Abstract Background Clinically relevant potential drug-drug interactions are considered preventable adverse drug reactions. Objective The aim of this study was to ascertain the frequency of potential drug-drug interactions in acute ischemic stroke patients and to explore factors associated with occurrence of potentially contraindicated drug-drug interactions. Methods This observational retrospective cohort and nested case-control study was carried out among patients treated for acute ischemic stroke at the Neurological Intensive Care Unit in the Clinical Centre Kragujevac, Serbia. The potentially drug-drug interactions for each day of hospitalization were identifi ed using Micromedex® soft ware. Based on the existence or absence of potentially contraindicated drug-drug interactions, the participants were divided into a group of cases (n=111) and the control group (n=444). Results A total of 696 patients were analysed. All patients had a minimum of one potential drug-drug interaction during hospitalization. The most common drugs involved in potential drug-drug interactions were aspirin (8.02%), diclofenac (7.49%) and warfarin (7.14%). The number of medications prescribed for simultaneous use during hospitalisation and the use of antipsychotics in therapy signifi cantly increased the likelihood of potentially contraindicated drug-drug interactions aft er adjustment by means of logistic regression for 1.2 and 3 times, respectively. Conclusions This study suggests that patients with acute ischemic stroke are frequently exposed to potential drug-drug interactions. It is essential to identify potentially drug-drug interactions in these patients as early as possible in order to prevent adverse drug reactions and ensure safe recovery. Besides, full attention should be paid when adding each new medication in therapy, particularly when a neurologist decides to prescribe antipsychotics, such as risperidone.

Background: The potential of angiography to evaluate the hemodynamic severity of a left main coronary artery (LM) stenosis is limited. Noninvasive transthoracic Doppler echocardiographic coronary flow velocity reserve (CFVR) evaluation of intermediate coronary stenosis has demonstrated remarkably high negative prognostic value. The aim of this study was to assess clinical outcomes in patients with angiographically intermediate LM stenosis and preserved CFVR (>2.0) as evaluated by transthoracic Doppler echocardiographic CFVR. Methods: The initial study population included 102 patients with intermediate coronary stenosis of the LM referred for transthoracic Doppler echocardiographic CFVR assessment. Peak diastolic CFVR measurements were performed in the distal segment of the left anterior descending coronary artery after intravenous adenosine (140 &mgr;g/kg/min), and CFVR was calculated as the ratio between maximal hyperemic and baseline coronary flow velocity. Nineteen patients had impaired CFVR (≤2.0) and were excluded from further analysis, as well as two patients with poor acoustic windows. The final group consisted of 81 patients (mean age, 60 ± 9 years; 76 men) evaluated for adverse cardiac events including death, myocardial infarction, and revascularization. Results: Mean follow‐up duration was 62 ± 26 months. Mean CFVR was 2.4 ± 0.4. Total event‐free survival was 75 of 81 (92.6%), as six patients were referred for revascularization (five patients with coronary artery bypass grafting, one patient with percutaneous coronary intervention). There were no documented myocardial infarctions or cardiovascular deaths in the follow‐up period. Conclusions: In patients with angiographically intermediate and equivocal LM stenosis and preserved CFVR values of >2.0, revascularization can be safely deferred. HIGHLIGHTSWe performed TDE CFVR of the intermediate coronary stenosis of LM.TDE CFVR>2 is associated with good long‐term clinical outcomes.TDE CFVR might be used as a valuable diagnostic tool in assessing LM stenosis.

Abstract As healthcare turns its focus to preventative community-based interventions, there is increasing interest in using in-home technology to support this goal. This study evaluates the design and use of socially assistive robots (SARs) and sensors as in-home therapeutic support for older adults with depression. The seal-like SAR Paro, along with onboard and wearable sensors, was placed in the homes of 10 older adults diagnosed with clinical depression for one month. Design workshops were conducted before and after the in-home implementation with participating older adults and clinical care staff members. Workshops showed older adults and clinicians sawseveral potential uses for robots and sensors to support in-home depression care. Long-term in-home use of the robot allowed researchers and participants to situate desired robot features in specific practices and experiences of daily life, and some user requests for functionality changed due to extended use. Sensor data showed that participants’ attitudes toward and intention to use the robot were strongly correlated with particular Circadian patterns (afternoon and evening) of robot use. Sensor data also showed that those without pets interacted with Paro significantly more than those with pets, and survey data showed they had more positive attitudes toward the SAR. Companionship, while a desired capability, emerged as insufficient to engage many older adults in long-term use of SARs in their home.

O plakatu kao sredstvu komunikacije Vrijeme u kojem živimo potpuno je usaglaseno sa novim medijima vizuelnih komunikacija u koje se nedvosmisleno ubraja i plakat, sa svojom apsolutno prijemcivom i likovno pretpostavljenom formom, koja prati, osluskuje, provocira, uzbuđuje, obavjestava i uvodi u kompleksan svijet likovnosti i dizajna. Brojni teoreticari, istoricari i umjetnici raznih profila su se bavili njegovom pojavom i analizom, te predlaganjem raznih mogucnosti definisanja samog pojma plakata i plakatske umjetnosti, pa najcesce nailazimo na informacije o plakatu kao umoženoj obavijesti koja se postavlja na javnim mjestima (moguce od rijeci plak -mrljica ili krpica)? U engleskom jeziku se koristi termin poster (prihvaceno i u nasem jeziku kao doslovni prevod), ili posted up (objavljeno, u smislu postavljanja na javno mjesto). U francuskom jeziku se koristi the World Biennial of Student Poster -A Case Study Abstract: The paper World Biennial of Student Poster -A Case Study aims to show the complex structure of the poster as an art form in a historico-analytical and content-wise manner. Viewing the poster in the light of the progressive technological and innovative possibilities of modern information technologies, constantly requires challenging of the scopes and justification of the existence of a "classic" poster. Its role in contemporary society has been analyzed through various forms of manifestation in the spheres of art and modern design. Insufficiently paid attention to the essence of artistic expression through the poster, which has historically been marginalized in relation to classical painting, has positively changed over time, and through the apostrofing of the strength and the range the poster reaches, it has pointed to the significant changes in the society that this type of communication has achieved. In this paper, a prominent event of the Academy of Arts in Novi Sad, the World Biennial of Student Poster, was selected for the case study, and through the analysis of eight exhibitions of the Biennial, its role since 2004 has been evaluated with an obvious improvement in pedagogical and creative work on the poster.

Fruit germplasm plays an important role in the glob a agrobiodiversity and is a source for both a direct use of fruit genetic resou rces as well for fruit breeding programme. The ex-situ field collection is still the main way to successf ully conserve fruit germplasm. Thirty pear accessions fr om Bosnia and Herzegovina were characterized during three years in the ex situ collection maintained by the Institute of Genetic Resources of the University of B anja Luka. The following characteristics were determined: flowering time, harv est maturity time and global tree architecture. The obtained results showed that 53.3% of pear accessions flowered during all three years, 40% of them during two years and 6.7% of them during only one year. The most present tree archite tur form was upright. According to the harvest maturity time, extremely ea rly ccessions were the most represented, than early, medium and very early pear accessions. Conserved pear germplasm in this ex situ collection represents a valuable material for dire ct use and future breeding programmes.

The aim of the present study was to evaluate the effect of one of the most important foliar diseases, powdery mildew, on the leaf physiological traits of Quercus robur L. using chlorophyll a fluorescence parameters in combination with parameters of leaf gas exchange. For this purpose, greenhouse semi-controlled experiment was conducted with 25 one-year-old seedlings kept in optimal conditions, and the same number of seedlings infected with the mentioned pathogen. Measurements were carried out when the coverage of epiphytic micelia visually reached more than 75% of the surface of leaves in the infected seedlings. The results of gas exchange measurement showed that Erysiphe alphitoides (Griffon and Maubl.) U. Braun and S. Takam caused a significant reduction of net photosynthesis (A) and a significant increase in substomatal CO2 concentration (Ci). Furthermore, considering the fast kinetics of chlorophyll a fluorescence, all of the observes parameters were significantly affected by oak powdery mildew. On the other hand, pulse amplitude modulated fluorescence parameters were mildly affected, with only minimal (Fo?) and maximal (Fm?) fluorescence of dark adopted leaves showing significant difference. This study presented the possibility of usage and the effectiveness of chlorophyll a fluorescence parameters in detection the severe stress conditions, on the example of leaves infected with oak powdery mildew over 75%. Some additional studies should be conducted in the future to determine the possibility of usage and the effectiveness of the observed fluorescence parameters of fast kinetics in detection of mild and early stress.

This paper describes the analysis of steel reel shaft as drive shaft in a process of umbilical spooling of wire rope. There is a need to investigate shaft behaviour in the conditions of increasing workload. The aim is to investigate avoiding possible redesign or enabling redesign with minimal costs. Stress analysis has been carried out by using finite element analysis (FEA) and results are compared with the analytically calculated values. Finite element analysis has been carried out using maximum stress criteria and the area of potential failure is found. The main objective of this paper is to find balance in results between "design by rule" and "design by analysis". Design by rule provides rules on how to design a steel reel shaft using analytical equations and other strict rules from design elements. Design by analysis provides rules on using numerical analysis, typically finite element analysis to design a steel reel shaft. The steel reel shaft has been geometrically modelled using SolidWorks. To check all stresses, linear static analysis is done using DSS Simulation and Ansys.

This Publication has to be referred as: Cekic, A[hmet]; Muhamedagic, K[enan]; Cohodar, M[aida]; Begic-Hajdarevic, D[erzija] & Biogradlija, S[amra] (2019). Experimental Investigation of Effect of Overhang Tool Length on Tool Vibration and Surface Roughness, Proceedings