIR genes. Geny utilizes available KIR allele databases and proposes a novel combination of expectation-maximization filtering schemes and integer linear programming-based combinatorial optimization models to resolve ambiguous reads, provide accurate copy number estimation, and estimate the correct allele of each copy of genes within the KIR region. Results & Discussion We evaluated Geny on a large set of simulated short-read datasets covering the known validated KIR region assemblies and a set of Illumina short-read samples sequenced from 40 validated samples from the Human Pangenome Reference Consortium collection and showed that it outperforms the existing state-of-the-art KIR genotyping tools in terms of accuracy, precision, and recall. We envision Geny becoming a valuable resource for understanding immune system response and consequently advancing the field of patient-centric medicine.

<p>To evaluate the surface water quality of the Drina River basin, samples were collected from the main river and its tributaries at selected monitoring sites. A total of 17 samples were collected from various locations during the years 2023 and 2024. Various physicochemical parameters and concentrations of heavy metals were analyzed. Overall, most tested samples indicated generally good water quality in terms of physicochemical indicators. However, the findings also suggest that certain human activities have a measurable influence on water quality in the basin. The results serve as an indication of existing pollution pressures and provide a basis for further investigations on the environmental status of the Drina River.</p>

Two highly invasive plant species, Lysimachia vulgaris and Lythrum salicaria are well-known for its anti-inflammatory, hemostatic, and antidiaroic activity. These plants are most widespread on the territory of Euroasia, where their traditional medicinal use has been reported. Due to their invasiveness, they are undesirable plants in  other parts of the world. Till this day, many studies were conducted regarding the biological and pharmacological activity of L. salicaria. In this study, the polyphenol content of plant extracts was examined using the Folin-Ciocalteou method. Antioxidant activity of selected plant species was also determined, using DPPH and FRAP methods. Extracts of different polarities were prepared using methanol, water, and acetone. Extraction was performed by maceration and ultrasonic extraction. The results of the study show that both plant species possess antioxidant activity. Lythrum salicaria extracts show a significant polyphenol content and antioxidant capacity, with results notably higher than the results of studies conducted so far. The different antioxidant activity of the prepared extracts confirms the influence of solvents and extraction methods on the utilization of the antioxidant potential of plants. Additionally, for the aqueous extracts prepared by ultrasonic extraction method, an in vitro study of antibacterial activity was conducted. Both plant species show antibacterial activity, with an emphasis on the very strong antibacterial activity of L. salicaria extracts against selected bacterial strains.

Bitter and sweet wormwoods are traditional plant species in the Asteraceae (Compositae). Their use in traditional medicine has long been known. Numerous preparations of bitter and sweet wormwood (teas, tinctures) are used in the treatment of diseases of the digestive system. The content of bioactive components (polyphenols and flavonoids) and antioxidant activity of Artemisia absinthium L. (bitter wormwood) and Artemisia annua L. (sweet wormwood) were examined in this paper. Extract's series were prepared by mixing selected organic solvents (methanol, ethanol and acetone) and water in different volume ratios for both analyzed species. Antioxidant activity was tested using FRAP and DPPH methods. Extracts of sweet wormwood contain more bioactive components and have a higher antioxidant capacity compared to extracts of bitter wormwood. In terms of extraction efficiency, the mixture of acetone and water (20:30 v/v) proved to be the most efficient. Regarding pure organic solvents, the most effective for the bioactive components isolation is ethanol, while acetone showed the weakest extraction power.

Cirsium (thistle) is one of the most taxonomically demanding genera within the Compositae. These taxonomic difficulties are hypothesized to result from limited morphological differentiation, incipient speciation and/or hybridization among taxa, and misinterpretations of faded and incomplete herbarium specimens. According to the latest data, the Dinarides and the Eastern Alps are inhabited by the endemic, diploid, newly described species Cirsium greimleri, which often occurs in sympatry with C. rivulare and C. erisithales. The area of the related, vicarious, tetraploid, and endemic species C. waldsteinii is limited to the southeastern Carpathians. Considering that the new knowledge refutes the existence of C. waldsteinii in Bosnia and Herzegovina, it was necessary to review all C. waldsteinii data discovered so far in Bosnia and Herzegovina. The results obtained from the distribution of the species, the predictive modelling of its ecological niche, and the analysis of the genome size confirmed the existence of the species C. greimleri in Bosnia and Herzegovina and its potential hybridization. This study indicates the need for further research into the sympatry of C. greimleri and its relatives, as well as the essential taxonomic revision of this complex.

Introduction: The early adolescence period represents a phase of turbulent physical development, characterized by disproportion in the musculoskeletal system, where the muscular system's inability to maintain a normal relationship between certain body segments results in poor posture among adolescents. Back pain is an increasing health problem among children and adolescents. Postural deviations and back pain are common issues among children, caused by the long-term effects of various risk factors associated with modern lifestyles. Methods: This study is a non-experimental (qualitative) research, specifically a scientific literature review. For the purposes of this paper, a search of relevant databases including Web of Science, Scopus, PubMed, and Med-Line was conducted for articles published between 2011 and 2024. Results: A significant number of articles were published between 2011 and 2024 in relevant scientific databases. After removing duplicates and irrelevant studies, 13 studies were included in the research. The studies used in this paper were published in Poland, the Czech Republic, Portugal, Tunisia, China, Egypt, Turkey, Pakistan, Brazil, Lebanon, Bosnia and Herzegovina, and Slovenia. Conclusion: Based on the review of scientific literature, it can be concluded that early identification of risk factors is essential, as it will reduce the frequency of postural deviations and back pain in children during early adolescence. Timely implementation of educational preventive programs on exercises, education about proper posture, sitting techniques, correct school bag carrying, the use of ergonomically adjusted school furniture, and promoting an active lifestyle at home and school, along with regular physical activity, is necessary.

The paper deals with the analysis of the fuel consumption of skidders during timber extraction from thinning of even-aged beech forest on mountain terrain. Fuel consumption research was conducted on the Ecotrac 140V cable skidder over 8 working days at the same worksite during real timber extraction work. The worksite was organized so that the empty skidder traveled uphill, and when loaded, it moved downhill. The skidder was equipped with measuring devices for collecting data from sensors, the motor, and data transfer. The key parameters measured include total fuel consumption (mL) and skidder GPS position, while slopes of skid trails and load volumes were measured directly on terrain. Fuel consumption (L, L/m3) was determined per work cycle and work cycle elements. The highest fuel consumption occurred while driving the unloaded skidder, accounting for 38% of the total. This is primarily because fuel usage during skidder movement is significantly affected by factors such as skidding distance, slope, and skid trail conditions, especially since the unloaded skidder was moving uphill. Guidelines for better and more efficient organization of work and reduction in fuel costs are presented, and the suitability of the skidder and harvesting system are considered based on the results of fuel consumption.

The study explored the antiviral potential of ethnobotanical plants in Bosnia and Herzegovina, aiming to identify plants with promising antiviral properties and commonly used plant organs and preparations. Three plant families, Lamiaceae, Compositae and Rosaceae showed significant antiviral potential based on the number of species mentioned in the literature. The most studied viruses were herpes simplex virus (HSV), influenza virus (Influenza), and SARS-CoV-2. Tea was the most popular herbal preparation, and aerial parts and leaves were the most frequently used for therapeutic applications. These findings highlight the potential of plants as natural sources of antiviral compounds, paving the way for further research and new therapeutic approaches.

Derviš Sušić is undoubtedly one of the most versatile writers of the 20th century Bosnia and Herzegovina. His opus, characterised by a peculiar stylistic expression contains metaphors that make the storyline, otherwise set in a certain historical period, timeless, i.e., ever-current and again-enlightening. This paper aims at analysing metaphors in the translation of Sušić’s novel Uhode, published in English in 2017 by the Academy of Arts and Sciences of Bosnia and Herzegovina as Spies. The methodological framework applied is Lakoff and Johnson’s linguistic approach, whereby the source text and the translation are compared within their source and target domains. In that sense, translatability, i.e. the possibility of achieving the identical content of the source and target domains in the translation is observed within Newmark’s model of translation strategies.

Pancreatic steatosis and metabolic-dysfunction-associated steatotic liver disease are characterised by fat accumulation in abdominal organs, but their correlation remains inconclusive. Recently proposed deep learning (DL) for proton density fat fraction (PDFF) estimation, which quantifies organ fat, has primarily been assessed for quantifying liver fat. This study aims to validate DL models for pancreatic PDFF quantification and compare pancreas and liver fat content. We evaluated three DL models—Non-Linear Variables Neural Network (NLV-Net), U-Net, and Multi-Decoder Water-Fat separation Network—against a reference PDFF measured using a graph-cut-based method. NLV-Net showed a strong correlation (Spearman rho) with the reference PDFF in the six-echo pancreatic head (slope: 1.02, rho: 0.95) and body (slope: 1.04, rho: 0.94) and a moderate correlation in the three-echo pancreatic head (slope: 0.44, rho: 0.40) and body (slope: 0.49, rho: 0.34). Weak correlations were found between liver and pancreatic body PDFF using graph cut in six-echo (slope: −0.041, rho: −0.12) and three-echo images (slope: 0.0014, rho: 0.073) and using NLV-Net in six-echo (slope: −0.053, rho: −0.12) and three-echo images (slope: −0.014, rho: −0.033). In conclusion, NLV-Net showed the best agreement with the reference for pancreatic fat quantification, and no correlation was found between liver and pancreas fat.