Mitochondria are essential organelles that are central to a multitude of cellular processes, including oxidative phosphorylation (OXPHOS), which produces most of the ATP in animal cells. Thus it is important to understand not only the mechanisms and biogenesis of this energy production machinery but also how it is regulated in both physiological and pathological contexts. A recent study by Ostojić et al. [Cell Metabolism (2013) 18, 567-577] has uncovered a regulatory loop by which the biogenesis of a major enzyme of the OXPHOS pathway, the respiratory complex III, is coupled to the energy producing activity of the mitochondria.

New approach in food safety and hygiene legislation gives the central role to HACCP for all food business operators, with an exception of primary production. Slowly ongoing transposition of the EU food safety legislation into regulatory framework of Bosnia and Herzegovina (B&H) also puts HACCP as an obligatory system for food operators. However, the implementation of HACCP is still on relatively low level, with some misunderstandings. The reasons are commonly found in lack of quality plans for implementation and control of implementation of the adopted regulation. As far there was not any systematic research of food operators' approaches and positions toward HACCP as obligatory and, according to some researches, costly system. The aim of the study was to find familiarity of B&H food business operators with impact of new regulatory framework on their business. The research was done by survey method in 18 companies. the surveyed operators, depending on their profile, had highly different opinions regarding costs pertaining to HACCP, administrative burden of HACCP implementation, and overall aims and benefits of its implementation. The results of the study pointed out necessity of further training and education of food business operators in B&H regarding food hygiene legislation and its purposes.

Genes that alter disease risk only in combination with certain environmental exposures may not be detected in genetic association analysis. By using methods accounting for gene‐environment (G × E) interaction, we aimed to identify novel genetic loci associated with breast cancer risk. Up to 34,475 cases and 34,786 controls of European ancestry from up to 23 studies in the Breast Cancer Association Consortium were included. Overall, 71,527 single nucleotide polymorphisms (SNPs), enriched for association with breast cancer, were tested for interaction with 10 environmental risk factors using three recently proposed hybrid methods and a joint test of association and interaction. Analyses were adjusted for age, study, population stratification, and confounding factors as applicable. Three SNPs in two independent loci showed statistically significant association: SNPs rs10483028 and rs2242714 in perfect linkage disequilibrium on chromosome 21 and rs12197388 in ARID1B on chromosome 6. While rs12197388 was identified using the joint test with parity and with age at menarche (P‐values = 3 × 10−07), the variants on chromosome 21 q22.12, which showed interaction with adult body mass index (BMI) in 8,891 postmenopausal women, were identified by all methods applied. SNP rs10483028 was associated with breast cancer in women with a BMI below 25 kg/m2 (OR = 1.26, 95% CI 1.15–1.38) but not in women with a BMI of 30 kg/m2 or higher (OR = 0.89, 95% CI 0.72–1.11, P for interaction = 3.2 × 10−05). Our findings confirm comparable power of the recent methods for detecting G × E interaction and the utility of using G × E interaction analyses to identify new susceptibility loci.