Acute erythroleukemia (AML-M6 or AEL) is a rare but aggressive hematologic malignancy. Previous studies showed that AEL leukemic cells often carry complex karyotypes and mutations in known AML-associated oncogenes. To better define the underlying molecular mechanisms driving the erythroid phenotype, we studied a series of 33 AEL samples representing three genetic AEL subgroups including TP53-mutated, epigenetic regulator-mutated (e.g. DNMT3A, TET2 or IDH2), and undefined cases with low mutational burden. We established an erythroid vs. myeloid transcriptomics-based space in which, independently of the molecular subgroup, the majority of the AEL samples exhibited a unique mapping different from both non-M6 AML and myelodysplastic syndrome samples. Notably, more than 25% of AEL patients, including in the genetically-undefined subgroup, showed aberrant expression of key transcriptional regulators, including SKI, ERG, and ETO2. Ectopic expression of these factors in murine erythroid progenitors blocked in vitro erythroid differentiation and led to immortalization associated with decreased chromatin accessibility at GATA1 binding sites and functional interference with GATA1 activity. In vivo models showed development of lethal erythroid, mixed erythroid/myeloid or other malignancies depending on the cell population in which AEL-associated alterations were expressed. Collectively, our data indicates that AEL is a molecularly heterogeneous disease with an erythroid identity that results in part from the aberrant activity of key erythroid transcription factors in hematopoietic stem or progenitor cells.

Recommender systems constitute the core engine of most social network platforms nowadays, aiming to maximize user satisfaction along with other key business objectives. Twitter is no exception. Despite the fact that Twitter data has been extensively used to understand socioeconomic and political phenomena and user behaviour, the implicit feedback provided by users on Tweets through their engagements on the Home Timeline has only been explored to a limited extent. At the same time, there is a lack of large-scale public social network datasets that would enable the scientific community to both benchmark and build more powerful and comprehensive models that tailor content to user interests. By releasing an original dataset of 160 million Tweets along with engagement information, Twitter aims to address exactly that. During this release, special attention is drawn on maintaining compliance with existing privacy laws. Apart from user privacy, this paper touches on the key challenges faced by researchers and professionals striving to predict user engagements. It further describes the key aspects of the RecSys 2020 Challenge that was organized by ACM RecSys in partnership with Twitter using this dataset.

Recommender systems constitute the core engine of most social network platforms nowadays, aiming to maximize user satisfaction along with other key business objectives. Twitter is no exception. Despite the fact that Twitter data has been extensively used to understand socioeconomic and political phenomena and user behaviour, the implicit feedback provided by users on Tweets through their engagements on the Home Timeline has only been explored to a limited extent. At the same time, there is a lack of large-scale public social network datasets that would enable the scientific community to both benchmark and build more powerful and comprehensive models that tailor content to user interests. By releasing an original dataset of 160 million Tweets along with engagement information, Twitter aims to address exactly that. During this release, special attention is drawn on maintaining compliance with existing privacy laws. Apart from user privacy, this paper touches on the key challenges faced by researchers and professionals striving to predict user engagements. It further describes the key aspects of the RecSys 2020 Challenge that was organized by ACM RecSys in partnership with Twitter using this dataset.

Increasing redox reaction rates on carbon electrodes is an important step to reducing the cost of all-vanadium redox flow batteries (VRFBs). Biomass-derived activated carbons (ACs) hold promise as ...

S-matrix theory is used in order to analyze the energy spectra of electron-atom potential scattering assisted by a bicircular (two-component circularly polarized) laser field having corotating field components. The double scattering (rescattering) is also included in the analysis by applying the second Born approximation in the expansion of the S-matrix element. We have investigated how the energy spectrum of scattered electrons is affected by the scattering angle. We have also analyzed the sensitivity of the energy spectrum to the relative phase and intensity ratio of the laser-field components. The calculated energy spectra are characterized by the plateau-like oscillatory structures with abrupt cutoffs. Positions of these cutoffs in the energy spectra are confirmed by a classical analysis. Rescattering effects can be observed in the calculated energy spectra for certain values of the scattering angle. These effects are represented by the second plateau in the energy spectrum. This is different from the process of above-threshold ionization/detachment by a bicircular laser field, where the (re)scattering effects in the photoelectron energy spectra cannot be observed in the case of corotating laser-field components.

This study presents a secret key sharing protocol that establishes cryptographically secured communication between two entities. A new symmetric key exchange scenario for smart city applications is presented in this research. The protocol is based on the specific properties of the Fuss-Catalan numbers and the Lattice Path combinatorics. The proposed scenario consists of three phases: generating a Fuss-Catalan object based on the grid dimension, defining the movement in the Lattice Path Grid and defining the key equalisation rules. In the experimental part, the authors present the security analysis of the protocol as well as its test. Also, they examine the equivalence of the proposed with Maurer's satellite scenario and suggest a new scenario that implements an information-theoretical protocol for the public key distribution. Additionally, a comparison with related studies and methods is provided, as well as a comparison with satellite scenario, which proves the advantages of solution presented by the authors. Finally, they propose further research directions regarding key management in smart city applications.

The role of women in society every day is growing. Women achieve significant business outcomes, along with men, although their efforts are often not evaluated in the same way. Despite their extraordinary commitment to the jobs they perform, women still find themselves in the so-called "glass ceiling" - barriers that prevent them from progressing to better careers and to be equally valued and paid as men. Nowadays, there is a great desire and engagement of all layers of society and the state to change that situation so that women can prove their abilities in the most responsible positions, both in companies and public sectors as well. This paper starts from the fact that there is no favoring of men in relation to women in management positions in the state administration in Serbia, and that the main preconditions for someone to perform these functions are knowledge, education and work experience.

Since the development of the original Support Intensity Scale—Adult Version (SIS-A) and the Support Intensity Scale—Child Version (SIS-C), the interest in supporting people with intellectual disabilities (ID) has changed. Resource allocation, better quality of resource utilization in the rehabilitation process, the development of support systems, and redefining the roles of organizations that support people with ID are just some of the changes. The aim of this study was to determine the factor structure of the SIS-C conducted on a sample of Bosnian–Herzegovinian (B&H) children (SISC B&H). The study included 377 children ID in B&H, aged 5-16. The data was analyzed with the SPSS 21 software (with the AMOS package). Exploratory factor analysis (EFA) was used to examine the factor structure of the SIS-C. Confirmatory factor analysis (CFA) was applied to determine the factor and constructive validity of SIS-C B&H. The CFA results indicated a poor fit of both the theoretical and empirical models even after modifications were made. The EFA showed the opposite results. This could be explained by the fact that within the factor solutions obtained from the EFA, various aslope or orthogonal models, linear or hierarchical, can be constructed. Among these models, some exhibited good fit to the data. Thus, data from the current study could be used to generate new hypotheses and deliver more conclusive answers.

BACKGROUND: Measles is a highly contagious infectious disease caused by morbillivirus which usually affects young children. Once thought to have been eradicated, measles continues to be the leading cause of morbidity and mortality in the world. AIM: The purpose of this research is to analyze the risk factors and clinical characteristics of children hospitalized at the Pediatric Clinic under the diagnosis of measles during the epidemic in Sarajevo Canton 2019. METHOD: We applied a retrospective analysis of medical histories of 23 patients who were hospitalized under the diagnosis of measles at the Pediatric Clinic of the Clinical Center in Sarajevo from January to June 2019. We divided patients into two groups: Infants and children over one year of age. We diagnosed measles clinically, or through the serum IgM ELISA test for measles virus. RESULTS: A total of 23 patients, aged 1 month to 14 years, were hospitalized at the Pediatric Clinic, accounting for 3.5% of the total number of the diseased children. The largest numbers of hospitalized patients were infants 9 (39.1%). Comorbidities were present in 9 (39.1%) subjects, and the most common complication was bronchopneumonia, present in as many as half of the infants. There were four patients who needed mechanical ventilation (17.39%); three of whom were infants; and two lethal outcomes (8.69%), both in infancy. CONCLUSION: Responsible behavior of parents, health professionals, and society as a whole can prevent the far-reaching consequences of non-vaccination. Infants are critically endangered, as the most sensitive part of population, especially if the collective immunity is impaired.

Four 4-hydroxycoumarin derivatives were synthesized and the structure was confirmed by NMR spectroscopy and Mass spectrometry. Tested compounds have shown significant antimicrobial activity against Bacillus subtilis subsp. spizizenii, Bacillus cereus, Staphylococcus aureus, and Staphylococcus epidermidis, and the effect of more halogens on the benzene nucleus, as well as the combination of halogen and alkyl groups, on the antimicrobial activity, was investigated. According to the docking study, these compounds can operate simultaneously on two enzymes, amylase and gyrase (1BAG and 1KZN), which are known to play an important role in bacterial life. Obtained docking study parameters for tested compounds showed an association with the in vitro results of the antimicrobial activity of these compounds. In silico tests of molecular properties of the tested compounds showed that the compounds met Lipinski's rule of five. In this paper, the ADME parameters of tested compounds were also calculated: Caco2 (in vitro Caco2 cell permeability), HIA (human intestinal absorption), MDCK (in vitro Mandin Darby Canine Kidney (MDCK) cell permeability), TPSA (topological polar surface area), etc.

Background. Monitoring the abilities of typically developed children is very important.Methods. This study aimed to determine the levels and differences in motor coordination of the upper extremities between first and third-grade primary school children using the subtest of the Bruininks-Oseretsky Test (BOT-2). The sample included 79 healthy subjects of both sexes, chronological age ranging from seven to nine years, body height 134.51 ± 8.43 cm (Mean ± SD), bodyweight 33.01 ± 8.65 kg (Mean ± SD). The Mann–Whitney U test determined differences between groups, for the benefit of the group of third-grade subjects in all upper extremity coordination variables.Results. The results showed that differences in age and biological growth and development in young children in some variables of upper-limb coordination influenced medium size (2ULC, 6ULC, 7ULC), but in most of the variables examined they had great influence (1ULC. 3ULC, 4ULC, 5ULC, TULC) according to Cohen’s criterion.Conclusion. It can be concluded that well-organized and expertly guided physical activities, as well as regular testing of children when it comes to developing coordination, can influence early detection of movement difficulties and eliminate problems in acquiring new coordination skills, and thus create an appropriate base for engaging in sports activities while growing up. Keywords: motor development, coordination, physical education.

The Web of Things (WoT) is a technology concept that allows the integration of the Internet of Things (IoT) with the World Wide Web (WWW). It will vastly affect our lives in the near future given that it offers new services and applications via the well-known web window. In todays’ world where one can hardly imagine everyday life without access to various online services and applications via a plethora of devices, one can notice that technology has a huge impact on our day-to-day quality of living. That is why a user’s Quality of Experience (QoE) towards used technology in general plays a crucial role in their Quality of Life (QoL). Furthermore, security perception in terms of technology is the feature that vastly affects QoE and, consequently, QoL, as the number of security and privacy threats, risks, and vulnerabilities in cyber space, i.e., the technology environment that we increasingly use, is constantly rising. In order to reach the ultimate goals—the adoption of WoT technology and improvement of our QoL—we must know how this important aspect of security is so far addressed and analyzed. Therefore, this paper gives a comprehensive and structured analysis of the existing literature in this field through a proposed framework and provides an overview of research opportunities that should be addressed and elaborated in future investigations.