Aim of the research was measuring the heat transfer coefficient of the external walls at the Mechanical Engineering Faculty building with heat flow method, in order to obtain the real value of heat transfer coefficient. After performing the measuring according to the ISO 9869 for in-situ measurement, the average measured heat transfer coefficient was 0.23 W/m2K, which is lower value compared to the calculated one, 0.33 W/m2K, according to the program (KiExpert). Difference between values is the result of limitations in selection of materials and because heat accumulation in building elements is not sufficiently considered in algorithms of the program.

Background: Despite being considered as a distinct diagnostic category in the current ILAR classification criteria, Juvenile Psoriasic Arthritis (JPsA) is known to be a heterogeneous clinical entity, with growing evidence suggesting at least two age-based distinct subgroups(1) Objectives: To identify and characterize subgroups of patients classified as JPsA according to the ILAR criteria and their possible differences in outcomes. Methods: Cross-sectional data from patients enrolled in The EPidemiology, treatment and Outcome of Childhood Arthritis (EPOCA) study and classified as JPsA according to ILAR criteria (n=308) were analyzed. Latent class analysis (LCA) was used to identify subgroups of subjects with similar profiles ILAR criteria for JPsA (presence at onset of psoriasis, dactylitis, nail changes, first-degree relative with psoriasis) and age of arthritis onset. Multinomial logistic regression (three-step method) was performed to explore differences across the obtained classes in clinical-laboratoristic features at onset and outcomes measures collected at visit, namely JADAS scores, VAS-measured Pain, Overall Well-Being (PGA) Pediatric Rheumatology Quality of Life Scale (PRQL). In patients with disease duration more than 2 years (n=233), the relation with Articular and Extraarticular Juvenile Arthritis Damage Index (JADI) was also assessed. Results: LCA revealed 5 classes: 1) late-onset patients with psoriasis, characterized by higher frequency of axial involvement at visit (n = 121); 2) early-onset patients with psoriasis, more likely to be ANA-positive (n = 66); 3) young females with dactylitis at onset and family history of psoriasis, more likely to present with symmetric joint involvement (n = 62); 4) subjects with nail changes and family history of psoriasis(n=34); 5) patients exhibiting dactylitis and nail changes at onset, mostly males, with higher rates of HLA-B27 positivity, small joint involvement and enthesitis at visit (n = 25). Class 1 is associated with higher scores of JADAS10, pain, PGA and JQ; these group also shows higher JADI-A than Class 3. Extraarticular damage is worst for Class 2 subjects. Conclusion: The data driven clustering approach revealed several subgroups, confirming the heterogeneity of JPSA in a multinational cohort. Later-onset subjects with psoriasis have more aggressive disease, being clearly distinct from early-onset ANA-positive patients with psoriasis. The results suggest the need to revise the current classification in order to identify groups that may benefit from different therapeutic choices. References [1] Stoll ML, Nigrovic PA. Clin Dev Immunol. 2006;13(2–4):377–80. Disclosure of Interests: Hala Etayari: None declared, Arūnė Ramanauskiene: None declared, Alessandra Alongi: None declared, Yaryna Boyko: None declared, Yosef Uziel: None declared, Tadej Avcin: None declared, Pierre Quartier Consultant for: AbbVie, Chugai-Roche, lilly, Novartis, Novimmune, Sanofi, and SOBI, Consultant for: AbbVie, Chugai-Roche, Lilly, Novartis, Novimmune, Sanofi, and SOBI, Speakers bureau: AbbVie, BMS, Chugai-Roche, Novartis, Pfizer, and SOBI, Speakers bureau: AbbVie, BMS, Chugai-Roche, Novartis, Pfizer, and SOBI, Nicolino Ruperto Grant/research support from: The Gaslini Hospital, where NR works as full-time public employee, has received contributions (> 10.000 USD each) from the following industries in the last 3 years: BMS, Eli-Lilly, GlaxoSmithKline, F Hoffmann-La Roche, Janssen, Novartis, Pfizer, Sobi. This funding has been reinvested for the research activities of the hospital in a fully independent manner, without any commitment with third parties., Consultant for: Received honoraria for consultancies or speaker bureaus (< 10.000 USD each) from the following pharmaceutical companies in the past 3 years: Ablynx, AbbVie, Astrazeneca-Medimmune, Biogen, Boehringer, Bristol-Myers Squibb, Eli-Lilly, EMD Serono, GlaxoSmithKline, Hoffmann-La Roche, Janssen, Merck, Novartis, Pfizer, R-Pharma, SanofiServier, Sinergie, Sobi and Takeda., Speakers bureau: Received honoraria for consultancies or speaker bureaus (< 10.000 USD each) from the following pharmaceutical companies in the past 3 years: Ablynx, AbbVie, Astrazeneca-Medimmune, Biogen, Boehringer, Bristol-Myers Squibb, Eli-Lilly, EMD Serono, GlaxoSmithKline, Hoffmann-La Roche, Janssen, Merck, Novartis, Pfizer, R-Pharma, SanofiServier, Sinergie, Sobi and Takeda., Angelo Ravelli Grant/research support from: Angelini, AbbVie, Bristol-Myers Squibb, Johnson & Johnson, Novartis, Pfizer, Reckitt Benkiser, and Roche, Consultant for: Angelini, AbbVie, Bristol-Myers Squibb, Johnson & Johnson, Novartis, Pfizer, Reckitt Benkiser, and Roche, Speakers bureau: Angelini, AbbVie, Bristol-Myers Squibb, Johnson & Johnson, Novartis, Pfizer, Reckitt Benkiser, and Roche, Alessandro Consolaro Grant/research support from: AbbVie, Pfizer,

In 2018, Croatia reported the largest outbreak of West Nile virus (WNV) infections as well as the re-occurrence of human Usutu virus (USUV) infections. For the first time, fatal WNV and USUV infections were detected in wild birds. We analysed epidemiological characteristics and molecular epidemiology of WNV and USUV infections detected during 2018 transmission season. From April to November, 178 patients with neuroinvasive disease and 68 patients with febrile disease were tested for WNV and USUV. Viral RNA was detected in cerebrospinal fluid (CSF) and urine samples using a real-time RT-PCR. Positive samples were tested by nested RT-PCR and nucleotide sequencing. IgM/IgG antibodies were detected in serum/CSF samples using ELISA with confirmation of cross-reactive samples by virus neutralization test (VNT). WNV neuroinvasive disease was confirmed in 54 and WNV fever in seven patients from 10 continental Croatian counties. Areas affected in 2018 were those in which cases occurred in previous seasons, while in three areas human cases were reported for the first time. Phylogenetic analysis of six strains from patients residing in different geographic areas showed circulation of WNV lineage 2. In three patients, neuroinvasive USUV infection was confirmed by RT-PCR or VNT. Sequence analysis of one detected strain revealed USUV Europe 2 lineage. During the same period, a total of 2,574 horse and 1,069 poultry serum samples were tested for WNV antibodies using ELISA. Acute asymptomatic WNV infection (IgM antibodies) was documented in 20/0.7% horses. WNV IgG antibodies were found in 307/11.9% horses and in 125/12.7% poultry. WNV RNA was detected in two goshawks and USUV RNA was detected in one blackbird from north-western Croatia. In the Zagreb area, 3,670 female mosquitoes were collected. One Culex pipiens pool collected in July tested positive for USUV RNA. Our results highlight the importance of continuous multidisciplinary 'One health' surveillance of these emerging arboviruses.

9574 Background: The introduction of immune checkpoint inhibitors (ICIs) or therapies targeting the MAPK-pathway (MAPKis) has significantly improved clinical outcomes in metastatic melanoma patients. Still, a large proportion of the patients become resistant to therapy and there is a need for treatment predictive biomarkers. The aim of this study was to analyze the treatment predictive biomarkers based on the plasma proteome of patients with metastatic melanoma treated with ICIs or MAPKis. Methods: We analyzed serial plasma samples from 48 patients with metastatic melanoma collected; 24 patients were treated with ICIs and with MAPKis, respcetively. A non-biased, high-resolution isoelectric focusing of peptides-liquid chromatography-mass spectrometry (HiRIEFLC-MS/MS)-based method, and with proximity ligation assays (PEA) targeting 92 immuno-oncology-related proteins were used.We analyzed the change in protein levels during treatment with a paired t-test, and their association with progression free survival (PFS) with Cox proportional hazards models. Results: HiRIEFLC-MS/MS detected 1,835 proteins.We detected statistically-significant log2-fold-changes in 109 protein levels out of 1,160 proteins tested (not corrected for multiple testing). PDCD-1 had the highest log2-fold change (FC = 1.27) after treatment (p = 0.02). After stratifying for treatment type, PDCD-1 levels increased in patients treated with ICIs (FC = 2.13, p= 0.0008), but not in MAPKis-treated patients. PEA analyses confirmed this observation. The PEA panel showed association between 44 proteins and shorter PFS (pcoefficient <0.05, pLRT<0.05, qLRT<0.05), among them: LGALS1, CSF1, VEGFA, CASP8, CCL2, TNFSF14, ANGPT2, IL10, IL6, and ADGRG1. Of these, increase in plasma levels during treatment of LGALS1, CCL2 and ADGRG1 were associated with longer PFS. HiRIEF LC-MS/MS detected 69 proteins associated with PFS (pcoefficient< 0.05, pLRT< 0.05, qLRT < 0.05). Conclusions: By using HiRIEFLC-MS/MS, we could detect putative treatment predictive proteins in plasma from patients with metastatic melanoma treated with ICIs or MAPKis. Our findings require further validation.

In order to be used for skill development and skill maintenance, virtual environments require accurate simulation of the physical phenomena involved in the process of the task being trained. The accuracy needs to be conveyed in a multimodal fashion with varying parameterisations still being quantified, and these are a function of task, prior knowledge, sensory efficacy and human perception. Virtual reality (VR) has been integrated from a didactic perspective in many serious games and shown to be effective in the pedological process. This paper interrogates whether didactic processes introduced into a VR serious game, by taking advantage of augmented virtuality to modify game attributes, can be effective for both beginners and experts to a task. The task in question is subjective performance in a clay pigeon shooting simulation. The investigation covers whether modified game attributes influence skill and learning in a complex motor task and also investigates whether this process is applicable to experts as well as beginners to the task. VR offers designers and developers of serious games the ability to provide information in the virtual world in a fashion that is impossible in the real world. This introduces the question of whether this is effective and transfers skill adoption into the real world and also if a-priori knowledge influences the practical nature of this information in the pedagogic process. Analysis is conducted via a between-subjects repeated measure ANOVA using a 2×2\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$2 \times 2$$\end{document} factorial design to address these questions. The results show that the different training provided affects the performance in this task (N=57\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$N=57$$\end{document}). The skill improvement is still evidenced in repeated measures when information and guidance is removed. This effect does not exist under a control condition. Additionally, we separate by an expert and non-expert group to deduce if a-priori knowledge influences the effect of the presented information, it is shown that it does not.

Future wireless networks are expected to constitute a distributed intelligent wireless communications, sensing, and computing platform, which will have the challenging requirement of interconnecting the physical and digital worlds in a seamless and sustainable manner. Currently, two main factors prevent wireless network operators from building such networks: (1) the lack of control of the wireless environment, whose impact on the radio waves cannot be customized, and (2) the current operation of wireless radios, which consume a lot of power because new signals are generated whenever data has to be transmitted. In this paper, we challenge the usual “more data needs more power and emission of radio waves” status quo, and motivate that future wireless networks necessitate a smart radio environment: a transformative wireless concept, where the environmental objects are coated with artificial thin films of electromagnetic and reconfigurable material (that are referred to as reconfigurable intelligent meta-surfaces), which are capable of sensing the environment and of applying customized transformations to the radio waves. Smart radio environments have the potential to provide future wireless networks with uninterrupted wireless connectivity, and with the capability of transmitting data without generating new signals but recycling existing radio waves. We will discuss, in particular, two major types of reconfigurable intelligent meta-surfaces applied to wireless networks. The first type of meta-surfaces will be embedded into, e.g., walls, and will be directly controlled by the wireless network operators via a software controller in order to shape the radio waves for, e.g., improving the network coverage. The second type of meta-surfaces will be embedded into objects, e.g., smart t-shirts with sensors for health monitoring, and will backscatter the radio waves generated by cellular base stations in order to report their sensed data to mobile phones. These functionalities will enable wireless network operators to offer new services without the emission of additional radio waves, but by recycling those already existing for other purposes. This paper overviews the current research efforts on smart radio environments, the enabling technologies to realize them in practice, the need of new communication-theoretic models for their analysis and design, and the long-term and open research issues to be solved towards their massive deployment. In a nutshell, this paper is focused on discussing how the availability of reconfigurable intelligent meta-surfaces will allow wireless network operators to redesign common and well-known network communication paradigms.

This paper deals with the architecture of the most prominent architect in Bosnia and Herzegovina during the Austro-Hungarian time, Josip Vancaš, and two of his most appreciated designs developed for Banja Luka: Landesbank branch office and villa Husedžinović. They both belong to what Vancaš promoted to be "Bosnian style" in architecture, while the latter one is widely accepted as one of his best single-family housing designs. The paper foremost shows Vancaš's biography and a short overview of his professional development and then focuses on the discussion of his contribution to the so-called Bosnian style in architecture, and its reflections to mentioned designs in Banja Luka, originally contributing to this still active question in the history of architecture.The paper gives data on the original status of the buildings, as well as their development throughout history, with reflections to contemporary time. The concluding discussion reviews Vancaš's contribution to architecture in the period of 1878-1918, as well as the promotion of new thoughts outside the usual work of a typical architect.

Purpose – The purpose of this paper is twofold: (1) to assess importance-performance analysis (IPA) and service performance (SERVPERF) conceptualizations of service quality, and to establish which one excels in predicting the tourists' satisfaction in hotel industry; and (2) to test the mediating role of satisfaction between quality conceptualization and hotel guests’ repurchase intentions and word of mouth recommendations regarding the hotel. Design – A conceptual framework was empirically tested on a sample of 311 tourists staying in six hotels in Sarajevo (Bosnia and Herzegovina), which is a tourist destination with increased relevance internationally. Methodology – Covariance-based structural equation modeling was used to estimate the model. Approach – Two conceptualizations were firstly estimated separately then they were contrasted and compared. Findings – The results showed a slight superiority of the IPA conceptualization over that of SERVPERF in predicting satisfaction and in affecting customer attitudinal and behavioral outcomes. This study also confirms the vital mediating role of satisfaction on customer outcomes. Originality of the research – This study utilizes and compares two relevant conceptualizations of hotel service quality and is based on a conceptual framework that establishes which one is better for predicting tourists’ behavioral outcomes. The study is of practical relevance since it gives suggestions on tools that should be used by hotel managers in assessing the quality perceived by their guests.

of the flaws of Bosnia’s political system, namely the strict nature of the ethnic power-sharing institutions that favour ethnically exclusive parties and zero sum politics, few will agree with his suggestions on how to fix the system. In short, Bennett asks all the right questions but gives, sadly, all the wrong answers. Bosnia does not need another externally imposed system, instead, it has become obvious that real change must come from within Bosnia. There are signs that the system can change, and protests in recent years have demonstrated that people are more and more dissatisfied with the system. In addition to the above-mentioned flaws in Bennett’s argument, there is also a lack of empirical evidence that his suggestion would work. This not only refers to a more and more passive international community when it comes to Bosnia, but also to the fact that Horowitz’s theory of centripetalism is barely used and has not been tried in other postwar societies. To assume people can be ‘re-programmed’ and will just change their preferences in voting if the electoral system changes also assumes that ethnic identity and clientelistic networks will just go away with new electoral rules. There is no empirical evidence for this, and when Horowitz’s electoral preference system was used in the 2000 election for Republica Srpska’s Presidency, it made absolutely no difference to the way people voted. Overall, the book is interesting for anyone interested in Bosnia, the Balkans and international state-building. While Bennett adds little to the academic debate on Bosnia, he provides some interesting insights on debates about topics such as constitutional reform, police reform, the implementation of the rule of law, and the inner workings of the Office of the High Representative. While generally well written, at times the book is repetitive, and it is not well referenced.

Istraživanje autohtone proizvodnje Livanjskog i Travničkog sira ima za cilj očuvanje tradicije, organizirane proizvodnje i plasmana na tržišta izvan domicilne regije. Autohtoni sirevi su raznovrsnijeg okusa, arome i konzistencije u odnosu na industrijski proizvedene sireve, gdje je tehnologija definirana, a uvjeti proizvodnje kontrolirani. Nadmorska visina, kvalitetna voda i hrana nisu dovoljni čimbenici za trajno održavanje kvalitete autohtonih sireva. Na osnovi standardizacije tehnoloških postupaka proizvodnje može se proizvesti sir specifičnog obilježja. Cilj istraživanja bio je odrediti i komparirati ukupni dušik i dušične frakcije u dva autohtona sira – Livanjskom i Travničkom, ovisno o terminu uzorkovanja (srpanj, kolovoz i rujan). Za anlizu su uzorci sira uzeti nakon 90 dana zrenja u izvornim uvjetima okoline. U uzorcima sira određivan je ukupni dušik i dušične frakcije. Određivanje sadržaja ukupnog dušika (TN), kao i dušika topljivog u vodi pri pH 4,6 (SN-4,6) i 12% trikloroctenoj kiselini (TCA-SN) provedeno je metodom po Kjeldahlu. Vrijednosti TN, SN-4,6 i TCA-SN u uzorcima Travničkog sira bile su niže u odnosu na uzorke Livanjskog sira pri svakom terminu uzorkovanja. Najveće vrijednosti indeksa SN-4,6/TN i TCA-SN/TN kod oba ispitivana sira utvrđene su u sirevima proizvedenim od mlijeka prikupljenog tijekom rujna. Indeksi zrenja su bili viši u uzorcima Travničkog sira, što ukazuje na povećanu primarnu proteolizu u odnosu na Livanjski sir, to može biti rezultat specifičnosti biljnog pokrivača i ispaše ovaca na nižoj nadmorskoj visini.

U radu su prikazani rezultati istraživanja opterećenosti teškim metalima na relaciji tlo-biljka-životinja područja Srednje-bosanskog kantona. Istraživanja su obuhvatila analizu sadržaja kadmija (Cd), žive (Hg) i željeza (Fe) u jetrenom i bubrežnom tkivu domaće janjadi. S područja općine Kakanj žrtvovano je 8 janjadi, od kojih su uzeti uzorci tkiva jetre i bubrega, a Zenice 7 janjadi, od kojih su također uzeti uzorci tkiva jetre i bubrega. Sadržaj teških metala (Cd, Hg i Fe) u uzetim uzorcima, utvrđen je na ICP-MS (masena spektrometrija s induktivno spregnutom plazmom), u skladu s evropskim standardima (EN 13805 : 2002, IDT) i (EN 15763, 2009, IDT). Utvrđena srednja količina Cd u uzorcima tkiva jetre s područja općine Kakanj iznosila je 0,115, a Zenice 0,261 mg/kg. Srednja vrijednost količine Cd u uzorcima tkiva bubrega sa područja općine Kakanj iznosila je 0,197, a Zenice 0,476 mg/kg. Sadržaj kadmija je veoma varijabilan na oba lokaliteta. Nije utvrđena statistički značajna razlika između lokaliteta. Općenito, sadržaj kadmija je ispod gornje granice dozvoljene količine prema Direktivi Europske Komisije. Utvrđene količine Fe na oba istraživana lokaliteta su znatno ispod gornje granice dozvoljenih vrijednosti. Na oba lokaliteta u uzetim uzorcima istraživanih tkiva nije utvrđena prisutnost žive.

In this paper, a novel interference mitigation and power allocation (PA) scheme is investigated for downlink non-orthogonal multiple access (NOMA) with multiple input multiple output (MIMO) technology in heterogeneous networks (HetNets). The proposed scheme, named PA based interference alignment and coordinated beamforming (PA-IA-CB), consists of two stages. The first stage applies two steps of IA-CB; one step for canceling the inter-cluster and the co-tier interference among small cells, whereas the other step deals with the inter-cluster interference within the macro cell. In the second stage, the cross-tier interference is proposed to be managed by properly handling the allocated power to the macro base station (MBS) and the small base stations (SBSs). The PA problem is modeled as a non-cooperative game between the MBS and the SBS with the aim of increasing the system sum rate. Simulation results verify the efficiency of the proposed technique in terms of total system sum rate and outage probability compared to the conventional schemes.