This paper introduces RVAF, a runtime verification (RV) extension of the Arrowhead Framework (AF) with container-based service-deployment and runtime-enforcement of a desired quality of service (QoS). AF is a service-oriented middleware architecture for IoT-applications, consisting of a set of core and auxiliary services and systems, respectively. The QoS manager (QoSM) is one AF’s most important auxiliary systems, which can be used to guarantee the application’s QoS for a wide set of parameters. In RVAF the QoS offered to a particular IoT-application is specified in signal temporal logic, and is continuously monitored by the RVAF-QoSM. In case of an imminent violation, RVAF automatically initiates a container-based reconfiguration, which is ensured to maintain the desired QoS. RVAF is beneficial to large IoT-applications, where the use of continuous-integration and continuous-deployment tools, is not only a recommended practice but also a necessity. Moreover, the use of RVAF is advantageous both during the development of an IoT application, and after its deployment. We describe the architecture of RVAF, provide its formal underpinning, and demonstrate the usefulness of RVAF supported by an industrial IoT application. The main contribution of this work is to show what it takes to incorporate RV concepts into modern SOA frameworks supporting the development of IoT applications.

The rapid increase in number of devices in Internet-of-Things generates astronomic amounts of data. Dealing with noisy and low quality data uses more effort than the data analysis itself. Dealing with noisy data at the source would significantly reduce the effort of pre-processing during analysis, as well as the storage and bandwidth overhead. In this paper we introduce an Adaptive Signal Processing Platform (ASPF) for CPS/IoT Ecosystems. It provides ability to dynamically detect noise variation in a signal and successfully filter these components out of the signal leaving only clean and useful data. The paper shows two approaches with different requirements on effort and scalability.

The worldwide spread of a new coronavirus (SARS-CoV-2) since December 2019 has posed a severe threat to individuals’ well-being. While the world at large is waiting that the released vaccines immunize most citizens, public health experts suggest that, in the meantime, it is only through behavior change that the spread of COVID-19 can be controlled. Importantly, the required behaviors are aimed not only at safeguarding one’s own health. Instead, individuals are asked to adapt their behaviors to protect the community at large. This raises the question of which social concerns and moral principles make people willing to do so. We considered in 23 countries (N = 6948) individuals’ willingness to engage in prescribed and discretionary behaviors, as well as country-level and individual-level factors that might drive such behavioral intentions. Results from multilevel multiple regressions, with country as the nesting variable, showed that publicized number of infections were not significantly related to individual intentions to comply with the prescribed measures and intentions to engage in discretionary prosocial behaviors. Instead, psychological differences in terms of trust in government, citizens, and in particular toward science predicted individuals’ behavioral intentions across countries. The more people endorsed moral principles of fairness and care (vs. loyalty and authority), the more they were inclined to report trust in science, which, in turn, statistically predicted prescribed and discretionary behavioral intentions. Results have implications for the type of intervention and public communication strategies that should be most effective to induce the behavioral changes that are needed to control the COVID-19 outbreak.

Abstract Healthcare waste (HCW) management is a complex and challenging problem. It is one of the priorities in health. An increase in the number of the health services provided leads to an increase in the amount of HCW, which has particularly been noticeable in recent years. Since this is the waste that may pose a risk to humans and the environment, it is necessary to ensure an adequate treatment of the same. HCW management is particularly important in developing countries, due to inappropriate disposal methods, underfunding and a lack of the infrastructure. In order to achieve the cost-effectiveness and sustainability of this area, HCW should be minimized through an adequate treatment of the same. The Public Enterprise Zdravstvo Brcko (Brcko Health System) has intensively been addressing the HCW management issue. They have decided to upgrade the HCW system by purchasing a new infectious waste treatment facility. The paper is aimed at creating a new original integrated multicriteria decision-making model based on D numbers for processing fuzzy linguistic information. This model will serve to support management in the procurement of the mentioned facility. The model integrates the benefits of different approaches and theories. An initial model was formed, consisting of the six potential solutions evaluated based on the 18 criteria classified into the following four groups: social, environmental, economic and technological. Four experts in this field evaluated the criteria and potential solutions. Then, a new Best-Worst Method based on D numbers (BWM-D) was applied in order to determine the significance of the criteria. After that, a Multi-Attributive Border Approximation Area Comparison Based on D numbers (MABAC-D) was developed and applied so as to evaluate and select an infectious waste treatment facility. The results have shown that the alternative A1 gives the best results, whereas the alternative A5 shows the worst results. Finally, a sensitivity analysis was performed to validate the obtained results. In this part of the paper, the Technique for Order of Preference by Similarity to Ideal Solution (TOPSIS-D) and VIsekriterijumska Optimizacija Kompromisnog Resenja (VIKOR-D) were developed in order to validate the results. When procuring a new Contagious Waste Treatment System, the characteristics of the available devices need be perceived and all the criteria need be taken into account in order to provide a device which will solve the HCW problem in the best way. This paper has shown how D numbers can be used when making a selection of an HCW management device, and also how all the characteristics of such a device can be perceived and how the device demonstrating the best characteristics can be selected.

The impacts of climate change are affecting human societies today. In parallel, socio-economic development has increased the capacity of countries around the global to adapt to those impacts although substantial challenges remain. Ongoing climate change will continue to result in a pressure to adapt, while socio-economic development could make it easier to do so. Countries’ effectiveness in fostering climate resilience will depend on the pace of both developments under different socio-economic and emission pathways. Here we assess trajectories of adaptation readiness in comparison with the continued emergence of hot days as a proxy for climate change hazards for different emission and socio-economic pathways over the 21st century. Putting the future evolution of both indices in relation to the observed dynamics over the recent past allows us to provide an assessment of the prospects of future climate resilience building beyond what has been experienced to date. We show that only an inclusive and sustainable stringent mitigation pathway allows for effective climate resilient development over the 21st century. Less inclusive or fossil-fuel driven development will not allow for improvements in resilience building beyond the recent past. Substantial differences emerge already in the 2020s. Our findings underscore the paramount importance of achieving the Paris Agreement goals to enable climate-resilient, sustainable development.

Rahmanzadeh et al. quantify—for the first time in vivo—the relative damage to myelin and axons across the multiple sclerosis spectrum, in different types of lesions and in normal-appearing tissue. The data confirm neuropathological findings and extend them by revealing the complexity of the disease in living patients.

The interference of matter waves is one of the intriguing features of quantum mechanics that has impressed researchers and laymen since it was first suggested almost a century ago. Nowadays, attosecond science tools allow us to utilize it in order to extract valuable information from electron wave packets. Intense laser fields are routinely employed to create electron wave packets and control their motion with attosecond and ångström precision. In this perspective article, which is based on our debate at the Quantum Battles in Attoscience virtual workshop 2020, we discuss some of the peculiarities of intense light-matter interaction. We review some of the most important techniques used in attosecond imaging, namely photoelectron holography and laser-induced electron diffraction. We attempt to ask and answer a few questions that do not get asked very often. For example, if we are interested in position space information, why are measurements carried out in momentum space? How to accurately retrieve photoelectron spectra from the numerical solution of the time-dependent Schrödinger equation? And, what causes the different coherence properties of high-harmonic generation and above-threshold ionization?

Introduction: Mixed adenoneuroendocrine carcinoma (MANEC) is a tumor of the gastrointestinal tract that contains both exocrine and endocrine components, with each component representing a minimum of 30% of the total tumor mass.

<jats:p />

From 1985 to 2016, the prevalence of underweight decreased, and that of obesity and severe obesity increased, in most regions, with significant variation in the magnitude of these changes across regions. We investigated how much change in mean body mass index (BMI) explains changes in the prevalence of underweight, obesity, and severe obesity in different regions using data from 2896 population-based studies with 187 million participants. Changes in the prevalence of underweight and total obesity, and to a lesser extent severe obesity, are largely driven by shifts in the distribution of BMI, with smaller contributions from changes in the shape of the distribution. In East and Southeast Asia and sub-Saharan Africa, the underweight tail of the BMI distribution was left behind as the distribution shifted. There is a need for policies that address all forms of malnutrition by making healthy foods accessible and affordable, while restricting unhealthy foods through fiscal and regulatory restrictions.

Parental involvement (PI) in education contributes to numerous positive outcomes in children, including educational outcomes and social competence. The goal of the present study was to examine differences in PI mechanisms between parents of children with autism spectrum disorder (ASD) and parents of typically developing (TD) children. An additional goal was to examine factors affecting PI mechanisms in education in parents of children with ASD. The sample for this study consisted of 50 parents of children with ASD and 50 parents of TD children. The results of this study indicate that parents of children with ASD had lower levels of PI mechanisms in education than parents of TD children. The strongest predictors of PI mechanisms in education in parents of children with ASD were subjective well-being and child’s emotional reactivity. Implications for future research and practice are discussed.

On global level there is a large supply-demand imbalance for the worker with the right set of skills. Similarly, it is observed in Bosnia as well. Even though the unemployment rate is high in the country, the industry is struggling to get talents they need from the local market. On the other hand, the job seekers are rather preferring to look for job opportunities in EU countries since the packages of benefits are more attractive there. Bosnian industry is mainly based on labor intensive business and it is focused on lower cost as competitive advantage. Using this competitive advantage, the industry generates insufficient added value to offer competitive package of benefit to demanded talents from the global labor market. They have to switch to a new competitive advantage on differentiated unique solutions to target groups that will provide them with increased added value.

Over the years, the Web has become a premier source of information in almost every area we can think about. When considering tourism, the Web became the primary source of information for travelers. When planning trips, people search for information about destinations, accommodations, attractions, means of transportation, in short, everything related to their future trip. Once done searching they reserve almost everything online. The blessing of the easily accessible information comes with the curse of information overload. This brings Web search techniques and recommendation systems come into play. This is especially true recently with the appearance of COVID-19 and the uncertainty and transformative power it brings to travelling. WebTour 2021 brings together researchers and practitioners working on developing and improving tools and techniques for improving users ability to better find relevant information that matches their needs.

Differentiated vulvar intraepithelial neoplasia (dVIN) is a premalignant lesion that is known to progress rapidly to invasive carcinoma. Accurate histological diagnosis is therefore crucial to allow appropriate treatment. To identify reliable diagnostic features, we evaluated the inter-observer agreement in the histological assessment of dVIN, among a bi-national, multi-institutional group of pathologists. Two investigators from Erasmus MC selected 36 hematoxylin-eosin-stained glass slides of dVIN and no-dysplasia, and prepared a list of 15 histological features of dVIN. Nine participating pathologists (i) diagnosed each slide as dVIN or no-dysplasia, (ii) indicated which features they used for the diagnosis, and (iii) rated these features in terms of their diagnostic usefulness. Diagnoses rendered by > 50% participants were taken as the consensus (gold standard). p53-immunohistochemistry (IHC) was performed for all cases, and the expression patterns were correlated with the consensus diagnoses. Kappa (ĸ)-statistics were computed to measure inter-observer agreements, and concordance of the p53-IHC patterns with the consensus diagnoses. For the diagnosis of dVIN, overall agreement was moderate (ĸ = 0.42), and pair-wise agreements ranged from slight (ĸ = 0.10) to substantial (ĸ = 0.73). Based on the levels of agreement and ratings of usefulness, the most helpful diagnostic features were parakeratosis, cobblestone appearance, chromatin abnormality, angulated nuclei, atypia discernable under × 100, and altered cellular alignment. p53-IHC patterns showed substantial concordance (ĸ = 0.67) with the consensus diagnoses. Histological interpretation of dVIN remains challenging with suboptimal inter-observer agreement. We identified the histological features that may facilitate the diagnosis of dVIN. For cases with a histological suspicion of dVIN, consensus-based pathological evaluation may improve the reliability of the diagnosis.

Aims. To investigate morbidity and mortality in a real‐life cohort of patients with type 2 diabetes (T2D) in relation to prevalence and severity of nonalcoholic fatty liver disease (NAFLD). Methods. Patients with T2D were referred for assessment of liver fibrosis by the FIB‐4 test and liver stiffness measurement (LSM) by vibration‐controlled transient elastography (VCTE). Liver steatosis was quantified by the controlled attenuation parameter (CAP). These patients were followed until death or censored date. Results. Among 454 patients (52% males, mean age 62.5 years, BMI 30.9 kg/m2), 82.6% was overweight, 77.8% had fatty liver, and 9.9% and 3.1% had LSM and FIB‐4 values suggestive of advanced fibrosis, respectively. During the follow‐up period of median 2 years, 106 (23%) patients experienced adverse event (11% cardiovascular) and 17 (3.7%) died, whereas no liver‐related morbidity or mortality was observed. Independent predictors of adverse outcomes were age and higher platelet count, while FIB‐4, LSM, and CAP were not. Conclusion. In a cohort of T2D patients, no liver‐related morbidity or mortality occurred during 2 years. Our patients probably have low real prevalence of advanced fibrosis which is likely overestimated by LSM ≥ 9.6 kPa. Liver fibrosis may be safely reassessed in the 2 years interval in noncirrhotic patients with T2D.