Background Histone deacetylase 9 (HDAC9) plays an important role in transcriptional regulation, cell cycle progression and developmental events; moreover, it has been investigated as a candidate gene in a number of conditions, including the onset and progression of atherosclerosis. We hypothesized that the rs2107595 HDAC9 gene polymorphism may be associated with advanced carotid artery disease in a Slovenian cohort. We also investigated the effect of this polymorphism on HDAC9 receptor expression in the internal carotid artery (ICA) specimens obtained by endarterectomy. Methods This case-control study enrolled 619 unrelated Slovenian patients: 311 patients with ICA stenosis > 75% as the study group and 308 patients with ICA stenosis < 50% as the control group. Patient laboratory and clinical data were obtained from the medical records. The rs2107595 polymorphisms were genotyped using TaqMan SNP Genotyping assay. HDAC9 expression was assessed by immunohistochemistry in 30 ICA specimens from patients with ICA atherosclerosis > 75%, and the numerical areal density of HDAC9 positive cells was calculated. Results The occurrence of advanced ICA atherosclerosis in the Slovenian cohort was 3.81 times higher in the codominant genetic model (OR = 3.81, 95%CI = 1.06–13.77, p  = 0.04), and 3.10 times higher in the recessive genetic model (OR = 3.10, 95%CI = 1.16–8.27, p  = 0.02). In addition, the A allele of rs2107595 was associated with increased HDAC9 expression in the ICA specimens obtained by endarterectomy. Conclusions We observed a significant association between the AA genotype of rs2107595 with the advanced carotid artery disease in our Slovenian cohort, indicating that this polymorphism may be a genetic risk factor for ICA atherosclerosis.

Histone deacetylase 9 (HDAC9) plays an important role in transcriptional regulation, cell cycle progression and developmental events; moreover, it has been investigated as a candidate gene in a number of conditions, including the onset and progression of atherosclerosis. We hypothesized that the rs2107595 HDAC9 gene polymorphism may be associated with advanced carotid artery disease in a Slovenian cohort. We also investigated the effect of this polymorphism on HDAC9 receptor expression in the internal carotid artery (ICA) specimens obtained by endarterectomy. This case-control study enrolled 619 unrelated Slovenian patients: 311 patients with ICA stenosis > 75% as the study group and 308 patients with ICA stenosis < 50% as the control group. Patient laboratory and clinical data were obtained from the medical records. The rs2107595 polymorphisms were genotyped using TaqMan SNP Genotyping assay. HDAC9 expression was assessed by immunohistochemistry in 30 ICA specimens from patients with ICA atherosclerosis > 75%, and the numerical areal density of HDAC9 positive cells was calculated. The occurrence of advanced ICA atherosclerosis in the Slovenian cohort was 3.81 times higher in the codominant genetic model (OR = 3.81, 95%CI = 1.06–13.77, p = 0.04), and 3.10 times higher in the recessive genetic model (OR = 3.10, 95%CI = 1.16–8.27, p = 0.02). In addition, the A allele of rs2107595 was associated with increased HDAC9 expression in the ICA specimens obtained by endarterectomy. We observed a significant association between the AA genotype of rs2107595 with the advanced carotid artery disease in our Slovenian cohort, indicating that this polymorphism may be a genetic risk factor for ICA atherosclerosis.

We profiled nine pure clear cell carcinomas of the breast using massively parallel DNA and RNA sequencing (NGS), in situ hybridization (ISH), and immunohistochemistry (IHC). All cases were primary mammary clear cell carcinomas that were diagnosed in female patients (mean age: 53.4 years; range: 31‐69 years). Based on our findings, we conclude that the majority of clear cell carcinomas are ER/PR positive and consequently amenable to anti‐ER treatment modalities. A subset of clear cell carcinomas also harbored alterations in PIK3CA/PTEN/AKT pathway, particularly PTEN, indicating a potential benefit of PI3K/Akt/mTOR inhibitors. The status of I‐O biomarkers in clear cell carcinomas indicates a limited therapeutic benefit of immune checkpoint inhibitors (against PD‐1/PD‐L1).

Abstract Background We previously investigated the association between 5 “first-generation” measures of epigenetic aging and cancer risk in the Melbourne Collaborative Cohort Study. This study assessed cancer risk associations for 3 recently developed methylation-based biomarkers of aging: PhenoAge, GrimAge, and predicted telomere length. Methods We estimated rate ratios (RRs) for the association between these 3 age-adjusted measures and risk of colorectal (N = 813), gastric (N = 165), kidney (N = 139), lung (N = 327), mature B-cell (N = 423), prostate (N = 846), and urothelial (N = 404) cancer using conditional logistic regression models. We also assessed associations by time since blood draw and by cancer subtype, and we investigated potential nonlinearity. Results We observed relatively strong associations of age-adjusted PhenoAge with risk of colorectal, kidney, lung, mature B-cell, and urothelial cancers (RR per SD was approximately 1.2-1.3). Similar findings were obtained for age-adjusted GrimAge, but the association with lung cancer risk was much larger (RR per SD = 1.82, 95% confidence interval [CI] = 1.44 to 2.30), after adjustment for smoking status, pack-years, starting age, time since quitting, and other cancer risk factors. Most associations appeared linear, larger than for the first-generation measures, and were virtually unchanged after adjustment for a large set of sociodemographic, lifestyle, and anthropometric variables. For cancer overall, the comprehensively adjusted rate ratio per SD was 1.13 (95% CI = 1.07 to 1.19) for PhenoAge and 1.12 (95% CI = 1.05 to 1.20) for GrimAge and appeared larger within 5 years of blood draw (RR = 1.29, 95% CI = 1.15 to 1.44 and 1.19, 95% CI = 1.06 to 1.33, respectively). Conclusions The methylation-based measures PhenoAge and GrimAge may provide insights into the relationship between biological aging and cancer and be useful to predict cancer risk, particularly for lung cancer.

Motivated by (approximate) dynamic programming and model predictive control problems, we analyse the stability of deterministic nonlinear discrete-time systems whose inputs minimize a discounted finite-horizon cost. We assume that the system satisfies stabilizability and detectability properties with respect to the stage cost. Then, a Lyapunov function for the closed-loop system is constructed and a uniform semiglobal stability property is ensured, where the adjustable parameters are both the discount factor and the horizon length, which corresponds to the number of iterations for dynamic programming algorithms like value iteration. Stronger stability properties such as global exponential stability are also provided by strengthening the initial assumptions. We give bounds on the discount factor and the horizon length under which stability holds and we provide conditions under which these are less conservative than the bounds of the literature for discounted infinite-horizon cost and undiscounted finite-horizon costs, respectively. In addition, we provide new relationships between the optimal value functions of the discounted, undiscounted, infinite-horizon and finite-horizon costs respectively, which are very different from those available in the approximate dynamic programming literature. These relationships rely on assumptions that are more likely to be satisfied in a control context. Finally, we investigate stability when only a near-optimal sequence of inputs for the discounted finite-horizon cost is available, covering approximate value iteration as a particular case.

ABSTRACT: This work aims to report our experience with Oral History, developed in the Special Topic Course in History Teaching of the Master's program Prof.Historia at UFS. This experience had as its culminating point a research practiced in the Florestan Fernandes Settlement, located in Caninde de Sao Francisco-SE, for that purpose we made use of the Oral History Methodology, which offers innumerable possibilities, among them the one of giving voice to “little men”, so that from their experiences and worldviews, we can have an unofficial understanding of the most varied events. It is worth highlighting the importance of our interviewee, Mrs. Maria de Lourdes, whose rich testimony contributed a lot to the elucidation of different issues. It is worth noting that the article had as its guiding concepts the aforementioned Oral History, as well as Memory, Social Identity and Places of Memory. KEYWORDS: Memory and Identity. Interviews. Settlement.

The use of computers with outstanding performance has become a real necessity in order to achieve greater efficiency and sustainability for the accomplishment of various tasks. Therefore, with the development of information technology and increasing dynamism in the business environment, it is expected that these computers will be more intensively deployed. In this paper, research was conducted in Danube region countries: Austria, Bosnia and Herzegovina, Bulgaria, Croatia, Czech Republic, Germany, Hungary, Moldova, Montenegro, Romania, Serbia, Slovakia, Slovenia, and Ukraine. The aim of the research was to determine what criteria are most significant for the introduction of high-performance computing and the real situation in each of the countries. In addition, the aim was to establish the infrastructure needed to implement such a system. In order to determine the partial significance of each criterion and thus the possibility of implementing high-performance computing, a multi-criteria model in a fuzzy environment was applied. The weights of criteria and their rankings were performed using the Fuzzy PIvot Pairwise RElative Criteria Importance Assessment—fuzzy PIPRECIA method. The results indicate different values depend on decision-makers (DMs) in the countries. Spearman’s and Pearson’s correlation coefficients were calculated to verify the results obtained.

The studies on the relationship between probiotics and prebiotics as well as probiotics and antioxidants have gained significant increase in popularity over the past decade. However, exposure to antibiotics can result in disrupting the human microbiome, causing several related diseases. Additionally, probiotics can lose some of their beneficial effects when in contact with stomach acid which has a pH between 2 and 3. The purpose of this study was to examine the effects of prebiotic fibres and antioxidants and B complex vitamins on the survival of probiotics. When combined with those, a sufficient amount of probiotics survives and carries out their beneficial functions. This study points out the importance of mentioned compounds in maintaining a healthy organism as well as their role in preserving the life of probiotics in our gut.

Drones-aided ubiquitous applications play more and more important roles in our daily life. Accurate recognition of drones is required in aviation management due to their potential risks and even disasters.Radio frequency (RF) fingerprinting-based recognition technology based on deep learning is considered as one of the effective approaches to extract hidden abstract features from RF data of drones. Existing deep learning-based methods are either a high computational burden or low accuracy.In this paper, we propose a deep complex-valued convolutional neural network (DC-CNN) method based on RF fingerprinting for recognizing different drones.Compared with existing recognition methods, the DC-CNN method has the advantages of high recognition accuracy, fast running time and small network complexity.Nine algorithm models and two datasets are used to represent the superior performance of our system.Experimental results show that our proposed DC-CNN can achieve recognition accuracy of 99.5\% and 74.1\% respectively on 4 and 8 classes of RF drone datasets.

Herein, a conductivity method was engaged to explore the effects of a fluoroquinolone drug, namely ciprofloxacin hydrochloride (CFH)/CFH + polyols (organic compounds with multiple hydroxyl groups (glucose and fructose)), on the aggregation phenomenon of sodium dodecyl sulfate (SDS) at different temperatures (298.15–318.15 K) while maintaining a gap of 5 K. In this study, the critical micelle concentration (cmc) of the SDS/SDS + CFH mixture in water and polyols media was determined from plots of the specific conductivity versus the concentration of SDS to gain knowledge of the effects of CFH/CFH + polyols on the micelle formation behavior of SDS. The cmc value of the surfactant decreases in the presence of CFH in an aqueous medium; thus, CFH favors the micellization of SDS. The cmc values of SDS and the SDS + CFH mixture were enhanced in polyols media. The cmc values of SDS/SDS + CFH show a U-shaped behavior with temperature. The counterion dissociation (α) of the pure surfactant is higher in the presence of the drug and is further enhanced through an increase in the CFH concentration in water/polyols media. Different thermodynamic parameters, such as the Gibbs free energy of micellization , standard enthalpy , entropy , different transfer energies and enthalpy–entropy compensation parameters of micellization were determined and illustrated in detail to compare these parameters between the pure SDS and SDS + CFH mixture in polyols media. The negative values of for the SDS/SDS + CFH mixture in all cases indicate spontaneous micelle formation. The and values indicate the presence of both hydrophobic and electrostatic interactions amongst the studied components.

BACKGROUND Coronary collateral circulation exerts protective effects on myocardial ischaemia due to coronary artery disease and can be promoted by exercise with heparin co-administration. Whether this arteriogenetic effect is accompanied by functional improvement of left ventricle during stress and lessening of angina symptoms remains unknown. AIMS To evaluate the anti-ischaemic efficacy of heparin plus exercise in coronary artery disease. METHODS In a prospective, single-centre, randomized, double-blind study we recruited 32 'no-option' patients (27 males; mean age 61 ± 8 years) with stable angina, exercise-induced ischaemia and coronary artery disease not suitable for revascularization. All underwent a two-week cycle of exercise (two exercise sessions per day, five days per week) and were randomized (n = 16 per group) to intravenous placebo (0.9% saline) versus unfractionated heparin (5.000 IU intravenously), 10 min prior to exercise. We assessed Canadian Cardiovascular Society angina class, stress electrocardiogram and echo parameters (wall motion score index) and computed tomography angiography for collaterals. RESULTS After two-week cycle, Canadian Cardiovascular Society class statistically decreased in both groups (heparin plus exercise group: 2.6 ± 0.7 to 1.9 ± 0.7, p < 0.001, exercise group: 2.4 ± 0.7 to 2.1 ± 0.9, p = 0.046). Only the heparin plus exercise group improved time-to-ST segment depression (before 270, 228-327 s vs. after 339, 280-360 s, p = 0.012) and wall motion score index (before 1.38 ± 0.25 vs. after 1.28 ± 0.18, p = 0.005). By multi-slice computed tomography angiography, collaterals improved in 12/15 (80%) in the heparin plus exercise group versus 2/16 (12.5%) in the exercise group (p < 0.001). CONCLUSION A two-week, 10-test cycle of heparin plus exercise is better than exercise in improving angina class, myocardial ischaemia and collaterals by computed tomography angiography.