ABSTRACT This paper presented the quality of the treated surface, which is most often followed by roughness representing micro-geometric irregularities of the treated surface. The processing influence parameters behaviour of on the roughness of the treated wood surface was considered, where the results of measurements of the average deviation of the roughness profile of the surface of beech and maple wood from the area of Bosnia and Herzegovina after processing with orthogonal cutting on a four-sided shaper was studied, at different feed speed and cutting depth . The mathematical model of the influence parameters on the treated surface roughness of solid wood was also presented. The paper presented a sample example of how a process can be predicted before it goes into production, avoiding exploitation testing and increased costs of the process itself.

Aim Barrett’s esophagus (BE) is a predisposing factor of esophageal adenocarcinoma/gastroesophageal junction adenocarcinoma (ECA/GEJ Aca). BE patients are stratified and subsequently monitored according to the risk of malignant progression by the combination of endoscopy and biopsy. This study is to evaluate the maspin expression patterns as early diagnostic markers of malignancy in BE patients. Materials and methods Immunohistochemistry (IHC) staining was performed on 62 archival core biopsies from 35 patients, including BE without dysplasia (intestinal metaplasia, IM), BE with low grade dysplasia, BE with high grade dysplasia, carcinoma in situ, and well to poorly differentiated ECA/GEJ Aca (PD-ECA/GEJ Aca). The intensity and the subcellular distribution of immunoreactivity were evaluated microscopically. Statistical analysis was performed using the χ2 and Fisher exact tests. Results The level of epithelial-specific tumor suppressor maspin protein inversely correlated with the progression from IM to PD-ECA/GEJ Aca. Lesions of each pathological grade could be divided into subtypes that exhibited distinct maspin subcellular distribution patterns, including nuclear only (Nuc), combined nuclear and cytoplasmic (Nuc+Cyt), cytoplasmic only (Cyt) and overall negligible (Neg). The Cyt subtype, which was minor in both IM and dysplasia (approximately 10%), was predominant in ECA/GEJ Aca as early as well-differentiated lesions (more than 50%: p = 0.0092). In comparison, nuclear staining of the tumor suppressor TP53 was heterogeneous in dysplasia, and did not correlate with the differentiation grades of ECA/GEJ Aca. Conclusion The Cyt subtype of maspin expression pattern in core biopsies of BE patients may serve as a molecular marker for early diagnosis of ECA/GEJ Aca.

Uvod Informisanost o nivou treniranosti sportista, te uzrocima i posljedicama takvog stanja, bitna je za njihov uspjeh. Poznato je da fudbaleri u igri ostvare veći broj kratkih sprinteva, te da primjenjuju različite načine vođenja lopte, pravolinijski i sa promjenom smjera kretanja. Struktura agilnosti s loptom je mnogo složenija u odnosu na takvo kretanje bez lopte (Sporiš, Milanović, Trajković, & Joksimović, 2011). Brzina i eksplozivna snaga se smatraju preduslovom za uspjeh u omladinskom fudbalu (Reilly, Bangsbo, & Franks, 2000), naglašavajući pritom ubrzanja na kratkim udaljenostima. Visina i tjelesna težina su značajno povezane sa fi zičkom izvedbom u slučaju mladih fudbalera ( Mathisen & Petersen, 2015). Ipak se sa sigurnošću ne može izolovati neka osobinu ili sposobnost koja donosi odlučujuću prednost u utakmici. Fudbaleri su tjelesno lakši od osoba koje žive sedentarnim načinom života (Popović, Akpinar, Jaksic, Matic, & Bjelica, 2013), ali i niži u odnosu košarkaše, odbojkaše i rukometaše juniorske kategorije (Masanovic & Vukasevic, 2009; Masanovic, 2018). Međutim, u sportovima gdje se traži velika brzina kretanja, nagla promjena pravca u velikoj brzini kretanja, grubi sudari sa protivnikom (fudbal i hokej), tjelesna visina ne samo da nije dominantna, nego je u određenoj mjeri i nepovoljna (Bjelica & Fratrić, 2011). Međusobni odnos tjelesne visine i težine (body mass index), te udio masne komponente (% fat mass) u ukupnoj tjelesnoj masi, za trenere može biti važna informacija. Optimalne vrijednosti BMI-a mogu rezultirati u poboljšanju opšteg nivoa tjelesne i anaerobne snage (Nikolaidis, 2014). Fudbaleri imaju povoljan sadržaj mišića sa niskim nivoom tjelesnih masti (Popovic, Bjelica, Jaksic, & Hadzic, 2014). Ipak, višak tjelesnih masti stvara nepotreban teret i umanjuje učinkovitost u igri, te značajno narušava elemente tehnike mladih fudbalera (Nemčić, Fiorentini, & Sporiš, 2018). Vrijednosti tjelesnih masti za vrhunske fudbalere su u prosjeku 7-12%, te su niže nego u slučaju sedentarnih ljudi, ali su takođe više u odnosu na trkače u sportovima izdržljivosti (Shephard, 1999.). Pored optimalizacije voluminoznosti mišića, na količinu potkožnog masnog tkiva se može uticati dopunskim treningom (Conroy i Earle, 2000), i to djelovanjem u pravcu njene redukcije. S obzirom da se takmičenja omladinskih liga organizuju shodno hronološkoj, a ne biološkoj starosti, često se pojedinci Abstract

Aberrant lipid accumulation and marked changes in cellular lipid profiles are related to breast cancer metabolism and disease progression. In vitro, these phenomena are primarily studied using cells cultured in monolayers (2D). Here, we employ multicellular spheroids, generated using the MCF10A cell line series of increasing malignancy potential, to better recapitulate the 3D microenvironmental conditions that cells experience in vivo. Breast cancer cell lipid compositions were assessed in 2D and 3D culture models as a function of malignancy using liquid chromatography coupled with mass spectrometry. Further, the spatial distribution of lipids was examined using Raman chemical imaging and lipid staining. We show that with changes in the cellular microenvironment when moving from 2D to 3D cell cultures, total lipid amounts decrease significantly, while the ratio of acylglycerols to membrane lipids increases. This ratio increase could be associated with the formation of large lipid droplets (>10 μm) that are spatially evident throughout the spheroids but absent in 2D cultures. Additionally, we found a significant difference in lipid profiles between the more and less malignant spheroids, including changes that support de novo sphingolipid production and a reduction in ether-linked lipid fractions in the invasive spheroids. These differences in lipid profiles as a function of cell malignancy and microenvironment highlight the importance of coupled spatial and lipidomic studies to better understand the connections between lipid metabolism and cancer.

Walking is classified as the oldest transport mode with the least impact on the environment. It is frequently one of the intermediate transport modes. Generally, while designing exclusive walking transit areas or structures with high human traffic volumes and considering different scenarios, it is advantageous to be able to foresee the congestion conditions and the relative problems. The study of pedestrian trajectories, which are strictly related to the characteristics of the walkers, is necessary and preliminary for the purposes of an in-depth analysis linked to the habits of populations and cultures. Often areas crowded by tourists run, of limited size such as bridges, must be considered in advance for emergencies. This article focuses on an old footbridge of Mostar located in a confined area with an increasing tourist flow. The peculiarity of the bridge lies in the double-flight geometry with elements that generate discontinuity in the trajectory as well as the steps. This analysis was carried out obtaining the traffic data from video cameras and analyzing different scenarios on holidays and weekdays. Also, the possible presence of obstacles on the bridge was taken into account, such as some areas not walkable for temporary work or the presence of obstacles. These scenarios have been calibrated and simulated through the definition of O/D matrices, arcs and nodes (or areas) through the pedestrian simulation tool Viswalk. This comparison is useful for understanding the variation of LOS (Level of Service) during the daily or emergency situations and the results can provide help to local authorities to plan and design an appropriate action plan. Therefore, this research work aims to compare scenarios under critical flow conditions in the order to define preventively possible actions that can guarantee an optimal LOS value during the bridge crossing and the surrounding areas.

Ship accidents that entail flooding may lead to disastrous consequences which could be avoided or mitigated based on the knowledge of damaged ship dynamics. The dynamic behaviour of a damaged hull is a complex phenomenon involving the interaction of the flooded water and the ship motions. The presence of a damage opening allows water flow into and out from the compartment, which further complicates the mathematical description of the problem. A fast simulation method, based on the lumped mass approach, is developed and presented. The lumped mass path in space depends on free-surface inclinations that differ from the ship angles of the roll and pitch. The viscous effects in the floodwater dynamics are implemented based on the model for the dissipation of the energy of standing waves in rectangular rooms. The method applies to both the transient stage of flooding and to the dynamic behaviour of a flooded ship in regular waves. In the first case, viscous effects are implemented considering the water in the compartment variable with time. Several case studies are carried out on three different hull models: Transient stage of flooding, roll decay of the damaged hull, and steady state responses in waves are simulated and compared with available experimental data.

Achieving high resolution time-of-arrival (TOA) estimation in multipath propagation scenarios from bandlimited observations of communication signals is challenging because the multipath channel impulse response (CIR) is not bandlimited. Modeling the CIR as a sparse sequence of Diracs, TOA estimation becomes a problem of parametric spectral inference from observed bandlimited signals. To increase resolution without arriving at unrealistic sampling rates, we consider multiband sampling approach, and propose a practical multibranch receiver for the acquisition. The resulting data model exhibits multiple shift invariance structures, and we propose a corresponding multiresolution TOA estimation algorithm based on the ESPRIT algorithm. The performance of the algorithm is compared against the derived Cramér Rao Lower Bound, using simulations with standardized ultra-wideband (UWB) channel models. We show that the proposed approach provides high resolution estimates while reducing spectral occupancy and sampling costs compared to traditional UWB approaches.

In the last 20 years, Bosnia-Herzegovina has witnessed the creation of a grand narrative about the Srebrenica genocide. Affecting perceptions, renditions, and understandings of this event, this grand narrative promotes a specific meaning and interpretation of the war in Bosnia and of Bosniak suffering. Thanks to the grand narrative, particular tropes of the story of the Srebrenica genocide have come to the fore in its commemoration, also affecting the existing artistic memorial works. In this article, I trace the effects of the grand narrative on commemorative music dedicated to the Srebrenica genocide by focusing on the oratorio “Srebrenički Inferno.” By analyzing the oratorio in relation to the grand narrative, I argue that this musical piece is not only influenced by, but also helps to maintain and reinforce, this dominant story about the genocide that represents an important segment of politically advantageous official collective memory and history of the war and genocide among Bosniaks.

Abstract. The paper presents the application of some Virtual Reality technologies developed in the Horizon 2020 i-MARECulture project to the case study of the sunken “Villa con ingresso a protiro”, dated around the II century AD, and located in the Marine Protected Area - Underwater Park of Baiae (Naples).The i-MARECulture project (www.imareculture.eu), in fact, aims to improve the public awareness about the underwater cultural heritage by developing new tool and techniques that take advantage of the virtual reality technologies to allow the general public to explore the archaeological remains outside of the submerged environment.To this end, the paper details the techniques and methods adopted for the development of an immersive virtual tour that allow users to explore, through a storytelling experience, a virtual replica and a 3D hypothetical reconstruction of the complex of the “Villa con ingresso a protiro”.

Purpose: This paper looked into the experiences of refugee parents with an aim to uncover the challenges of parenting encountered during and after the asylum procedures in Bulgaria - a country placed at the bottom of the asylum recognition scale in Europe. Methods: Qualitative research through semi-structured interviews of eight parents originating from Iraq, Syria and Palestine was conducted during the 3 months’ period in 2016. Results: Empiric research conducted revealed that procedural shortcomings of refugee protection system in Bulgaria causes severe psychosocial stresses to families in that the factors, such as slow and deficient asylum procedures, inadequate social protection and absence of integration programs, have a direct impact on the family life, parenting and children’s wellbeing. Discussion: These results point to a clear need for improvement of the access to asylum right and subsequent refugee integration in Bulgaria. They also call for a systemic approach in which the refugee rights are fully respected and vulnerability inherent to the refugee parents’ liminal position properly addressed. We further recommend the interventions of social work and mental health professions in ameliorating existent stresses of exclusion and marginalisation of refugee families with an aim to advance their full integration rights.