Writing of scientific articles requires high competence and scientific awareness, and the respect of scientific patterns of behavior. Every article should essentially be followed by the IMRAD structure, which is generally represented, with minor modifications, in the entire modern scientific publishing. Writing articles must follow the thread, have a meaningful beginning and end, and from each and every part of the context. Also, it is indicate the benefits of the paper, to its defect, defining ambiguous points that would have the process for further analysis in some subsequent studies by the same or another group of authors. It means, the chapter - Discussion represents the heart of every scientific article. The writing of the discussion itself must point to the specificity of the results of the work itself. Author wants to point out the importance of quality description of chapter Discussion, when scientists prepare their articles with presenting own results comparing it with results of other authors with similar topic.

In December of the 2017 passed away Kasim Muminhodzic, professor emeritus of the Faculty of Medicine, University of Tuzla, on the subject of Gastroenterology. He was born in Lukavac near Tuzla in 1941. Graduated at the Medical Faculty in Belgrade, then the capital of former Yugoslavia. Completed specialization in Internal Medicine at one of the most prestigious medical institutions in the former Yugoslavia–the Military Medical Academy (MMA) in Belgrade.

Warner V. Slack (1933-2018), MD, FACMI worked as Professor at Harward Medical School (1-4). Dr. Slack was a 1955 graduate of Princeton, and a 1959 graduate of Columbia UniversityÂ’s College of Physicians and Surgeons. Dr. Warner Slack received his bachelorÂ’s degree from Princeton University. His medical internship and residency training in neurology at the University of Wisconsin.

Introduction: Recent research reported that prolonged use of AET is associated with changes in bone metabolism, with consequent reduction in bone mineral density (BMD) and increased risk of fractures. Objectives: Therefore, the aim of our study was to investigate the effects of carbamazepine on serum levels of 25 -hydroxyvitamin D and on biomarker of bone formation and resorption (serum levels of osteocalcin). Material and methods: We measured serum levels of 25-OHD and osteocalcin (OCLN) in normal controls (n=30) and in epilepsy patients taking carbamazepine (CBZ) (n=50) in monotherapy for a period of at least twelve months. For each participant, mineral density (BMD) was evaluated by dual-energy X-ray absorptiometry method. Results: The average value of vitamin D in serum was significantly lower in CBZ group than in control group (Vit D 17.03+12.86 vs. 32.03+6.99, p=0.0001). The average value of osteocalcin in serum was significantly higher in CBZ group than in control group (26.06+10.78 vs. 19.64+6, 54, p=0.004).BMD value in CBZ group was significantly lower than in control group (T. score CBZ: 0.08+1.38 vs. T. score control: 0.73+ 1.13, p=0.031; Z score CBZ:-0.05+1.17 vs. Z. score control: 0.55+0.79, p=0.015). Conclusion: AEDs are associated with bone disease, as evidenced by biochemical abnormalities and decreased BMD. Patients on long-term antiepileptic therapy, especially with enzyme-inducing agents, could benefit of routine measurement of biochemical markers of bone turnover, and BMD measurement as part of osteoporosis investigation.

Introduction: Several analysis for different population conclude that endothelial plasminogen activator inhibitor 1 gene polymorphism, -675 ID, 4G/5G PAI-1 (ref SNP ID: rs1799889, also described as rs34857375, has merged into rs1799762) may increase risk of pregnancy loss (PL). However, there is a disagreement as to the association 4G allele with pregnancy loss. Aim: Therefore, we decided to investigate the -675 ID, 4G/5G PAI-1 as a potential genetic factor linked to PL in European and worldwide populations. A systematic review of the scientific literature was conducted with the use of the PubMed and Scopus electronic databases (1991-present), using the following search terms: pregnancy loss, miscarriage, genetic risk of thrombophilia, rs1799889 PAI-1 gen, 4G/5G PAI-1 gene polymorphism, PAI-1 gene locus 4G/5G polymorphism. Results: Among European populations, the statistically significant association between 4G allele and recurrent PL only in Czechs and Bulgarian women was found (p<0.002 and p=0.018, respectively); while, among populations outside Europe in Iranian, Tunisian and Turkish women (each p<0.001). Conclusions: We concluded, that both in Europe and elsewhere in the world, the high frequency of 4G allele in population, is not unambiguously linked with the risk of pregnancy loss.

Introduction: Time management is an important aspect of successful leadership and involves mastering your own work and time instead of allowing them to master you. Time management is a daily process that is applied in order to rationally use time, work schedules, lists of tasks, delegation of responsibilities and everything else that helps to efficiently use time. Material and methods: This research was prospective, descriptive, analytical and controlled. There was 100 medical worker involved, who have managing jobs of different levels and 100 medical workers who do not have managing jobs, who represented the control group. The questionnaire on „time stealers“ according to Sewert. Demographic data was gathered according to the questionnaire on self construction. Results and Conclusions: Based on conducted research, it was established that there were differences in frequencies of certain „time stealers“ in managers of different levels of University Clinical Center Tuzla; the „time stealers“ are more frequent among these with shorter length of service; These differences are significantly more frequent (p<0.05) for some questions e.g. being distracted by phone calls, meetings that are held just for the sake of having a meetings, insufficient, one-way or bad communication with superiors, and have negative effects on management of business hours.

Aim: The aim of this case report is to show the significance of the cardiac tamponade, it’s timely diagnosis and to present the unusual approach of the treatment. That was conducted with corticosteroids when the surgical procedure gave no results in rare cases like this. Case Report: This paper presents the case of a man aged 72 years with a verified tamponade of pericardium. A large pericardial effusion with tamponade signs was verified by ultrasound and computerized tomography (CT) of the chest in a hemodynamically stable patient, and in the inability to evacuate the same, with pericardial fenestration, was successfully treated with corticosteroids. Conclusion: A large pericardial effusion with the signs of tamponade verified by echocardiography and computerized tomography, in hemodynamically stable patient, and in the inability to evacuate the same by fenestration, was treated successfully with corticosteroids.