Objectives: The global burden of the current severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causing the corona virus disease-19 (COVID-19) is enormous No definitive treatment and prophylactic guidelines for COVID-19 currently exist except for physical distancing and aerial barriers between individuals This work explored the natural compound-binding efficiency of SARS-CoV-2 proteins essential for host cell interaction and infection Methods: The binding activity of artemisinin to SARS-CoV-2 spike glycoprotein (Protein Data Bank (PDB) ID: 6VYB), SARS-CoV-2 main protease (3C-like main protease (3CLpro);PDB ID: 6Y84) and SARS-CoV-2 papain-like protease (PLpro;PDB ID: 6W9C), were tested using in silico methods Moreover, chloroquine and hesperidin were used as the positive control of binding affinity and proven therapeutic effect, respectively Results: The highest affinities for binding to all tested SARS-CoV-2 proteins are observed for hesperidin (-5 8,-10 0, and -8 1 kcal/mol), then for artemisinin (-4 8,-8 3, and -6 0 kcal/mol), and the lowest for chloroquine (-4 1,-8 2, and -4 8 kcal/mol) Artemisinin, hesperidin, and chloroquine had similar positioning toward targeted proteins at specific sites when these interactions were visualized Conclusion: This study shows that artemisinin has the potential to bind and inhibit the SARS-CoV-2 spike protein, the 3CLpro main protease, and PLpro proteinase similar to hesperidin and chloroquine that have been proven as antivirals in previous preclinical and clinical studies

Background/Aim: Pulmonary embolism (PE) is a diagnostic challenge, particularly in prehospital care. The aim of this study was to determine to what extent the evaluation of D-dimer value helps physicians with differentiation of PE and whether D-dimer values are in correlation with the values of revised Geneva score. Methods: Data have been collected for the patients whose D-dimer has been evaluated at the Emergency Care Department of the City of Banja Luka in 2018. Gender, age, symptoms, working diagnosis and D-dimer value have all been recorded and also the fact whether the patient was referred to hospital treatment or not. For each patient the revised Geneva score was determined. Results: Sixty-eight tests were done in 2018. Out of 68 tests, 41 were negative (60.3 %). D-dimer results helped in making decisions about referring patients to the hospital or not (ch2 = 36.32, p < 0.001). Patients with elevated D-dimer levels, especially where the values were four times higher than the reference ones typically were referred to hospital treatment, whereas 67.5% patients with negative D-dimer results were sent home after giving a treatment and advice. In the elderly patients D-dimer was statistically more positive (F = 10.82, p < 0.001). Values of D-dimer were not significantly different regarding gender (ch2 = 2.19, p = 0.33). According to the results of the revised Geneva score, 5.1 % of patients had high risk of PTE, while moderate and low risk had 47.5 % each. Although it has been found that the values of D-dimer were slightly more elevated at higher values of the revised Geneva score and that the difference was not statistically significant (ch2 = 7.71, p = 0.10). Conclusion: Values of D-dimer considerably helped in differentiation of PE in the Emergency Care Department. D-dimer has a high negative predictive value and should be used to exclude PE diagnosis for patients with low clinical probability of PE.

In diagnosing COVID-19, false negative findings from the biological sample taken from a mucosal swab of the upper respiratory tract and tested with the real-time reverse-transcription polymerase chain reaction (RT-PCR) technique have been reported. This patient has had a proven contact with an infected person, clear symptoms of viral respiratory disease, yet negative test results on the fifth day of self-isolation. On repeated test after 48 hours, on the 7th day of isolation, due to persistence of some symptoms, he tested positive for SARS-CoV-2. The existence of symptoms and characteristic sings after laboratory and radiological analysis of the patient prompted the repetition of the tests, which at the end led to the confirmed diagnosis and the possibility for adequate treatment of the patient as well.

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This article should be cited as follows: Igić R. Pharmacologist's view of the new corona virus. Scr Med 2020;51(1):6-8. Despite many advances in the prevention and treatment of infectious diseases, the global spread of infections is accelerated by close contact among concentrated populations. A pandemic caused by a new type of coronavirus (SARS-CoV-2) continues to spread across the globe. This new disease attributed to COVID-19 emerged a century after the Spanish flu pandemic, which affected one-third of the world's population, killing more than 50 million people.1 The disease, caused by the H1N1 virus, has been around for less than two years and it is still unclear what contributed to its termination; possibly a mutation of the virus reduced its viral strength. Since information about biological sciences and human medicine is far more advanced today than at the beginning of the 20th century, it is expected that the current pandemic will be contained, regardless of the potential for viral mutation. Scientists and doctors now face an urgent task how to treat numerous sick people and stop the spread of this infection. The pandemic urgently requires identification of preventive measures, along with optimum means of diagnosis and treatment and data on dissemination of the infection, duration of incubation, clinical features of the disease, along with the best means of diagnosis and treatment for a very large number of people, and ultimately the long lasting consequences of the disease. In addition, we must identify pathways for the spread of the virus, its persistence on various surfaces and means of its inactivation.2

The aim of the work was to carry out a modal analysis of a multiple structure. Own forms of oscillation of the structure for five tones were obtained through the vector iteration process and were presented in table and graphic form. Using the different methods (Time history, SRSS and CQC), a calculation of the displacements was performed. Theoretically, all three methods are described and the results of the calculation for each of them are obtained. A comparison of the results, for the three methods in a given time interval, is graphically shown. Also, the results are compared which are all the same in all three methods. The modal seismic analysis of Spectral Theory was also performed. It can be concluded that by comparing the method of Time history and Spectral theory their results correspond to the maximum modal displacement.

The position of regional geography in the system of geographical sciences is a topic that has been the subject of intense epistemologically and methodologically focused discussion within scientific realm at the global level since the middle of the 20th century. The initial outcome of these processes at the academic level was the marginalization of regional geography in the study of spatial phenomena, but since then there was a partial revitalization of the regional approach. In view of these changes, the place of regional geography within geographical education also began to be problematized. In this paper, it is conducted a critical review of selected academic articles from the last few decades that at least in a certain segment touch on this topic, as well as analysis of recent trends in school geography. This analysis suggests that it is difficult to find an adequate replacement for regional content, especially in the geographical education at lower levels of education, and that in many countries it still represents the basis or at least an important part of the geographical curriculum. However, at the same time, the need for change of teaching approach based on the excessive so-called regional inventory of space, by introducing general geographical concepts in the study of regional units of various levels, and putting them in the service of the development of critical thinking in students.

The main urgent problem of humanity is related to clean water availability. Shortage of drinking water in most parts of the world has been a growing concern in recent times. This chapter will consider emerging contaminants present in the aquatic environment. The commonly present concentrations are in the range from mg/L to ng/L in wastewater, surface water, ground water, and drinking water. The challenges in wastewater and drinking water purification are dependent on the origin of the water. Solar photocatalysis is a new promising technology for the water purification. With solar, photocatalysis is possible to reduce organic contaminants present in water by using the sunlight. This chapter addresses the fundamental reaction mechanism, different type of photocatalytic nanomaterials based on TiO2, and recent developments in the reactor design for solar photocatalytic water purification from lab scale-up to large-scale application.

The interaction between geogrid/wire fabric reinforcement and fill material in reinforced earth walls, as well as its quantification, is a complex problem that depends on a number of factors. This paper presents and discusses state of the art related to numerical simulations of pull-out tests used for investigation of interaction between cohesionless fill and reinforcement. In addition, the results of a specially designed group of numerical simulations are presented and compared with recommendations of American and European standards related to such experiments.