Aim: To simulate the stability and degradation of superparamagnetic iron oxide nanoparticles (MNP) in vitro as part of their life cycle using complex simulated biological fluids. Materials & methods: A set of 13 MNP with different polymeric or inorganic shell materials was synthesized and characterized regarding stability and degradation of core and shell in simulated biological fluids. Results: All MNP formulations showed excellent stability during storage and in simulated body fluid. In endosomal/lysosomal media the degradation behavior depended on shell characteristics (e.g., charge, acid-base character) and temperature enabling the development of an accelerated stress test protocol. Conclusion: Kinetics of transformations depending on the MNP type could be established to define structure-activity relationships as prediction model for rational particle design.

Neurological adverse events from immune checkpoint inhibition are increasingly recognised, especially with combination anti-cytotoxic T-lymphocyte antigen 4 (CTLA4) and anti-programmed death receptor 1 (anti-PD-1) therapies. Their presenting symptoms and signs are often subacute and highly variable, reflecting the numerous components of the nervous system. Given the risk of substantial morbidity and mortality, it is important to inform patients of symptoms that may be of concern, and to assess any suspected toxicity promptly. As with other immune-related adverse events, the cornerstone of management is administration of corticosteroids. Specialist neurology input is vital in this group of patients to guide appropriate investigations and tailor treatment strategies.

Abstract The paper first investigates the influence of daily mobility of population on evaluation of aircraft noise effects. Then, a new air traffic assignment model that considers this activity is proposed. The main objective is to reduce the number of people affected by noise via lowering as much as possible the noise exposure level Lden of individuals or groups of people who commute to the same locations during the day. It is hereby intended to reduce the noise impact upon individuals rather than to reduce the impact in particular – typically densely populated – areas. However, sending aircraft farther away from populated regions to reduce noise impact may increase fuel burn, thus affecting airline costs and sustainability. Therefore, a multi-objective optimization approach is utilized to obtain reasonable solutions that comply with overall air transport sustainability. The method aims at generating a set of solutions that provide proper balance between noise annoyance and fuel consumption. The reliability and applicability of the proposed method are validated through a real case study at Belgrade airport in Serbia. The investigation shows that there is a difference between the number of people annoyed (NPA) evaluated based on the census data and the NPA evaluated based on the mobility data. In addition, these numbers differ significantly across residential locations. The optimal results show that the proposed model can offer a considerable reduction in the NPA, and in some cases, it can gain up to 77%, while maintaining the same level of fuel consumption compared with the reference case.

O presente artigo é fruto do recente trabalho de implantação do Núcleo de Pesquisa e Extensão (NUPEx) na Faculdade Unimed. Tal percurso envolveu um esforço coletivo e colaborativo, por parte da equipe técnica do NUPEx/Faculdade Unimed, para sistematizar as diretrizes e normas voltadas às atividades de extensão no atual contexto do ensino superior brasileiro. A proposta central deste trabalho é refletir sobre o papel da Extensão Universitária na formação do aluno de graduação, considerando, em especial, a portaria nº 1.350 de 17/12/2018 a qual declara homologado o Parecer CNE/CES nº 608/2018, da Câmara de Educação Superior do Conselho Nacional de Educação e institui as diretrizes para as Políticas de Extensão da Educação Superior Brasileira. Esse importante marco legal para o campo da extensão universitária sintetiza o trabalho realizado na última década no sentido de conceituar a extensão universitária de forma indissociável ao ensino e à pesquisa e ainda integrar os diferentes segmentos de entidades de educação superior que compõem o Sistema Federal de Educação, contemplando as dimensões avaliativas e regulatórias já em vigência no contexto do ensino superior. O presente trabalho pode ser útil a gestores e agentes mantenedores de Instituição de Ensino Superior (IES), pró-reitores, coordenadores, professores e estudantes interessados em implementar as ações de extensão no âmbito da sua IES. Acrescenta ainda uma reflexão crítica da práxis sócio-histórica da extensão universitária no país.

Due to a growing awareness of environmental protection, an interest in replacing toxic corrosion inhibitors with more environmentally acceptable alternatives is also growing. Chromates, as one of the best inhibitors, have been eliminated as technically viable inhibitors because of their high toxicity, and the use of polyphosphates has diminished as they disrupt the balance in the Plantae kingdom. The emphasis is on exploration and testing of organic compounds that can be obtained from plant material. Rosemary extracts (leaf and flower) have been shown to have inhibitory activity on iron corrosion in 3% NaCl and seawater. Corrosion rate values ​​show that rosemary flower extracts are better inhibitors of corrosion than the leaf extracts and that the maximum inhibitory protection has not been achieved in the range of tested concentrations.

U radu su prikazani rezultati utvrđivanja sadržaja arsena u plodovima dvije sorte nektarina na tri lokacije Hercegovine (Mostar, Čapljina i Stolac) tijekom 2015. i 2016. godine. Nakon utvrđivanja sadržaja arsena u plodovima nektarina, uradio se proračun procjene rizika proračunom nekancerogenog indeksa opasnosti (Hazard Quotient Index, HQI; Indeks koeficijenta opasnosti). Na istraživanim lokacijama uzgajane su dvije sorte nektarina (Big Top i Caldesi 2000). Sadržaj arsena u 2015. godini je utvrđen samo na lokaciji Stolac. U 2016. godini na svim lokacijama je bio ispod LQO (Limit of Quantification, Granica kvantifikacije). Procjenom dnevnog unosa (Estimated daily intake, EDI) i tjednog unosa (Estimated weekly intake, EWI) arsena navedenim sortama nektarina utvrđeno je da nema akutnog ni kroničnog rizika na zdravlje ljudi.

Jam (traditionally called pekmez) is a product produced by concentrating of fresh thick apple juice. In this study, 20 jam samples, from different apple cultivars, were analyzed, including: ‘Samoniklica’, ‘Paradija’, ‘Habikusa’, ‘Zuja’, ‘Srebrenicka’ and mixed cultivars. The aim of this study was to determine physicochemical properties of jam from different apple cultivars and mixed jam. The analyses have shown that the average value of the dry matter was 77.38%, the ash 1.26%, pH value 4.25, electrical conductivity 2.90 mS/cm. The nitrogen content was 685.10 mg/100 g. The relative density was 1.36 g/mL. The potassium content (K) was 430.70 mg/100 g, sodium (Na) 99.31 mg/100 g, calcium (Ca) 43.65 mg/100 g, magnesium (Mg) 30.80 mg/100 g, iron (Fe) 5.61 mg/100 g, zinc (Zn) 1.07 mg/100 g, copper (Cu) 0.41 mg/100 g, manganese (Mn) 0.26 mg/100 g. The total polyphenols were 0.78 g/kg. Hydroxymethylfurfural (HMF) was 162.02 mg/kg. Apple jam is recommended in recovery from many diseases because of its special nutritional value, especially for people who suffer from anaemia sidropenica and similar diseases, and for the athletes as well.

Cilj rada bio je prikazati rezultate Programa socijalnopedagoških intervencija za učenike koji su u rizičnoj skupini razvijanja problema u ponašanju. Program se provodio u trima osnovnim školama na području grada Tuzle u Bosni i Hercegovini, a realiziran je tijekom 2016./2017. školske godine. Provedena je procjena 500 učenika (248 dječaka i 252 djevojčice) u dobi od 10 do 15 godina, od čega je izdvojeno 86 učenika (39 dječaka i 47 djevojčica) kod kojih je procijenjeno da su u rizičnoj skupini za razvoj problema u ponašanju. Za procjenu je korištena Achenbachova dimenzionalna klasifikacija poremećaja ponašanja (Achenbach, Rescorla, 2001), a da bi se utvrdili efekti Programa, učenici su testirani u inicijalnoj, medijalnoj i finalnoj fazi. Strukturiranim pedagoškim postupcima putem skupnoga i individualnog pristupa došlo je do promjene u ponašanju učenika prema društveno poželjnim modelima. Skupni i individualni susreti s učenicima realizirani su u trajanju od dva sata tjedno, a Programom su putem radionica educirani nastavnici i roditelji. Da bi se prikazale promjene kod učenika s eksternaliziranim i internaliziranim problemima, korištene su deskriptivne statističke metode na Youth Self Report skalama. Programom je potvrđeno očekivanje da će, pravovremenom identifikacijom učenika rizičnih za nastanak problema u ponašanju i pravovremenom i adekvatnom socijalnopedagoškom intervencijom u radu s djecom i njihovim roditeljima, doći do pozitivnih pomaka u ponašanju.

The Bihać tourism geographical region is rich in diverse, pollution-free, natural tourism potentials that can be the basis for the development of more specific forms of tourism (mountain, hunting, rural, excursion-recreational, adventure, recreational-sports, fishing and ecotourism) of local and regional as well as national and international significance. This paper will present the most important natural tourism potentials of the Bihać tourism geographical region, their valorization, as well as their possibility of exploitation for tourist purposes. Moreover, the tourist traffic and accommodation capacities of this tourism geographic region will be shown. Finally, it will be concluded how these unique still unpolluted natural phenomena should be treated in order for them to remain the same for future generations.

Today, there are several well-known global ranking lists for ranking universities in the world. While some of them ranked only a few hundreds of best and most influential universities, there are those that include a much larger number of ranking scientific institutions. One such global list which ranks the largest number of scientific institutions and scientists in the world is called Webometrics list. This list is very important for less developed economies and developing countries which have not established a sufficient quality control system of higher education quality, so this list serves as a corrective to the international evaluation of a wide range of universities in the world. In such a complex IT system of ranking an extremely large number of institutions and scientists, this system shows some disadvantages when ranking, which of course can be overcome by introducing certain improvements within the system of ranking. Systems that perform the collection, analysis, and indexing data have their advantages and disadvantages, which can sometimes lead to a misinterpretation of the data collected. Among other things, we will consider the possible solutions which would improve the rating system and prevent possible manipulation and uncertainty in the presentation of current and final results ranking.