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s. After _104_____ title, _105_____ abstract is _106_____ second most read part (frequently _107_____ only other red part) of paper, and so is likely to_108_____ basis on which _109_____work is judged by uncritical readers. It is also _110_____ first part of _111_____ paper that an editor reads carefully, and it may provoke _112_____ choice of references. Like _113_____ title, _114_____ abstract will reward time spent on it and should be short, intelligible, informative, and interesting. It should be _115_____ digest of _116_____ whole paper and contain its essence. It should consist of four basic parts, which can vary individually in length. These should describe succinctly (a) why what was done was done; (b) what was done; (c) what was found; and (d) what was concluded. 117_____ permissible length may be defined by the journal in question, but 200 words is a good average target that should be exceeded only in exceptional circumstances. 118_____ Vancouver Group suggests a maximum of 150 words for _119_____unstructured abstracts and 250 for fully structured formats. The process takes time. Remember, _120_____text that is easy to read is usually hard to write. Statistical methods. 'Statistics' is _121_____ science of collecting, describing and analyzing data that are subject to random variation. It consists of two main areas: (i) descriptive statistics, whereby _122_____ collection of data is summarized in order to characterize features of its distribution, and (ii) inferential statistics, whereby these summary data are processed in order to estimate, or predict, characteristics of another (usually larger) group. Before _123_____ research study is undertaken it is important to consider the nature of _124_____ 62 Škrbić and Igić. Scr Med 2019;50(1):56-63.

This brief review describes how two complex systems, the renin-angiotensin system (RAS) and the kallikrein-kinin system (KKS), affect the retina. It emphasises the important physiological actions of components of these systems, the protective effectiveness of angiotensin I converting enzyme (ACE) inhibitors and angiotensin receptor blockers (ARB) in diabetic retinopathy and suggests as well the therapeutic possibilities for treatment of diabetic retinopathy by selective activation of bradykinin receptors (B1 and B2).

Lafora progressive myoclonus epilepsy (Lafora disease, LD) is a fatal autosomal recessive neurodegenerative disorder (with an onset in teenage years in previously normal adolescents). This paper represents a view of a patient diagnosed with Lafora progressive myoclonus epilepsy, over a course of seven years. A description of the initial manifestation of symptoms, doctors' attempts to combat the symptoms with drug treatment, further attempts towards reaching the correct diagnosis, the final confirmation of the Lafora diagnosis (mutation in the NHLRC1 gene), and the current state of the patient is presented. The absence of a positive family history, the lack of staff specialized in dealing with this or similar pathology, and the diagnostic inability to characterize this type of disorder in Bosnia and Herzegovina have led to a fair delay in diagnosing and beginning of an adequate pharmacological treatment. Overall, recent identification of LD cases in Bosnia and Herzegovina warrants an establishment of a Centre for Genetic Testing in order to ensure more humane counseling of an entire family whose family member(s) might be diagnosed with this devastating and currently an incurable disorder.

In the world of global competition, customers have increasing demands that companies must meet in order to remain active in the global market. For this reason, it is necessary to use new technologies in the production processes, i.e. to implement Industry 4.0. In other words, we need to create a connected company through the digital transformation that enables production processes to discover new ways to increase productivity and improve overall business performance. Companies need to get involved and start a digital system, and from supplier to customer. It is a key to the hidden value that can contribute to the company’s productivity, compliance, profitability, as well as the quality of the finished product, and eventually the introduction of flexible industrial automation of production processes. The aforementioned technologies and Internet of Things connect the physical and virtual world with a purpose to better collect and analyze data, transforming them into information that reaches decision-makers. To do this, it is necessary to implement smart sensors that provide information at all times. The implementation of Industry 4.0 in production processes is unthinkable without smart sensors and provides the following: faster product development time, lower overall costs, improved use of production processes and their optimization, as well as company risk management. The paper will outline the motives for the implementation of smart sensors and applications of smart sensors in production processes. Keywords: production process, smart sensor, Industry 4.0, production automation, digital transformation, flexible automation.