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Investment is one of the most important generators for growth and development of national economies. In case of B&H there is a great need for domestic as well as international investments. Therefore, it is necessary to improve, in the first place, the legal environment including ease of company registration, unification of rules at the state level, simplification of administrative procedures etc. It could attract more domestic and international investors to invest in important projects and to improve overall economical situation in B&H. To achieve this goal, it is necessary to meet the essential requirement for successful implementation of various reforms related to macroeconomic stability, financial and technological infrastructure, openness to international trade and transparency of political and legislative environment. The Reform Agenda for Bosnia and Herzegovina was adopted in 2015 and provides, among other things, the creation of conditions and appropriate environment for increase of investments and modernization of the B&H economy, with the aim of economic growth and creation of new jobs. It also assumes strengthening the rule of law, administrative capabilities and increase efficiency in public institutions at all levels of government. In order to contribute to enforcement of this document and to present current advantages and obstacles for investments in Bosnia and Herzegovina, this paper analyzed the provisions of applicable laws relating to foreign investments and economic indicators as a consequence of such legal framework and current position of B&H. Research findings indicate that the implementation of the abovementioned structural reforms is a condition sine qua non for increase of foreign direct investments in Bosnia and Herzegovina as well as for its path towards integration with the European Union.

S. Vranić, R. Feldman, Z. Gatalica

Apocrine carcinoma of the breast is a rare, primary breast cancer characterized by the apocrine morphology, estrogen receptor-negative and androgen receptor-positive profile with a frequent overexpression of Her-2/neu protein (~30%). Apart from the Her-2/neu target, advanced and/or metastatic apocrine carcinomas have limited treatment options. In this review, we briefly describe and discuss the molecular features and new theranostic biomarkers for this rare mammary malignancy. The importance of comprehensive profiling is highlighted due to synergistic and potentially antagonistic molecular events in the individual patients.

Himzo Dukic, M. Nožić, Darko Šunjić

The cold drawing process takes places very quickly and during the conversion of mechanical energy into the heat energy the work peace and the tool heat up considerably. In order to achieve a stabile drawing process, it is necessary to keep tracks of the temperature growth of the work piece and the tool. The tool temperature has to be below the established limits, and it is regulated by the amount of the coolant, which is at the same time also a lubricant. The expressions for the temperature growth calculation in the conditions of adiabatic processes that can also be applied to the deep drawing process with the reduction of the wall thickness, due to the high deformation rate, have been presented in the work. The heat balance equation enables the determination of the coolant mass which will maintain the stabile tool temperature, what is confirmed by the experimental researches.

Introduction: In the present study we investigated the performance, precision, and recovery of three different automated methods in determining cancer antigen (CA) 15-3 levels.Methods: Serum samples were obtained from 60 hospitalized female patients. As controls, commercially available samples were used. Cancer antigen (CA) 15-3 levels were measured using ARCHITECT CA 15-3, Elecsys® CA 15-3, and Vitros CA 15-3 immunoassays. A comparison of the results between the three methods was conducted, and the precision and recovery were analyzed.Results: Coefficient of variations (CVs), determined with low- and high-level-CA 15-3 control samples, and reproducibility values were: 2.56-2.80% and 3.10-4. 20% for ARCHITECT i2000SR immunoassay analyzer; 3.50-5.55% and 4.88-6.47% for Cobas E 601 analyzer; 3.30-4.0% and 4.30-4.80% for VITROS 5600 Integrated System, respectively. The percent recoveries were 95-98% for Elecsys® CA 15-3 assay, 93-105% for Vitros CA 15-3 assay, and 92-95% for ARCHITECT CA 15-3 assay. Method comparison results demonstrated correlation coefficient (r) in range from 0.994 to 1. The average CA 15-3 concentrations measured by Vitros, ARCHITECT, and Elecsys® were 157.24 +/- 329.75 U/mL, 100.91 +/-213.75 U/mL, and 80.93 +/- 173.29 U/mL, respectively.Conclusions: Tumor marker CA 15-3 in individual patients should be monitored using the same immunoassay method, reagents, and analyzer. Different immunoassays tested on different analyzers, often show large discrepancies in reported values for individual patients. Different immunoassay technologies quantify analytes of clinical interest using monoclonal or polyclonal antibodies. Thus, the usage of antibodies with different specificities could explain the differences in CA 15-3 serum values between different methods.

Introduction: Diffusion weighted imaging (DWI) is a form of magnetic resonance imaging (MRI) based on measuring the random Brownian motion of water molecules within a tissue. The aim of this study was to show the significance of diffusion-weighted imaging (DWI) in differentiating pancreatic cystic formations from normal pancreatic parenchyma using MRI 1.5 T.Methods: A total of 52 patients were included in the study (25 with pancreatic cystic formations and 27 with normal MRI findings of the pancreas). DWI technique was used with b values of 0.500 and 1 000 mm2/s at 1.5 T. The signal intensity was measured, as well as apparent diffusion coefficient (ADC). Visual estimation of the signal intensity of detected cystic lesions was performed and compared to the normal appearance of pancreas.Results: The highest signal intensity of the cystic lesions with hyper-signal was observed with DWI b0 value in the pancreatic head (M 185.1 ± 47.205, p 0.05.Conclusions: Differences in signal intensity and ADC values have an important diagnostic value in differentiating the cystic formations from normal pancreatic parenchyma in MRI examination.

Z. Hundozi, N. Ibishi, F. Jashari, Jehona Rrustemi, B. Gjikolli

Cerebral venous sinus thrombosis is an uncommon cause of stroke presenting with varied presentation patterns. We report a case of a 21-year-old woman with superior sagittal sinus (SSS) thrombosis (SSST) developing after childbirth, presenting with visual hallucinations, severe headache, and tonic-clonic seizures. Time-of-flight magnetic resonance angiography (TOFMRA) demonstrated the presence of thrombus in SSS. She was treated with low molecular weight heparin (LMWH) followed by warfarin. She had excellent recovery a few weeks after admission and was regularly followed up. Although this condition can be presented with different neurological symptoms, it does not typically present with hallucinations. We suggest that CSVT should be suspected even when a patient presents with an atypical picture in a category of patients at higher risk. (Int J Biomed. 2016; 6(4):294-297.)

M. Titlić, M. Mihalj, A. Petrovic, E. Suljic

Cognitive functions can be assessed and followed up over a period of time with cognitive evoked potentials (CEP) P300. In this context, brainstem auditory evoked potentials (BAEP) are most commonly used, but visual evoked potentials (VEP) are utilized as well. The research in this area has demonstrated that these techniques could be used as a supplemental method in diagnostics of numerous diseases such as Alzheimer's disease, mild cognitive impairment, vascular dementia, epilepsy, craniocerebral trauma, Parkinson's disease, multiple sclerosis, and other degenerative diseases. In addition, P300 can also be used as an auxiliary method in the diagnostics of mental disorders conditions such as schizophrenia, panic disorders, narcotic drug addiction, nicotinism, alcoholism, etc. The method assists in monitoring the course of diseases leading to encephalopathy, such as liver and kidney damage and grave anaemia. The advantages of P300 testing are easy application, non-invasiveness, and an unlimited number of potential applications. Moreover, the results obtained with this method are measurable and can be compared.

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