Alzheimer disease (AD) is common worldwide and almost every case has comorbidities. One of the most common comorbidities of AD is Diabetes mellitus (DM), with or without metabolic syndrome. Both diseases effect nerve tissue and successful treatment would improve the status of the patient. In patients with Alzheimer disease treatment of DM, the treatment could be harmful to the AD, because of that high insulin intake. This may lead to progression of AD. Insulin is considered the best treatment for DM, but insulin therapy could increase comorbidity with AD. No specific therapy for AD is known up to date, so because of that DM is one of the most important risk for AD, concomitant therapy for DM should be planned very carefully. All options of DM therapy should be considered, and different mechanisms of anti-diabetic drugs are preferable. Treatment of AD is more complex metabolic syndrome is present. Any inflammation causes local tissue damage, including brain tissue during AD. Release of interleukins, primarily TNF-α, IL-6, IL-1β in the presence of adipokine leptin, maintains chronic inflammatory status in local brain tissue. Thus, low doses of immunosuppressant therapy should be considered for treatment of AD in future. To delay apoptosis of nerve tissue cells, brain and nerve tissue defend against free oxygen radicals and improve metabolic status.

Introduction. Primary appendiceal adenocarcinoma is a very rare malignancy which accounts for 0.1% of all appendectomy specimens. In both patients presented in this paper, appendectomy was performed due to suspected acute complicated appendicitis. Case Reports. The first patient, a 77-year-old man, presented with a low grade colonic-type pT3 adenocarcinoma of the appendix, diagnosed by histopathological examination of the resected appendix delivered in a fixative. A month after appendectomy, the patient underwent right hemicolectomy of a tumor at the edge of the resection. Due to a cardiovascular disease, adjuvant chemotherapy was not indicated. The second patient, a 74-year-old female, presented with a low grade mucinous adenocarcinoma of the appendix with subserous infiltration, diagnosed by histopathological analysis of the resected appendix. Eight months after appendectomy, the patient developed a recurrent tumor in the cecal area. After radical surgical excision of the recurrent tumor, the patient received adjuvant chemotherapy. Both patients had a 5-year survival without relapse. Conclusion. Preoperative diagnosis of appendiceal adenocarcinoma is a challenge due to overlapping symptoms of complicated acute appendicitis. Our results suggest that in elderly patients with symptoms of complicated acute appendicitis, appendectomy should be done with intraoperative histopathological frozen section consultation. In advanced stages of adenocarcinoma, right hemicolectomy is a better choice than appendectomy.

Introduction: During the course and development of diverse cardiological diseases different central nervous system complications may develop. These are most frequently related to the nature of the cardiovascular entity itself. Aim: To evaluate the association between atherogenesis factors and border zones strokes within the cerebral medial artery vascularization territories. Methods: In total 30 patients were enrolled in the study. Stroke diagnosis was based according to clinical and neurological examination and brain CT findings. The study analyzed risk factors correspondingly to World Health Organization criteria. Results: In majority of patients (18; 60%) arterial hypertension was diagnosed. Additionally, following condition and risk factors were identified: cardiological diseases (17; 23.3%), cigarette smoking (13, 43.3%), hypercholeterolaemia (9; 30%) and diabetes (7; 23.3%). In the group with cardiological diseases most frequent was myocardial infarction (9; 56.2%), AV block II and III (5, 29.4%), atrial fibrillation with slow ventricular response (3; 17.6%). Conclusion: Results of the study point to conclusion that myocardial infarction, AV block II and III, atrial fibrillation with slow ventricular response, iatrogenic hypertension and traditional risk factors for atherogenesis significantly influences presentation of the border zone strokes within the cerebral medial artery vascularization territories.

Twiddler's syndrome is a rare complication after pacemaker implantation usually caused by patient manipulation with generator. We describe a case of 70-year-old female patient with pacemaker who was admitted to the neurological clinic with syncope and suspicion for neurological disease. After neurological diagnostic tests that were negative and consultation with a cardiologist, Twiddler's syndrome was diagnosed.

Ljudski kapital je od velikog značaja za svaku organizaciju koja želi u potpunosti ostvariti svoje ciljeve. Jedna od ključnih komponenti uspješnog upravljanja ljudskim resursima je procjena performansi. Glavni cilj procene performanse je pružanje podrške zaposlenima u smanjenju nedostataka u radu ili podsticanju na održavanje dobrog posla, istovremeno ujedno usklađivanje sa ciljevima organizacije. Percepcija zaposlenih o sistemu ocenjivanja performansi je od velikog značaja jer može uticati na njihove rezultate rada. Svrha ove studije je da analizira odnos između percepcija učinka zaposlenih i njihovog učinka, afektivne posvećenosti organizaciji i namere 18 | Senad Bušatlić, Azra Musić Kilic prometa. Podaci su prikupljeni od 154 zaposlena u malim i srednjim preduzećima u Bosni i Hercegovini, oblasti istraživanja koja je slabo istražena. Rezultati ukazuju na to da je odnos između percepcije zaposlenih o proceni učinka i performansi rada, kao i afektivnoj posvećenosti organizaciji, pozitivan sa visokim do umerenim stepenom korelacije, dok je odnos sa namerom prometa opisan kao negativan sa umerenom korelacijom. Ključne reči: Ocenjivanje performanse, radni učinak, afektivna organizaciona posvećenost, intencija prometa, upravljanje ljudskim resursima. JEL code: L15, L19

Poster: "ECR 2018 / C-2986 / Percutaneous transthoracic CT guided biopsies – what have we found" by: "I. Kavelj, L. Novosel, N. BABIC, D. Zadravec; Zagreb/HR"

Poster: "ECR 2018 / C-3158 / Buried bumper syndrome: where did that PEG tube go?!" by: "I. Kavelj, N. BABIC, G. Lovrencic-Prpic, D. Zadravec; Zagreb/HR"