Vehicle Routing Problem (VRP) is the process of set selection of the most convenient route in a network of roads vehicles are supposed to drive along when serving customers. Although vehicle problems solutions are being researched and improved in science, this problem is also important in industry, and the reason is the potential reduction of the shipping cost. Transport management is the central problem in logistics of one company, and the choice of optimal routes is one of the crucial functions in that process. However, as much as routes are algorithmically optimal, and as much as they include predefined limitations, there are some factors in the realistic environment which perhaps are not adequately treated during the creating the given routes. The innovative approach of adjustment of most of the parameters and factors necessary for the VRP algorithms being used in reality is presented in this work. It is based on the principle of successful feasibility of the given routs in realistic environment. The feasibility of the routes on the realistic example of one of the greatest distribution companies in Bosnia and Herzegovina has been significantly increased by introducing the realistic settings and improvements by comparative results before and after the introduction of the suggested modifications.

ABSTRACT Introduction The goal of this study was to examine socialization in adults with intellectual disability in relation to gender, level of intellectual disability, mental illness, and setting type. Methods The sample consisted of 120 participants (60 males and 60 females), aged between 20 and 56 years, divided into two groups: 1. participants with intellectual disability without the diagnosis of mental illness (ID only) and 2. participants with dual diagnosis (intellectual disability and mental illness). Socialization subscale from the Vineland Adaptive Behavior Scale was used for the assessment of socialization. Results Level of intellectual disability and mental illness had significant effects on socialization scores. In addition to this, interaction effect of gender and level of intellectual disability had a significant effect on socialization. Setting type did not have a significant effect on socialization. Conclusion These results can be very useful in identifying participants with intellectual disability who might need additional individualized support programs in the area of socialization.

The concentrations and composition of Polychlorinated biphenyls (PCBs) were determined in soils in an industrial zone. Total PCB concentrations (∑PCB congeners: PCB28, PCB52, PCB101, PCB118, PCB138, PCB153 and PCB180) varied in range from 0.26 to 6722 mg/kg in soil, with a median of 31.80 mg/kg. These values indicated that the soil is highly polluted. PCB in the subjected area was the result of anthropogenic activities. The principal component analysis showed that the commercial PCB products (PCB101, PCB118, PCB138, PCB153 and PCB180) are the main cause of pollution (PC1 factor), with 79.38% of total variance. The PC2 factor is in relation with the combustion (residential heating and fire in location), with 17.65% of total variance (lighter chlorinated congeners PCB52 and PCB28). Hierarchical cluster analysis indicated that the PCB congeners in the similar group might have similar sources, which was also confirmed by PCA.

Humidity sensing is important to a variety of technologies and industries, ranging from environmental and industrial monitoring to medical applications. Although humidity sensors abound, few available solutions are thin, transparent, compatible with large-area sensor production and flexible, and almost none are fast enough to perform human respiration monitoring through breath detection or real-time finger proximity monitoring via skin humidity sensing. This work describes chemiresistive graphene-based humidity sensors produced in few steps with facile liquid phase exfoliation followed by Langmuir–Blodgett assembly that enables active areas of practically any size. The graphene sensors provide a unique mix of performance parameters, exhibiting resistance changes up to 10% with varying humidity, linear performance over relative humidity (RH) levels between 8% and 95%, weak response to other constituents of air, flexibility, transparency of nearly 80%, and response times of 30 ms. The fast response to humidity is shown to be useful for respiration monitoring and real-time finger proximity detection, with potential applications in flexible touchless interactive panels.

Aluminum alloys are widely used in military and aviation industry due to their properties such as low density and high strength. During the aircraft operation there are mechanical failures of various structural components caused by numerous mechanisms such as corrosion, material defects, high cycle fatigue and the like. One of the frequent mechanical failures on air-cooled piston engines is the cylinder head cracking. This paper is the continuation a comprehensive research of the Lycoming IO-360-B1F aircraft cylinder head failure. The failure of this type has already occurred during flight and about 50 failures like this have been registered from around the world, some of them with a fatal outcome and therefore require detailed research. The paper consists of machining of the tested specimens and their testing at many different locations and in many different laboratories throughout Bosnia and Herzegovina, Serbia and Slovenia. This paper is based on a research that includes the experimental analysis of mechanical properties of Aluminum alloy 242.0 which is a constituent material of the cylinder head of the Lycoming IO-360-B1F aircraft engine on which a crack appeared. Based on chemical, metallographic, static and dynamic experimental tests of the material properties, Aluminum alloy 242.0 static and fatigue properties were obtained, S-N curve was formed and endurance limit was determined. Results of numerical simulations of experiments, confirmed by experimental results, were performed to make numerical procedures reliable due to further research. The results of the research are planned to be implemented in numerical modeling of the cylinder assembly stress-strain state under workload and in further numerical research of Lycoming IO-360-B1F cylinder assembly integrity assessment.

Bone plays critical roles in support, protection, movement, and metabolism. Although bone has an innate capacity for regeneration, this capacity is limited, and many bone injuries and diseases require intervention. Biomaterials are a critical component of many treatments to restore bone function and include non-resorbable implants to augment bone and resorbable materials to guide regeneration. Biomaterials can vary considerably in their biocompatibility and bioactivity, which are functions of specific material parameters. The success of biomaterials in bone augmentation and regeneration is based on their effects on the function of bone cells. Such functions include adhesion, migration, inflammation, proliferation, communication, differentiation, resorption, and vascularization. This review will focus on how different material parameters can enhance bone cell function both in vitro and in vivo.

© The Author 2020. Published by ARDA. Abstract Clean water is essential to our existence and problems might arise when it becomes contaminated with different pathogens, which might pose a threat to human health. Tap water is generally considered drinkable since it passes different forms of disinfection during processing. Some households have additional disinfection procedures, the most common one being the usage of charcoal filters, in order to further clean the tap water from both undesirable solvents and microorganisms. In the first independent study of this kind, we have tested tap water for bacteria from five different locations in Sarajevo, and we have tested the efficiency of charcoal filter in trapping of bacteria. According to regulations in Bosnia and Herzegovina, there should be 1 colony forming unit (CFU) per 50ul of water sample, which was satisfied in only one location from Sarajevo, while one had significantly higher levels (6.7, p val. 0.0148). Overall, the charcoal filter has decreased the number of bacteria in the water, with the exception of one sample.

1 Department for Architectural Structures and Building Technologies, Faculty of Architecture, University of Sarajevo, Patriotske lige 30., 71 000 Sarajevo, Bosnia and Herzegovina 2 Department of Cardiology, Pediatric Clinic, Clinical Center University of Sarajevo, Patriotske lige 81., 71 000 Sarajevo, Bosnia and Herzegovina, email: nedim_begic91@hotmail.com 3 Department of Cardiology, General Hospital "Prim.Dr. Abdulah Nakas", Kranjčevićeva 12., 71 000 Sarajevo, Bosnia and Herzegovina, email:edinbegic90@gmail.com 4 Department of Pharmacology, Sarajevo Medical School, Sarajevo School of Science and Technology, 71 000 Sarajevo, Bosnia and Herzegovina, email:edinbegic90@gmail.com 5 Faculty of Medicine, University of Tuzla, Univerzitetska 1., 75 000 Tuzla, Bosnia and Herzegovina, email: zumreta.kusljugic@ukctuzla.ba 6 Department for Pathophysiology, Faculty of Medicine, University of Sarajevo, Čekaluša 90, 71 000 Sarajevo, Bosnia and Herzegovina, email:damir.secic@mf.unsa.ba

ABSTRACT As a main input for economic growth and competitiveness, foreign direct investments (FDI) remain one of the most important sources in both emerging and developing countries. This study emphasizes the importance of FDI into Serbia’s economy by analysing the forecasts between FDI, GDP, the unemployment rate and global competitive index (GCI). In this paper, authors focussed on a comparison of FDI inflows from China, Russia and the EU countries. According to the multiplicative and seasonal aspects of trend analysis considered, projections show a gradual increase in GDP, FDI, competitive ranks and a decrease in the unemployment rate for the following 5 years. These results shed light on the future potential directions under which investment and other public policies should be created. Theoretical and practical implications are also discussed.

Checkpoint inhibitors (CPIs) augment adaptive immunity. Systematic pan-tumor analyses may reveal the relative importance of tumour cell intrinsic and microenvironmental features underpinning CPI sensitization. Here we collated whole-exome and transcriptomic data for >1000 CPI-treated patients across eight tumor-types, utilizing standardized bioinformatics-workflows and clinical outcome-criteria to validate multivariate predictors of CPI-sensitization. Clonal-TMB was the strongest predictor of CPI response, followed by TMB and CXCL9 expression. Subclonal-TMB, somatic copy alteration burden and HLA-evolutionary divergence failed to attain significance. Discovery analysis identified two additional determinants of CPI-response supported by prior functional evidence: 9q34.3 (TRAF2) loss and CCND1 amplification, both independently validated in >1600 CPI-treated patients. We find evidence for collateral sensitivity, likely mediated through selection for CDKN2A-loss, with 9q34.3 loss as a passenger event leading to CPI-sensitization. Finally, scRNA sequencing of clonal neoantigen-reactive CD8-TILs, combined with bulk RNAseq analysis of CPI responding tumors, identified CCR5 and CXCL13 as T cell-intrinsic mediators of CPI-sensitisation.

We introduce a two-dimensional network model that realizes a higher-order topological insulator (HOTI) phase. We find that in the HOTI phase a total of 16 corner states are protected by the combination of a four-fold rotation, a phase-rotation, and a particle-hole symmetry. In addition, the model exhibits a strong topological phase at a point of maximal coupling. This behavior is in opposition to conventional network models, which are gapless at this point. By introducing the appropriate topological invariants, we show how a point group symmetry can protect a topological phase in a network. Our work provides the basis for the realization of HOTI systems in alternative experimental platforms implementing the network model.