Abstract Plant bioflavonoids are widely present in the human diet and have various protective properties. In this study, we have demonstrated the capacity of delphinidin and luteolin to increase human telomerase reverse transcriptase (hTERT) expression level and act as protective agents against halogenated boroxine-induced genotoxic damage. Halogenated boroxine K2(B3O3F4OH) (HB), is a novel compound with potential for the treatment of both benign and malignant skin changes. In vivo and in vitro studies have confirmed the inhibitory effects of HB on carcinoma cell proliferation and cell cycle progression as well as enzyme inhibition. However, minor genotoxic effects of HB are registered in higher applied concentrations, but those can be suppressed by in vitro addition of delphinidin and luteolin in appropriate concentrations. Fresh peripheral blood samples were cultivated for 72 h followed by independent and concomitant treatments of HB with luteolin or delphinidin. We analyzed the differences in relative hTERT expression between series of treatments compared with controls, which were based on normalized ratios with housekeeping genes. The obtained results have shown that selected bioflavonoids induce upregulation of hTERT that may contribute to the repair of genotoxic damage in vitro.

The significant contribution of R&D to economic development and sustainability has been shown by various studies. Therefore, governments offer different fiscal instruments to attract R&D, especially regarding multinational entities (MNEs). One of the fiscal instruments are tax incentives for R&D. Furthermore, the EU has been working on the switch from Separate Taxation (ST) to Common Consolidated Corporate Tax Base (CCCTB) for longer than a decade, which will lead to harmonized R&D tax allowances, however without harmonizing the tax rates. Hence, this study aims at analyzing how ST and CCCTB impact the location of MNEs' R&D activities, tax burden and countries' tax revenue through a case study. The results show that, under ST, tax jurisdictions can stimulate MNEs' R&D activities by means of attractive tax allowances and lower tax rates. Especially for high-tax countries, the tax allowances represent an important tool for attracting R&D activities. However, under CCCTB, the location of R&D activities additionally depends on the Formula Apportionment (FA) factors of the tax base, where the countries cannot exert a direct influence. Hence, the reduction of tax rates remains the only tool left to Member States, which can lead to revenue loss on the whole. Furthermore, the FA of the tax base under CCCTB mitigates the impact of any dislocation of R&D to a low-tax country, which, under ST, leads to larger tax savings of MNEs and its impact on jurisdictions' tax revenue is greater.

In past five years, there has been a rapid increase in the publication on additive manufacturing (AM). Many technologies have been introduced in a rapidly growing market. The designers are confronted with many challenges in designing products for additive manufacturing. AM offers significant advantages, but there are also many constraints for AM to be used in its full potential. This paper explores trends, issues and challenges in design for AM, including associated costs, design options, quality considerations. It has been found that AM is in its infancy, there is insufficient understanding of the process, method, strategies, tools applied in design for additive manufacturing process, while process quality and capabilities are continuously improving

ABSTRACT Background: It is widely known that for many students it is very difficult to correctly predict how thermal expansion affects the appearance of a metal plate with a circular hole. Interviews with school teachers show that the source of this difficulty could stem from the fact that students’ internal visualizations of an arbitrary object’s thermal expansion often boil down to visualizing changes along one dimension only. Purpose: In this study, we investigated how students’ mental models about one-dimensional expansion can be extended for purposes of running mental simulations about expansion along two dimensions. Sample: To that end a pretest-posttest quasi-experiment has been conducted, with 100 students in the control group and 95 students in the experimental group. Design and methods: Whereas control group students received traditional instruction with a focus on formal representations, in the experimental group the students were led to draw an analogy between heating of a straight rod and a circular rod of same length, whereby the internal structure of the rods was represented by springs. Results: Eventually, it has been found that students from the experimental group were significantly more successful at predicting the effects of thermal expansion, especially within contexts of objects with holes. Conclusion: Analogies and extreme case reasoning can be effectively used for helping the students to correctly transfer their mental models about one-dimensional expansion to situations that require reasoning about expansion along two dimensions.

According to the U.S. Department of Justice (2004), victimization occurs when “…a person suffers direct or threatened physical, emotional, and/or financial harm.” Victimization can include physical violence, sexual violence, psychological or emotional abuse, and neglect. The Centers for Disease Control and Prevention (CDC) acknowledges such victimization as a serious and preventable public health problem.Victimologists hypothesize that a number of individual victimologist factors determine a person’s- the perpetrators of the crime to commit an act. Motivation at a particular point in time is the result of interactions over a person’s life course between biological, socio-cultural, and developmental factors—as well as contemporaneous opportunity. Psychological factors are the result of interactions between biological and socio-cultural factors. Victimologists do not imagine that some simple consitutional factor is a satisfactory explanation for mativational factors.Multilevel (or contextual) analyses have been proposed as one solution to these limitations and a variety of studies have been conducted to study individuals’ risk for crime within and across different types of communities. Ecological factors involve interactions between people and their activities. This category includes things associated with the physical environment such as geography and topography, crowding, pollution, and recreational opportunities. These ecological factors can affect how people develop physically and emotionally over their lives as well as the level of hostility, fear, or well-being they feel from moment to moment as they experience (For example: a crowded subway, dark lonely parking lot, or serene park). Discussion focuses on theoretical, methodological, and policy implications.

Many scholars have so far attempted to answer the question as to what constitutes translation competence. In doing so, it has been established that this competence requires a combination of various types of knowledge and skills, which consequently results in the complexity of the matter. It is precisely this complexity that has yielded in a number of approaches to defining and analyzing translation competence, which is considered to be a number one prerequisite for a successful professional in this field.Since many scholars who study translation competence agree that it is most effectively developed at an academic institution, modern language faculties that educate future translators and interpreters need to adapt their curricula so as to increase students’ translation competence and skills. This article looks at one of the possible ways in which translation classes have been designed in order to pursue this goal. It explores students’ perceptions on the presence of a native English speaker during translation classes and direct benefits (or the lack thereof) and presents possible guidelines for the improvement of translation classes.

Glioma surgery has been the main component of glioma treatment for decades. The surgi- cal approach changed over time, making it more complex and more challenging. With molecular knowledge and diagnostic improvement, this challenge became maximally safe resection of tumor, which resulted in prolonged overall survival, progression-free period, and a better quality of life. Today, the standard glioma treatment includes maximally safe resection, if feasible, administration of temozolomide, radiotherapy, and chemotherapy. Surgical resection is performed as subtotal resection, gross total resection, and supratotal resection. Subtotal resection is the resection where a part of tumor is left. Gross total resection is a complete removal of the magnetic resonance imaging (MRI) visible tumor tissue. Supratotal resection is performed as gross total resection with excising the MRI visible tumor tissue borders into the unaffected brain tissue. Before we make final decision on which type of resection should be performed, many factors have to be considered. The question has to be answered: what the actual impact of resection on the progression of glioma is and what the functional risk of resection is.

In modern, turbulent and unstable times, the most important resource for companies are people. People are going to help for all the changes happen, they will adjust the technology, optimize production, calculate wages and ultimately bring profit to the company. It is certain that a new, neoliberal economy brings new business trends, but what is certain is that, just like people, organizations differ from one another. In 1979, Henry Mintzberg talked about a number of different - basic types of organization, such as: mechanical, entrepreneurial, professional and innovative organization. Each of these organizations has its own characteristics, a specific type of management, a specific system of control and leadership. Each has "something" that makes it different from the rest. If organizations change, as well as socio-political systems, over time, then certainly there is a need for change of an integral part of the organization - human potential. In modern times, looking at this function is not the same as before, this function experiences transformation, becomes dominant, that is, it becomes the focus of the managers themselves. This is the time of the Fourth industrial revolution. There is a change of technology, which in the last 200 years could not be assumed that will happen. There are changes in the world economy, and every turn that is happening in the world, due to the process of globalization, can have an impact on every small or medium enterprise in any country in the world. In such a time, the role of human resources becomes even more significant, even more valuable for businesses and their managers. The focus of the research is precisely the need to transform the function of human resources in each of the above basic types of organization, that is, in different organizational configurations. More specifically, it is interesting to examine and investigate how functions such as: a strategic partner, an administrative expert, a change agent, and employee representatives are important in each of these different basic types of organization. These functions have their own meaning, importance, and value in the process of human resources management. In addition, it is also important to examine management support in this context, as well as managers at high, medium and low levels, as well as human resources managers. The survey will show which managers provide the greatest support to employees in the process of their promotion. Has the relationship of managers and employees changed over time, and if so, how and in which way? Also, the paper will examine the division of labor into different types of organizations, and the way of career advancement. How much time is needed for career advancement in an innovative organization, professional, machine, and whether it is more or less time compared to an entrepreneurial organization, is just one of the questions that will be answered in the work. All of the above will be described in the course of work, and the research will be carried out on enterprises in Bosnia and Herzegovina, at various basic organizations in Bosnia and Herzegovina.

Is not this still the truth? Or, are we today, over 100 years after the first glioma operation, however, nearer to the option that we can treat, even cure, most of gliomas or at least keep the disease under control for very many years? The most frequent primary brain tumor, glioma, is still a nightmare for neurooncologists, neuropathologists, neurosurgeons, and other related professionals, but for patients and their families first of all.

The Franciscan monastery of Tolisa, in the Bosanska Posavina (Bosnian Sava valley region), houses a fine collection of Roman military equipment and defensive weapons, collected over the years or acquired as chance finds. These artefacts include arrows, spears, lead projectiles, plumbatae, appliqués, buttons, buckles, horse harness, strainers and bowls. Most of them are on display in the museum’s permanent exhibition. Having been acquired somewhat haphazardly, they have not yet been the subject of serious expert analysis in published works.

Article deals with the freedom of religion in the legal system of Bosnia and Herzegovina granted by the Constitution and further regulated by the Law on Freedom of Religion, as well as the other statutory provisions. In Bosnia and Herzegovina, religion has a specific status given that it is a building block of ethnic identity of the constituent people, e.g. Bosniaks, Serbs, and Croats. Having this in mind, an introduction of the collective rights can be indirectly understood as the protection of religion. Furthermore, the article gives an analysis of relevant constitutional provisions as well as the European Convention on Human Rights. In concrete, Article 9, which grants freedom of thought, conscience and religion. Moreover, the article gives an analysis of the relevant case law developed before the European Court for Human Rights, domestic institutions and the documented violations of the freedom of religion in the county.