This study argues that the shift to open business models relies on aligning value-creation and value-capture activities through interactive processes that involve both provider and customer. Yet, l...

Defibrotide is approved for the treatment of sinusoidal obstruction syndrome after allogeneic stem cell transplantation. The exact mode of action of defibrotide is unclear and human in vivo data are scarce. In this randomized, double blind, crossover trial we included 20 healthy volunteers. Four were randomized to receive placebo, while 16 received a 2 ng/kg bodyweight bolus of lipopolysaccharide (LPS). Infusion of 6.25 mg/kg defibrotide or placebo was started one hour before the injection of the LPS bolus. Plasma levels of prothrombin fragments F1 + 2, thrombin-antithrombin complexes, von Willebrand factor, E-selectin, tissue-type plasminogen activator (t-PA), plasminogen activator inhibitor-1 (PAI-1), plasmin-antiplasmin complexes (PAP), tumor necrosis factor-α, interleukin 6, and C-reactive protein were measured. Thromboelastometry was performed. Infusion of defibrotide did not reduce the LPS-induced activation of coagulation, the endothelium or the release of pro-inflammatory cytokines. However, defibrotide increased t-PA antigen levels by 31% (Quartiles: 2–49%, p = 0.026) and PAP concentrations by 13% (−4–41%, p = 0.039), while PAI-1 levels remained unaffected. Moreover, defibrotide reduced C-reactive protein levels by 13% (0–17%, p = 0.002). A transient increase in the clotting time in thromboelastometry and a decrease in F1 + 2 prothrombin fragments suggests modest anticoagulant properties. In conclusion, defibrotide infusion enhanced fibrinolysis and reduced C-reactive protein levels during experimental endotoxemia.

The periodicity of Vostok ice core climate temperature and gas concentration data indicate inherent long term past regularity of Earth’s climate, with a period of around 100,000 years, warming around 15,000 and cooling of around 85,000 years. At this point we are at the top of one of the warming periods. Vostok data cover around 430,000 years, ie 4 climate cycles (warming-cooling), of similar but not quite the same duration. In this paper we perform a detailed time and frequency analysis of these data for each of the cycles as well as their various combinations, including a full tested period of 430,000 years. Time correlation analysis allows for more accurate time lag estimate in each cycle already noted between temperature change and carbon dioxide content. We estimate these lags to lie between 1000-2500 years, longer than previously concluded. On the frequency side we perform Fast Fourier Analysis and identify full spectrum of harmonics for various cycles, and then perform energy analysis to identify which of the harmonics contributes the most. The idea is to reduce the computational load for further modeling and analysis using Kalman Filter based prediction method. Once the prediction model is defined (a follow up paper) data will be split into two segments, Learning and Testing, in preparation of a Machine Learning fine tunning methodology. We can use last three or last two or even just last cycle to learn on, and then the current on going cycle to test on. This will result in real time prediction of relevant climate data. Assuming causal time regularity, more of these cycles are employed in training, more the prediction error for the next cycle should be reduced. Hence it is critical to perform very detailed time and frequency analysis of Vostok data as a solid data base for the prediction model to follow.

A hypothesis that the increasing application of both surface and ground water for irrigation of crops is a significant source of anthropogenic global warming is tested. In climate models, water is already assigned a major secondary amplifying role in warming, solely as a positive feedback from an atmosphere previously warmed by other GHGs. However, this conclusion ignores the direct anthropogenic forcing from increasing use of water in dry regions to grow crops for the human population. The area irrigated worldwide increased by around 1.5% annually between 1960 and 2000, almost trebling in magnitude. Importantly, though only a small proportion of the Earth’s surface, this additional water vapour is dynamically focussed on dry land, intensifying its potential to elevate the troposphere and reduce the regional OLR. Our modelling analysis suggests that the increase in atmospheric water vapour from irrigation could be significantly more than 1% by 2050 compared to 1950, imposing a global forcing exceeding 1.0 W/m2. Fortunately, this hypothesis can be tested, for example, using the satellite data on OLR acquired since the 1970s, relating this to local trends of increasing irrigation or major floods in arid regions. If found consistent with the data, current proposals to mitigate climate change by limiting combustion of fossil fuels may prove less effective. This prediction regarding the warming effect of increasing irrigation is tested using NCAR reanalysis data made possible by the natural experiments of the periodic flooding of Lake Eyre in Australia's semi-arid interior. It is recommended that this hypothesis be tested using data from local studies in irrigated regions such as changes in outgoing longwave radiation and in increased absorption of incoming shortwave radiation in air.

Background: Some of main raisons for the elderly graft occlusion after successful aortal-iliac, aortal Femoral and Femoral Distal Vein Bypass, progression of main disease, continuing bad life Habits and uncontrolled risk factors such are mostly: poor nutrition traditional or fast food, Smocking and Lacks of Walking and Physical Activity Habits. Objective: The primary objective of the study was to estimate influence of Interval Walking Training Program combine with Tribulus Terrestris, 3-5 gram of Taurine and high dose of 1800mg supplementation of ALA on primary potency and vascular treatment. Secondary goals of this study is determinate by establishing better understanding connection between ordinary vascular walking therapy 30-45 min and interval walking program combine with Tribulus Terrestris, Taurine and high dose of and ALA as secondary supplementation after surgical and endovascular treatment. Methodology: The study included 112 patients, at the Clinic of cardiovascular surgery, Clinical Center University of Sarajevo, age between 50 and 75 (50 patients surgical treated with aortic-iliac, aortic-femoral and femoral distal vein bypass with and without Linton-patch/Taylor patch-first group) and (62 endovascular Iliac treated patients (indication TASC II A and B) with and without support Tribulus Terrestris, high dose of ALA and Taurine - second group). Results: Final analysis has reveal the rehabilitation outcome in 83% patients with bypass above the knee was fully rehabilitated compared to 46,6% patients with bypass below the knee was statistically considered significant by using p value less than (p<0,05) In anamnestic history in 83% patient with amputation above the knee was documented the presence of hypertension, hyperlipidemia, nicotinismus and diabetes compared to 66,7% of patients with amputation level below the knee but there was no statistically significant difference (p>0,05). Conclusion: Interval Walking Training Program on Tribulus Terrestris, Taurine and high dose of ALA had a significantly and successfully higher bypass potency and rehabilitation prognosis compare to patients without supplementation and postsurgical physical therapy concept. It is obviously the is certain link between physical activity, life style modification and serum testosterone on primary bypass potency.

Difference between industrial designer and product designer is not precisely defined. There is a lot of discussions and misunderstandings about these two professions. What is the job of industrial designer and what is the job of product designer? This question if often asked from people, which want to hire someone to design a new product for them. Through this research, same real-life design contest is given to group of students from Faculty of Mechanical Engineering, Department of Mechanical Design, at Industrial design course and to group of students from Academy of Fine Arts, Department of Product Design as product design project. Goal of the contest was to design an upholstered chair for indoor use with a modern and refined style. Goal of this research was to find some unique characteristic of designs from industrial designers and product designers. Resulted designs were evaluated analysing the fulfilment of the requirements criteria defined by contest and analysing additional criteria, which is important for new product design. Analysing the resulted designs some important conclusions are made. Most important conclusion is that industrial designer can be product designer but product designer cannot be industrial designer. For product design, engineering knowledge is not necessary, but for industrial design, it is most important.

Druga polovina prošlog vijeka okarakterisana je vrtoglavim razvojem računarskeindustrije koja je ubrzo postala osnovni preduslov razvoja svih sektora privrede.Uzimajući u obzir pomenuto, porasla je i potreba za stručnjacima koji će u segmentuposlovanja biti u stanju povezati tehničke i upravljačke zajednice. Rezultat je biopokretanje studija poslovne informatike, pod tim istim, sličnim ili različitim imenima,najčešće u okviru poslovnih škola kao studij prvog ciklusa. Međutim, razvojem upodručju poslovanja, a pogotovo kompjutinga, u novom mileniju se ovaj studij sve višepojavljuje kao samostalan sa tendencijom da postane ravnopravna organizacijskajedinica unutar hijerarhije univerziteta. Ovaj rad ima za cilj da predstavi teoretskuosnovu kurikuluma i praktičan primjer studija Poslovna informatika koji je rezultatzajedničkog rada Ekonomskog fakulteta i Fakulteta informacijskih tehnologijaUniverziteta „Džemal Bijedić“ u Mostaru.

Ovaj rad istražuje problem malih i srednjih preduzeća (MSP) vezane za pristup izvorima finansiranja uFederaciji Bosne i Hercegovine (FBiH). Fokus istraživanja je na analiziranju potreba MSP za eksternimfinansiranjem, karakteristikama nedavno dobijenih eksternih izvora finansiranja te preprekama zadobijanje finansijskih izvora, kao i da se pomogne u razumijevanju budućih potreba MSP i finansijskeklime. Kako bi se procijenila adekvatnost pristupa finansiranju MSP u FBiH, istraživanje je provedenokorištenjem SAFE metodologije Evropske centralne banke, i to na uzorku MSP u FBiH. Podaci suprikupljeni u 2016. godini, a uzorak je činilo 80 MSP. Adaptirani upitnik za ovo istraživanje kreiran jena način da analizira percepcije MSP u FBiH u pogledu dostupnosti i adekvatnosti finansijskihproizvoda/usluga, koje nude banke i druge finansijske institucije. Očekuje se da će istraživanje pružitiinformacije o identifikaciji problema iz perspektive MSP prilikom traženja eksternih finansijskih izvorai može se koristiti kao smjernica za poboljšanje postojećeg institucionalnog okvira u FBiH radi boljegpristupa finansijama za MSP.

Abstract Background and aims Wastewater‐based epidemiology is an additional indicator of drug use that is gaining reliability to complement the current established panel of indicators. The aims of this study were to: (i) assess spatial and temporal trends of population‐normalized mass loads of benzoylecgonine, amphetamine, methamphetamine and 3,4‐methylenedioxymethamphetamine (MDMA) in raw wastewater over 7 years (2011–17); (ii) address overall drug use by estimating the average number of combined doses consumed per day in each city; and (iii) compare these with existing prevalence and seizure data. Design Analysis of daily raw wastewater composite samples collected over 1 week per year from 2011 to 2017. Setting and Participants Catchment areas of 143 wastewater treatment plants in 120 cities in 37 countries. Measurements Parent substances (amphetamine, methamphetamine and MDMA) and the metabolites of cocaine (benzoylecgonine) and of Δ9‐tetrahydrocannabinol (11‐nor‐9‐carboxy‐Δ9‐tetrahydrocannabinol) were measured in wastewater using liquid chromatography–tandem mass spectrometry. Daily mass loads (mg/day) were normalized to catchment population (mg/1000 people/day) and converted to the number of combined doses consumed per day. Spatial differences were assessed world‐wide, and temporal trends were discerned at European level by comparing 2011–13 drug loads versus 2014–17 loads. Findings Benzoylecgonine was the stimulant metabolite detected at higher loads in southern and western Europe, and amphetamine, MDMA and methamphetamine in East and North–Central Europe. In other continents, methamphetamine showed the highest levels in the United States and Australia and benzoylecgonine in South America. During the reporting period, benzoylecgonine loads increased in general across Europe, amphetamine and methamphetamine levels fluctuated and MDMA underwent an intermittent upsurge. Conclusions The analysis of wastewater to quantify drug loads provides near real‐time drug use estimates that globally correspond to prevalence and seizure data.