The Qur’an does not mention a lot of alcohol, but pedagogically it explains its gradual ban in a convenient way by pointing out that alcohol is not used in a “good” benefit. Say, “My Lord has only forbidden immoralities what is apparent of them and what is concealed and sin, and oppression without right, and that you associate with Allah that for which He has not sent down authority, and that you say about Allah that which you do not know (Chapter: Al-A’raf, verse: 33). The item (verses) of the Qur’an makes only one step in the prohibition of alcohol, but the verses are not listed nor are the examples of the alcohol prohibition. In fact, the Qur’an wants to make people give up alcohol, but the great difficulty is the fact that they have been united with him and what he’s become a habit and tradition. They ask you about wine and gambling. Say, “In them is great sin and [yet, some] benefit for people. But their sin is greater than their benefit.” And they ask you what they should spend. Say, “The excess [beyond needs].” Thus Allah makes clear to you the verses [of revelation] that you might give thought”(Chapter: Al-Baqara, verse 219). Here it is quite clear that the “bad” benefit is actually alcohol and gambling.

BackgroundThe peripheral blood (PB) monocyte pool contains osteoclast progenitors (OCPs), which contribute to osteoresorption in inflammatory arthritides and are influenced by the cytokine and chemokine milieu. We aimed to define the importance of chemokine signals for migration and activation of OCPs in rheumatoid arthritis (RA) and psoriatic arthritis (PsA).MethodsPB and, when applicable, synovial fluid (SF) samples were collected from 129 patients with RA, 53 patients with PsA, and 110 control patients in parallel to clinical parameters of disease activity, autoantibody levels, and applied therapy. Receptors for osteoclastogenic factors (CD115 and receptor activator of nuclear factor-κB [RANK]) and selected chemokines (CC chemokine receptor 1 [CCR1], CCR2, CCR4, CXC chemokine receptor 3 [CXCR3], CXCR4) were determined in an OCP-rich subpopulation (CD3−CD19−CD56−CD11b+CD14+) by flow cytometry. In parallel, levels of CC chemokine ligand 2 (CCL2), CCL3, CCL4, CCL5, CXC chemokine ligand 9 (CXCL9), CXCL10, and CXCL12 were measured using cytometric bead array or enzyme-linked immunosorbent assay. Sorted OCPs were stimulated in culture by macrophage colony-stimulating factor and receptor activator of nuclear factor-κB ligand, and they were differentiated into mature osteoclasts that resorb bone. Selected chemokines (CCL2, CCL5, CXCL10, and CXCL12) were tested for their osteoclastogenic and chemotactic effects on circulatory OCPs in vitro.ResultsThe OCP population was moderately enlarged among PB cells in RA and correlated with levels of tumor necrosis factor-α (TNF-α), rheumatoid factor, CCL2, and CCL5. Compared with PB, the RANK+ subpopulation was expanded in SF and correlated with the number of tender joints. Patients with PsA could be distinguished by increased RANK expression rather than total OCP population. OCPs from patients with arthritis had higher expression of CCR1, CCR2, CCR4, CXCR3, and CXCR4. In parallel, patients with RA had increased levels of CCL2, CCL3, CCL4, CCL5, CXCL9, and CXCL10, with significant elevation in SF vs PB for CXCL10. The subset expressing CXCR4 positively correlated with TNF-α, bone resorption marker, and rheumatoid factor, and it was reduced in patients treated with disease-modifying antirheumatic drugs. The CCR4+ subset showed a significant negative trend during anti-TNF treatment. CCL2, CCL5, and CXCL10 had similar osteoclastogenic effects, with CCL5 showing the greatest chemotactic action on OCPs.ConclusionsIn our study, we identified distinct effects of selected chemokines on stimulation of OCP mobilization, tissue homing, and maturation. Novel insights into migratory behaviors and functional properties of circulatory OCPs in response to chemotactic signals could open ways to new therapeutic targets in RA.

Testimony psychotherapy is a brief individual psychotherapeutic method for working with survivors of state-sponsored violence. First described by a group of Chilean mental health professionals who were working with survivors of political violence during the Pinochet dictatorship it was further described by Agger and Jensen in their work with refugees in Denmark and with Holocaust survivors.  All groups report that testimony functions both in private and in public realm as a means for individual recovery and a means of bearing witness to historical truths.Although testimony approach is not strictly a clinical intervention, many have noted that it offers the survivor clinical benefits. This observation was confirmed in our study  of testimony psychotherapy with survivors from Bosnia and Herzegovina.As part of  research activities of the ‘Project on Genocide, Psychiatry and Witnessing’ of The University of Illinois at Chicago, dr Stevan Weine and I conducted a pilot clinical trial of testimony psychotherapy, at the same time creating oral history archives, and creating awareness in the community of Bosnian refugees of the importance of documenting the survivors’ narratives. In this work we were functioning as witnessing professionals, committed to helping individual survivor's recovery, but also to addressing the social and historical tragedy of genocide.. Because we saw testimony work from an interdisciplinary perspective, we also sought to create testimony documents that would move outside of the psychotherapeutic dyad and make connections with others in the scholarly, human rights, artistic, and survivors' communities.

In this paper, we consider the nonlinear superposition operator F in lp spaces of sequences (1 ≤ p ≤ ∞), generated by the function f(s,u)=a(s) + arctan u or f(s,u) = a(s) - arctan u. We find out the Rhodius spectra σR(F) and the Neuberger spectra σN(F) of these operators and finally the radii of these spectra. The superposition operator generated by the function f(s,u) = a(s) ∓ arccot u appears to be a special case of above mentioned operator.