Smart Ecosystem reflects in the control decisions of entities of different nature, especially of its software components. Particularly, the malicious behavior requires a more accurate attention. This paper discusses the challenges related to the evaluation of software smart agents and proposes a first solution leveraging the monitoring facilities for a) assuring conformity between the software agent and its digital twin in a real-time evaluation and b) validating decisions of the digital twins during runtime in a predictive simulation.

The last decade was marked by rapid growth and development of technology. One example of that is the automotive industry. This industry has made an enormous progress, and its main goal is to achieve safer and better driving. The vehicle incorporates GPS devices that send information about the current location and speed of the vehicle. Large amounts of collected data can be used in companies for tracking vehicles and various analysis and statistics. Sometimes, however, GPS data is not accurate. In this paper, the potential of real data sets will be used to analyze possible anomalies that may occur when reading GPS position of vehicles. The approach for solving this problem used in this paper consists of calculating distance and time, based on GPS measurements, then calculating average speed based on these two values, and comparing that speed with the speed given by GPS device.

Paper illustrates the process of topic modeling and text classification. Specifically, the dataset used is a corpus consisting of scientific publications published by Neural Information Systems Processing Conference. Topic modeling itself is performed using Latent Dirichlet Allocation model. It is followed by optimization of a number of topics on the basis of topic coherence, a quality measure of human interpretability. Results of topic modeling are used for labeling data prior to text classification. Labels are determined based on the distribution of assigned papers' topics over time. Specifically, peak changes used for differentiating between time periods dominated by specific topics are calculated as a Kullback-Leibler divergence. Finally, transforming data into the feature vectors, several different text classification approaches are evaluated. As observed, the greatest accuracy score is recorded for the use of extreme gradient boosting classifier being 77.1%.

Cilj rada bio je ispitati odnos opšteg samopoštovanja, procijenjenog preko Rosenbergove skale samopoštovanja, i prilagodbe na studij, operacionalizirane preko skorova na Baker-Siryk-ovoj skali prilagodbe na studij SACQ. Prilagodba na studij modelirana je preko četiri dimenzije prilagodbe: emocionalne, socijalne, akademske, i institucionalne. Studija je provedena na uzorku od 808 studenata (62.9% ženski; M = 21.88; SD = 2.35). Diskriminativnom analizom preko četiri modaliteta prilagodbe procijenjena je alokacija studenata na grupu visoko/nisko samopoštovanje. Izdvojena je značajna diskriminativna funkcija koja bi se mogla svesti na aspekte emocionalno-socijalne prilagodbe. Ukupno je obuhvaćeno oko 17% preklapanja između studentske prilagodbe i samopoštovanja. Studenti sa višim stepenom samopoštovanja imali su u prosjeku statistički značajno viši nivo prilagodbe na studij u odnosu na studente s nižim samopoštovanjem.

Chronic obstructive pulmonary disease (COPD) is a chronic disease characterized by a progressive decline in lung function due to airflow limitation, mainly related to IL-1β-induced inflammation. We have hypothesized that single nucleotide polymorphisms (SNPs) in NLRP genes, coding for key regulators of IL-1β, are associated with pathogenesis and clinical phenotypes of COPD. We recruited 704 COPD individuals and 1238 healthy controls for this study. Twenty non-synonymous SNPs in 10 different NLRP genes were genotyped. Genetic associations were estimated using logistic regression, adjusting for age, gender, and smoking history. The impact of genotypes on patients’ overall survival was analyzed with the Kaplan–Meier method with the log-rank test. Serum IL-1β concentration was determined by high sensitivity assay and expression analysis was done by RT-PCR. Decreased lung function, measured by a forced expiratory volume in 1 s (FEV1% predicted), was significantly associated with the minor allele genotypes (AT + TT) of NLRP1 rs12150220 (p = 0.0002). The same rs12150220 genotypes exhibited a higher level of serum IL-1β compared to the AA genotype (p = 0.027) in COPD patients. NLRP8 rs306481 minor allele genotypes (AG + AA) were more common in the Global Initiative for Chronic Obstructive Lung Disease (GOLD) definition of group A (p = 0.0083). Polymorphisms in NLRP1 (rs12150220; OR = 0.55, p = 0.03) and NLRP4 (rs12462372; OR = 0.36, p = 0.03) were only nominally associated with COPD risk. In conclusion, coding polymorphisms in NLRP1 rs12150220 show an association with COPD disease severity, indicating that the fine-tuning of the NLRP1 inflammasome could be important in maintaining lung tissue integrity and treating the chronic inflammation of airways.

Pulmonary embolism (PE) can lead to multi-organ damage including an acute renal dysfunction which is associated with adverse events and high long-term mortality rate. The aim of our study was to investigate the predictive role of renal dysfunction on intrahospital mortality risk in patients hospitalized due to PE. The study was performed in intensive care units of six university hospitals. The prospective cohort study comprised 665 consecutive patients with acute PE which was confirmed using MDCT. All patients underwent echocardiography examination on admission and blood samples were collected for troponin I (TnI), B-type natriuretic peptide (BNP) and routine laboratory analyses. Based on estimated glomerular filtration rate (GFR), patients were divided into three groups: first with the GFR <30ml/min, second with GFR 30–60 ml/min, and third with GFR >60 ml/min. During hospitalization in the first group the overall incidence of death was recorded in 28 (45.9%), in the second in 42 (18.9%), and in the third in 30 (7.9%) patients (p<0.0001). Pulmonary embolism as a cause of death was recorded in the first group in 18 (29.5%) patients, in the second in 25 (11.3%) and in the third in 17 (4.5%) patients (p<0.0001). Fatal bleeding was recorded in the first group in 1 (1.6%), in the second in 1 (0.5%) and in the third group in 3 (0.8%) patients (p<0.05). There were no significant differences regarding major bleeding frequency among the groups. Multivariate analysis showed that age, comorbidities, hemodynamic status, TnI, and GFR were strongly associated with an overall mortality rate and with death due to PE, while the use of anticoagulation therapy influenced the fatal bleeding rate. After controlling for age, we found that GFR on admission had a significant effect on in-hospital survival. Compared with patients in the third group, those from the second group had more than 2 fold increased mortality risk [OR 2.17 (CI 1.301–3.625), p=0.001], and patients in the first group had 6 fold higher risk of mortality [OR 6.006 (CI 3.487–6.006)]. In the ROC analysis GFR showed significant predictive value for intra-hospital mortality risk in PE patients [AUC= 0.725, 95% CI (0.68–0.78), p<0.001]. The highest sensitivity (64%) and specificity (70%) had GFR “cutoff” value of 59.12/min. Renal dysfunction, on admission, in patients with acute PE is strongly associated with high intrahospital mortality risk and fatal bleeding. The estimation of GFR in these patients is important not only for prediction of the outcome but also for the prevention of bleeding complications, regarding the optimal dosage of anticoagulants. Even though it seems that GFR calculation is not still the clinical routine in PE.

Results of currently available randomized trials have shown divergent outcomes in diabetic patients undergoing percutaneous coronary intervention (PCI) or coronary artery bypass grafting (CABG). The 2018 ESC/EACTS guidelines on myocardial revascularization do not recommend PCI in patients with diabetes and SYNTAX score ≥23. We aimed to compare the all-cause 4-year mortality after revascularization for complex coronary artery disease (CAD) in diabetics. The study group comprised consecutive diabetics with angiographically proven three-vessel CAD (≥50% diameter stenosis) and/or unprotected left main CAD (≥50% diameter stenosis) without major hemodynamic instability, who were treated in two institutions with PCI or referred for CABG between 2008 and 2010. All-cause mortality was ascertained by telephone contacts and/or from Mortality Registries. Using the hospital data system, 5145 patients were screened and 4803 elected not to follow the inclusion criteria. Out of 342 included patients, 177 patients underwent PCI and 165 patients were referred for CABG. Patients with whom CABG was performed were significantly older (64.69±8.8 vs. 62.6±9.4, p=0.03), more often on insulin treatment (91/165=55.2% vs. 26/177=14.7%, p<0.01), had more complex anatomical characteristics i.e. higher SYNTAX scores (32.5 IQR (15) vs. 18.0 IQR (15), p<0.01) and with left main stenosis (70/165=42.4% vs. 7/177=4.0%, p<0.01), compared to patients treated with PCI. The cumulative incidence rates of all-cause death were significantly different between PCI and CABG at 4 years (16/177=9.0% vs. 26/165=15.7%, respectively, log-rank p=0.03). There was a higher incidence of all-cause mortality in PCI patients with intermediate (23–32) and high (≥33) SYNTAX scores compared with those with low (0–22) SYNTAX scores (6/32=18.8% vs. 6/124=4.8%, log-rank p=0.01; 4/21=19.1% vs. 6/124=4.8%, log-rank p=0.02, respectively). On the contrary, patients who underwent CABG displayed similar morality rates irrespective of the SYNTAX scores (SYNTAX 0–22: 5/34=14.7%; SYNTAX 23–32: 9/54=16.7%; SYNTAX ≥33: 12/77=15.6%; log-rank p=0.9). Finally, when compared with CABG, more deaths were observed following PCI with intermediate and high SYNTAX scores (intermediate SYNTAX (23–32) PCI: 6/32=18.8% vs. CABG: 26/165=15.8%, log-rank p=0.94; high SYNTAX (≥33) PCI: 4/21=19.1% vs. CABG 26/165=15.8%, log-rank p=0.87). During a 4-year follow-up, CABG in comparison with PCI was associated with a higher rate of all-cause death, which can be accounted for by older age and comorbidities. In diabetics, our analysis is suggestive that PCI probably should be avoided in patients with SYNTAX ≥23, which is in concordance with the most recent guidelines. Individualized risk assessment as well as quantification of CAD by SYNTAX score remains essential in choosing appropriate revascularization method in patients with diabetes and complex CAD. None

Anomalous origin of the left coronary artery from the pulmonary artery (ALCAPA) is rare, but life-threatening condition. The treatment of choice in patients with ALCAPA is the establishment of a dual coronary artery system with surgical reimplantation of the left coronary artery in the left coronary sinus. Percutaneous coronary intervention is infrequent in the pediatric population but can be a life-saving by promptly restoring flow to an obstructed coronary artery. It is a highly demanding and high-risk procedure in infants due to the technical difficulties and the small coronary artery diameter in infants.

This letter studies the stabilization of non-linear networked control systems (NCSs) where the information between plant and controller is sent over a lossy wireless multi-hop network under a carrier-sense multiple access with collision avoidance (CSMA-CA) scheme. We present a hybrid model for the overall NCS that captures time-varying transmission instants, both inter-and at-transmission behavior, packet dropouts, field device dynamics, and CSMA-CA scheduling. We then use this model to provide sufficient conditions in terms of the intensity of transmission that ensure closed-loop $ \mathcal {L}_{p}$ stability-in-expectation. In doing so, we exploit the mathematical structure of our NCS model to improve previous results in the literature.

This article presents an overview of integrability of procedural modeling techniques needed to create a complete virtual city with streets, roads, building lots, exteriors and interiors with arranged furniture. Techniques are distributed into four hierarchies: urban plan, buildings, interior and furniture. Each technique is analyzed from the aspect of control of space definition, style uniformity, automatic interaction with other hierarchies and ability to procedurally generate a result around existing content. Each paper presented in this survey contributes either as a new control feature that has a potential of integrating with other techniques of higher, lower or same level of hierarchy, or as a new important part for creating a complete procedural city from highest to lowest level of hierarchy. The paper is concluded with a discussion of strong links between each area in the chain and important challenges in procedural generation of a complete city.

Introduction: Diabetes is the fastest growing chronic diseases worldwide and in Bosnia and Herzegovina. International standards for diabetes care have recognized the crucial role of pharmacists in diabetes management. Community pharmacists can provide services beyond medication dispensing inducing patient identification, assessment, education, referral, monitoring and behavioral counseling. Pharmacists’ attitudes toward diabetes are generally positive but do not correlate with the degree of their involvement in diabetes management and frequency of providing diabetes-related services varied throughout countries. Aim: To measure pharmacists’ attitude toward diabetes management and to identify pharmacy services that are currently provided to patients with diabetes. Material and Methods: We have conducted a descriptive, cross-sectional survey-based study among pharmacists from Bosnia and Herzegovina attending on of the conferences in May 2018. Majority of pharmacist attending such conferences are from community pharmacies across the whole country considering surveyed sample was representative. The questionnaire contained 3 different sections: a) participants’ demographics, b) measured participants’ attitude toward diabetes using the DAS-3 to measure participants’ degree of agreement to 33 diabetes-related statements, on a 5-point Likert type scale and c) a list of possible diabetes patient support activities that could be delivered by pharmacists based on authors experience and available literature. Results: The majority of respondents (86,5%) were female and 53,8% work in private owned pharmacies. Interest in diabetes was indicated by 94,2% while 59,6% completed special diabetes continuing education in the past. All the respondents expressed positive attitudes in all DAS-3 with no significant difference between overall DAS-3 and subscale values. Provided services differ but mainly drug oriented and partially include comorbidity counseling. Conclusion: Pharmacists had positive attitudes toward diabetes but they provided limited diabetes-related services to patients. Additional special education is needed.