In this paper we are presenting scopeand restrictions on the use of cryptocurrencies in internationalbusiness, banking and in financial marketsThe subject of this research is to analyzeutilization of cryptocurrencies in the internationalbusiness. The goals of the research are to provide tothe researchers and to practitioners and to the scientificand professional public, an overview of currentresearch on blockchain technology in the economyand to determine the impact of the wider use of cryptocurrenciesin international business and their impacton the future of financial markets..The researchwas realized by the method description, literatureanalysis and conducted research. The selected examplesare presenting the possibility of earning, buyingand storing cryptocurrencies, paying with cryptomoneyand invest in them. In the paper we aresearching for an answer to the question “What arethe advantages and disadvantages of using cryptocurrenciesin international payment and what is the securityof using cryptocurrencies in the future?” In theanswer, this paper will present in what direction theuse of crypts will develop in the future. Results arepresenting the blockchain technology, though backgroundtechnology, which would not be known thatcryptocurrencies did not gain popularity, has a brightperspective. Conclusion presents that as long as thetransaction costs are lower than the cost of paymenttransactions, the rational behavior of legal and naturalpersons requires that they should encourage the useof cryptocurrencies among themselves in order to reducethe costs of the transactions when paying and toovercome the existence of an intermediary.

Youth unemployment rate in Bosnia andHerzegovina (BiH) is one of the largest in the world. Ahigh percentage of unemployed and inactive young peopleis the result of on the one hand, insufficiently rapid economicdevelopment of small post-transition economies andon the other hand, the mismatch of supply and demand inthe labor market. In the long run, reformed modern formaleducation at all levels, as well as non-formal education,particularly entrepreneurship and STEAMeducation, could make a significant contribution to economicgrowth and development of small post-transitiondeveloping economies, by strengthening the entrepreneurialecosystem of educational institutions at all levels and thedevelopment of entrepreneurship. The goal of the researchis, through the review of empirical studies, to analyze successfulpractices of applying entrepreneurship educationand building the entrepreneurial ecosystem in primary, secondaryand higher education and modeling strategic directionsof curriculum reforms at all levels of the educationsystem in small post-transition developing economies, witha focus on the reform of the education system of higher educationin the Republic of Srpska and Bosnia and Herzegovina.We used historical method, method ofclassification, method of analysis and synthesis, and a casestudy. In the case study, on the example of the University ofBanja Luka (UNIBL), we can conclude that UNIBL stilldoes not have the characteristics of entrepreneurship universityand that the reform of the University is necessary.

Irritable bowel syndrome (IBS) is a brain‐gut disorder, of which the natural course varies between patients and is difficult to predict. This study aimed to evaluate symptom evolution over a 5‐year follow‐up period and to identify baseline predictors for symptom severity and quality of life (QoL) at follow‐up.

Artefacts caused by the presence of metallic implants and prosthesis appear as dark and bright streaks in computed tomography (CT) images, that obscure the information about underlying anatomical structures. These phenomena can severely degrade the image quality and hinder the correct diagnostic interpretation. Although many techniques for the reduction of metal artefacts have been proposed in literature, their effectiveness is still limited. In this paper, an application of a convolutional neural networks (CNN) to the problem of metal artefact reduction (MAR) in the image domain is investigated. Experimental results show that image-domain CNN can substantially suppresses streaking artefacts in the reconstructed images.

TPS3155 Background: Genomic signatures are revolutionizing the definition, identification, and treatment of breast cancer. To precisely stratify breast cancers into actionable subgroups, full genome expression data and matching clinical data must be aggregated into a large data set. Such a data set will accelerate research and discovery, especially for smaller patient subsets who are not as widely represented within the current body of literature. Methods: FLEX is a multicenter, prospective, population-based, observational trial for patients with Stage I, II, and III breast cancer. All patients with stage I to III breast cancer who receive MammaPrint, with or without BluePrint on a primary breast tumor are eligible for enrollment. The study’s primary aim is to create a large scale, population-based registry of full genome expression data matched with clinical data to investigate new gene associations with prognostic and/or predictive value. Secondary objectives include utilizing the shared study infrastructure to examine and generate hypotheses for targeted subset analyses and/or trials based on full genome expression data. The design of FLEX allows targeted sub-studies and sub-analyses to be added as appendices after the initial baseline study is opened. Patients enrolled in the initial study are also eligible for inclusion in sub-studies where they meet all criteria and additional consent is not required. Additional clinical data will be collected as specified in the appendix protocols. The FLEX collaborative platform allows participating investigators the opportunity to author their own sub-study protocols, as approved by the FLEX Steering Committee of their peers. 13 sub-studies have already been identified and are under development. Eligibility: The study will enroll a minimum of 10000 patients aged ≥18 years with histologically proven invasive stage I-III breast cancer who signed informed consent. Enrollment began April 2017 and 1506 patients have been enrolled. Clinical trial information: NCT03053193.

Aspiration is the most serious complication of dysphagia, which may lead to pneumonia. Detection of aspiration is limited by the presence of its signs like coughing and choking, which may be absent in many cases. High resolution cervical auscultations (HRCA) represent a promising non-invasive method intended for the detection of swallowing disorders. In this study, we investigate the potential of HRCA in detection of penetration-aspiration in patients suspected of dysphagia. A variety of features were extracted from HRCA in both time and frequency domains and they were tested for association with the presence of penetration-aspiration. Multiple classifiers were implemented also for aspiration detection using the extracted signal features. The results showed the presence of strong association between some HRCA signal features and penetration-aspiration, furthermore, they direct towards future directions to enhance prediction capability of aspiration using HRCA signals.

Background: The aim of the study was to highlight the importance of adequate anticoagulant therapy and the correlation of higher risk of stroke. Methods: This study analyzed data obtained from 103 patients with diagnosis of atrial fibrillation (AF) (39 of them had a stroke). Patients were divided into groups according to the CHADS2, CHA2DS2-VASc, and HASBLED scores. Results: An analysis showed that anticoagulant drugs were more often prescribed to subjects <75 years of age (P = 0.001). Patients with a higher CHADS2 score had a higher CHA2DS2-VASc score and vice versa (rho = 0.513; P = 0.0001). According to the CHA2DS2-VASc, 91.3% of the patients examined were prescribed an anticoagulant medication as a therapy at discharge from the hospital. The result was statistically significant compared to the practice where an anticoagulant was prescribed to 55.9% of high-risk subjects as estimated by the CHA2DS2-VASc score (P < 0.05). Our results also show that rivaroxaban is more commonly prescribed as a discharge therapy than warfarin (χ2 = 12.401; P = 0.0001). Furthermore, a significantly higher number of patients who were being prescribed aspirin (38.5%) had a stroke compared to 12.8% of patients who were being prescribed warfarin (χ2 = 12.259; P = 0.0001). Conclusions: Novel oral anticoagulants (NOACs) seem to be a better choice as a pharmacological therapy in the treatment of AF, due to a lack of adequate monitoring of patients' international normalized ratio (INR) values. CHA2DS2-VASc and HASBLED scores must be used as a part of routine clinical diagnostics when dealing with patients with AF.

For the first time, the dicationic biological molecule agmatine in the synthesis of three novel ionic liquids, agmatine ibuprofenate, agmatine salicylate, and agmatine nicotinate, as well as of six...

Australian & New Zealand Journal of Psychiatry, 53(12) Anorexia nervosa (AN) is associated with the highest death rate of any mental illness, among the highest relapse rates of any psychiatric condition, and a long-term recovery rate of less than 50% among those who survive it. Despite AN first being described in the scientific literature in the late 19th century, we have arguably made little progress in uncovering the aetiological and maintenance factors involved in the illness, and in developing effective treatments. This is in stark contrast to many other mental illnesses (e.g. schizophrenia, major depressive disorder) which have evidence-based treatments available that are largely successful in remitting symptoms. A recent systematic review and meta-analysis concluded that specialised eating disorder treatments are no more successful than control treatments in remitting the psychological symptoms of AN at end of treatment or follow-up; instead, they are only successful at increasing body weight at end of treatment which does not carry through to follow-up (Murray et al., 2019). Indeed, our current clinical practice guidelines for the treatment of eating disorders conclude that there is limited evidence to support current therapies for AN given the scarcity of randomised controlled trials (Hay et al., 2014). Why is this the case? Why have we failed to develop evidence-based treatments to specifically treat AN while so much progress has arguably been achieved in other mental illnesses? It is widely acknowledged that all mental illnesses involve, at least to some degree, both environmental and biological influences, i.e., nature and nurture. In AN, the biopsychosocial model of the illness is well accepted, with biological, psychological and sociocultural factors all thought to contribute to the development and maintenance of the condition. Historically, the greatest focus in AN research and treatment has, however, undoubtedly been on environmental factors contributing to the illness. The biological underpinnings of the condition, on the other hand, have been largely overlooked; and when biological mechanisms have been examined, there has been little consistency and replication between studies (Phillipou et al., 2014). Partly due to advances in technology, recent times have seen greater focus on the biological contributions to AN, including behavioural determinants of biological features on long-term outcomes, but still to a lesser degree than the psychological and sociocultural factors involved in the illness. The lack of a comprehensive biological framework has resulted in a paucity of neurobiologically inspired therapies specifically prescribed to treat AN, including psychotropic medications and brain stimulation techniques that are available to successfully treat other mental illnesses. Currently, the psychotropic medications prescribed to individuals with AN are often to alleviate the frequently comorbid symptoms of depression and/or anxiety rather than to treat the core neurobiological features of the illness. An additional problem is that the different factors of the biopsychosocial model of AN are not regularly assessed synergistically, and the majority of the literature in AN focuses on single or specific aspects of the model without integrating environmental and biological components. Almost all factors that are thought to contribute to the aetiology and maintenance of AN, or act as barriers to successful treatment, involve an interaction of environmental and biological influences. Figure 1 represents a proposed model of this interaction, with factors theoretically arranged by the degree of environmental and biological load. This model does not encompass all factors proposed to be involved in AN in the literature, but a summary of some of the most important influences described to date. Sociocultural and psychosocial factors are proposed to load the heaviest on the environmental end of the spectrum, whereas genetic influences (i.e. DNA) are proposed to load the heaviest on the biological end. However, even the factors on the opposite ends of the spectrum are not clear-cut. Psychosocial factors such as exposure to trauma, A biopsychosocial proposal to progress the field of anorexia nervosa