Rolf Hansen (1931-1993) was one of pioneers of Medical informatics. He was an organized and pragmatic medical IT scientist who developed respected and pioneering health information systems at the Norwegian Institute of Public Health, Oslo, Norway (1-4).

Abstract This study offers the first report on variation sequence of the mitochondrial cytochrome b (MT-CYTB) gene in populations from Bosnia (northeastern Bosnia). This study was designed on the analysis of the genetic diversity of two populations of different cultural-anthropological and genetic origin, Roma population and native/non-Roma population. The main aim of our study was to estimate the usefulness of the CYTB sequence in the analysis of genetic categorization of different populations and intergroup diversity, as well as to provide some additional information on haplogroup-associated polymorphisms within the CYTB region in defining haplogroup status. Estimation of the genetic diversity was done using intra and intergroup genetic indices. The population-specific polymorphisms have been found in both categories of the populations. The results of the analysis of genetic differentiation show significant pairwise Fst differences between the Romani and native populations. Also, registered significant genetic differentiation is illustrated on the level of genetic variation between subpopulations of the Roma and non-Roma origin. The important result in our study is the confirmation of the significance of the triad of polymorphisms T14783C-G15043A-G15301A, indicating the influence of Asian component of the maternal gene pool on the genetic structure of the studied population of the Roma. Our data show that the haplogroup polymorphisms exist in the CYTB region and can provide useful information on the haplogroups that were defined only by the control region of the mtDNA. The results of this study indicate the region of CYTB gene can be a benefit in providing some additional information in the analysis of genetic structure of human populations and can be additionally applied in population studies.

Introduction: Beneficial effect of local administration of lysozyme in patients with recurrent aphthous stomatitis was demonstrated, but there are no published studies focused on treatment of chemotherapy or radiotherapy induced oral mucositis with lysozyme. Aim: The aim of this study was to compare efficacy and safety of Lysobact Complete spray (lysozyme, cetylpyridinium, and lidocaine) and compounded medication for local use in the treatment of radio- and chemo-therapy induced oral mucositis. Patients and Methods: This observational, phase IV study was designed as prospective cohort investigation, and conducted at two sites, Clinical Hospital Zenica and University Clinical Center Tuzla, Bosnia & Herzegovina, from August to November, 2018. The patients with oral mucositis after radio- or chemo-therapy were treated by either registered lysozyme-based or compounded medication (standardized and bicarbonate-based) for 21 days. Results: Both lysozyme-based (Lysobact Complete Spray) spray (lysozyme, cetylpyridinium and lidocaine) and compounded medication for local use were effective in local treatment of chemotherapy and radiotherapy-induced oral mucositis. However, lysozyme-based preparation was more effective, since signs of inflammation, number of oral ulcers and intensity of pain during eating and speaking withdrew to a greater extent than with highly variable compounded medication for local use. No adverse events were recorded in both treatment arms. Conclusions: Locally administered spray with fixed combination of lysozyme, cetylpyridinium and lidocaine (Lysobact Complete Spray) is very efficient and completely safe treatment of both radiotherapy and chemotherapy-induced oral mucositis.

Abstract The economic authorities of each country seek to maintain the expansion phase through the implementation of various economic policy measures, namely, to prevent or mitigate the recessionary phase in economic development. In that context, it is of considerable importance to understand how monetary policy decisions affect the movement of macroeconomic variables. The paper aims to examine and evaluate the contribution of monetary policy to mitigating the effects of the global economic and financial crisis, using the Autoregressive Distributed Lag model, by analysing the impact of the real exchange rate, reference interest rate and money supply on the level of economic activity in Poland. Econometric analysis encompasses the period from 2006 to 2017. The research results suggest that there is a significant relationship between real economic activity and the real exchange rate both in the short and long term, but not between the reference interest rate and the money supply.

Introduction: Genital warts are a frequent form of sexually transmitted disease. Cryotherapy represents the first line of therapy. Healing occurs in 94%, and recurrence in 10% . Side effects are common during the treatment. Aim: The aim of this study is to determine the successfulness of cryotherapy of genital warts, frequency of recurrence, and side effects. Patients and methods: In a retrospective study, data from 50 women with genital warts who were treated in the Gynecological Centre “Dr Mahira Jahić” in Tuzla in a period from 2012–2018 were analyzed. Every woman was treated with cryotherapy. Treatments were repeated every 7 days, maximal number of treatments being 7. In processing of data, X2statistical method was used. Results: 50% (N-25) of genital warts eliminated after 3 treatments with cryotherapy . Genital warts are eliminated in 78% (N-39) of women, while this treatment was unsuccessful in 18% (N-9). Recurrence after 3 months in 4% (N-2). Most common side effect was exudation in 78% (N-39), swelling in 72% (N-36) and pain in 66% (N-33). PAP smears in women with genital warts in 64% (N-34) of cases were inflammatory benign changes, while in 36% (N-18) mild abnormal changes in cells ASCUS and LSIL were found. LSIL lesions of cervix are more common (p<0,01) in women with genital warts of vulva. Conclusion: Cryotherapy is a method with a high success rate in healing of genital warts, and it decreases the concentration of HPV virus and removes the trigger that allows the development of cancer.

This review considers the unique characteristics of Chinese cattle and intramuscular fat content (IMF) as factors influencing meat quality, including tenderness, flavor, and juiciness of meat. Due to its nutritional qualities, meat contributes to a healthy and balanced diet. The intramuscular fat content and eating quality of beef are influenced by many factors, which can generally be divided into on-farm and pre-slaughter factors (breed, sex of cattle, age at slaughter, housing system, diet, and pre-slaughter handling) and postmortem factors (post-slaughter processing, chilling temperature, and packaging). Meat quality traits can also be influenced by the individual genetic background of the animal. Worldwide, the function of genes and genetic polymorphisms that have potential effects on fattening of cattle and beef quality have been investigated. The use of DNA markers is recognized as a powerful and efficient approach to achieve genetic gain for desirable phenotypic characteristics, which is helpful for economic growth. The polymorphisms of the SIRT4, SIRT6, SIRT7, CRTC3, ABHD5, KLF6, H-FABP, and ELOVL6 genes for body and growth characteristics of cattle, and also for beef quality, are considered with the aim of highlighting the significance of beef intramuscular fat content, and that growth, body, and meat quality characteristics are polygenically regulated.

SUMMARY This study aimed to investigate whether infertility and its treatment affect couple sexuality. A systematic literature review was performed, focusing on female and male sexual dysfunctions due to infertility. The method was descriptive, using a meta-synthesis of scientific research published between 2012 and 2017 in the English language. The search for suitable studies was carried out with the research databases Medline, CINAHL, PubMed and ScienceDirect using the following keywords: infertility, sexual dysfunctions, couple. It can be concluded that infertility negatively affects the sexuality of an infertile couple, which is further proven by a high percentage of sexual dysfunctions (43%-90% among women and 48%-58% among men). Couples report less satisfaction with sexuality. Since lower satisfaction and dysfunctions are closely connected with infertility and its treatment, couples might benefit from sexual therapy and support during the process of infertility treatment. Further research should focus on the evaluation of different psychological interventions that would address sexuality in couples when diagnosed and treated for infertility.

New technologies introduce more services which will call for significant advances and changes in Multiprotocol Label Switching (MPLS) networks. Networks will have to go in the direction of network programmability, virtualization and cloud-based services. In this paper, we examined Software Defined Wide Area Network solution, its architecture and benefits of use. In order to analyze benefits of using SD-WAN two scenarios are compared: (i) Policy-based routing on WAN links in classical IP/MPLS network, and (ii) Using SDN controller to manage traffic on WAN links. Aim in both scenarios is to use the most optimal path for specific network.

The aim of this research is to create fully functional environment for real-life testing of various algorithms in mobile robotic. Main advantage, beside low-cost, is dealing with challenges of real-life implementation. Unlike simulation environments (e.g. MathLab), this setting will allow researchers to test their path planning, collision detection and other algorithms with real challenges, real robots and real static and dynamic obstacles. Environment is particularly adapted for swarm robotics and any other mobile robotics including 2D and 3D scenarios. Enabling researches to prove their algorithms in this environment allows significantly faster path to real implementation in industry, military and science. Concept is based on OpenCV library and low-cost hardware. Solution is based on visual positioning and motion vector detection. System allows controlling mobile robots via radio communication with the range up to 100m which allows practical application of the system. This research paper should be considered as a part of series of research papers published earlier.

The process of beer brewing is very complex as it has to fulfill strict demands on the product quality as well as on the availability and the performance of the plant. As a consequence, a condition monitoring of the beer brewing process and its visualization plays an important role such that all relevant deviations are detected as early as possible by the production manager. While a general process for condition monitoring already exists, there currently exists no approach to realize this process for the domain of beer brewing.Therefore, this paper presents a condition monitoring system for the beer brewing process developed in an industrial project. This condition monitoring system is based on Key Performance Indicators (KPIs) that support the production manager in evaluating the actual state of the production processes. A set of brewery-specific KPIs are determined and discussed in the paper. In addition, software architecture and visualization of the KPIs in a brewery-specific dashboard are presented. We evaluate our concept at various beer breweries and report about lessons that we have learned.

Condition monitoring enables companies from all industrial branches to maintain high availability of their automation systems. Thus, condition monitoring is a fundamental technology to maximize operational productivity by predicting potential fault occurrences that lead to unavailability of the automation systems. Today, performing condition monitoring is successfully achieved using custom-developed software solutions. However, the development of these software solutions is a challenging task as it requires extensive knowledge from multiple engineering disciplines. In this context, there is a high need for a systematic way to formalize this knowledge. Ontologies have had significant success in fulfilling this need by providing a formal model of domain concepts and their relations.In this paper, we present our condition monitoring ontology for automation systems and contribute with a conceptual model. This ontology incorporates ISO standards for condition monitoring and key performance indicators (KPIs). KPIs aggregate numerous sensor values in a few understandable numbers and, therefore, provide more efficient insight in condition of automation systems. To evaluate our work, we developed a condition monitoring knowledge-based system for a centrifugal separator based on the proposed ontology in an industrial project and report about lessons learned.