Aerogels are the least dense and most porous materials known to man, with potential applications from lightweight superinsulators to smart energy materials. To date their use has been seriously hampered by their synthesis methods, which are laborious and expensive. Taking inspiration from the life cycle of the damselfly, a novel ambient pressure‐drying approach is demonstrated in which instead of employing low‐surface‐tension organic solvents to prevent pore collapse during drying, sodium bicarbonate solution is used to generate pore‐supporting carbon dioxide in situ, significantly reducing energy, time, and cost in aerogel production. The generic applicability of this readily scalable new approach is demonstrated through the production of granules, monoliths, and layered solids with a number of precursor materials.

Summary Introduction Caries and orthodontic anomalies in school-age children lead to disturbed aesthetics, oral functions (chewing, swallowing, and speech), predisposition to trauma and the onset of periodontal diseases. The aim was to assess dental health and frequency of orthodontic anomalies in children aged 8-9 years in the municipality of Foča. Methods The research was conducted in the primary school Sveti Sava in Foča, where the total of 112 children age 8-9 years were examined. An informed consent was obtained from parents and school director for each student. Dental examination was performed using standard dental method, a mirror and a probe under artificial lighting. Children received instructions on proper nutrition, oral hygiene, tooth protection and elimination of bad habits. Results Among 112 examined boys and girls of selected ages, very high person caries index (PCI) was found (78.57%). A total of 548 caries affected teeth were found (boys 331 (24.62%), girls 217 (16.14%) (p <0.05)). Fifty-nine children had caries lesions on permanent teeth (boys 39 (2.9%), girls 20 (1.5%) (p <0.05)). Sagital abnormalities of the bite were present in 39 (34.82%) children, while 38 (33.92%) anomalies were related to vertical bite irregularities, 10 (8.92%) of them had open bite and 28 subjects (25%) had deep bite (p> 0.05). Conclusion Large number of teeth was affected with caries lesions (548) in eighth-year-olds, while orthodontic anomalies, mostly sagital abnormalities of bite were found in 39 subjects.

The pathogenesis, clinical course, and response to treatment in systemic juvenile idiopathic arthritis (SJIA) differ from other types of juvenile idiopathic arthritis and are similar to other interleukin-1 (IL-1)-mediated diseases. The main cytokine involved in the pathogenesis of SJIA is IL-1β, which can be neutralized by targeted anti-IL-1 therapy. In SJIA, no antibodies have been found and there is growing evidence that it is mainly an autoinflammatory and not an autoimmune disease. Before the era of biologic therapy, treatment of SJIA was primarily based on long-term treatment with high doses of glucocorticosteroids (GCS). The side effects of GCS could have a significant impact on the outcome of the disease and could cause long-term damage. Treatment with anti-IL-1 agents early in the disease course has revolutionized the management principles of SJIA. However, not all SJIA patients respond equally well to anti-IL-1 therapy, and it has been shown that age at the onset of disease, duration of the disease, number of affected joints, neutrophil count, and ferritin level can predict the response to anti-IL-1 therapy. In particular, an elevated ferritin level should prompt testing for macrophage activation syndrome (MAS), the most severe complication of SJIA. Anti-IL-1 therapy has been shown to be effective also in patients with MAS. Although anti-IL-1 agents are currently not recommended as first-line treatment, there is growing evidence that anti-IL-1 agents introduced at the beginning of SJIA could enable lower doses and a shorter duration of GCS therapy, change the long-term disease outcome, and even influence molecular disease patterns. There are currently three anti-IL-1 agents available: anakinra, canakinumab, and rilonacept. In this review, we present the current knowledge on the pathogenesis of SJIA, the rational for anti-IL-1 treatment, and future perspectives on the treatment of SJIA.

Background Juvenile systemic scleroderma (jSSc) is an orphan disease, with an estimated prevalence of 3 per 1000 000 children. Most jSSc patients primarily present with Raynaud phenomenon (RP). We investigated in our patient of the juvenile scleroderma inception cohort, how fare patients with (RP+) and without (RP-) RP differed in their clinical presentation at enrolment. Methods The jSSc is a prospective cohort of jSSc patients. Patients were enrolled who were diagnosed with jSSc, had a jSSc onset age under 16 years and were younger as age of 18 years at the time of inclusion. The patients are prospectively assessed every 6 months according to a standardised protocol. We reviewed the organ involvement pattern of our patients currently followed in the cohort. Results 100 patients are currently followed in the cohort and 89 (89%) of them had RP. The female/male ratio was lower in the RP +group, 3.7:1 compared to 4.5:1(p=0.808). Diffuse subtype was more common in the RP +group, 72% compared to 63%. Mean age of onset of first non- Raynaud symptomatic was 10.4 years in both groups. Mean disease duration was slightly higher in the RP +group, 3.4 compared to 2.2 years. ANA positivity was higher in the RP +group, 88% compared to 70% (p=0.48). Anti-Scl70 was 34% in the RP +and 20% in the RP-group (p=0.34). Interestingly 7% of RP +but none of the RP +were anti-centromere positive. The mean modified skin score was lower in RP +group (mean of 14.8 compared to 17.0). There were significantly more nailfold capillary changes (70% compared to 18%, p=0.001) and a higher rate of history of ulceration in the RP +group (49% compared to 20%, p=0.083). Decreased DLCO and FVC <80% was higher in the RP-negative group with 45%/50% compared to 37.5%/31% respectively. Pulmonary hypertension occurred in 7% in the RP +group and there was no case in the RP- group (p=0.335). RP- group had a higher rate of urinary sediment changes 18% compared to 4.5% in the RP +group (p=0.07). No renal crisis or hypertension was reported in neither groups. Gastrointestinal involvement was similar between the two groups with around 35%. Occurrence of swollen joints was similar in both groups as the frequency of muscle weakness with around 20%. The tendon friction rub occurred around 10% in both groups. In the patient related outcomes, there was only a difference in rating of Raynauds activity. Conclusions The RP– group differed from RP +group in the clinical presentation at enrolment. The absence of Raynaud phenomenon was associated with a decreased rate of history of ulceration, no occurrence of pulmonary hypertension. Interestingly higher rate of urinary sedimentary changes and no anticentromere positivity was observed in RP- patients. Disclosure of Interest None declared

Background: Dental fear and anxiety (DFA) are present worldwide globally, as well as in children. These psychological clinical entities in its progressive phase lead to avoiding of dentists and dental appointments, and consequtive impairments of oral health. If we ignore these facts, we would have the strenghtening of this relationship in a way of further oral health impairments and lost of dental hard and soft tissues, as well as appearance of dental phobia as the most negative form of psychological reaction to dental stimuli. Original CFSS-DS scale and its modifications, as the most used instruments for evaluation of DFA presence so far, showed various disadvantages. These were the reasons why we wanted to design new psychometric instrument for better evaluation of DFA presence in children compared to evaluation which the existed scales could offer nowadays, in a form of the Modified Version of CFSS-DS scale (CFSS-DS-mod scale). Materials and methods: There were 809 schoolchildren from 8 cities of Bosnia and Herzegovina aged 9-12 years that participated in the study. There was one school per city where the schoolchildren answered to the questions from the CFSS-DS-mod scale. Results: 636 schoolchildren correctly answered to the scale questions. The CFSS-DS-mod scale showed excellent internal consistency reliability values (with Cronbach α>0.9), and also validity results (mostly over 60% of explained variance of obtained results) with two-dimensional concept of DFA presence. Conclusion: The CFSS-DS-mod scale represents good psychometric instrument for evaluation of the DFA presence in 9-12 year old schoolchildren in Bosnia and Herzegovina. Some of normative values of this psychometric instrument should be determined, in order to expand its usage in children.

Introduction: Prior to the 1990s, the most common sources of HCV infections were blood transfusions, unsafe injections and I.V drug use. Screening of blood products for HCV has eradicated transfusion-transmitted hepatitis C in most countries since 1992–in Bosnia and Herzegovina, however, since 1995, due to the war. Aim: To investigate the impact of the source of HCV infection on the therapeutic response in patients treated for chronic HCV infection with dual combined therapy. Methods: We diagnosed chronic HCV infections amongst 246 patients over a period of five years and selected them according to the reported source of infection. Pegylated interferon alfa 2a or alfa 2b with ribavirin was administered during the time that was genotype-dependent. HCV RNA levels in sera were measured by real time PCR. Liver histology was evaluated in accordance with the level of necroinflammation activity and the stadium of fibrosis. Results: Regardless of the genotype of the virus and the source of infection, SVR was achieved in 67% of the patients. Therapeutic response (ETR) was not achieved in 25% of the patients who were infected with an untested blood transfusion and 6% of the patients who had had wartime surgery. Amongst the different sources of infections, patients with a war-surgery source of infection responded better to therapy than those with a blood transfusion source of infection (p = 0.023). A blood transfusion source of infection implies a larger fibrosis stage than in blood donors; (g = 1.177; s2 = 0.577). A blood transfusion source of infection implies a significantly larger necroinflammatory activity than in blood donors; (g = 1.456; s2 = 0.618). Conclusions: An untested blood transfusion was a significant risk factor for more advanced liver diseases in regards to necroinflammatory activity and the fibrosis stage. This source of infection was also a risk factor for low responses to antiviral therapy. At the same time, I.V. drug users had more progressive necroinflammatory activity, but a high therapeutic response to antiviral therapy.

630*8:620.95(497.6 Kakanj) 620.9:582.632.2(497.6 Kakanj) Biomass has a huge renewable energy source potential, forest biomass in particular. Forest biomass effectively includes aboveground parts of tree trunk including: stem, treetop with leaves/needles, bark, seeds, and cones. Although it is biomass, stump is not used in natural forests. Beech (Fagus sylvatica L.) is a dominant tree in the forests of Bosnia and Herzegovina and it is important raw material used in wood assortment production. Once beech assortment is cut down, processing and hauled there is a significant quantity of unused wood biomass which can be effectively used as source of renewable energy. This is way the objective of this paper was to determine overall quantity of beech tree biomass in Compartment 92, Subcompartment „a”, MU „Žuća-Ribnica“, assess quantity of forest biomass (usable timber left after felling and branches - biomass above 7 cm), determine quantity of forest biomass (wood biomass from 3 to 7 cm), and also quantity of bark. The research included 60 beech trees. Volume of tree trunk and trunk bark was determined by sectioning method and branch mass was determined by weighting. Adjusted values of tree trunk and bark volumes were converted in dry matter mass using information provided by. The research findings showed that 73% (1,605.24 tons) of beech wood biomass is used in Compartment 92, Subcompartment „a”, MU „Žuća-Ribnica“, while 27% (582.59 tons) remain unused in the forest. This altogether indicates that a large portion of beech biomass is not used as energy source.

Background Several manifestations strongly associated with APS have been excluded as classification criteria.1 2 Objectives The aim of this study was to investigate correlation between circulating immune-complexes of IgG or IgM antibodies bound to B2GPI (B2G-CIC and B2M-CIC) and clinical manifestations in Serbian cohort of APS patients. Methods A total of 57 patients with APS were evaluated: 35 with PAPS and 22 patients with SAPS. Mean age was 47.6±1.6 years; 36 (63.2%) were women. All patients have met the 2006 revised Sydney criteria for APSQuantification of B2G-CIC and B2M-CIC levels was performed as previously, for detect B2G-CIC was used anti-human IgG HRP-conjugate and for B2M-CIC human IgM HRP- conjugate, both from INOVA (INOVA Diagnostics Inc., San Diego, CA, USA). Results In our cohort Serbian APS patients the prevalence of CIC was 19.29% (11/57); 8 patients with B2M-CIC and the remain 3 patients with B2G-CIC. Livedo reticularis was diagnosed with higher prevalence in patients with CIC compared with patients without CIC; 63.6% and 23.9%, respectively (OR: 5.57, p=0.01). In patients with CIC, thrombocytopenia and leukopenia were more prominent; 54.4% vs 17.4% (OR: 5.70, p=0.01) and 45.5% vs 13.0% (OR: 5.56, p=0.01), respectively. Ophthalmic sicca was more prevalent in patients with CIC; 54.4% vs 8.7% (OR: 12.6, p<0.001). Although complement consumption was more frequent in patients with CIC (figure 1). Figure 1 Mean levels of C3 (A) and C4 (B) complement in groups. Mean levels of C3 (115.6±9.2 mg/dL and 140.9±4.3 mg/dL, group-1 and group-2 respectively) and mean levels of C4 (140.9±4.3 mg/dL and 30.8±1.6 mg/dL, group-1 and group-2, respectively). Conclusions B2G-CIC and B2M-CIC are strongly associated with clinical manifestations related to APS. Widening the APS spectrum is indispensable to better understand this syndrome. References [1] Stojanovich L, Kontic M, Djokovic A, Marisavljevic D, Ilijevski N, Stanisavljevic N, et al. Association between systemic non-criteria APS manifestations and antibody type and level: results from the Serbian national cohort study. Clin Exp Rheumatol. 2013 Mar-Apr;31(2):234–42. [2] Stojanovich L, Markovic O, Marisavljevic D, Elezovic I, Ilijevski N, Stanisavljevic N. Influence of antiphospholipid antibody levels and type on thrombotic manifestations: results from the Serbian National Cohort Study. Lupus. 2012Mar;21(3):338–45. Acknowledgements This work was supported by research grant number 175041, and TR 32040 for 2011–2018, issued by the Ministry of Science of the Republic of Serbia. Disclosure of Interest None declared

Abstract The aim of this study was to analyze the values of biochemical parameters in patients with diabetic ketoacidosis and ketonuria. In this prospective comparative study conducted at the Clinical Center of the University of Sarajevo, hundred patients of both genders with diabetes mellitus were enrolled. Newly diagnosed diabetic patients with complications like acute ketoacidosis (n = 50) and ketonuria (n = 50) were included in this study and compared. The values of biochemical parameters in these patients were analyzed. We found that mean values of pH, base excess, hydrogencarbonate, sodium, glucose, urea and creatinine concentrations in patients with ketoacidosis were significantly different compared to patients with ketonuria. The values of potassium and calcium serum concentrations were not significantly different. Also, values of pH, base excess, as well as concentrations of hydrogencarbonate, sodium, potassium, calcium, glucose, urea and creatinine were not significantly different between male and female patients with diabetic ketoacidosis. In patients with diabetic ketonuria we found a correlation between admission glucose concentration and acid-base balance.

Mapping an unknown large-scale marine area by a side-scan sonar onboard a marine vehicle as quickly as possible is often of great importance. It is also important that a-priori unknown interesting parts of the area are scanned in more detail, i.e. with the removal of sonic shadows. In contrast to the standard overlap-all-sonar-ranges lawnmower pattern, which is an offline static coverage problem solution for side-scan sonar missions, here a novel online side-scan sonar data-driven coverage solution is proposed. The proposed coverage algorithm provides a coverage solution based on local information gain from side-scan sonar data. At the same time, the solution is generated in such a way that coverage path length is minimized while covering the same area as the standard lawnmower. Upper and lower bounds of the proposed algorithm's improvement compared to the overlap-all-sonar-ranges lawnmower method are estimated analytically and validated through extensive mission parameters variation simulations. Simulation results show that our approach can cut down coverage path length significantly compared to the standard lawnmower method in most application cases.

Analysis of electric power system reliability presented in this paper, refers to complex (composite) systems. General issue of assessment of complex electric power system reliability is how to implement and solve mathematical system equivalents and their possible states, taking into account as many possible effects, impacts and conditions of their real functions. Number of possible states of the system in real conditions can be very big, so it is extremely difficult to explore all cases of assessing the reliability of such systems. In this paper, the methods of determining possible states of the system, as well as the methods of determining system deficit, are presented and analysed. For calculations of electric power system reliability, in order to carry out a complete analysis and calculation of characteristic system reliability parameters, it is necessary to determine deficit of electricity. The paper also presents the concrete results obtained using the developed mathematical model and software program developed on its basis.

The paper analyzes the problem of the construction of utility-scale solar photovoltaic power plants (US-PV). Two main problems of this construction are: occupying usable areas and the connection and integration of the power plant into the electricity system. The construction of US-PV power plants on water accumulations of existing hydro power plants was analyzed, as one of the solutions to these problems. The Jablanica Lake was taken as an example. Jablanica Lake is an artificial accumulation lake on the river Neretva with an area of 13 km2 within the hydroelectric power plant (HPP) Jablanica with 180 MW of installed power. It was shown that on a surface of less than 3% of the total area of the accumulation of HPP Jablanica, there could be built a floating photovoltaic (PV) plant with a power of 30 MW. This power would add another generator of 30 MW to HPP Jablanica, which would increase the current number of the 6 generators to 7. This would enable significantly better exploitation of the Neretva and Rama river basins, and increase production in the summer period with a decrease in lake level oscillations. Suitable locations for the installation of floating solar power plant were analyzed. Locations are selected on the basis of requirements for the preservation of existing lake functions, and provide the possibility of installing a 3 MW power plant. 10 of these plants, connected by a 20 kV power grid, represent one US-PV 30 MW plant, which at one point connects to the transmission network of 220 kV. The specifications of one 3 MW power plant are given in terms of the required area, number of modules and number of inverters. A preliminary techno-economic analysis of the total plant was carried out. In this analysis, the possible production, the indicative price of the plant, and the price of the produced kWh of electricity are calculated.