In the past decades, insulation materials such as petrochemical and inorganic have been used for building insulation. The production of these insulation materials consumes a large amount of energy, which has a significant effect on the environment throughout the life cycle. Comparative performance analyses of renewable (natural) insulation materials for building application in terms of their impact on the environment, the useful lifetime, cost, insulation performance, thermal diffusivity water vapor resistance and flammability were analyzed using statistical tools. It was found that renewable insulating materials have competitive performances with traditional nonrenewable materials in terms of heat insulation performances, fire resistance and cost. Also it was found that renewable materials have significantly better performances such as less impact to the global warming, longer useful lifetime, and lower thermal diffusivity.

Software Defined Networking (SDN) is a promising solution because of many advantages over the traditional network. Due to these advantages, SDN can be considered as a tool for energy efficiency in ICT (Information and Communication Technology) networks. In this paper, we have made a comparison between energy consumption in real IP/MPLS (Internet Protocol/Multi-Protocol Label Switching) network and designed SDN network. The results show that a significant reduction of energy consumption is achieved for a scenario with designed SDN solution.

Aim To determine risk factors for deep vein thrombosis (DVT) in hospitalized patients in a 10-year follow-up. Methods In this observational study data were collected from the disease history of patients admitted to the Department of Angiology of the Clinical Centre University of Sarajevo in the period of 10 years (2008-2017). Of 6246 hospitalized patients, 1154 were with established diagnosis of DVT and included in the study as a basic inclusion criterion. Results Provoked venous thromboembolism was recorded in 45.75% of hospitalized patients. In 54.25% cases DVT was classified as idiopathic; in the remaining cases with DVT external risk factors were identified. Every fourth patient had a history of malignancy, and this risk factor was significantly more common among women and younger patients. Cancer of female reproductive organs, colon, lung, breast and prostate cancer were most common. One of 10 women had DVT during pregnancy or postpartum period. Out of the total number, 10.9% patients had DVT after surgery, 2.3% after injury. DVT was found in 1.6% of drug addicts. Rethrombosis was diagnosed in 5.2% patients within a year, while 9.2 % patients had rethrombosis within five years. Conclusion Provoked venous thromboembolism is an entity that can be prevented. Malignancy and surgical treatment are the most common risk factors and these patients should be treated with special care. The creation of a register of patients with venous thromboembolism in Bosnia and Herzegovina would enable the development of a preventive strategy in the groups of patients at risk.

Modulation signal classification (MSC) is an indispensable technique to make the possible applications of non-cooperative communications. Currently, convolutional neural network (CNN) based MSC techniques can achieve an outstanding performance at a fixed noise regime. However, they are hard to generalize to all of noise scenarios. Because these conventional methods are trained on specific signal samples with fixed SNR and they only perform well under corresponding noise condition. Unlike the conventional methods, in this paper, we propose a robust CNN based generalized MSC (GMSC) method with powerful generality capability. This capability stems from the mixed dataset, containing in-phase and quadrature (IQ) samples under various SNR regimes. Experimental results show that the proposed method is robust under varying noise conditions, while merely losing a slight performance with comparing with conventional methods.

Introduction: Laparoscopic cholecystectomy is now considered the procedure of choice that achieves a shorter recovery period after the surgery and reduction in the cost of treatment. Aim: The aim of the study is to prove which method: early or delayed laparoscopic cholecystectomy is the method of choice in the treatment of acute cholecystitis by examining: duration of hospitalization, conversion rate, duration of surgery, postoperative complications, and total cost. Methods: The study was conducted at the University Clinical Center of Republika Srpska as a retrospective-prospective study from May 1st 2013 until December 31st 2019. Patients diagnosed with acute cholecystitis were divided into two groups: Patients designated for early laparoscopic cholecystectomy within 72 hours of admission (group A–42 patients), Patients designated for initial conservative treatment followed by a delayed interval of 6-12 weeks until surgery (group B-42 patients). Results: In both groups, there were statistically significantly more female respondents. The results showed that the average cost of treatment in the early treated group was statistically significantly lower than the cost of treatment in the delayed treatment group. The patients in the early group had shorter hospitalization times (an average of 2.8 days and 5.6 days in the delayed group of patients), a smaller percentage of conversions (4.8% in the early and 16.7 in the delayed group of patients), the total cost of in the early group it was 1300.83 KM, while in the delayed group it was 1645.43 KM. Conclusion: Early laparoscopic cholecystectomy is a method to be preferred in surgical treatment.

Committee of Publishing Ethics (COPE) announced great problem with retraction of the papers published in journals which are cited in Web of Science data base, before and after retractions from the journals were papers published, because of unethical behaviours of the authors - https://retractionwatch.com/the-retraction-watch-leaderboard/top-10-most-highly-cited-retracted-papers/ (1).

Síndrome de Down é uma limitação que impõe múltiplos desafios não apenas para a criança mas também a todos os seus familiares. A síndrome de Down ocorre por conta de uma desordem cromossômica, que resulta na trissomia do cromossomo 21, tendo como fator de risco predominante a idade materna avançada, geralmente, acima de 35 anos. A educação destas crianças passou a ser obrigatória a partir da LDB 9.393/96, no qual garante a todos o direito a educação na escola regular de ensino. Porém, embora seja muito discutida, nota-se que ainda há dificuldades para a inclusão destes alunos, seja pelo despreparo dos professores ou pela falta de estrutura da escola. Por conta de sua dificuldade intelectual o processo de alfabetização e desenvolvimento torna-se comprometido dificultando a concentração e com isso o processo é mais demorado. Por isso é preciso que o professor tenha melhor preparo para integrar e auxiliar as crianças com Down na escola. Para que haja de fato uma aprendizagem satisfatória é essencial que o profissional conheça os métodos que contribuirão para que o aluno se adapte e adquira conhecimento, tornando indispensável a discussão a respeito da temática. A partir de uma pesquisa bibliográfica será analisado como ocorre o processo de aprendizagem destes alunos.

A key mutational process in cancer is structural variation, in which rearrangements delete, amplify or reorder genomic segments that range in size from kilobases to whole chromosomes1–7. Here we develop methods to group, classify and describe somatic structural variants, using data from the Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium of the International Cancer Genome Consortium (ICGC) and The Cancer Genome Atlas (TCGA), which aggregated whole-genome sequencing data from 2,658 cancers across 38 tumour types8. Sixteen signatures of structural variation emerged. Deletions have a multimodal size distribution, assort unevenly across tumour types and patients, are enriched in late-replicating regions and correlate with inversions. Tandem duplications also have a multimodal size distribution, but are enriched in early-replicating regions—as are unbalanced translocations. Replication-based mechanisms of rearrangement generate varied chromosomal structures with low-level copy-number gains and frequent inverted rearrangements. One prominent structure consists of 2–7 templates copied from distinct regions of the genome strung together within one locus. Such cycles of templated insertions correlate with tandem duplications, and—in liver cancer—frequently activate the telomerase gene TERT. A wide variety of rearrangement processes are active in cancer, which generate complex configurations of the genome upon which selection can act. Whole-genome sequencing data from more than 2,500 cancers of 38 tumour types reveal 16 signatures that can be used to classify somatic structural variants, highlighting the diversity of genomic rearrangements in cancer.

Advances in cloud computing make cloud services as an appealing solution for enabling services flexibility and availability on demand to accommodate users' needs. The terms and the guarantees of service provision are negotiated and then stated in a Service Level Agreement (SLA). To facilitate a wider acceptance of such services, beside the standard properties, security has to be taken into consideration as well. One way to facilitate this is to provide a corresponding security assurance case. For that purpose, in this work we propose to split the security service assessment between an independent third party and a service user, where the former assess a security assurance case and the latter negotiates particular security solutions implemented for a service. For the systematic part of the security process that is independently assessed, in this paper we focus on the formal realizability check of service constraints expressed within an SLA. To enable this, we formalize the check at both service design-, and run-time, needed due to frequent updates required to maintain an agreed security level. The formalization is tailored for the SLAC language specifically, which is extended to cover a proposed set of security objectives. Moreover, we use an example of an SLA expressed in terms of SLAC language, which includes security guarantees to illustrate the approach.