Traditional software testing methods are inefficient in cases where data inputs alone do not determine the outcome of a program's execution. In order to verify such software, testing is often complemented by analysis of the execution trace. For monitoring the execution trace, most approaches today insert additional instructions at the binary level, making the monitoring intrusive. Binary instrumentation operate on a low level, making it difficult to properly modify a program's states and to quantify its code coverage. In this paper, we present a framework for testing complex embedded multithreaded software on the logical level. Testing software on this level avoids dependency on concrete compilers and relates the execution to the source code, thus enabling coverage. Our non-intrusive execution monitoring and control is implemented using the LLVM interpreter compiler infrastructure. Instead of forcing thread interleaving, we suggest simulating interleaving effects through non-intrusive changes of shared variables. This makes it possible to test a single thread without executing the full software stack, which is especially useful in situations where the full software stack is not available (e.g., pre-integration testing). We complement existing approaches with new features such as dynamic configuration of monitoring and execution rollback to the checkpoints. Our approach introduces acceptable overhead without any complex setup.

Abstract The transplantation of organs is one of the most successful medical advances in recent decades, and transplantation is the treatment of choice for severe organ failure worldwide. Despite this situation and the general acknowledgment of organ donation (OD) as a global priority, the demand for organs outstrips the supply in virtually every country in the world. The study aims to elucidate whether age, gender and religion influence decision-making about organ donation in religious Muslims living in Sweden Data were collected through three group interviews using open-ended questions and qualitative content analysis. Twenty-seven participants, 15 males and 12 females from four countries, participated in the focus group interviews. The analysis of the collected data resulted in three main categories: “Information and knowledge about organ donation,” “The priorities when deciding about organ donation” and “The religious aspects of organ donation,” including a number of subcategories. Good information about and knowledge of OD, priorities in OD, importance of the fact that religion must be studied and taught daily and religious education were only a few of the factors informants emphasized as predictors of the total and successful donation of organs. Age, gender or religion did not have an impact on organ donation. High levels of education through religious education and good information via various media, as well as a good knowledge of the Swedish language, are predictors of improved OD. In order to overcome religious ideology as a source of misinformation relating to OD and to promote increased OD in the future, specific intervention studies and the improved involvement of religious communities and education in schools and the healthcare system are vital and must be a starting point for improved OD.

The category of Cohen–Macaulay modules of an algebra $B_{k,n}$ is used in Jensen et al. (A categorification of Grassmannian cluster algebras, Proc. Lond. Math. Soc. (3) 113(2) (2016), 185–212) to give an additive categorification of the cluster algebra structure on the homogeneous coordinate ring of the Grassmannian of $k$-planes in $n$-space. In this paper, we find canonical Auslander–Reiten sequences and study the Auslander–Reiten translation periodicity for this category. Furthermore, we give an explicit construction of Cohen–Macaulay modules of arbitrary rank. We then use our results to establish a correspondence between rigid indecomposable modules of rank 2 and real roots of degree 2 for the associated Kac–Moody algebra in the tame cases.

The aim of this paper is to determine the differences in the level of morphological characteristics, speed abilities and aerobic endurance according to the team positions of top female football players. The study included 18 female football players (age 21.33±3.67, body mass index 20.94±1.95). Female football players are classified under the following team positions: defenders (n = 7 ; 23±16.4 years), midfielders (n = 6, 20.5±14.3 years) and attackers (n = 5 ; 20±31.3 years). The following tests were used: 0-5m sprint (s), 0-10m sprint (s), 0-20m sprint (s), 0-30m sprint (s) and Beep test. Body mass index (BMI) was calculated based on the ratio of body weight (kg) and body height (cm). Based on the Beep test, the maximum oxygen consumption (VO2max) was calculated and presented in its relative value (ml/kg/min). The attackers had a higher body height (170.1±7.46) and weight (59.60±8.84) than those playing in midfield and defense positions. Also, the attackers were faster in the sprint on the 5m (1.17±.06), 10m (1.91±.06), 20m (3.27±.10) and 30m (4.51±.17) than female players in midfield and defense positions. Midfield players had higher level of VO2max (50.03±2.69) than female players in defensive and offensive team positions. Test results of univariate analysis of variance (ANOVA) showed that there are significant differences in the level of morphological features, speed and aerobic endurance capabilities between the top female football players, regardless of their team position (p>0.05). It is obvious that good speed abilities on short sprint sections as well as high level of aerobic endurance at high intensity are required regardless of players team position in the women’s football. It is important to note that selection for team positions can not only be based on morphological characteristics, speed abilities and aerobic endurance of players. Also, tactical tasks as well as technical characteristics of players need to be considered for selection of team positions in the women’s football.

In mobile communication systems, the transmitted RF signal is subject to mutually independent deterministic path loss and stochastic multipath and shadow fading. As at each spatial location mostly the composite signal samples are measured, their components are distinguished by averaging out the multipath-caused signal level variations, while preserving just the ones due to shadowing. The prerequisite for this is the appropriateness of the local area averaging path length that enables obtaining the local mean (composed of mean path loss and shadow fading) and the multipath fading as difference between the composite signal sample and the local mean. However, the so far reported analytical approaches to estimation of the averaging path length are based on considering either the multipath or just the shadow fading, with applicability limited to only specific topologies and frequencies. Therefore, in this paper, the most widely used Lee analytical method is generalized and improved by considering multipath and shadowing concurrently, so providing the general closed-form elementary-function based estimation of the optimal averaging path length as a function of common multipath and shadow fading parameters characterizing particular propagation environment. The model enables recommendations for the optimal averaging length for all propagation conditions facing the mobile receiver.

Abstract.The isobar model EtaMAID has been updated with new and high precision data for $\eta$η and $\eta^{\prime}$η photoproduction on protons and neutrons from MAMI, ELSA, GRAAL and CLAS. The background is described in a recently developed Regge cut model, and for the resonance part the whole list of nucleon resonances has been investigated with 21 $N^{\ast}$N* states contributing to $\eta$η photoproduction and 12 $N^{\ast}$N* states contributing to $ \eta^\prime$η photoproduction. A new approach is discussed to avoid double counting in the overlap region of Regge and resonances. A comparison is done among four newly updated partial waves analyses for observables and partial waves. Finally, the possibility of a narrow resonance near $W = 1900$W=1900 MeV is discussed, that would be able to explain unexpected energy and angular dependence of observables in $ p(\gamma,\eta^{\prime})p$p(γ,η)p near $\eta^{\prime}$η threshold.

There is little evidence to support choice of technique and configuration for stapled anastomoses after right hemicolectomy and ileocaecal resection. This study aimed to determine the relationship between stapling technique and anastomotic failure.

Cladribine Tablets (MAVENCLAD®) are used to treat relapsing multiple sclerosis (MS). The recommended dose is 3.5 mg/kg, consisting of 2 annual courses, each comprising 2 treatment weeks 1 month apart. We reviewed the clinical pharmacology of Cladribine Tablets in patients with MS, including pharmacokinetic and pharmacometric data. Cladribine Tablets are rapidly absorbed, with a median time to reach maximum concentration (Tmax) of 0.5 h (range 0.5–1.5 h) in fasted patients. When administered with food, absorption is delayed (median Tmax 1.5 h, range 1–3 h), and maximum concentration (Cmax) is reduced by 29% (based on geometric mean). Area under the concentration–time curve (AUC) is essentially unchanged. Oral bioavailability of cladribine is approximately 40%, pharmacokinetics are linear and time-independent, and volume of distribution is 480–490 L. Plasma protein binding is 20%, independent of cladribine plasma concentration. Cladribine is rapidly distributed to lymphocytes and retained (either as parent drug or its phosphorylated metabolites), resulting in approximately 30- to 40-fold intracellular accumulation versus extracellular concentrations as early as 1 h after cladribine exposure. Cytochrome P450-mediated biotransformation of cladribine is of minor importance. Cladribine elimination is equally dependent on renal and non-renal routes. In vitro studies indicate that cladribine efflux is minimally P-glycoprotein (P-gp)-related, and clinically relevant interactions with P-gp inhibitors are not expected. Cladribine distribution across membranes is primarily facilitated by equilibrative nucleoside transporter (ENT) 1, concentrative nucleoside transporter (CNT) 3 and breast cancer resistance protein (BCRP), and there is no evidence of any cladribine-related effect on heart rate, atrioventricular conduction or cardiac repolarisation (QTc interval prolongation). Cladribine Tablets are associated with targeted lymphocyte reduction and durable efficacy, with the exposure–effect relationship showing the recommended dose is appropriate in reducing relapse risk.