Background: Pseudotumor formation following total hip arthroplasty (THA) is a well-known complication mainly associated with metal-on-metal (MoM) bearings and taper corrosion on modular-neck femoral stems. The purpose of this study was to determine the prevalence of revision surgery for symptomatic pseudotumors in a large cohort of patients treated with primary THA with a standard stem and a non-MoM articulation. Methods: We included 2,102 patients treated with a total of 2,446 THAs from 1999 until May 2016 in a prospective, observational cohort study. All patients underwent THA with the same uncemented, non-modular-neck femoral stem and metal-on-polyethylene (MoP) (n = 2,409) or ceramic-on-polyethylene (n = 37) articulation. All patients were followed by means of a combination of surgical and medical chart review, follow-up visits, and the Swedish Hip Arthroplasty Register. Metal artifact reduction sequence magnetic resonance imaging (MARS MRI) was used for diagnosis of the pseudotumors, and serum metal ion levels and inflammatory marker levels were measured for all patients who underwent a revision due to pseudotumor. Results: The prevalence of revision for symptomatic pseudotumor formation was 0.5% (13 cases) at a mean follow-up time of 7 years. The incidence rate was 0.9 case per 1,000 person-years. All 13 revisions were done in patients with an MoP articulation. Conclusions: This study demonstrated a 0.5% prevalence of revision due to symptomatic pseudotumor formation in a cohort of patients who underwent THA with a non-MoM construct. Surgeons should be aware that symptomatic pseudotumor formation requiring revision surgery is a tangible complication even after standard MoP THA. Level of Evidence: Therapeutic Level IV. See Instructions for Authors for a complete description of levels of evidence.

Na uzorku ispitanika od 30 dječaka prvog razreda banjalučke Gimnazije, uzrasta 15 godina +/_ 6 mjeseci, i 28 učenika prvog razreda srednje Tehničke škole u Gradišci primjenjeno je sedam testova iz Euro fit baterije. Cilj ovog istraživanja je da se primjenom Eurofita utvrde razlike u motoričkim sposobnostima učenika prvog razreda, između dvije srednje škole, a u svrhu procjene njihovog trenutnog motoričkog statusa i daljeg programiranja rada na osnovu dobijenih rezultata. Rezultati su pokazali da testovi skok u dalj iz mjesta i trbušnjaci za 30 sekundi najviše diskriminišu rezultati između dvije škole.Takodje se može zaljučiti da su učenici iz Gimnazije u većini testova imali bolje rezultate.

The objective of the study was to evaluate major adverse cardiovascular events (MACE) after successful versus failed percutaneous coronary intervention for chronic total occlusion (PCI-CTO).Limited data are available on long-term clinical follow-up in the treatment of chronic total occlusion (CTO).Between January 2009 and December 2010 PCI-CTO was attempted in 283 consecutive patients with 289 CTO lesions. Procedural success was 62.3% and clinical follow-up covered 83% (235/283) of the study population with a median follow-up of 66 months (range, 59-74).The total incidence of MACE was 57/235 (24.3%), and was significantly higher in the procedural failure group than in the procedural success group (33/87 (37.9%) versus 24/148 (16.2%), P < 0.001). All-cause mortality was significantly lower in patients with successful PCI-CTO compared to failed PCI-CTO (10.8% versus 20.7%, P < 0.05). Also, the rate of cardiovascular death in the procedural failure group (14.9%) was slightly higher than that in the procedural success group (7.4%, P = 0.066). The rate of TVR was statistically higher in the procedural failure group (P < 0.009). Propensity score-adjusted Cox regression showed that procedural success remained a significant predictor of MACE (adjusted HR 0.402; 95% CI 0.196-0.824; P = 0.013).Our study emphasizes the importance of CTO recanalization in improving long-term outcome including all-cause mortality with a borderline effect on cardiovascular mortality.

I first met Ulf Svante von Euler when he came to Belgrade, in 1968, to attend an international symposium on the occasion of the 50th anniversary of the Medical Faculty. I was at that time a graduate student at the Medical Faculty in Sarajevo, and a new researcher. I had finished medical school in Belgrade and had worked for two years as a physician in the northern part of Serbia. This article is protected by copyright. All rights reserved.

Amateurish and unprofessional handling of agricultural resources has lasting und unprecedented consequences for plant production, manifesting itself through the loss of soil quality, reduced crop yields, soil erosion, etc. The main focus of this research was to establish the characteristics of the agricultural soil within the municipality of Bužim, applying the FAO method AEZ (Agro-ecological Zoning), (FAO, 1978), and based on the achieved results, to assess the soil suitability for plum (Prunus domestica) cultivation. The assessment of the soil suitability has led to the conclusion that a significant part of land (classified S1 to N in quality), out of the total 13.026,27 ha of agricultural area belonging to the municipality of Bužim is well suited for fruit production. The following has been observed: areas with the best rated S1 class make up a total of 1.23% (159.52 ha), the S2 class takes up a total of 5.51% (717.24 ha), the S3 suitable class makes up a 2.29 % (298.24 ha) in total, and the largest area totaling 36.68 % (4.772.60 ha) is classified as N - meaning unsuitable soil. The main restraints imposed on intensive plum cultivation within the examined area are lack of nourishment, tilt, depth, rock-strewn soil and soil reaction.

Four new heteroleptic copper(II) complexes having chalcone or flavonol ligands and Schiff base (N-phenyl-5-chlorosalicylideneimine) as co-ligand were prepared, chemically and structurally characterized and investigated as functional biomimetic catecholase models. The complexes were prepared by the solution synthesis and crystal and molecular structures were determined by X-ray diffraction. Complexes were chemically characterized by elemental analysis, infrared and electronic absorption spectroscopy as well as by electrochemical measurements. Copper(II) chalcone complexes, with square-pyramidal CuO4N core, are binuclear, featuring phenolate oxygen from the Schiff base as a bridging atom, while copper(II) flavonol complexes are mononuclear, and reveal a square planar CuO3N coordination core. Catalytic activity of the complexes in 3, 5-di-tert-butylcatechol oxidation was confirmed by spectrophotometric and electrochemical measurements. Kinetic measurements revealed that the binuclear (chalcone-containing) complexes have enhanced catalytic activity as compared to the mononuclear Cu(II) flavonol complexes. Relatively high kcat values (300 – 750 h–1) confirmed their respectable biomimetic catecholase-like activity.

ABSTRACT Introduction:The anticonvulsant activity of cannabinoids attracted much attention in the last decade. Cannabinoids that are currently investigated with the intention of making them drugs for the treatment of epilepsy are cannabidiol, cannabidivarin, Δ9-tetrahydrocannabivarin, and Δ9-tetrahydrocannabinolic acid. Areas covered:In this review, the authors look at the results of preclinical and clinical studies with investigational cannabinoids. Relevant literature was searched for in MEDLINE, SCOPUS, EBSCO, GOOGLE SCHOLAR, and SCINDEX databases. Expert opinion: Preclinical studies confirmed anticonvulsant activity of cannabidiol and cannabidivarin in a variety of epilepsy models. While the results of clinical trials with cannabidivarin are still awaited, cannabidiol showed clear therapeutic benefit and good safety in patients with therapy-resistant seizures associated with Dravet syndrome and in patients with Lennox–Gastaut syndrome who have drop seizures. However, the full therapeutic potential of cannabinoids in treatment-resistant epilepsy needs to be investigated in the near future.

This paper describes the transient performance and voltage regulation of a stand-alone self-excited induction generator (SEIG). All characteristics are calculated with a ftux-based mathematical model of the induction machine in the stationary reference frame appropriate for the stand-alone SEIG. The generator model and the control system model are developed using Matlab/Simulink. A presented generator model takes into account significant effects of magnetic saturation on the SEIG performance. The simulation was performed by loading the SEIG with a variable resistive load. Some of the computed characteristics are compared with experimental results. Both uncontrolled and controlled response of the SEIG to load variations were analyzed. It is shown that voltage variations can be reduced by using voltage source inverter and terminal voltage controller.

Chemerin is an adipokine associated with parameters of inflammation and the metabolic syndrome. Small observational studies suggested that high circulating chemerin levels are also related to bone erosion. We aimed to determine whether plasma chemerin levels are related to bone quality in the general population and to investigate the influence of body mass index (BMI) on that relation. For our analyses, we obtained data from 3583 adults who participated in the population-based Study of Health in Pomerania-Trend. The participants were divided into three groups according to their BMI: lean (<25 kg/m2), overweight (25 to 30 kg/m2), and obese (≥30 kg/m2). Chemerin concentrations were determined in EDTA plasma. Bone quality was assessed using quantitative ultrasound at the heel. Broadband ultrasound attenuation (BUA), speed of sound (SOS), stiffness index, and osteoporotic fracture risk were derived from this measurement. Sex- and BMI-specific linear regression models revealed inverse associations between chemerin levels and BUA in obese men. In obese women, inverse relations between chemerin levels and SOS or stiffness index were found. Logistic regression models revealed positive associations between chemerin levels and osteoporotic fracture risk. In lean or overweight subjects, no statistically significant associations were found. Our sex- and BMI-specific analyses showed that inverse associations between chemerin levels and bone quality are restricted to obese men and women. The observed association may be due to a chemerin-induced negative affect on bone metabolism, possibly due to abrogation of osteoblastogenesis or stimulation of adipogenesis.

A company follows the concept of corporate social responsibility (CSR) when, in addition to its basic economic functions, it fulfi lls other functions to achieve greater social goals. Corporate social responsibility is an imperative in the modern world of business while in theory, it is still the subject of discussions. Nevertheless, within diff erent theories, there is a certain consensus specifi cally related to the understanding of the importance of stakeholders and the existence of diff erent levels of CSR. Th e main aim of this paper is to explore and analyze employee perceptions of CSR activities in Bosnia and Herzegovina. Th is paper will present a survey of the perception of 100 corporate representatives related to CSR, with an analysis of the infl uence of sociodemographic factors and job characteristics on their attitudes. In addition, the paper off ers the conclusion, with a number of recommendations for improving the current state of CSR in Bosnia and Herzegovina.