Fernando Alfonso MD1*, Parounak Zelveian MD2, Jean-Jacques Monsuez MD3, Michael Aschermann MD4, Michael Boehm MD5, Alfonso Buendia Hernandez MD6, Tzung-Dau Wang MD7, Ariel Cohen MD8, Sebija Izetbegovic MD9, Anton Doubell MD10, Dario Echeverri MD11, Nuray Enç MD12, Ignacio Ferreira-González MD13, Anetta Undas MD14, Ulrike Fortmüller MD15, Plamen Gatzov MD16, Carmen Ginghina MD17, Lino Goncalves MD18, Faouzi Addad MD19, Mahmoud Hassanein MD20, Gerd Heusch MD21, Kurt Huber MD22, Robert Hatala MD23, Mario Ivanusa MD24, Chu-Pak Lau MD25, Germanas Marinskis MD26, Livio Dei Cas MD27, Carlos Eduardo Rochitte MD28, Kjell Nikus MD29, Eckart Fleck MD30, Luc Pierard MD31, Slobodan Obradović MD32, María del Pilar Aguilar Passano MD33, Yangsoo Jang MD34, Olaf Rødevand MD35, Mikael Sander MD36, Evgeny Shlyakhto MD37, Çetin Erol MD38, Dimitris Tousoulis MD39, Dilek Ural MD40, Jan J. Piek MD41, Albert Varga MD42, Andreas J. Flammer /François Mach MD43, Alban Dibra MD44, Faiq Guliyev MD45, Alexander Mrochek MD46, Mamanti Rogava MD47, Ismael Guzman Melgar MD48, Giuseppe Di Pasquale MD49, Kanat Kabdrakhmanov MD50, Laila Haddour MD51, Zlatko Fras MD52, Claes Held MD53, Valentyn Shumakov MD54 On behalf of the Editors’ Network, European Society of Cardiology (ESC) Task Force.

The beginning of the 21st century in the Federation of Bosnia and Herzegovina (henceforth referred to as ?the Federation?) has been characterised by a decrease in the primary-school-age population. As such, the main objective of this work is to define and explain the factors that have influenced the decrease in the primary-school-age population in this part of Bosnia and Herzegovina. The research methodology applied in this work is oriented towards defining the degree of influence of demographic factors on the development of the primary-school-age population in the Federation. By using statistical methods and GIS analysis of statistical data, negative demographic trends were confirmed in the Federation at the end of the 20th and the beginning of the 21st century. These trends included intensive migration, a decrease in the total number of inhabitants, a decrease in the birth rate, an increased mortality rate, a decreased rate of natural population change, and the ageing of the population. Due to adverse economic, social, political, and other circumstances after 1995, population emigration has been intensified, most noticeably within the population aged between 20 and 40. The most important result of the research is the fact that the decrease in the natural population dynamics and intensive emigration are the most significant factors influencing the decrease in the primary-school-age population in the Federation. Such negative demographic trends influence the primary education system adversely. In the future, it will be necessary to plan and implement a population-revitalisation process as part of the federation?s overall population policy.

: pABA (p-aminobenzoic acid or 4-aminobenzoic acid) is a chemical component of the folate mole-cule produced by plants and bacteria, and found in many foods. It is best known as a UV-blocking sunscreen applied to the skin, and is sometimes taken orally for certain medical conditions. Today it is known that many organic molecules in the human body can react with biometals such as copper, cobalt, manganese, iron and others. This study was performed to investigate the interaction of Cu(II) ions with p-aminobenzoic acid. Spectroscopic methods (FTIR and UV/Vis spectroscopy) were used to characterize the product obtained. The antimicrobial activity of the synthesized complex was tested by diffusion techniques. The results of spectroscopic analysis indicate the interaction of Cu(II) ions with pABA. Interaction is realized through oxygen donor atom of ligand. It was found that the Cu(II) complex has significant antimicrobial activity compared to the pABA ligand.

Purpose – The purpose of this paper is twofold: (1) to assess importance-performance analysis (IPA) and service performance (SERVPERF) conceptualizations of service quality, and to establish which one excels in predicting the tourists' satisfaction in hotel industry; and (2) to test the mediating role of satisfaction between quality conceptualization and hotel guests’ repurchase intentions and word of mouth recommendations regarding the hotel. Design – A conceptual framework was empirically tested on a sample of 311 tourists staying in six hotels in Sarajevo (Bosnia and Herzegovina), which is a tourist destination with increased relevance internationally. Methodology – Covariance-based structural equation modeling was used to estimate the model. Approach – Two conceptualizations were firstly estimated separately then they were contrasted and compared. Findings – The results showed a slight superiority of the IPA conceptualization over that of SERVPERF in predicting satisfaction and in affecting customer attitudinal and behavioral outcomes. This study also confirms the vital mediating role of satisfaction on customer outcomes. Originality of the research – This study utilizes and compares two relevant conceptualizations of hotel service quality and is based on a conceptual framework that establishes which one is better for predicting tourists’ behavioral outcomes. The study is of practical relevance since it gives suggestions on tools that should be used by hotel managers in assessing the quality perceived by their guests.

OBJECTIVES Dinuclear ruthenium(II) Schiff base complex was selected for in vivo study among many other novel metal-based compounds, because of its previously proved in vitro anticancer and antibacterial properties. The aim was to investigate the potential toxicity of this compound in animal model through biochemical and histopathological assessment. METHODS Adult Swiss albino mice of both sexes were divided into high-dose and low-dose group that received a single intraperitoneal dose of ruthenium complex (175 mg/kg and 25 mg/kg, respectively) and one control group (vehicle only). After a follow-up period of 14 days, animals were sacrificed to obtain blood samples and organs. RESULTS The test compound was well tolerated in a low-dose group and did not cause any mortality. The histological findings and serum biochemistry suggested a reversible character of alterations found in vital organs of this group. However, in the high-dose group, adverse effects were more severe and indicated dose and gender-related toxicity. CONCLUSION Mild side effects found in a low-dose group together with excellent in vitro properties, made dinuclear ruthenium(II) Schiff base complex a promising candidate for further investigation and development as anticancer and antimicrobial agent (Tab. 4, Fig. 6, Ref. 32).

The paper presents the results of the analysis of phenological and morphological characteristics of 3 hazelnut cultivars present in the production plantation in the north-western Bosnia and Herzegovina. The 'Rimski', 'Istarski dugi' and 'Tonda Gentile Romana' cultivars served as research material. Blooming time ranged from December to March. For all cultivars, the occurrence of dichogamy, precisely protandry, was observed. The longest flowering period of both male and female flowers was found in the 'Tonda Gentile Romana' cultivar. The 'Rimski' cultivar had the highest fruit weight (3.04 g). 'Tonda Gentile Romana' had the highest kernel weight (1.50 g). The highest kernel percentage (49%) was found in 'Istarski dugi'. The length of male catkins ranged from 21.73 cm to 29.76 cm. Statistically significant differences among cultivars were found for the following traits: the length of male catkins, the number of female flowers in glomeruli, and the number of nuts on a fruiting shoot. The 'Istarski' cultivar had the highest average length of male catkins (29.76) and the highest number of female flowers in the glomeruli (7.32). 'Tonda Gentile Romana' had the highest number of fruits (20.93) on the shoots. All three cultivars have proven to be good varieties in terms of phenological and morphological characteristics, so they can be recommended for intensive production of this nut crop.