OBJECTIVES The European Single Hub and Access point for paediatric Rheumatology in Europe initiative aimed to optimize care for children with rheumatic diseases. Kawasaki disease (KD) is the most common cause of acquired heart disease in children and an important cause of long-term cardiac disease into adulthood. Prompt diagnosis and treatment of KD is difficult due to the heterogeneity of the disease but is crucial for improving outcome. To date, there are no European internationally agreed, evidence-based guidelines concerning the diagnosis and treatment of KD in children. Accordingly, treatment regimens differ widely. The aim of this study is to provide consensus-based, European-wide evidence-informed recommendations for diagnosis and treatment of children with KD. METHODS Recommendations were developed using the EULAR's standard operating procedures. An extensive systematic literature search was performed, and evidence-based recommendations were extrapolated from the included papers. These were evaluated by a panel of international experts via online surveys and subsequently discussed in three consensus meetings, using nominal group technique. Recommendations were accepted when ⩾80% agreed. RESULTS In total, 17 recommendations for diagnosis and 14 for treatment of KD in children were accepted. Diagnostic recommendations included laboratory and imaging workup for complete as well as incomplete KD. Treatment recommendations included the importance of early treatment in both complete and incomplete KD, use of intravenous immunoglobulin, aspirin, corticosteroids for high-risk cases, and other treatment options for those with resistant disease. CONCLUSION The Single Hub and Access point for paediatric Rheumatology in Europe initiative provides international evidence-based recommendations for diagnosing and treating KD in children, facilitating improvement and uniformity of care.

OBJECTIVES The European initiative Single Hub and Access point for paediatric Rheumatology in Europe (SHARE) aimed to optimize care for children with rheumatic diseases. Systemic vasculitides are very rare in children. Consequently, despite recent advances, paediatric-specific information is sparse. The lack of evidence-based recommendations is an important, unmet need. This study aimed to provide recommendations for diagnosing and treating children with rare forms of childhood systemic vasculitis. METHODS Recommendations were developed by a consensus process in accordance with the European League Against Rheumatism standard operating procedures. A systematic literature review informed the recommendations, which were devised and evaluated by a panel of experts via an online survey, and two consensus meetings using nominal group technique. Recommendations were accepted when ⩾ 80% of experts agreed. RESULTS Ninety-three relevant articles were found, and 78 recommendations were accepted in the two consensus meetings. General, cross-cutting recommendations and disease-specific statements regarding the diagnosis and treatment of childhood-onset PAN, granulomatosis with polyangiitis, microscopic polyangiitis, eosinophilic granulomatosis with polyangiitis, and Takayasu arteritis are provided. CONCLUSION These Single Hub and Access point for paediatric Rheumatology in Europe recommendations were formulated through an evidence-based consensus process to support uniform, high-quality standard of care for children with rare forms of paediatric systemic vasculitis.

Estimation of additive white Gaussian noise levels in images has a variety of image processing applications including image enhancement, segmentation and feature extraction. Designing an algorithm with a consistent performance across a range of noise levels and image contents is a challenging problem; without any prior information, it is difficult to differentiate the noise signal from the underlying image signal. In this paper, an adaptive block-based noise level estimation algorithm in the singular value decomposition domain is proposed. The algorithm has the ability to change the singular value tail length according to the observed noise levels. A number of different choices of block size are considered and, for each choice, a mathematical model is proposed to describe how to adjust the singular value tail length as a function of the initial noise level estimates. In comparison with a seminal fixed singular value tail length algorithm, the proposed algorithm significantly improves the noise level estimation accuracy at low noise levels at the expense of a small increase in computational time; for example, for the block size of 64 × 64 and AWGN level σ = 1 , the MSE is reduced by 65%, whilst the computational time is increased by less than 1.3%.

The second half of the 20th century in Bosnian literature is marked by the new tendencies of avant-garde writers, who will create their work through a different form of artistic creation, compared to the one that was presented at the beginning of this period. It is important to clarify the specificity of the various procedures that have positively directed dramatic creativity towards the modern lines of European literary circles. Derviš Sušić (1925-1990.), the Bosnian-Herzegovinian tradition and the reality of images, presented in a completely new artistic vision, make oscillation, in the writer's creation, between the determinants of historical facts and the legacy of oral tradition. Derviš Sušić Within the avant-garde tendencies of contemporary writers of the regional region, which appear in the mid-20th century, Sušić dominates in his virtuous creations of dramatic situations and dilemmas, in which his protagonists act. In a specific presentation of crucial culmination points, within the framework of the process of "drama of the flow of consciousness," a modern process in the conduct of drama, this writer analytically approaches the individual's dialectical duplication. Through artistically shaped fragments taken from historical records, this literary virtuoso presents in his texts a culmination point of Bosnian survival, very picturesque dramatic shaped historical characters and crucial events. It is symptomatic that Susić's characters become prototypes of stage characters, without temporal or location restrictions, transmitting a universal message of a unique attitude about the value of human activity and existence, outperform stereotypical models recognizable in the additional drama literature. Through the colorful of seeing and a range of specific dramatic characters, without the diversity of their differentiation in national status or sociopolitical affiliation, this writer creates a special ambient effect in the construction of his poetic fabrics based on historical background. The task of this paper is to prove the causality and conditionality of altruistic (social) and egoistic (individual) agonies in the actions and actions of Sušić's characters, in the examples of dramatic texts "Veliki vezir" (1969) and "Posljednja ljubav Hasana Kaimija "(1973), as well as the influence of emotional indicators on the concrete initiation of the dramatic conflict. It is therefore very interesting to explore and verify the models that will dominantly dominate the regional scene for almost half a century and be accepted as models in the way of writing its contemporaries, among the readers' population, but also at the same time with very successful placement in the theater audience.

Human-Robot

A presente pesquisa tem por objetivo identificar a partir da legislação, da doutrina e da jurisprudência o reconhecimento da família multiparental e analisar os desdobramentos de efeitos no direito sucessório. A família, como um fenômeno sociológico, sujeita-se à dinâmica que emerge das relações de convivência entre os indivíduos. Hodiernamente, esta entidade apresenta-se sob novos formatos, afetando outras dimensões que a ela se relacionam, como o aspecto patrimonial. A multiparentalidade é considerada um avanço no campo do direito familiarista, que demonstra a essencialidade do vínculo afetivo como forma de garantia da dignidade da pessoa humana no âmbito familiar. Nesta seara, se verifica a deficiência do ordenamento jurídico brasileiro quando da previsão e solução dos efeitos jurídicos advindos do reconhecimento da multiparentalidade. O legislador civil deixou de regulamentar a transferência de patrimônio dos ascendentes multiparentais em concorrência com o cônjuge supérstite e a sucessão dos ascendentes multiparentais na modalidade pura.

Author(s): Blas, J de; Franceschini, R; Riva, F; Roloff, P; Schnoor, U; Spannowsky, M; Wells, JD; Wulzer, A; Zupan, J; Alipour-Fard, S; Altmannshofer, W; Azatov, A; Azevedo, D; Baglio, J; Bauer, M; Bishara, F; Blaising, J-J; Brass, S; Buttazzo, D; Chacko, Z; Craig, N; Cui, Y; Dercks, D; Dev, PS Bhupal; Luzio, L Di; Vita, S Di; Durieux, G; Fan, J; Ferreira, P; Frugiuele, C; Fuchs, E; Garcia, I; Ghezzi, M; Greljo, A; Grober, R; Grojean, C; Gu, J; Hunter, R; Joglekar, A; Kalinowski, J; Kilian, W; Kilic, C; Kotlarski, W; Kucharczyk, M; Leogrande, E; Linssen, L; Liu, D; Liu, Z; Lombardo, DM; Low, I; Matsedonskyi, O; Marzocca, D; Mimasu, K; Mitov, A; Mitra, M; Mohapatra, RN; Moortgat-Pick, G; Muhlleitner, M; Najjari, S; Nardecchia, M; Neubert, M; No, JM; Panico, G; Panizzi, L; Paul, A; Perello, M; Perez, G; Plascencia, AD; Pruna, GM; Redigolo, D; Reece, M; Reuter, J; Riembau, M; Robens, T; Robson, A; Rolbiecki, K; Sailer, A; Sakurai, K; Sala, F; Santos, R; Schlaffer, M; Shim, SY; Shuve, B; Simoniello, R; Sokolowska, D | Abstract: The Compact Linear Collider (CLIC) is a mature option for the future of high energy physics. It combines the benefits of the clean environment of $e^+e^-$ colliders with operation at high centre-of-mass energies, allowing to probe scales beyond the reach of the Large Hadron Collider (LHC) for many scenarios of new physics. This places the CLIC project at a privileged spot in between the precision and energy frontiers, with capabilities that will significantly extend knowledge on both fronts at the end of the LHC era. In this report we review and revisit the potential of CLIC to search, directly and indirectly, for physics beyond the Standard Model.

Introduction:  Identification of the risk factors that can be modified is an essential aspect in the development of the effective strategy for therapeutic intervention with the purpose to improve mobility and injury prevention and post-fall consequences. This research aimed to analyze the impact of programmed therapeutic exercises on the fall risk factors in the elderly. Methods: We included 260 patients older than 65 years, and assigned them randomly into three groups. Group A: 65 patients subjected to therapeutic exercises for moderate-intensity muscle strengthening with Theraband stretch straps (corresponding to 11-14 on the Borg rating of perceived exertion scale). Group B: 65 patients subjected to therapeutic anti-gravity exercises. Control group: 130 patients not participating in programmed therapeutic exercises. Presence of fall risk factors was assessed in all three groups with standardized Fast Evaluation of Mobility, Balance, and Fear test (FEMBAF) before the initiation of therapy, after three and after six months of treatment. Results: At the end of the study, the subjects of the group A had significantly fewer limitations in performing basic life activities at home compared to the patients of the control and Group B, p = 0.037. The control group subjects were statistically significantly more likely to complain of vertigo than subjects of the experimental groups, p = 0.021. The subjects of the experimental groups had more than two falls than the control group subjects, p = 0.003 statistically. In the control group, the number of fractures after the fall at the end of the study increased significantly, statistically higher than in the subjects of the experimental groups, P = 0.037. Conclusion: Programmed therapeutic exercise significantly reduces the risk of falling factors, and significant effects have been achieved among subjects who have exercised with elastic strips.