The size and shape of an organism is tightly controlled during embryonic and postembryonic development to ensure proper functionality. However, in the light of the breath-taking diversity of body forms observed in nature, developmental processes must have evolved to allow evolutionary changes in adult morphology. Therefore, gene regulatory networks (GRNs) that orchestrate organ development are mostly constrained, but nodes and edges within such networks must change to give rise to morphological divergence. Identifying such tuning nodes remains a major challenge in evolutionary developmental biology. Here, we combined comparative transcriptomics and chromatin accessibility data to study developmental differences leading to natural variation in compound eye size and head shape in the two closely related Drosophila species D. melanogaster and D. mauritiana. We show that variation in expression of the GATA transcription factor Pannier (Pnr) is associated with extensive remodeling of the transcriptomic landscape during head development. Since U-shaped (Ush), a co-factor of Pnr, is involved in the same regulatory context, we argue that variation in expression of both factors may be a driver of divergence in head morphology. Applying functional genetics and geometric morphometrics we confirmed that manipulation of pnr expression in D. melanogaster largely phenocopies D. mauritiana dorsal head shape and ommatidia number. Therefore, we propose that the regulatory module composed of Pnr and Ush represents a tuning node within the otherwise highly conserved GRN underlying head development in Drosophila.

This paper integrates a different perspective into the diaspora literature, by placing it within the frame of digital diasporas and war time engagement in actions and initiatives traditionally considered as diplomatic. We reconstruct how digital diaspora diplomacy developed during a time when the Internet was relatively new and diplomatic tools were limited due to an ongoing conflict in Bosnia and Herzegovina. We examine BOSNET, an online epistemic community of Bosnian diaspora IT pioneers, with a shared set of normative and principled set of beliefs about the independence of their homeland, and collected, shared and spread information about what was going on in their country. We label their work as ‘policy innovation’ engagement and performativity as 'informal' behaviour, as it was unscripted, uncoded and unregulated by any written conventions or state strategies.

Background: Necrotizing enterocolitis (NEC) is the most common life-threatening gastrointestinal emergency associated with prematurity. Timely diagnosis and adequate treatment are crucial to reduce the morbidity and mortality of the affected infants. The aim of this study was to evaluate the diagnostic yield of bowel dilatation on plane abdominal radiography (AR) in the early diagnosis and NEC severity in preterm infants. Methods: We retrospectively reviewed initial ARs of 50 preterm infants with NEC ≥ stage II admitted to the neonatal intensive care unit (NICU) in a tertiary-care hospital. The largest bowel loops diameters (AD), the latero-lateral diameters of the peduncle of the first lumbar vertebra (L1), and the distance of the upper edge of the first lumbar vertebra and the lower edge of the second one, including the disc space (L1–L2), were measured. All anteroposterior ARs were done in a supine projection on the day of onset of the initial symptoms of NEC. Results: Preterm infants with surgical NEC showed a statistically significant increase in the AD/L1 ratio (p < 0.001) and AD/L1-L2 ratio (p < 0.001) compared with preterm infants with medical NEC. We found no significant association between the site of the most distended bowel loop and the severity of NEC (p > 0.05). Conclusion: Bowel loop distension on initial AR may serve as an additional diagnostic tool in the early diagnosis and severity of stages II/III NEC. Further prospective clinical studies should validate the results from this study.

Nonorthogonal multiple access (NOMA) significantly improves the connectivity opportunities and enhances the spectrum efficiency (SE) in the fifth generation and beyond (B5G) wireless communications. Meanwhile, emerging B5G services demand for higher SE in the NOMA-based wireless communications. However, traditional ground-to-ground (G2G) communications are hard to satisfy these demands, especially for the cellular uplinks. To solve these challenges, this article proposes a multiple unmanned-aerial-vehicles (UAVs)-aided uplink NOMA method. In detail, multiple hovering UAVs relay data for a half of ground users (GUs) and share the spectrums with the other GUs that communicate with the base station (BS) directly. Furthermore, this article proposes a K-means clustering-based UAV deployment scheme and location-based user pairing (UP) scheme to optimize the transceiver association for the multiple UAVs-aided NOMA uplinks. Finally, a sum power minimization-based resource allocation problem is formulated with the lowest Quality-of-Service (QoS) constraints. We solve it with the message-passing algorithm and evaluate the superior performances of the proposed scheduling and paring schemes on SE and energy efficiency (EE). Extensive simulations are conducted to compare the performances of the proposed schemes with those of the single UAV-aided NOMA uplinks, G2G-based NOMA uplinks, and the proposed multiple UAVs-aided uplinks with a facility location framework-based UAV deployment. Simulation results demonstrate that the proposed multiple UAVs deployment and UP-based NOMA scheme significantly improves the EE and the SE of the cellular uplinks at the cost of only a little relaying power consumption of UAVs.

The paper proposes a problem-solving approach in the area of underground mining, related to the evaluation and selection of the optimal mining method, employing fuzzy multiple-criteria optimization. The application of fuzzy logic to decision-making in multiple-criteria optimization is particularly useful in cases where not enough information is available about a given system, and where expert knowledge and experience are an important aspect. With a straightforward objective, multiple-criteria decision-making is used to rank various mining methods relative to a set of criteria and to select the optimal solution. The considered mining methods represent possible alternatives. In addition, various criteria and subcriteria that influence the selection of the best available solution are defined and analyzed. The final decision concerning the selection of the optimal mining method is made based on mathematical optimization calculations. The paper demonstrates the proposed approach as applied in a case study.

We show that scattering from the boundary of static, higher-order topological insulators (HOTIs) can be used to simulate the behavior of (time-periodic) Floquet topological insulators. We consider D-dimensional HOTIs with gapless corner states which are weakly probed by external waves in a scattering setup. We find that the unitary reflection matrix describing back-scattering from the boundary of the HOTI is topologically equivalent to a (D-1)-dimensional nontrivial Floquet operator. To characterize the topology of the reflection matrix, we introduce the concept of `nested' scattering matrices. Our results provide a route to engineer topological Floquet systems in the lab without the need for external driving. As benefit, the topological system does not to suffer from decoherence and heating.

Abstract The goal of this study was to determine the content of 12 metals in 23 samples of teeth from two cities in Bosnia and Herzegovina (B&H): Sarajevo, a capital city with heavy traffic, industrial facilities, and long periods of smog during winter and Bihac, a picturesque small city, with no industrialization, settled among vivid national park and rivers. The teeth were separated into enamel and dentin. Dissolution of samples was performed in concentrated HNO3 with the addition of H2O2 followed by flame atomic absorption spectroscopy (FAAS) analysis. The results showed expected high contents of Ca, Na, Mg, and K, while elevated contents of Cu, Fe, and Zn were present in some samples. K and Na showed uniform distributions throughout enamel and dentin. Alkaline and earth-alkaline metals showed significant positive correlations. Zinc and manganese exhibited differences in the dentin content based on the place of residence. Zinc also displayed statistically significant differences between smokers’ and nonsmokers’ dentin samples. The differences were more pronounced between intra groups (within one sample) than for inter groups (within different groups, such as location, gender, and smoking).

BACKGROUND The Emergency Severity Index (ESI) is a widely used tool to triage patients in emergency departments. The ESI tool is used to assess all complaints and has significant limitation for accurately triaging patients with suspected acute coronary syndrome (ACS). OBJECTIVE We evaluated the accuracy of ESI in predicting serious outcomes in suspected ACS and aimed to assess the incremental reclassification performance if ESI is supplemented with a clinically validated tool used to risk-stratify suspected ACS. METHODS We used existing data from an observational cohort study of patients with chest pain. We extracted ESI scores documented by triage nurses during routine medical care. Two independent reviewers adjudicated the primary outcome, incidence of 30-day major adverse cardiac events. We compared ESI with the well-established modified HEAR/T (patient History, Electrocardiogram, Age, Risk factors, but without Troponin) score. RESULTS Our sample included 750 patients (age, 59 ± 17 years; 43% female; 40% black). A total of 145 patients (19%) experienced major adverse cardiac event. The area under the receiver operating characteristic curve for ESI score for predicting major adverse cardiac event was 0.656, compared with 0.796 for the modified HEAR/T score. Using the modified HEAR/T score, 181 of the 391 false positives (46%) and 16 of the 19 false negatives (84%) assigned by ESI could be reclassified correctly. CONCLUSION The ESI score is poorly associated with serious outcomes in patients with suspected ACS. Supplementing the ESI tool with input from other validated clinical tools can greatly improve the accuracy of triage in patients with suspected ACS.