BACKGROUND European Action on Secondary and Primary Prevention by Intervention to Reduce Events (EUROASPIRE) V in primary care was carried out by the European Society of Cardiology EURObservational Research Programme in 2016-2018. The main objective was to determine whether the 2016 Joint European Societies' guidelines on cardiovascular disease prevention in people at high cardiovascular risk have been implemented in clinical practice. METHODS The method used was a cross-sectional survey in 78 centres from 16 European countries. Patients without a history of atherosclerotic cardiovascular disease either started on blood pressure and/or lipid and/or glucose lowering treatments were identified and interviewed ≥ 6 months after the start of medication. RESULTS A total of 3562 medical records were reviewed and 2759 patients (57.6% women; mean age 59.0 ± 11.6 years) interviewed (interview rate 70.0%). The risk factor control was poor with 18.1% of patients being smokers, 43.5% obese (body mass index ≥30 kg/m2) and 63.8% centrally obese (waist circumference ≥88 cm for women, ≥102 cm for men). Of patients on blood pressure lowering medication 47.0% reached the target of <140/90 mm Hg (<140/85 mm Hg in people with diabetes). Among treated dyslipidaemic patients only 46.9% attained low density lipoprotein-cholesterol target of <2.6 mmol/l. Among people treated for type 2 diabetes mellitus, 65.2% achieved the HbA1c target of <7.0%. CONCLUSION The primary care arm of the EUROASPIRE V survey revealed that large proportions of people at high cardiovascular disease risk have unhealthy lifestyles and inadequate control of blood pressure, lipids and diabetes. Thus, the potential to reduce the risk of future cardiovascular disease throughout Europe by improved preventive cardiology programmes is substantial.

Son yillarda ilac yeniden konumlandirma calismalarinin hiz kazanmasi ile ozellikle zararsiz oldugu kanitlanmis, farmakokinetik ve optimal dozu iyi bilinen ilaclar farkli endikasyonlarda kullanilmak uzere yeniden arastirmalara tabi tutulmaktadir. Gunumuzde pandemiye neden olan SARS-CoV-2'ye karsi ozellikle klinik olarak etkinligi kanitlanmis tedavi ya da asi henuz bulunmamistir. COVID-19 hastaliginin tedavisinde klorokin ve hidroksiklorokinin tedavi potansiyeli buyuk olcude dikkat cekmistir. Bu derlemede COVID-19'un tedavisi ile yeniden gundeme gelen eski bir ilac olan klorokin/hidroksiklorokinin farmakokinetik, farmakodinamik ozellikleri, ozel populasyonlardaki kullanimi ve guvenligi ile ilgili mevcut veriler incelenmis ve literaturdeki guncel arastirmalar dogrultusunda SARS-CoV-2 enfeksiyonundaki etkinlik ve guvenligine iliskin veriler sunulmaktadir. Klorokin/Hidroksiklorokinin COVID-19 hastaliginin tedavi algoritmalarinda ilk sirada yer almasi ile birlikte daha fazla randomize kontrollu klinik calismanin da gerekli oldugu gorulmektedir.

Including biodiversity assessments in forest management planning is becoming increasingly important due to the importance of biodiversity for forest ecosystem resilience provision and sustainable functioning. Here we investigated the potential to include biodiversity indicators into forest management planning in Europe. In particular, we aimed to (i) identify biodiversity indicators and data collection methods for biodiversity assessments at the stand and landscape levels, and (ii) evaluate the practicality of those indicators for forest management planning. We performed a literature review in which we screened 188 research studies published between 1990 and 2020. We selected 94 studies that fulfilled the inclusion criteria and examined in more detail. We considered three aspects of biodiversity: structure, composition, and function, and four forest management categories: unmanaged, managed, plantation, and silvopastoral. We used three criteria to evaluate the practicality of forest biodiversity indicators: cost-effectiveness, ease of application, and time-effectiveness. We identified differences in the practicality of biodiversity indicators for their incorporation into management plans. Stand-level indicators are more practical than landscape-level indicators. Moreover, structural biodiversity indicators (e.g., large trees, canopy openness, and old forest stands) are more useful in management plans than compositional indicators, as these are easily observable by non-professionals and can be obtained by forest inventories. Compositional indicators such are vascular plants, fungi, bryophyte, lichens, and invertebrate species are hard to identify by non-professionals and thus are impractical. Functional indicators (e.g., nutrient cycling) are not sufficiently addressed in the literature. Using recently updated existing databases (e.g., national forest inventories and bird atlases) is very time and cost-efficient. Remote sensing and other technology (e.g., smartphone applications) are promising for efficient data collection in the future. However, more research is needed to make these tools more accurate and applicable to a variety of ecological conditions and scales. Until then, forest stand structural variables derived from inventories can help improve management plans to prepare European forests towards an uncertain future.

U prvom delu rada se razmatraju teorijska stanovišta faza životnog ciklusa projekta. Pojasniće se sve što te faze obuhvataju i objasniti neke od metoda i tehnika koje se koriste radi lakšeg upravljanja projektom. U drugom delu se na primeru Projekta sanacije i adaptacije objekta KBC “Dr Dragiša Mišović” u Beogradu prikazuju faze životnog ciklusa sa stanovišta izvođača radova, od iniciranja projekta i ciljeva koji će se ostvariti, detaljnog planiranja kako će se ostvariti, realizacije projekta, te nadzora i kontrolisanja u svim fazama projekta.

Hyperkalemic periodic paralysis (hyperkalemic PP) is a rare muscle disease that has onset in infancy or early childhood and is manifested by transient episodes of paralysis. In this case we presented a young male adult with attacks of weakness, after commencement of the antiepileptic drug - Carbamazepine. We hypothesize that Carbamazepine, as voltage-gate sodium channel blocker, aggravated the symptoms of hyperkalemic PP, as sodium channelopathies, in this young-male-patient, trough influence on membrane depolarization.

Daily rhythms are disrupted in patients suffering from mood disorders. The lateral habenula (LHb) and dorsal raphe nucleus (DRN) contribute to circadian timekeeping and regulate mood. Thus, pathophysiology in these nuclei may be responsible for aberrations in daily rhythms during mood disorders. Using the chronic social defeat stress (CSDS) paradigm and in-vitro slice electrophysiology we measured the effects of stress on diurnal rhythms in firing of LHb cells projecting to the DRN (cellsLHb→DRN) and DRN cells alone. We also performed optogenetic experiments to investigate if increased firing in cellsLHb→DRN during exposure to subthreshold social defeat stress (SSDS), induces stress-susceptibility. Last we investigated whether exposure to CSDS affected the ability of mice to phototentrain to a new LD cycle. The cellsLHb→DRN and DRN cells alone of stress-susceptible mice express greater blunted diurnal firing compared to stress-naive (control) and stress-resilient mice. Day-time optogenetic activation of cellsLHb→DRN during SSDS induces stress-susceptibility which shows the direct correlation between increased activity in this circuit and putative mood disorders. Finally, we found that stress-susceptible mice are slower, while stress-resilient mice are faster, at photoentraining to a new LD cycle. Our findings suggest that CSDS induces blunted daily rhythms in firing in cellsLHb→DRN and slow rate of photoentrainment in susceptible-mice. In contrast, resilientmice may undergo homeostatic adaptations that maintain daily rhythms in firing in cellsLHb→DRN and also show rapid photoentrainment to a new LD-cycle.

This study proposes a technique for the enhancement of the stability of microgrids during unsymmetrical temporary faults in the distribution network. In order to enhance the transient stability and the quality of voltage in the microgrid during different disturbances caused by faults in the distribution network, this study proposes a concept with a centralised battery energy storage system. The battery is connected to the network through single-phase converter units which are to be implemented in every phase so that they can inject independently both the active and reactive power in certain phases. The proposed technique enhances the transient stability of microgrids and provides symmetrical operating conditions for consumers and generators in it during all temporary symmetrical and unsymmetrical faults in the distribution network. An innovative concept has been proposed for managing the balance of active and reactive power that uses, as control variables, magnitude and voltage phase angle at the point of connection of the microgrid to the distribution system. The proposed concept and technique have been tested on the IEEE 33 BUS system with additional sources. The dynamic simulations of disturbances and the verification of the proposed technique have been performed in DIgSILENT PowerFactory software.

The purpose of this paper is two-sided. First, we obtain the correct estimate of the error term in the classical prime geodesic theorem for compact symmetric space SL4. As it turns out, the corrected error term depends on the degree of a certain polynomial appearing in the functional equation of the attached zeta function. This is in line with the known result in the case of compact Riemann surface, or more generally, with the corresponding result in the case of compact locally symmetric spaces of real rank one. Second, we derive a weighted form of the theorem. In particular, we prove that the aforementioned error term can be significantly improved when the classical approach is replaced by its higher level analogue.

Our object of research are certain higher order counting functions of Chebyshev type, associated to the compact symmetric space SL4. In particular, we consider the functionψ1(x)resp.ψ3(x), of order1resp.3.As it is well known, any such function can be represented as a sum of some explicit part, and the corresponding error term. The explicit part is usually indexed over singularities of the attached Selberg zeta functions, while the error term depends on the dimension of the underlying symmetric space. Thus, these functions generalize the classical yes functionπ(x)counting prime geodesics of appropriate length. More precisely, the Chebyshev functions divided by adequate power of x, represent quite natural approximations for the functionπ(x). In this research, we are particularly interested in the error terms ofψ1(x)/xandψ3(x)/x3.

Significant investments to upgrade and construct large-scale scientific facilities demand commensurate investments in R&D to design algorithms and computing approaches to enable scientific and engineering breakthroughs in the big data era. Innovative Artificial Intelligence (AI) applications have powered transformational solutions for big data challenges in industry and technology that now drive a multi-billion dollar industry, and which play an ever increasing role shaping human social patterns. As AI continues to evolve into a computing paradigm endowed with statistical and mathematical rigor, it has become apparent that single-GPU solutions for training, validation, and testing are no longer sufficient for computational grand challenges brought about by scientific facilities that produce data at a rate and volume that outstrip the computing capabilities of available cyberinfrastructure platforms. This realization has been driving the confluence of AI and high performance computing (HPC) to reduce time-to-insight, and to enable a systematic study of domain-inspired AI architectures and optimization schemes to enable data-driven discovery. In this article we present a summary of recent developments in this field, and describe specific advances that authors in this article are spearheading to accelerate and streamline the use of HPC platforms to design and apply accelerated AI algorithms in academia and industry.

ABSTRACT We recently performed two studies exploring the presence of Epstein–Barr virus (EBV) and high-risk human papillomaviruses (HPVs) types 16, 18, 31, 33 and 35 in human colorectal cancers from the Syrian population. Herein, we report that EBV and high-risk HPVs are co-present in colorectal cancers from Syria. We reveal that 17 (~17%) of 102 cancer samples are positive for both EBV and high-risk HPVs and their co-presence is associated with high/intermediate grade invasive carcinomas. These data suggest that EBV and high-risk HPVs are co-present in human colorectal cancers where they might cooperate on the initiation and/or progression of these cancers. Thus, we believe that future studies are necessary to confirm the co-presence of these oncoviruses and their cooperative role in human colorectal carcinogenesis.

The percolation properties in anisotropic irreversible deposition of extended objects are studied by Monte Carlo simulations on a triangular lattice. Depositing objects of various shapes and sizes are made by directed self-avoiding walks on the lattice. Anisotropy is introduced by imposing unequal probabilities for placing the objects along different directions of the lattice. The degree of the anisotropy is characterized by the order parameter p  determining the probability for deposition in the chosen (horizontal) direction. For each of the other two directions adsorption occurs with probability . It is found that the percolation threshold increases with the degree of anisotropy, having the maximum values for fully oriented objects. Percolation properties of the elongated shapes, such as k-mers, are more affected by the presence of anisotropy than the compact ones. Percolation in anisotropic deposition was also studied for a lattice with point-like defects. For elongated shapes a slight decrease of the percolation threshold with the impurity concentration d can be observed. However, for these shapes, significantly increases with the degree of anisotropy. In the case when depositing objects are triangles, results are qualitatively different. The percolation threshold decreases with d, but is not affected by the presence of anisotropy.